Søren Brunak

Søren Brunak

Professor

ORCID: 0000-0003-0316-5866

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  1. Published

    Propionibacterium acnes: disease-causing agent or common contaminant? Detection in diverse patient samples by next-generation sequencing

    Mollerup, S., Friis-Nielsen, J., Vinner, Lasse, Hansen, T. A., Richter, S. R., Fridholm, E. M. H., Herrera, J. A. R., Lund, O., Brunak, Søren, Izarzugaza, J. M. G., Mourier, T., Nielsen, L. P. & Hansen, Anders Johannes, 2016, In: Journal of Clinical Microbiology. 54, 4, p. 980-987 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Cutavirus in cutaneous malignant melanoma

    Mollerup, S., Fridholm, E. M. H., Vinner, Lasse, Kjartansdóttir, K. R., Friis-Nielsen, J., Asplund, M., Romero, J. A. H., Steiniche, T., Mourier, T., Brunak, Søren, Willerslev, Eske, Izarzugaza, J. M. G., Hansen, Anders Johannes & Nielsen, L. P., Feb 2017, In: Emerging Infectious Diseases . 23, 2, p. 363-365 3 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  3. Published

    High-Throughput Sequencing-Based Investigation of Viruses in Human Cancers by Multienrichment Approach

    Mollerup, S., Asplund, M., Friis-Nielsen, J., Kjartansdóttir, K. R., Fridholm, H., Hansen, T. A., Herrera, J. A. R., Barnes, C. J., Jensen, R. H., Richter, S. R., Nielsen, I. B., Pietroni, C., Alquezar-Planas, D. E., Rey-Iglesia, A., Olsen, P. V. S., Rajpert-De Meyts, E., Groth-Pedersen, L., von Buchwald, C., Jensen, D. H., Gniadecki, R. & 20 others, Høgdall, Estrid Vilma Solyom, Langhoff, J. L., Pete, I., Vereczkey, I., Baranyai, Z., Dybkaer, K., Johnsen, H. E., Steiniche, T., Hokland, P., Rosenberg, Jacob, Baandrup, U., Sicheritz-Pontén, Thomas, Willerslev, Eske, Brunak, Søren, Lund, O., Mourier, T., Vinner, Lasse, Izarzugaza, J. M. G., Nielsen, L. P. & Hansen, Anders Johannes, 15 Oct 2019, In: The Journal of Infectious Diseases. 220, 8, p. 1312-1324

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study

    Molnos, S., Wahl, S., Haid, M., Eekhoff, E. M. W., Pool, R., Floegel, A., Deelen, J., Much, D., Prehn, C., Breier, M., Draisma, H. H., van Leeuwen, N., Simonis-Bik, A. M. C., Jonsson, A., Willemsen, G., Bernigau, W., Wang-Sattler, R., Suhre, K., Peters, A., Thorand, B. & 24 others, Herder, C., Rathmann, W., Roden, M., Gieger, C., Kramer, M. H. H., van Heemst, D., Pedersen, H. K., Gudmundsdottir, V., Schulze, M. B., Pischon, T., de Geus, E. J. C., Boeing, H., Boomsma, D. I., Ziegler, A. G., Slagboom, P. E., Hummel, S., Beekman, M., Grallert, H., Brunak, Søren, McCarthy, M. I., Gupta, R., Pearson, E. R., Adamski, J. & 't Hart, L. M., 2018, In: Diabetologia. 61, 1, p. 117-129 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Reply to: Immortal time bias in the analysis of drug prescription trajectories

    Mortensen, Laust Hvas & Brunak, Søren, 2022, In: npj Digital Medicine. 5, 1, 1 p., 191.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  6. Published

    Identifying Sepsis Phenotypes

    Moseley, P. L. & Brunak, Søren, 2019, In: J A M A: The Journal of the American Medical Association. 322, 14, p. 1416-1417 2 p.

    Research output: Contribution to journal › Comment/debate › Research

  7. Published

    Genetic prediction of 33 blood group phenotypes using an existing genotype dataset

    Moslemi, C., Sækmose, S. G., Larsen, R., Bay, J. T., Brodersen, T., Didriksen, M., Hjalgrim, H., Banasik, K., Nielsen, K. R., Bruun, M. T., Dowsett, J., Dinh, K. M., Mikkelsen, S., Mikkelsen, C., Hansen, T. F., Ullum, H., Erikstrup, C., Brunak, S., Krogfelt, K. A., Storry, J. R. & 3 others, Ostrowski, Sisse Rye, Olsson, M. L. & Pedersen, Ole Birger Vesterager, 2023, In: Transfusion. 63, 12, p. 2297-2310 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory

    Moulder, R., Välikangas, T., Hirvonen, M. K., Suomi, T., Brorsson, C. A., Lietzén, N., Bruggraber, S. F. A., Overbergh, L., Dunger, D. B., Peakman, M., Chmura, Piotr Jaroslaw, Brunak, Søren, Schulte, A. M., Mathieu, C., Knip, M., Elo, L. L., Lahesmaa, R. & on behalf of the INNODIA consortium, O. B. O. T. I. C., 2023, In: Diabetologia. 66, p. 1983-1996

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Population-wide analysis of hospital laboratory tests to assess seasonal variation and temporal reference interval modification

    Muse, V. P., Aguayo-Orozco, A., Balaganeshan, Sedrah Butt & Brunak, Søren, 2023, In: Patterns. 4, 8, 14 p., 100778.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Seasonally adjusted laboratory reference intervals to improve the performance of machine learning models for classification of cardiovascular diseases

    Muse, V. P., Placido, Davide, Haue, Amalie Dahl & Brunak, Søren, 2024, In: BMC Medical Informatics and Decision Making. 24, 62.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Protocol for EHR laboratory data preprocessing and seasonal adjustment using R and RStudio

    Muse, V. P. & Brunak, Søren, 2024, In: STAR Protocols. 5, 1, 11 p., 102912.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    An atlas of genetic determinants of forearm fracture

    Nethander, M., Movérare-Skrtic, S., Kämpe, A., Coward, E., Reimann, E., Grahnemo, L., Borbély, É., Helyes, Z., Funck-Brentano, T., Cohen-Solal, M., Tuukkanen, J., Koskela, A., Wu, J., Li, L., Lu, T., Gabrielsen, M. E., Mägi, R., Hoff, M., Lerner, U. H., Henning, P. & 15 others, Ullum, H., Erikstrup, C., Brunak, Søren, Langhammer, A., Tuomi, T., Oddsson, A., Stefansson, K., Pettersson-Kymmer, U., Ostrowski, Sisse Rye, Pedersen, Ole Birger Vesterager, Styrkarsdottir, U., Mäkitie, O., Hveem, K., Richards, J. B. & Ohlsson, C., 2023, In: Nature Genetics. 55, 11, p. 1820-1830 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Pharos: Collating protein information to shed light on the druggable genome

    Nguyen, D-T., Mathias, S., Bologa, C., Brunak, S., Fernandez, N., Gaulton, A., Hersey, A., Holmes, J., Jensen, L. J., Karlsson, A., Liu, G., Ma'ayan, A., Mandava, G., Mani, S., Mehta, S., Overington, J., Patel, J., Rouillard, A. D., Schürer, S., Sheils, T. & 10 others, Simeonov, A., Sklar, L. A., Southall, N., Ursu, O., Vidovic, D., Waller, A., Yang, J., Jadhav, A., Oprea, T. I. & Guha, R., Jan 2017, In: Nucleic Acids Research. 45, D1, p. D995–D1002

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Survival prediction in intensive-care units based on aggregation of long-term disease history and acute physiology: a retrospective study of the Danish National Patient Registry and electronic patient records

    Nielsen, A. B., Thorsen-Meyer, H. C., Belling, K., Nielsen, A. P., Thomas, Cecilia Engel, Chmura, Piotr Jaroslaw, Lademann, M., Moseley, P. L., Heimann, M., Dybdahl, L., Spangsege, L., Hulsen, P., Perner, Anders & Brunak, Søren, 2019, In: The Lancet Digital Health. 1, 2, p. e78-e89 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    A Brief History of Protein Sorting Prediction

    Nielsen, H., Tsirigos, Konstantinos, Brunak, Søren & von Heijne, G., 2019, In: The Protein Journal. 38, 3, p. 200-216 17 p.

