Julien Duxin

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Julien Duxin’s research focuses in understanding basic mechanisms of genome maintenance using Xenopus egg extracts as a model system. Particularly, he studies how DNA lesions induced by chemotherapeutic agents are repaired. This has led to the first system that recapitulates DNA-protein crosslink (DPCs) repair in vitro (Duxin et al. Cell, 2014). This initial discovery opened an entire new area of investigation, highly relevant to human health as DPC-inducers are commonly used in the clinic to treat cancer. Julien’s lab is now investigating how DPC-repair is intrinsically linked to DNA replication and interrogating which are the main players orchestrating the repair reaction (Larsen et al. Molecular Cell, 2018). His ultimate goal is to unravel new molecular mechanisms of DNA repair and identify novel chemotherapeutic targets that could be used in the clinic to sensitize patients to commonly used anti-cancer drugs.

Selected publications

1. Published

   The ubiquitin ligase RFWD3 is required for translesion DNA synthesis

   Gallina, I., Hendriks, Ivo Alexander, Hoffmann, Saskia, Larsen, N. B., Johansen, Joachim, S.Colding-Christensen, Camilla, Schubert, Lisa, Sellés Baiget, Selene, Fábián, Zita, Kühbacher, U., Gao, A. O., Räschle, M., Rasmussen, Simon, Nielsen, Michael Lund, Mailand, Niels & Duxin, Julien, 2021, In: Molecular Cell. 81, 3, p. 442-458.e9 27 p.

   Research output: Contribution to journal › Journal article › peer-review

2. Published

   How to fix DNA-protein crosslinks

   Kühbacher, U. & Duxin, Julien, 2020, In: DNA Repair. 94, 14 p., 102924.

   Research output: Contribution to journal › Journal article › peer-review

3. Published

   A safe fix for alcohol-derived DNA damage: [Alcohol-derived DNA damage fixed in two ways]

   Gallina, I. & Duxin, Julien, 2020, In: Nature. 579, 7800, p. 499-500 2 p.

   Research output: Contribution to journal › Comment/debate

4. Published

   Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts

   Larsen, N. B., Gao, A. O., Sparks, J. L., Gallina, I., Wu, R. A., Mann, Matthias, Räschle, M., Walter, J. C. & Duxin, Julien, 2019, In: Molecular Cell. 73, 3, p. 574-588.e7 23 p.

   Research output: Contribution to journal › Journal article › peer-review

5. Published

   The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

   Sparks, J. L., Chistol, G., Gao, A. O., Räschle, M., Larsen, N. B., Mann, Matthias, Duxin, Julien & Walter, J. C., 2019, In: Cell. 176, 1-2, p. 167-181.e21

   Research output: Contribution to journal › Journal article › peer-review

6. What is the DNA repair defect underlying Fanconi anemia?

   Duxin, Julien & Walter, J. C., Dec 2015, In: Current Opinion in Cell Biology. 37, p. 49-60 12 p.

   Research output: Contribution to journal › Review › peer-review

7. Repair of a DNA-protein crosslink by replication-coupled proteolysis

   Duxin, Julien, Dewar, J. M., Yardimci, H. & Walter, J. C., 9 Oct 2014, In: Cell. 159, 2, p. 346-57 12 p.

   Research output: Contribution to journal › Journal article › peer-review

8. Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication

   Duxin, Julien, Moore, H. R., Sidorova, J., Karanja, K. K., Honaker, Y., Dao, B., Piwnica-Worms, H., Campbell, J. L., Monnat, R. J. & Stewart, S. A., 22 Jun 2012, In: The Journal of Biological Chemistry. 287, 26, p. 21980-91 12 p.

   Research output: Contribution to journal › Journal article › peer-review

9. DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network

   Karanja, K. K., Cox, S. W., Duxin, Julien, Stewart, S. A. & Campbell, J. L., 1 Nov 2012, In: Cell Cycle. 11, 21, p. 3983-96 14 p.

   Research output: Contribution to journal › Journal article › peer-review

10. Human Dna2 is a nuclear and mitochondrial DNA maintenance protein

    Duxin, Julien, Dao, B., Martinsson, P., Rajala, N., Guittat, L., Campbell, J. L., Spelbrink, J. N. & Stewart, S. A., Aug 2009, In: Molecular and Cellular Biology. 29, 15, p. 4274-82 9 p.

    Research output: Contribution to journal › Journal article › peer-review