Matthias Mann

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Matthias Mann is Research Director and Group leader at the Proteomics Program at Novo Nordisk Foundation Center for Protein Research (CPR, www.cpr.ku.dk) at the University of Copenhagen. He also holds a Director position at the Max-Planck Institute of Biochemistry in Munich. Matthias Mann is one of the most highly cited researchers in the world with h-index 216 and more than 200,000 citations. He is a pioneer of mass spectrometry-based proteomics and has made landmark contributions to the development of electrospray ionization. He has also contributed to making mass spectrometry applicable to molecular biology, including by developing computer algorithms to connect mass-spectrometric data with sequence databases.

Matthias Mann and his teams work in proteomics technology development and applying that technology to biological and clinical problems. Their large-scale proteomics and phosphoproteomics studies have shed light on a wide variety of questions in the life sciences. The focus of the Clinical Proteomics group at CPR is to identify biological markers for diabetes, obesity and other metabolic disorders. The group has already established robust and reproducible high-throughput proteomics workflows, are routinely applied for proteomic screening of clinical cohorts.

Selected publications

1. Published

   The proteome landscape of the kingdoms of life

   Müller, J. B., Geyer, P. E., Colaço, A. R., Treit, P. V., Strauss, M. T., Oroshi, M., Doll, S., Virreira Winter, S., Bader, J. M., Köhler, N., Theis, F., Santos, A. & Mann, Matthias, 2020, In: Nature. 582, p. 592-596

   Research output: Contribution to journal › Journal article › Research › peer-review

2. Published

   Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease

   Niu, Lili, Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Treit, P. V., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Müller, T. D., Tschöp, M. H., Hofmann, S. M. & Mann, Matthias, 2019, In: Molecular Systems Biology. 15, 16 p., e8793.

   Research output: Contribution to journal › Journal article › Research › peer-review

3. Published

   High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform

   Humphrey, S. J., Karayel, O., James, D. E. & Mann, Matthias, 2018, In: Nature Protocols (Print). 13, p. 1897-1916 20 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

4. Published

   Plasma Proteome Profiling to detect and avoid sample-related biases in biomarker studies

   Geyer, P. E., Voytik, E., Treit, P. V., Doll, S., Kleinhempel, A., Niu, Lili, Müller, J. B., Buchholtz, M., Bader, J. M., Teupser, D., Holdt, L. M. & Mann, Matthias, 2019, In: EMBO Molecular Medicine. 11, 11, e10427.

   Research output: Contribution to journal › Journal article › Research › peer-review

5. Published

   Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer

   Coscia, F., Lengyel, E., Duraiswamy, J., Ashcroft, B., Bassani-Sternberg, M., Wierer, M., Johnson, A., Wroblewski, K., Montag, A., Yamada, S. D., López-Méndez, B., Nilsson, Jakob, Mund, Andreas, Mann, Matthias & Curtis, M., 2018, In: Cell. 175, 1, p. 159-170.e16

   Research output: Contribution to journal › Journal article › Research › peer-review

6. Published

   A Primer on Concepts and Applications of Proteomics in Neuroscience

   Hosp, F. & Mann, Matthias, 1 Nov 2017, In: Neuron. 96, 3, p. 558-571 14 p.

   Research output: Contribution to journal › Review › Research › peer-review

7. Published

   Region and cell-type resolved quantitative proteomic map of the human heart

   Doll, S., Dreßen, M., Geyer, P. E., Itzhak, D. N., Braun, C., Doppler, S. A., Meier, F., Deutsch, M., Lahm, H., Lange, R., Krane, M. & Mann, Matthias, 13 Nov 2017, In: Nature Communications. 8, 1, 13 p., 1469.

   Research output: Contribution to journal › Journal article › Research › peer-review

8. Published

   Mass-spectrometric exploration of proteome structure and function

   Aebersold, R. & Mann, Matthias, 15 Sep 2016, In: Nature. 537, 7620, p. 347-55 9 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

9. Published

   Plasma Proteome Profiling to Assess Human Health and Disease

   Geyer, P. E., Kulak, N. A., Pichler, G., Holdt, L. M., Teupser, D. & Mann, Matthias, 23 Mar 2016, In: Cell Systems. 2, 3, p. 185-95 11 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

10. A human interactome in three quantitative dimensions organized by stoichiometries and abundances

    Hein, M. Y., Hubner, N. C., Poser, I., Cox, J., Nagaraj, N., Toyoda, Y., Gak, I. A., Weisswange, I., Mansfeld, J., Buchholz, F., Hyman, A. A. & Mann, M., 22 Oct 2015, In: Cell. 163, 3, p. 712-23 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

11. Published

    Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry

    Wilm, M., Shevchenko, A., Houthaeve, T., Breit, S., Schweigerer, L., Fotsis, T. & Mann, Matthias, 1 Feb 1996, In: Nature. 379, 6564, p. 466-9 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

12. Published

    Error-tolerant identification of peptides in sequence databases by peptide sequence tags

    Mann, Matthias & Wilm, M., 15 Dec 1994, In: Analytical Chemistry. 66, 24, p. 4390-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review