    Research output: Contribution to journal › Review › Research › peer-review

  16. Published

    Mapping the human genetic architecture of COVID-19

    Niemi, M. E. K., Karjalainen, J., Liao, R. G., Neale, B. M., Daly, M., Ganna, A., Pathak, G. A., Andrews, S. J., Kanai, M., Veerapen, K., Fernandez-Cadenas, I., Schulte, E. C., Striano, P., Marttila, M., Minica, C., Marouli, E., Karim, M. A., Wendt, F. R., Savage, J., Sloofman, L. & 41 others, Butler-Laporte, G., Kim, H., Kanoni, S., Okada, Y., Byun, J., Han, Y., Uddin, M. J., Smith, G. D., Willer, C. J., Buxbaum, J. D., Karjalainen, J., Mehtonen, J., Folkersen, L., Moltke, Ida, Hinney, A., Wang, C., Ellinghaus, D., Brunak, Søren, Castro, P., Guindo Martínez, Marta, Lee, J. Y., Loos, Ruth, Zhao, J. H., Sun, Y. V., Wang, B., Parker, R., Garcia, S. M., Smith, O., Davis, C., COVID-19 Host Genetics Initiative, C. H. G. I., 23andMe COVID-19 Team, 2. C. T., Norwegian SARS-CoV-2 Study Grp, N. S. S. G., Humanitas COVID-19 Task Force, H. C. T. F., Humanitas Gavazzeni COVID-19 Task, H. G. C. T., FHoGID, F., RegCOVID, R., P-PredictUs, P., SeroCOVID, S., CRiPSI, C., Genes & Hlth Res Team, G. &. H. R. T. & UCLA Hlth ATLAS Data Mart Working, U. H. A. D. M. W., 2021, In: Nature. 600, p. 472-477

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Effects of active farnesoid X receptor on GLUTag enteroendocrine L cells

    Niss, K., Jakobsson, M. E., Westergaard, David, Belling, K. G., Olsen, Jesper Velgaard & Brunak, Søren, 2020, In: Molecular and Cellular Endocrinology. 517, 9 p., 110923.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Complete Topological Mapping of a Cellular Protein Interactome Reveals Bow-Tie Motifs as Ubiquitous Connectors of Protein Complexes

    Niss, K., Gomez-Casado, C., Hjaltelin, Jessica Xin, Joeris, T., Agace, W. W., Belling, K. G. & Brunak, Søren, 2020, In: Cell Reports. 31, 11, 15 p., 107763.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population

    Nissen, J., Trabjerg, B., Pedersen, M. G., Banasik, K., Pedersen, O. B., Sørensen, E., Nielsen, K. R., Erikstrup, C., Petersen, M. S., Paarup, H. M., Bruun-Rasmussen, P., Westergaard, D., Hansen, T. F., Pedersen, C. B., Werge, T., Torrey, F., Hjalgrim, H., Mortensen, P. B., Yolken, R., Brunak, S. & 2 others, Ullum, H. & Burgdorf, K. S., Oct 2019, In: Psychoneuroendocrinology. 108, p. 150-154

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Roadmap for a precision-medicine initiative in the Nordic region

    Njølstad, P. R., Andreassen, O. A., Brunak, S., Børglum, A. D., Dillner, J., Esko, T., Franks, P. W., Freimer, N., Groop, L., Heimer, H., Hougaard, D. M., Hovig, E., Hveem, K., Jalanko, A., Kaprio, J., Knudsen, G. P., Melbye, M., Metspalu, A., Mortensen, P. B., Palmgren, J. & 11 others, Palotie, A., Reed, W., Stefánsson, H., Stitziel, N. O., Sullivan, P. F., Thorsteinsdóttir, U., Vaudel, M., Vuorio, E., Werge, Thomas, Stoltenberg, C. & Stefánsson, K., 2019, In: Nature Genetics. 51, p. 924-930

    Research output: Contribution to journal › Comment/debate › Research

  21. Published

    Investigating the impact of missense mutations in hCES1 by in silico structure-based approaches

    Nzabonimpa, G. S., Rasmussen, Henrik Berg, Brunak, Søren, Taboureau, O. & INDICES Consortium, I. C., Jun 2016, In: Drug Metabolism and Personalized Therapy. 31, 2, p. 97-106 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study

    Obura, M., Beulens, J. W. J., Slieker, R., Koopman, A. D. M., Hoekstra, T., Nijpels, G., Elders, P., Koivula, R. W., Kurbasic, A., Laakso, M., Hansen, T. H., Ridderstråle, M., Hansen, T., Pavo, I., Forgie, I., Jablonka, B., Ruetten, H., Mari, A., McCarthy, M. I., Walker, M. & 19 others, Heggie, A., McDonald, T. J., Perry, M. H., De Masi, F., Brunak, Søren, Mahajan, A., Giordano, G. N., Kokkola, T., Dermitzakis, E., Viñuela, A., Pedersen, Oluf Borbye, Schwenk, J. M., Adamski, J., Teare, H. J. A., Pearson, E. R., Franks, P. W., Hart, L. M. T., Rutters, F. & for the IMI-DIRECT Consortium, F. T. I. C., 2020, In: PLoS ONE. 15, 11, 11 p., e0242360.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality

    Oddsson, A., Sulem, P., Sveinbjornsson, G., Arnadottir, G. A., Steinthorsdottir, V., Halldorsson, G. H., Atlason, B. A., Oskarsson, G. R., Helgason, H., Nielsen, H. S., Westergaard, D., Karjalainen, J. M., Katrinardottir, H., Fridriksdottir, R., Jensson, B. O., Tragante, V., Ferkingstad, E., Jonsson, H., Gudjonsson, S. A., Beyter, D. & 31 others, Moore, K. H. S., Thordardottir, H. B., Kristmundsdottir, S., Stefansson, O. A., Rantapää-Dahlqvist, S., Sonderby, I. E., Didriksen, Maria, Stridh, P., Haavik, J., Tryggvadottir, L., Frei, O., Walters, G. B., Kockum, I., Hjalgrim, Henrik, Olafsdottir, T. A., Selbaek, G., Nyegaard, M., Erikstrup, C., Brodersen, T., Saevarsdottir, S., Olsson, T., Nielsen, K. R., Hansen, Thomas Folkmann, Brunak, Søren, Jacobsen, R. L., Brunak, Søren, Banasik, Karina, Askling, J., Pedersen, Ole Birger Vesterager, Ostrowski, Sisse Rye & DBDS Genomic Consortium, D. G. C., 2023, In: Nature Communications. 14, 15 p., 3453.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis

    Olsen, Jesper Velgaard, Vermeulen, M., Santamaria, A., Kumar, C., Miller, M. L., Jensen, Lars Juhl, Gnad, F., Cox, J., Jensen, T. S., Nigg, E. A., Brunak, Søren & Mann, Matthias, 2010, In: Science Signaling. 3, 104, p. ra3 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Unexplored therapeutic opportunities in the human genome

