Niels Mailand

Niels Mailand

Professor, head of research, Professor


  1. 2019
  2. Published

    The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

    Singh, A. N., Oehler, J., Torrecilla, I., Kilgas, S., Li, S., Vaz, B., Guerillon, C., Fielden, J., Esperanza Hernandez-Carralero, Cabrera, E., Tullis, I. D. C., Meerang, M., Barber, P. R., Freire, R., Parsons, J., Vojnovic, B., Kiltie, A. E., Mailand, Niels & Ramadan, K., 2019, In: EMBO Journal. 38, 25 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2020
  4. Published

    FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease

    Hoffmann, Saskia, Pentakota, S., Mund, Andreas, Haahr, Peter Thorlund, Coscia, F., Gallo, M., Mann, Matthias, Taylor, Nicholas M I & Mailand, Niels, 2020, In: EMBO Reports. 21, 10, 14 p., e50662.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Multisite SUMOylation restrains DNA polymerase η interactions with DNA damage sites

    Guerillon, Claire Aline, Smedegaard, S., Hendriks, Ivo Alexander, Nielsen, Michael Lund & Mailand, Niels, 2020, In: Journal of Biological Chemistry. 295, p. 8350-8362

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2021
  7. Published

    Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway

    Liu, Julio, Kühbacher, U., Larsen, N. B., Borgermann, N., Garvanska, Dimitriya Hristoforova, Hendriks, Ivo Alexander, Ackermann, Leena, Haahr, Peter Thorlund, Gallina, I., Guérillon, C., Branigan, E., Hay, R. T., Azuma, Y., Nielsen, Michael Lund, Duxin, Julien & Mailand, Niels, 2021, In: E M B O Journal. 40, 21 p., e107413.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination

    Nakamura, K., Kustatscher, G., Alabert, C., Hödl, M., Forne, I., Völker-Albert, M., Satpathy, S., Beyer, T. E., Mailand, Niels, Choudhary, Chunaram, Imhof, A., Rappsilber, J. & Groth, Anja, 2021, In: Molecular Cell. 81, 3, 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The ubiquitin ligase RFWD3 is required for translesion DNA synthesis

    Gallina, I., Hendriks, Ivo Alexander, Hoffmann, Saskia, Larsen, N. B., Johansen, Joachim, S.Colding-Christensen, Camilla, Schubert, Lisa, Sellés Baiget, Selene, Fábián, Z., Kühbacher, U., Gao, A. O., Räschle, M., Rasmussen, Simon, Nielsen, Michael Lund, Mailand, Niels & Duxin, Julien, 2021, In: Molecular Cell. 81, 3, p. 442-458.e9 27 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Ubiquitylation at Stressed Replication Forks: Mechanisms and Functions

    Mirsanaye, Ann Schirin, Typas, D. & Mailand, Niels, 2021, In: Trends in Cell Biology. 31, 7, p. 584-597

    Research output: Contribution to journalReviewResearchpeer-review

  11. 2022
  12. Published

    Chemogenetic profiling reveals PP2A-independent cytotoxicity of proposed PP2A activators iHAP1 and DT-061

    Vit, G., Duro, Joana Maria, Rajendraprasad, G., Hertz, Emil Peter Thrane, Holland, L. K. K., Weisser, Melanie, McEwan, B. C., Lopez-Mendez, B., Sotelo-Parrilla, P., Jeyaprakash, A. A., Montoya, Guillermo, Mailand, Niels, Maeda, K., Kettenbach, A., Barisic, Marin & Nilsson, Jakob, 2022, In: EMBO Journal. 41, 14, e110611.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation

    Shearer, Robert Francis, Typas, D., Coscia, F., Schovsbo, Sofie Ulfbeck, Kruse, Thomas, Mund, Andreas & Mailand, Niels, 2022, In: E M B O Journal. 41, 9, 18 p., e110145.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy

    Grange, L. J., Reynolds, J. J., Ullah, F., Isidor, B., Shearer, R. F., Latypova, X., Baxley, R. M., Oliver, A. W., Ganesh, A., Cooke, S. L., Jhujh, S. S., McNee, G. S., Hollingworth, R., Higgs, M. R., Natsume, T., Khan, T., Martos-Moreno, G., Chupp, S., Mathew, C. G., Parry, D. & 28 others, Simpson, M. A., Nahavandi, N., Yüksel, Z., Drasdo, M., Kron, A., Vogt, P., Jonasson, A., Seth, S. A., Gonzaga-Jauregui, C., Brigatti, K. W., Stegmann, A. P. A., Kanemaki, M., Josifova, D., Uchiyama, Y., Oh, Y., Morimoto, A., Osaka, H., Ammous, Z., Argente, J., Matsumoto, N., Stumpel, C. T. R. M., Taylor, A. M. R., Jackson, A. P., Bielinsky, A. K., Mailand, Niels, Le Caignec, C., Davis, E. E. & Stewart, G. S., 2022, In: Nature Communications. 13, 22 p., 6664.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published
  16. 2023
  17. Published

    A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ

    Mailand, Niels, 2023, In: Molecular Cell. 83, 1, p. 3-5 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  18. Published

    ATXN3 controls DNA replication and transcription by regulating chromatin structure

    Hernández-Carralero, E., Cabrera, E., Rodríguez-Torres, G., Hernández-Reyes, Y., Singh, A. N., Santa-María, C., Fernández-Justel, J. M., Janssens, R. C., Marteijn, J. A., Evert, B. O., Mailand, Niels, Gómez, M., Ramadan, K., Smits, V. A. J. & Freire, R., 2023, In: Nucleic Acids Research. 51, 11, p. 5396–5413

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Profiling ubiquitin signalling with UBIMAX reveals DNA damage- and SCFβ-Trcp1-dependent ubiquitylation of the actin-organizing protein Dbn1

    S.Colding-Christensen, Camilla, Kakulidis, Ellen Sofia, Arroyo Gomez, Javier, Hendriks, Ivo Alexander, Arkinson, C., Fábián, Z., Gambus, A., Mailand, Niels, Duxin, Julien & Nielsen, Michael Lund, 2023, In: Nature Communications. 14, 19 p., 8293.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Sustainability and molecular biology: An interview with Prof. Niels Mailand and Ann Schirin Mirsanaye

    Mailand, Niels & Mirsanaye, Ann Schirin, 2023, In: Molecular Cell. 83, 18, p. 3222-3224 3 p.

    Research output: Contribution to journalComment/debateResearch

  21. Published

    The SUMO–NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure

    Hertz, Emil Peter Thrane, Alonso de Vega, Ignacio, Kruse, Thomas, Wang, Y., Hendriks, Ivo Alexander, Bizard, A. H., Eugui-Anta, A., Hay, R. T., Nielsen, Michael Lund, Nilsson, Jakob, Hickson, Ian David & Mailand, Niels, 2023, In: Nature Structural and Molecular Biology. 30, p. 1303-1313

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2024
  23. Published

    VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates

    Mirsanaye, Ann Schirin, Hoffmann, Saskia, Weisser, Melanie, Mund, Andreas, Lopez Mendez, B., Typas, D., van den Boom, J., Benedict, Bente, Hendriks, Ivo Alexander, Nielsen, Michael Lund, Meyer, H., Duxin, Julien, Montoya, Guillermo & Mailand, Niels, 2024, In: Nature Communications. 15, 1, 16 p., 2459.

    Research output: Contribution to journalJournal articleResearchpeer-review

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