ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization

Research output: Contribution to journalJournal articleResearchpeer-review

  • Francesco Pappalardo
  • Mark D Halling-Brown
  • Nicolas Rapin
  • Ping Zhang
  • Davide Alemani
  • Andrew Emerson
  • Paola Paci
  • Laurent Patrice Duroux
  • Marzio Pennisi
  • Arianna Palladini
  • Olivo Miotto
  • Daniel Churchill
  • Elda Rossi
  • Adrian J Shepherd
  • David S Moss
  • Filippo Castiglione
  • Massimo Bernaschi
  • Marie-Paule Lefranc
  • Santo Motta
  • Pier-Luigi Lollini
  • Kaye E Basford
  • Vladimir Brusic
Vaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines conceptual models of the immune system, models of antigen processing and presentation, system-level models of the immune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines. ImmunoGrid modules share common conceptual models and ontologies. The ImmunoGrid portal offers access to educational simulators where previously defined cases can be displayed, and to research simulators that allow the development of new, or tuning of existing, computational models. The portal is accessible at .
Original languageEnglish
JournalBriefings in Bioinformatics
Issue number3
Pages (from-to)330-40
Number of pages11
Publication statusPublished - 2009

    Research areas

  • Computational Biology, Computer Systems, Database Management Systems, Databases, Factual, Drug Design, Humans, Immune System, Major Histocompatibility Complex, Models, Biological, Systems Integration, Vaccines

ID: 40804498