    Oprea, T. I., Bologa, C. G., Brunak, S., Campbell, A., Gan, G. N., Gaulton, A., Gomez, S. M., Guha, R., Hersey, A., Holmes, J., Jadhav, A., Jensen, L. J., Johnson, G. L., Karlson, A., Leach, A. R., Ma'ayan, A., Malovannaya, A., Mani, S., Mathias, S. L., McManus, M. T. & 21 others, Meehan, T. F., von Mering, C., Muthas, D., Nguyen, D., Overington, J. P., Papadatos, G., Qin, J., Reich, C., Roth, B. L., Schürer, S. C., Simeonov, A., Sklar, L. A., Southall, N., Tomita, S., Tudose, I., Ursu, O., Vidovic, D., Waller, A., Westergaard, David, Yang, J. J. & Zahoránszky-Köhalmi, G., 2018, In: Nature Reviews. Drug Discovery. 17, 5, p. 317-332 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  26. Published

    In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects

    Orozco, A. A., Audouze, K., Brunak, Søren & Taboureau, O., 2016, In: Current Pharmaceutical Design. 22, 46, p. 6895-6902 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Integrative pathway enrichment analysis of multivariate omics data

    Paczkowska, M., Barenboim, J., Sintupisut, N., Fox, N. S., Zhu, H., Abd-Rabbo, D., Mee, M. W., Boutros, P. C., Abascal, F., Amin, S. B., Bader, G. D., Beroukhim, R., Bertl, J., Boroevich, K. A., Brunak, S., Campbell, P. J., Carlevaro-Fita, J., Chakravarty, D., Chan, C. W. Y., Chen, K. & 30 others, Choi, J. K., Deu-Pons, J., Dhingra, P., Diamanti, K., Feuerbach, L., Fink, J. L., Fonseca, N. A., Frigola, J., Gambacorti-Passerini, C., Garsed, D. W., Gerstein, M., Getz, G., Gonzalez-Perez, A., Guo, Q., Gut, I. G., Haan, D., Hamilton, M. P., Haradhvala, N. J., Harmanci, A. O., Helmy, M., Herrmann, C., Hess, J. M., Hobolth, A., Hodzic, E., Hong, C., Hornshøj, H., Nielsen, M. M., Pedersen, J. S., Sidiropoulos, N. & Weischenfeldt, Joachim Lütken, 5 Feb 2020, In: Nature Communications. 11, 1, 735.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    SNP mining porcine ESTs with MAVIANT, a novel tool for SNP evaluation and annotation

    Panitz, F., Stengaard, H., Hornshøj, H., Gorodkin, J., Hedegaard, J., Cirera, S., Thomsen, B. S., Madsen, L. B., Høj, A., Vingborg, R., Zahn, B., Wang, X., Wang, X., Wernersson, R., Jørgensen, C. B., Scheibye-Knudsen, K., Arvin, T., Lumholdt, S., Sawera, M., Green, T. & 5 others, Nielsen, B., Havgaard, Jakob Hull, Brunak, Søren, Fredholm, Merete & Bendixen, C., 2007, In: Bioinformatics. 23, 13, p. i387-91 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization

    Pappalardo, F., Halling-Brown, M. D., Rapin, N., Zhang, P., Alemani, D., Emerson, A., Paci, P., Duroux, L. P., Pennisi, M., Palladini, A., Miotto, O., Churchill, D., Rossi, E., Shepherd, A. J., Moss, D. S., Castiglione, F., Bernaschi, M., Lefranc, M-P., Brunak, S., Motta, S. & 3 others, Lollini, P., Basford, K. E. & Brusic, V., 2009, In: Briefings in Bioinformatics. 10, 3, p. 330-40 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. A DNA structural atlas for Escherichia coli

    Pedersen, A. G., Jensen, L. J., Brunak, Søren, Staerfeldt, H. H. & Ussery, D., 2000, In: Journal of Molecular Biology. 299, 4, p. 907-30 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Pancreatic Islet Protein Complexes and Their Dysregulation in Type 2 Diabetes

    Pedersen, H. K., Gudmundsdottir, V. & Brunak, Søren, 2017, In: Frontiers in Genetics. 8, 43.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Ranking factors involved in diabetes remission after bariatric surgery using machine-learning integrating clinical and genomic biomarkers

    Pedersen, H. K., Gudmundsdottir, V., Pedersen, M. K., Brorsson, C., Brunak, Søren & Gupta, R., 2016, In: npj Genomic Medicine. 1, 16035.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    A computational framework to integrate high-throughput "-omics" datasets for the identification of potential mechanistic links

    Pedersen, H. K., Forslund, S. K., Gudmundsdottir, V., Petersen, A. Ø., Hildebrand, F., Hyötyläinen, T., Nielsen, T., Hansen, Torben, Bork, P., Ehrlich, S. D., Brunak, Søren, Oresic, M., Pedersen, Oluf Borbye & Nielsen, H. B., 2018, In: Nature Protocols. 13, 12, p. 2781-2800 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Human gut microbes impact host serum metabolome and insulin sensitivity

    Pedersen, H. K., Gudmundsdottir, V., Nielsen, H. B., Hyotylainen, T., Nielsen, T., Jensen, B. A. H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., Le Chatelier, E., Levenez, F., Doré, J., Mattila, I., Plichta, D. R., Pöhö, P., Hellgren, L. I., Arumugam, M., Sunagawa, S., Vieira-Silva, S. & 14 others, Jørgensen, T., Holm, J. B., Trošt, K., Kristiansen, Karsten, Brix, Susanne, Raes, J., Wang, J., Hansen, Torben, Bork, P., Brunak, Søren, Oresic, M., Ehrlich, S. D., Pedersen, Oluf Borbye & MetaHIT Consortium, M. C., 2016, In: Nature. 535, 7612, p. 376-381 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    A unidirectional mapping of ICD-8 to ICD-10 codes, for harmonized longitudinal analysis of diseases

    Pedersen, M. K., Eriksson, R., Reguant, R., Collin, C., Pedersen, H. K., Sørup, Freja Karuna Hemmingsen, Simon, C., Birch, A. M., Larsen, Michael, Nielsen, A. P., Belling, K. & Brunak, Søren, 2023, In: European Journal of Epidemiology. 38, p. 1043–1052 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    MetaRanker 2.0: a web server for prioritization of genetic variation data

    Pers, T. H., Dworzynski, P., Thomas, C. E., Hansen, K. L. & Brunak, Søren, 1 Jul 2013, In: Nucleic Acids Research. 41, W1, p. W104-W108

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes

    Pers, T. H., Hansen, N. T., Hansen, K. L., Koefoed, P., Dworzynski, P., Miller, M. L., Flint, T. J., Mellerup, E., Dam, H., Andreassen, O. A., Djurovic, S., Melle, I., Børglum, A. D., Werge, T., Purcell, S., Ferreira, M. A., Kouskoumvekaki, I., Workman, C., Hansen, T., Mors, O. & 1 others, Brunak, Søren, 11 Apr 2011, In: Genetic Epidemiology. 35, 5, p. 318-332 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    SignalP 4.0: discriminating signal peptides from transmembrane regions

    Petersen, T. N., Brunak, Søren, von Heijne, G. & Nielsen, H., 2011, In: Nature Methods. 8, 10, p. 785-6 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Development and validation of a dynamic prediction model for unplanned ICU admission and mortality in hospitalized patients

    Placido, Davide, Thorsen-Meyer, H., Kaas-Hansen, Benjamin Skov, Reguant, R. & Brunak, Søren, 2022.

    Research output: Working paper › Preprint › Research

  40. Published

    A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories

    Placido, D., Yuan, B., Hjaltelin, J. X., Zheng, C., Haue, A. D., Chmura, P. J., Yuan, C., Kim, J., Umeton, R., Antell, G., Chowdhury, A., Franz, A., Brais, L., Andrews, E., Marks, D. S., Regev, A., Ayandeh, S., Brophy, M. T., Do, N. V., Kraft, P. & 5 others, Wolpin, B. M., Rosenthal, M. H., Fillmore, N. R., Brunak, Søren & Sander, C., 2023, In: Nature Medicine. 29, p. 1113-1122

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Development of a dynamic prediction model for unplanned ICU admission and mortality in hospitalized patients

    Placido, Davide, Thorsen-Meyer, H., Kaas-Hansen, Benjamin Skov, Reguant, R. & Brunak, Søren, 2023, In: PLOS Digital Health. 2, 6, 18 p., e0000116.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Transcriptional interactions suggest niche segregation among microorganisms in the human gut

    Plichta, D. R., Juncker, A. S., Bertalan, M., Rettedal, E., Gautier, L., Varela, E., Manichanh, C., Fouqueray, C., Levenez, F., Nielsen, T., Doré, J., Machado, A. M. D., de Evgrafov, M. C. R., Hansen, T., Jørgensen, T., Bork, P., Guarner, F., Pedersen, O., Metagenomics of the Human Intestinal Tract (MetaHIT) Consortium, Sommer, M. O. A. & 4 others, Ehrlich, S. D., Sicheritz-Pontén, T., Brunak, Søren & Nielsen, H. B., 26 Aug 2016, In: Nature Microbiology. 1, p. 1-6 6 p., 16152.

    Research output: Contribution to journal › Letter › Research › peer-review

  43. Published

    KinMutRF: a random forest classifier of sequence variants in the human protein kinase superfamily

    Pons, T., Vazquez, M., Matey-Hernandez, M. L., Brunak, Søren, Valencia, A. & Izarzugaza, J. M., 23 Jun 2016, In: BMC Genomics. 17, Suppl 2, 11 p., 396.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1+ precursors

    Pærregaard, S. I., Wulff, L., Schussek, S., Niss, K., Mörbe, U., Jendholm, J., Wendland, K., Andrusaite, A. T., Brulois, K. F., Nibbs, R. J. B., Sitnik, K., Mowat, A. M. I., Butcher, E. C., Brunak, Søren & Agace, W. W., 2023, In: Nature Communications. 14, 1, 2307.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors

    Pérez-Alós, L., Armenteros, J. J. A., Madsen, J. R., Hansen, C. B., Jarlhelt, I., Hamm, S. R., Heftdal, L. D., Pries-Heje, M. M., Møller, D. L., Fogh, K., Hasselbalch, R. B., Rosbjerg, A., Brunak, S., Sørensen, E., Larsen, M. A. H., Ostrowski, S. R., Frikke-Schmidt, R., Bayarri-Olmos, R., Hilsted, L. M., Iversen, K. K. & 3 others, Bundgård, Henning, Nielsen, Susanne Dam & Garred, Peter, 2022, In: Nature Communications. 13, 1, 11 p., 1614.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    A human gut microbial gene catalogue established by metagenomic sequencing

    MetaHIT Consortium, M. C., 2010, In: Nature. 464, 7285, p. 59-65 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Lapatinib potentiates cytotoxicity of  YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter

    Radic-Sarikas, B., Halasz, M., Huber, K. V. M., Winter, G. E., Tsafou, K. P., Papamarkou, T., Brunak, Søren, Kolch, W. & Superti-Furga, G., 8 Jun 2017, In: Scientific Reports. 7, 1, p. 3091

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Modelling the human immune system by combining bioinformatics and systems biology approaches

    Rapin, N., Kesmir, C., Frankild, S., Nielsen, M., Lundegaard, C., Brunak, Søren & Lund, O., 2006, In: Journal of Biological Physics. 32, 3-4, p. 335-53 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Nomenclature for alleles of the human carboxylesterase 1 gene

    INDICES Consortium, I. C., 1 Jan 2017, In: Pharmacogenetics and Genomics. 27, 2, p. 78-80 3 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  50. Published

    Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics

    Rasmussen, Henrik Berg, Bjerre, D., Linnet, Kristian, Jürgens, G., Dalhoff, Kim, Stefansson, H., Hankemeier, T., Kaddurah-Daouk, R., Taboureau, O., Brunak, Søren, Houmann, T., Jeppesen, Pia, Pagsberg, Anne Katrine, Plessen, K., Dyrborg, J., Hansen, Peter Riis, Hansen, P. E., Hughes, T., Werge, Thomas & INDICES Consortium, I. C., Apr 2015, In: Pharmacogenomics. 16, 6, p. 649-65

    Research output: Contribution to journal › Review › Research › peer-review

  51. Published

    An Aboriginal Australian genome reveals separate human dispersals into Asia

    Rasmussen, M., Guo, X., Wang, Y., Lohmueller, K. E., Rasmussen, S., Albrechtsen, A., Skotte, L., Lindgreen, S., Metspalu, M., Jombart, T., Kivisild, T., Zhai, W., Eriksson, A., Manica, A., Orlando, L., De La Vega, F. M., Tridico, S., Metspalu, E., Nielsen, K., Avila Arcos, M. D. C. & 38 others, Moreno Mayar, J. Víctor, Muller, C., Dortch, J., Gilbert, M Thomas P, Lund, O., Wesolowska, A., Karmin, M., Weinert, L. A., Wang, B., Li, J., Tai, S., Xiao, F., Hanihara, T., van Driem, G., Jha, A. R., Ricaut, F., de Knijff, P., Migliano, A. B., Gallego Romero, I., Kristiansen, Karsten, Lambert, D. M., Brunak, Søren, Forster, P., Brinkmann, B., Nehlich, O., Bunce, M., Richards, M., Gupta, R., Bustamante, C. D., Krogh, Anders, Foley, R. A., Lahr, M. M., Balloux, F., Sicheritz-Pontén, T., Villems, R., Nielsen, Rasmus, Wang, J. & Willerslev, Eske, 2011, In: Science. 334, 6052, p. 94-98 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Ancient human genome sequence of an extinct Palaeo-Eskimo

    Rasmussen, M., Li, Y., Lindgreen, S., Pedersen, J. S., Albrechtsen, A., Moltke, I., Metspalu, M., Metspalu, E., Kivisild, T., Gupta, R., Bertalan, M., Nielsen, K., Gilbert, T., Wang, Y., Raghavan, M., Campos, P., Kamp, H. L. M., Wilson, A. S., Gledhill, A., Tridico, S. & 32 others, Bunce, M., Lorenzen, Eline, Binladen, J. K. M. A., Guo, X., Zhao, J., Zhang, X., Zhang, H., Li, Z., Chen, M., Orlando, L. A. A., Kristiansen, Karsten, Bak, M., Tommerup, Niels, Bendixen, C., Pierre, T. L., Grønnow, B., Meldgaard, Morten, Andreasen, C., Fedorova, S. A., Osipova, L. P., Higham, T. F. G., Ramsey, C. B., Hansen, Thomas van Overeem, Nielsen, Finn Cilius, Crawford, M. H., Brunak, Søren, Sicheritz-Pontén, T., Villems, R., Nielsen, Rasmus, Krogh, Anders, Wang, J. & Willerslev, Eske, 11 Feb 2010, In: Nature. 463, 7282, p. 757-762 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Early divergent strains of Yersinia pestis in Eurasia 5,000 years ago

    Rasmussen, S., Allentoft, M. E., Nielsen, K., Orlando, L. A. A., Sikora, M., Sjögren, K-G., Pedersen, A. G., Schubert, M., Van Dam, A., Kapel, C. M. O., Nielsen, H. B., Brunak, S., Avetisyan, P., Epimakhov, A., Khalyapin, M. V., Gnuni, A., Kriiska, A., Lasak, I., Metspalu, M., Moiseyev, V. & 11 others, Gromov, A., Pokutta, D., Saag, L., Varul, L., Yepiskoposyan, L., Sicheritz-Ponten, T., Foley, R. A., Lahr, M. M., Nielsen, R., Kristiansen, K. & Willerslev, Eske, 2015, In: Cell. 163, 3, p. 571-582 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Lineage-specific interface proteins match up the cell cycle and differentiation in embryo stem cells

    Re, A., Workman, C. T., Waldron, L., Quattrone, A. & Brunak, Søren, 4 Aug 2014, In: Stem Cell Research. 13, 2, p. 316-328 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae

    Regenberg, Birgitte, Grotkjaer, T., Winther, Ole, Fausbøll, A., Akesson, M., Bro, C., Hansen, L. K., Brunak, Søren & Nielsen, Jens Bo, 2006, In: Genome Biology (Online Edition). 7, 11, p. R107

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Understanding inherent image features in CNN-based assessment of diabetic retinopathy

    Reguant, R., Brunak, Søren & Saha, S., 2021, In: Scientific Reports. 11, 12 p., 9704.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Pathway and network analysis of more than 2500 whole cancer genomes

    Reyna, M. A., Haan, D., Paczkowska, M., Verbeke, L. P. C., Vazquez, M., Kahraman, A., Pulido-Tamayo, S., Barenboim, J., Wadi, L., Dhingra, P., Shrestha, R., Getz, G., Lawrence, M. S., Pedersen, J. S., Rubin, M. A., Wheeler, D. A., Brunak, S., Izarzugaza, J. M. G., Khurana, E., Marchal, K. & 32 others, von Mering, C., Sahinalp, S. C., Valencia, A., Abascal, F., Amin, S. B., Bader, G. D., Bandopadhayay, P., Beroukhim, R., Bertl, J., Boroevich, K. A., Busanovich, J., Campbell, P. J., Carlevaro-Fita, J., Chakravarty, D., Chan, C. W. Y., Chen, K., Choi, J. K., Deu-Pons, J., Diamanti, K., Feuerbach, L., Fink, J. L., Fonseca, N. A., Frigola, J., Gambacorti-Passerini, C., Garsed, D. W., Gerstein, M., Larsson, E., Nielsen, M. M., Sidiropoulos, N., Weischenfeldt, Joachim Lütken, PCAWG Drivers and Functional Interpretation Working Group, P. D. A. F. I. W. G. & PCAWG Consortium, P. C., 2020, In: Nature Communications. 11, 1, p. 1-17 729.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Drug interactions in hospital prescriptions in Denmark: Prevalence and associations with adverse outcomes

    Rodríguez, C. L., Kaas-Hansen, Benjamin Skov, Eriksson, R., Biel, J. H., Belling, K. G., Andersen, Stig Ejdrup & Brunak, Søren, 2022, In: Pharmacoepidemiology and Drug Safety. 31, 6, p. 632-642 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Patient stratification and identification of adverse event correlations in the space of 1190 drug related adverse events

    Roitmann, E., Eriksson, R. & Brunak, Søren, 11 Sep 2014, In: Frontiers in Physiology. 5, 14 p., 332.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Uncovering the molecular machinery of the human spindle--an integration of wet and dry systems biology

    Rojas, A. M., Santamaria, A., Malik, R., Jensen, T. S., Körner, R., Morilla, I., de Juan, D., Krallinger, M., Hansen, D. A., Hoffmann, R., Lees, J., Reid, A., Yeats, C., Wehner, A., Elowe, S., Clegg, A. B., Brunak, S., Nigg, E. A., Orengo, C., Valencia, A. & 1 others, Ranea, J. A. G., 2012, In: P L o S One. 7, 3, p. e31813

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Semen quality and waiting time to pregnancy explored using association mining

    Romero Herrera, J. A., Bang, A. K., Priskorn, L., Izarzugaza, J. M. G., Brunak, Søren & Jørgensen, N., 2021, In: Andrology. 9, 2, p. 577-587 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    A proteomic study of the regulatory role for STAT-1 in cytokine-induced beta-cell death

    Rondas, D., Gudmundsdottir, V., D'Hertog, W., Crèvecoeur, I., Waelkens, E., Brunak, Søren, Mathieu, C. & Overbergh, L., Oct 2015, In: Proteomics - Clinical Applications. 9, 9-10, p. 938–952 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Using electronic patient records to discover disease correlations and stratify patient cohorts

    Roque, F. S., Jensen, P. B., Schmock, H., Dalgaard, M., Andreatta, M., Hansen, T., Søeby, K., Bredkjær, S., Juul, Anders, Werge, Thomas, Jensen, Lars Juhl & Brunak, Søren, 2011, In: P L o S Computational Biology. 7, 8, p. e1002141 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

    Roychowdhury, T., Klarin, D., Levin, M. G., Spin, J. M., Rhee, Y. H., Deng, A., Headley, C. A., Tsao, N. L., Gellatly, C., Zuber, V., Shen, F., Hornsby, W. E., Laursen, I. H., Verma, S. S., Locke, A. E., Einarsson, G., Thorleifsson, G., Graham, S. E., Dikilitas, O., Pattee, J. W. & 74 others, Judy, R. L., Pauls-Verges, F., Nielsen, J. B., Wolford, B. N., Brumpton, B. M., Dilmé, J., Peypoch, O., Juscafresa, L. C., Edwards, T. L., Li, D., Banasik, Karina, Brunak, Søren, Jacobsen, Rikke Vita Borre, Garcia-Barrio, M. T., Zhang, J., Rasmussen, L. M., Lee, R., Handa, A., Wanhainen, A., Mani, K., Lindholt, J. S., Obel, L. M., Strauss, E., Oszkinis, G., Nelson, C. P., Saxby, K. L., van Herwaarden, J. A., van der Laan, S. W., van Setten, J., Camacho, M., Davis, F. M., Wasikowski, R., Tsoi, L. C., Gudjonsson, J. E., Eliason, J. L., Coleman, D. M., Henke, P. K., Ganesh, S. K., Chen, Y. E., Guan, W., Pankow, J. S., Pankratz, N., Pedersen, Ole Birger Vesterager, Erikstrup, C., Tang, W., Hveem, K., Gudbjartsson, D., Gretarsdottir, S., Thorsteinsdottir, U., Holm, H., Stefansson, K., Ferreira, M. A., Baras, A., Kullo, I. J., Ritchie, M. D., Christensen, Alex Hørby, Iversen, Kasper, Eldrup, Nikolaj, Sillesen, Henrik, Ostrowski, Sisse Rye, Bundgård, Henning, Ullum, H., Burgess, S., Gill, D., Gallagher, K., Sabater-Lleal, M., Dudbridge, F., Samani, N. J., Surakka, I., Jones, G. T., Bown, M. J., Tsao, P. S., Willer, C. J. & Damrauer, S. M., 2023, In: Nature Genetics. 55, p. 1831–1842 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Comorbidity landscape of the Danish patient population affected by chromosomal abnormalities

    Russo, F., Jørgensen, Isabella Friis, Westergaard, David, Jensen, A. B., Hjaltelin, Jessica Xin, Belling, K. & Brunak, Søren, 2018, In: European Journal of Human Genetics. 26, p. 697-698

    Research output: Contribution to journal › Conference abstract in journal › Research

  66. Published

    miRandola 2017: a curated knowledge base of non-invasive biomarkers

    Russo, F., Di Bella, S., Vannini, F., Berti, G., Scoyni, F., Cook, H. V., Santos, A., Nigita, G., Bonnici, V., Laganà, A., Geraci, F., Pulvirenti, A., Giugno, R., De Masi, F., Belling, K., Jensen, Lars Juhl, Brunak, Søren, Pellegrini, M. & Ferro, A., 1 Jan 2018, In: Nucleic Acids Research. 46, D1, p. D354-D359 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    The hunt for fatal myocardial infarction biomarkers: predictive circulating microRNAs

    Russo, F., Rizzo, M., Belling, K., Brunak, Søren & Folkersen, L., Oct 2016, In: Journal of Translational Medicine. 4, Suppl 1, 4 p., S1.

    Research output: Contribution to journal › Editorial › Research

  68. Published

    Combing the Hairball: Improving Visualization of miRNA-Target Interaction Networks

    Russo, F., Hjaltelin, Jessica Xin, Romero Herrera, J. A. & Brunak, Søren, 2019, MicroRNA Target Identification: Methods and Protocols. Laganà, A. (ed.). Humana Press, p. 279-289 11 p. (Methods in Molecular Biology, Vol. 1970).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  69. Published

    The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease

    Russo, F., De Masi, F., Brunak, Søren & Belling, K. G., 2018, Systems Biology. Rajewsky, N., Jurga, S. & Barciszewski, J. (eds.). Springer, p. 229-238 (RNA Technologies).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  70. Published

    MicroRNAs, Regulatory Networks, and Comorbidities: Decoding Complex Systems

    Russo, F., Belling, K., Jensen, A. B., Scoyni, F., Brunak, Søren & Pellegrini, M., 2017, In: Methods in molecular biology (Clifton, N.J.). 1580, p. 281-295 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

    Saevarsdottir, S., Stefansdottir, L., Sulem, P., Thorleifsson, G., Ferkingstad, E., Rutsdottir, G., Glintborg, B., Westerlind, H., Grondal, G., Loft, I. C., Sorensen, S. B., Lie, B. A., Brink, M., Ärlestig, L., Arnthorsson, A. O., Baecklund, E., Banasik, K., Bank, S., Bjorkman, L. I., Ellingsen, T. & 31 others, Erikstrup, C., Frei, O., Gjertsson, I., Gudbjartsson, D. F., Gudjonsson, S. A., Halldorsson, G. H., Hendricks, O., Hillert, J., Høgdall, Estrid Vilma Solyom, Jacobsen, Søren, Jensen, D. V., Jonsson, H., Kastbom, A., Kockum, I., Kristensen, S., Kristjansdottir, H., Larsen, M. H., Linauskas, A., Hauge, E., Loft, A. G., Ludviksson, B. R., Lund, S. H., Ostrowski, Sisse Rye, Sørensen, E., Sørensen, I. J., Brunak, Søren, Andersen, V., Hetland, Merete Lund, Askling, J., Pedersen, Ole Birger Vesterager & Members of the DBDS Genomic Consortium, M. O. T. D. G. C., 2022, In: Annals of the Rheumatic Diseases. 81, 8, p. 1085-1095

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    eTRANSAFE: data science to empower translational safety assessment

    Sanz, F., Pognan, F., Steger-Hartmann, T., Díaz, C., Asakura, S., Amberg, A., Bécourt-Lhote, N., Blomberg, N., Bosc, N., Briggs, K., Bringezu, F., Brulle-Wohlhueter, C., Brunak, S., Bueters, R., Callegaro, G., Capella-Gutierrez, S., Centeno, E., Corvi, J., Cronin, M. T. D., Drew, P. & 41 others, Duchateau-Nguyen, G., Ecker, G. F., Escher, S., Felix, E., Ferreiro, M., Frericks, M., Furlong, L. I., Geiger, R., George, C., Grandits, M., Ivanov-Draganov, D., Kilgour-Christie, J., Kiziloren, T., Kors, J. A., Koyama, N., Kreuchwig, A., Leach, A. R., Mayer, M. A., Monecke, P., Muster, W., Nakazawa, C. M., Nicholson, G., Parry, R., Pastor, M., Piñero, J., Oberhauser, N., Ramírez-Anguita, J. M., Rodrigo, A., Smajic, A., Schaefer, M., Schieferdecker, S., Soininen, I., Terricabras, E., Trairatphisan, P., Turner, S. C., Valencia, A., van de Water, B., van der Lei, J. L., van Mulligen, E. M., Vock, E. & Wilkinson, D., 2023, In: Nature Reviews Drug Discovery. 22, 8, p. 605-606 2 p.

    Research output: Contribution to journal › Comment/debate › Research

  73. Legacy data sharing to improve drug safety assessment: the eTOX project

    Sanz, F., Pognan, F., Steger-Hartmann, T., Díaz, C., Cases, M., Pastor, M., Marc, P., Wichard, J., Briggs, K., Watson, D. K., Kleinöder, T., Yang, C., Amberg, A., Beaumont, M., Brookes, A. J., Brunak, S., Cronin, M. T. D., Ecker, G. F., Escher, S., Greene, N. & 17 others, Guzmán, A., Hersey, A., Jacques, P., Lammens, L., Mestres, J., Muster, W., Northeved, H., Pinches, M., Saiz, J., Sajot, N., Valencia, A., van der Lei, J., Vermeulen, N. P. E., Vock, E., Wolber, G., Zamora, I. & eTOX, E., Dec 2017, In: Nature Reviews. Drug Discovery. 16, 12, p. 811-812 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  74. Published

    Author Correction: Leveraging European infrastructures to access 1 million human genomes by 2022

    Saunders, G., Baudis, M., Becker, R., Beltran, S., Béroud, C., Birney, E., Brooksbank, C., Brunak, S., Van den Bulcke, M., Drysdale, R., Capella-Gutierrez, S., Flicek, P., Florindi, F., Goodhand, P., Gut, I., Heringa, J., Holub, P., Hooyberghs, J., Juty, N., Keane, T. M. & 21 others, Korbel, J. O., Lappalainen, I., Leskosek, B., Matthijs, G., Mayrhofer, M. T., Metspalu, A., Navarro, A., Newhouse, S., Nyrönen, T., Page, A., Persson, B., Palotie, A., Parkinson, H., Rambla, J., Salgado, D., Steinfelder, E., Swertz, M. A., Valencia, A., Varma, S., Blomberg, N. & Scollen, S., Nov 2019, In: Nature Reviews. Genetics. 20, 11, p. 702

    Research output: Contribution to journal › Comment/debate › Research

  75. Published

    Leveraging European infrastructures to access 1 million human genomes by 2022

    Saunders, G., Baudis, M., Becker, R., Beltran, S., Béroud, C., Birney, E., Brooksbank, C., Brunak, S., Van den Bulcke, M., Drysdale, R., Capella-Gutierrez, S., Flicek, P., Florindi, F., Goodhand, P., Gut, I., Heringa, J., Holub, P., Hooyberghs, J., Juty, N., Keane, T. M. & 21 others, Korbel, J. O., Lappalainen, I., Leskosek, B., Matthijs, G., Mayrhofer, M. T., Metspalu, A., Navarro, A., Newhouse, S., Nyrönen, T., Page, A., Persson, B., Palotie, A., Parkinson, H., Rambla, J., Salgado, D., Steinfelder, E., Swertz, M. A., Valencia, A., Varma, S., Blomberg, N. & Scollen, S., 2019, In: Nature Reviews. Genetics. 20, p. 693-701 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  76. Published

    High-throughput sequencing of circulating plasma microRNAs in newly diagnosed type 1 diabetes identifies four different patient clusters

    Sebastiani, G., Grieco, G. E., Fignani, D., Chmura, Piotr Jaroslaw, Brorsson, C. A., Bruggraber, S., Pugliese, A., Evans-Molina, C., Knip, M., Peakman, M., Schulte, A. M., Brunak, Søren, Dunger, D. B., Mathieu, C. & Dotta, F., 2020, In: Diabetologia. 63, Suppl. 1, p. S160 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  77. Published

    A genome-wide association study of social trust in 33,882 Danish blood donors

    Sequeros, C. B., Hansen, T. F., Westergaard, D., Louloudis, I., Kalamajski, S., Röder, T., Rohde, P. D., Schwinn, M., Clemmensen, L. H., Didriksen, M., Nyegaard, M., Hjalgrim, H., Nielsen, K. R., Bruun, M. T., Ostrowski, S. R., Erikstrup, C., Mikkelsen, S., Sørensen, E., Pedersen, O. B. V., Brunak, S. & 3 others, Banasik, Karina, Giordano, G. N. & DBDS Genomic Consortium, D. G. C., 2024, In: Scientific Reports. 14, 12 p., 1402.

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. Published

    Combined burden and functional impact tests for cancer driver discovery using DriverPower

    Shuai, S., Abascal, F., Amin, S. B., Bader, G. D., Bandopadhayay, P., Barenboim, J., Beroukhim, R., Bertl, J., Boroevich, K. A., Brunak, S., Campbell, P. J., Carlevaro-Fita, J., Chakravarty, D., Chan, C. W. Y., Chen, K., Choi, J. K., Deu-Pons, J., Dhingra, P., Diamanti, K., Feuerbach, L. & 32 others, Fink, J. L., Fonseca, N. A., Frigola, J., Gambacorti-Passerini, C., Garsed, D. W., Gerstein, M., Getz, G., Guo, Q., Gut, I. G., Haan, D., Hamilton, M. P., Haradhvala, N. J., Harmanci, A. O., Helmy, M., Herrmann, C., Hess, J. M., Hobolth, A., Hodzic, E., Hong, C., Hornshøj, H., Isaev, K., Izarzugaza, J. M. G., Johnson, R., Johnson, T. A., Juul, M., Juul, R. I., Kahles, A., Pedersen, J. S., Sidiropoulos, N., Weischenfeldt, Joachim Lütken, PCAWG Drivers and Functional Interpretation Working Group, P. D. A. F. I. W. G. & PCAWG Consortium, P. C., 2020, In: Nature Communications. 11, 1, 12 p., 734.

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. Published

    Accurate genotyping across variant classes and lengths using variant graphs

    Sibbesen, Jonas Andreas, Maretty, L., Krogh, Anders, Petersen, Bent, Sibbesen, Jonas Andreas, Liu, S., Have, C. T., Bork-Jensen, J., Guo, X., Hansen, Torben, Krogh, Anders, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye, Wang, J. & Brunak, Søren, 2018, In: Nature Genetics. 50, p. 1054-1059 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Disease trajectory browser for exploring temporal, population-wide disease progression patterns in 7.2 million Danish patients

    Siggaard, T., Reguant, R., Jørgensen, Isabella Friis, Haue, Amalie Dahl, Lademann, M., Aguayo-Orozco, A., Hjaltelin, Jessica Xin, Jensen, A. B., Banasik, Karina & Brunak, Søren, 2020, In: Nature Communications. 11, 1, 10 p., 4952.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Deep integrative models for large-scale human genomics

    Sigurdsson, Arnór Ingi, Louloudis, Ioannis, Banasik, Karina, Westergaard, David, Winther, Ole, Lund, O., Ostrowski, Sisse Rye, Erikstrup, C., Pedersen, Ole Birger Vesterager, Nyegaard, Mette, Brunak, Søren, Vilhjálmsson, B. & Rasmussen, Simon, 2023, In: Nucleic Acids Symposium Series. 51, 12, 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    Analysis of 62 hybrid assembled human Y chromosomes exposes rapid structural changes and high rates of gene conversion

    Skov, L., Schierup, M. H., Danish Pan Genome Consortium, D. P. G. C., Sørensen, L. M., Petersen, Bent, Sibbesen, Jonas Andreas, Liu, S., Belling, K. G., Have, C. T., Bork-Jensen, J., Hansen, Torben, Krogh, Anders, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye, Rasmussen, Simon, Kristiansen, Karsten & Brunak, Søren, 2017, In: PLOS Genetics. 13, 8, p. e1006834

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. The atlas visualisation of genome-wide information

    Skovgaard, M., Jensen, L. J., Friis, C., Stærfeldt, H. H., Worning, P., Brunak, Søren & Ussery, D. W., 2002, Methods in Microbiology. Vol. 33. p. 49-63

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  84. Published

    On the total number of genes and their length distribution in complete microbial genomes

    Skovgaard, M., Jensen, Lars Juhl, Brunak, Søren, Ussery, D. & Krogh, Anders, 2001, In: Trends in Genetics. 17, 8, p. 425-8 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome

    Skuladottir, A. T., Bjornsdottir, G., Ferkingstad, E., Einarsson, G., Stefansdottir, L., Nawaz, M. S., Oddsson, A., Olafsdottir, T. A., Saevarsdottir, S., Walters, G. B., Magnusson, S. H., Bjornsdottir, A., Sveinsson, O. A., Vikingsson, A., Hansen, T. F., Jacobsen, R. L., Erikstrup, C., Schwinn, M., Brunak, S., Banasik, K. & 11 others, Ostrowski, Sisse Rye, Troelsen, Anders, Henkel, C., Pedersen, Ole Birger Vesterager, Jonsdottir, I., Gudbjartsson, D. F., Sulem, P., Thorgeirsson, T. E., Stefansson, H., Stefansson, K. & DBDS Genetic Consortium, D. G. C., 2022, In: Nature Communications. 13, 1, 9 p., 1598.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    Identification of biomarkers for glycaemic deterioration in type 2 diabetes

    Slieker, R. C., Donnelly, L. A., Akalestou, E., Lopez-Noriega, L., Melhem, R., Güneş, A., Abou Azar, F., Efanov, A., Georgiadou, E., Muniangi-Muhitu, H., Sheikh, M., Giordano, G. N., Åkerlund, M., Ahlqvist, E., Ali, A., Banasik, K., Brunak, S., Barovic, M., Bouland, G. A., Burdet, F. & 46 others, Canouil, M., Dragan, I., Elders, P. J. M., Fernandez, C., Festa, A., Fitipaldi, H., Froguel, P., Gudmundsdottir, V., Gudnason, V., Gerl, M. J., van der Heijden, A. A., Jennings, L. L., Hansen, M. K., Kim, M., Leclerc, I., Klose, C., Kuznetsov, D., Mansour Aly, D., Mehl, F., Marek, D., Melander, O., Niknejad, A., Ottosson, F., Pavo, I., Duffin, K., Syed, S. K., Shaw, J. L., Cabrera, O., Pullen, T. J., Simons, K., Solimena, M., Suvitaival, T., Wretlind, A., Rossing, Peter, Lyssenko, V., Legido Quigley, C., Groop, L., Thorens, B., Franks, P. W., Lim, G. E., Estall, J., Ibberson, M., Beulens, J. W. J., 't Hart, L. M., Pearson, E. R. & Rutter, G. A., 2023, In: Nature Communications. 14, 18 p., 2533.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    Complex effects of sequence variants on lipid levels and coronary artery disease

    Snaebjarnarson, A. S., Helgadottir, A., Arnadottir, G. A., Ivarsdottir, E. V., Thorleifsson, G., Ferkingstad, E., Einarsson, G., Sveinbjornsson, G., Thorgeirsson, T. E., Ulfarsson, M. O., Halldorsson, B. V., Olafsson, I., Erikstrup, C., Pedersen, O. B., Nyegaard, M., Bruun, M. T., Ullum, H., Brunak, S., Iversen, K. K., Christensen, A. H. & 14 others, Olesen, Morten Steen Salling, Ghouse, Jonas, Banasik, Karina, Knowlton, K. U., Arnar, D. O., Thorgeirsson, G., Nadauld, L., Ostrowski, Sisse Rye, Bundgård, Henning, Holm, H., Sulem, P., Stefansson, K., Gudbjartsson, D. F. & DBDS Genomic Consortium, D. G. C., 2023, In: Cell. 186, 19, p. 4085-4099.e15

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte

    Sonne, Si Brask, Almstrup, Kristian, Dalgaard, M., Juncker, A. S., Edsgard, D., Ruban, L., Harrison, N. J., Schwager, C., Abdollahi, A., Huber, P. E., Brunak, Søren, Gjerdrum, L. M., Moore, H. D., Andrews, P. W., Skakkebæk, Niels Erik, Rajpert-De Meyts, E. & Leffers, H., 15 Jun 2009, In: Current Cancer Research. 69, 12, p. 5241-50 10 p.

    Research output: Contribution to journal › Journal article › Research

  89. Analysis of cell death inducing compounds

    Spicker, J., Pedersen, H. T., Brunak, Søren & Nielsen, H. B., 2007, In: Archives of Toxicology. 81, 11, p. 803-11 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Integration of clinical chemistry, expression, and metabolite data leads to better toxicological class separation

    Spicker, J., Brunak, Søren, Frederiksen, K. & Toft, H., 2008, In: Toxicological sciences : an official journal of the Society of Toxicology. 102, 2, p. 444-54 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Complete genes may pass from food to human blood

    Spisák, S., Solymosi, N., Ittzés, P., Bodor, A., Kondor, D., Vattay, G., Barták, B. K., Sipos, F., Galamb, O., Tulassay, Z., Szállási, Z., Rasmussen, Simon, Sicheritz-Ponten, T., Brunak, Søren, Molnár, B. & Csabai, I., 2013, In: PloS one. 8, 7, p. e69805

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    Endotrophin is associated with chronic multimorbidity and all-cause mortality in a cohort of elderly women

    Staunstrup, L. M., Bager, C. L., Frederiksen, P., Helge, Jørn Wulff, Brunak, Søren, Christiansen, C. & Karsdal, M., 2021, In: EBioMedicine. 68, 10 p., 103391.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology

    Steentoft, C., Vakhrushev, Sergey, Joshi, Hiren Jitendra, Kong, Y., Vester-Christensen, M. B., Schjoldager, Katrine Ter-Borch Gram, Lavrsen, K., Dabelsteen, Sally, Pedersen, N. B., da Silva, L. P. M., Gupta, R., Bennett, Eric Paul, Mandel, Ulla, Brunak, Søren, Wandall, Hans H., Levery, S. B. & Clausen, Henrik, 15 May 2013, In: E M B O Journal. 32, 10, p. 1478-1488 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. E-pub ahead of print

    Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effect on recombination

    Steinthorsdottir, V., Halldorsson, B. V., Jonsson, H., Palsson, G., Oddsson, A., Westergaard, D., Arnadottir, G. A., Stefansdottir, L., Banasik, K., Esplin, M. S., Hansen, T. F., Brunak, S., Nyegaard, M., Ostrowski, S. R., Pedersen, O. B. V., Erikstrup, C., Thorleifsson, G., Nadauld, L. D., Haraldsson, A., Steingrimsdottir, T. & 8 others, Tryggvadottir, L., Jonsdottir, I., Gudbjartsson, D. F., Hoffmann, Eva, Sulem, P., Holm, H., Nielsen, Henriette Svarre & Stefansson, K., 2024, (E-pub ahead of print) In: Nature Structural and Molecular Biology. 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. The cancer exome generated by alternative mRNA splicing dilutes predicted HLA class I epitope density

    Stranzl, T., Larsen, M. V., Lund, O., Nielsen, M. & Brunak, Søren, 2012, In: PloS one. 7, 9, p. e38670

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. E-pub ahead of print

    Obesity variants in the GIPR gene do not associate with risk of fracture or bone mineral density

    Styrkarsdottir, U., Tragante, V., Stefansdottir, L., Thorleifsson, G., Oddsson, A., Sørensen, E., Erikstrup, C., Schwarz, Peter, Jørgensen, Henrik Løvendahl, Lauritzen, Jes Bruun, Brunak, Søren, Knowlton, K. U., Nadauld, L. D., Ullum, H., Pedersen, Ole Birger Vesterager, Ostrowski, Sisse Rye, Holm, H., Gudbjartsson, D. F., Sulem, P. & Stefansson, K., 2024, (E-pub ahead of print) In: Journal of Clinical Endocrinology and Metabolism.

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Gene expression signature predicts rate of type 1 diabetes progression

    Suomi, T., Starskaia, I., Kalim, U. U., Rasool, O., Jaakkola, M. K., Grönroos, T., Välikangas, T., Brorsson, C., Mazzoni, G., Bruggraber, S., Overbergh, L., Dunger, D., Peakman, M., Chmura, P., Brunak, S., Schulte, A. M., Mathieu, C., Knip, M., Lahesmaa, R., Elo, L. L. & 4 others, Pociot, Flemming, Johannesen, Jesper, Rossing, Peter & INNODIA consortium, I. C., 2023, In: EBioMedicine. 92, 18 p., 104625.

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Data Resource Profile: The Copenhagen Hospital Biobank (CHB)

    Sørensen, E., Christiansen, L., Wilkowski, B., Larsen, M. H., Burgdorf, Kristoffer Sølvsten, Thørner, L. W., Nissen, J., Pedersen, Ole Birger Vesterager, Banasik, Karina, Brunak, Søren, Bundgård, Henning, Stefánsson, H., Stefánsson, K., Melbye, M. & Ullum, H., 2021, In: International Journal of Epidemiology. 50, 3, p. 719-720e

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

    Sørensen, L. M., Jensen, J. M., Petersen, B., Sibbesen, J. A., Liu, S., Villesen, P., Skov, L., Belling, K. G., Have, C. T., Izarzugaza, J. M. G., Grosjean, M., Bork-Jensen, J., Grove, J., Als, T. D., Huang, S., Chang, Y., Xu, R., Ye, W., Rao, J., Guo, X. & 39 others, Sun, J., Cao, H., Ye, C., van Beusekom, J., Espeseth, T., Flindt, E., Friborg, R. M., Halager, A. E., Le Hellard, S., Hultman, C. M., Lescai, F., Li, S., Lund, O., Løngren, P., Mailund, T., Matey-Hernandez, M. L., Mors, O., Pedersen, C. N. S., Sicheritz-Pontén, T., Sullivan, P., Syed, A., Westergaard, David, Yadav, R., Li, N., Xu, X., Hansen, Torben, Krogh, Anders, Bolund, L., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye, Gupta, R., Rasmussen, Simon, Besenbacher, S., Børglum, A. D., Wang, J., Eiberg, Hans Rudolf Lytchoff, Kristiansen, Karsten, Brunak, Søren & Schierup, M. H., 2017, In: Nature. 548, 7665, p. 87-91 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  100. Published

    Association between antipsychotic drug dose and length of clinical notes: a proxy of disease severity?

    Sørup, Freja Karuna Hemmingsen, Brunak, Søren & Eriksson, R., 2020, In: BMC Medical Research Methodology. 20, 1, 7 p., 107.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 12895347