Anja Groth

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Prof. Anja Groth leads a research group at the the Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen. Anja Groth received her PhD in Molecular Biology from the University of Copenhagen in 2004 for her research in the laboratory of Drs. Lukas and Bartek. She did her postdoctoral training from 2005 to 2007 with Dr. Almouzni at Institut Curie, Paris, focusing on histone dynamics during DNA replication. In 2008 Dr. Groth started as a junior group leader at BRIC, supported by a Junior Group Leader Fellowship from the Lundbeck Foundation. She was tenured in 2013 and promoted to professor in 2016. Prof. Anja Groth has received several prestigious awards, including the Danish Research Council Young Elite Researcher Prize (2009), the Danish Cancer Society Junior Research Prize (2011), the Heirloom Award for Women Scientist Leaders (2014), the Elite Research Prize by the Danish Ministry of Higher Education and Science (2018) and Queen Margrethe II's Research Prize (2020). She was elected as a member of the Royal Danish Academy of Sciences and Letters in 2016 and EMBO in 2017. The scientific focus of Anja Groth is epigenetic cell memory, chromatin replication and the interplay between genome and epigenome stability. Her research group has contributed with seminal discoveries on histone chaperone function, chromatin replication mechanisms, inheritance of histone post-translational modifications and DNA repair pathway choice. The Groth group has a strong record track in collaborative interdisciplinary research and developing new tailored technologies to address chromatin replication and epigenetic cell memory (NCC-proteomics, ChOR-seq, SCAR-seq, and repli-ATAC-seq). In 2018, Prof. Groth founded Ankrin Therapeutics, a drug discovery company with the aim to develop new targeted cancer therapy based on her discovery of a new chromatin-linked DNA repair mechanism. In 2020, Anja Groth moved her research group to CPR and became director of the Protein Memory research program focused on protein-based epigenetic memory.

 

Fields of interest

• Epigenetics
• Genome maintenance
• Cancer biology

Primary fields of research

• Histone metabolism
• Chromatin replication
• Epigenetic cell memory
• Genome stability and cancer

Selected publications

1. Published

   Chromatin replication and epigenetic cell memory

   Stewart-Morgan, Kathleen, Petryk, N. & Groth, Anja, 2020, In: Nature Cell Biology. 22, p. 361-371

   Research output: Contribution to journal › Review › Research › peer-review

2. Published

   Transcription Restart Establishes Chromatin Accessibility after DNA Replication

   Stewart-Morgan, Kathleen, Reveron-Gomez, Nazaret & Groth, Anja, 2019, In: Molecular Cell. 75, 2, p. 284-297 20 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

3. Published

   MCM2 promotes symmetric inheritance of modified histones during DNA replication

   Petryk, N., Dalby, M., Wenger, Alice, Stromme, C. B., Strandsby, A., Andersson, Robin & Groth, Anja, 2018, In: Science. 361, 6409, p. 1389-1392 3 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

4. Published

   Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication

   Reveron-Gomez, Nazaret, González-Aguilera, C., Stewart-Morgan, Kathleen, Petryk, N., Flury, Valentin, Graziano, S., Johansen, Jens Vilstrup, Jakobsen, J. S., Alabert, C. & Groth, Anja, 2018, In: Molecular Cell. 72, 2, p. 239-249 11 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

5. Published

   H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

   Saredi, G., Huang, H., Hammond, Colin, Alabert, C., Bekker-Jensen, Simon Holst, Forne, I., Reveron-Gomez, Nazaret, Foster, B. M., Mlejnkova, L., Bartke, T., Cejka, P., Mailand, Niels, Imhof, A., Patel, D. J. & Groth, Anja, 30 Jun 2016, In: Nature. 534, 7609, p. 714-8 5 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

6. Published

   A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks

   Huang, H., Strømme, C. B., Saredi, G., Hödl, M., Strandsby, A., González-Aguilera, C., Chen, S., Groth, Anja & Patel, D. J., 2015, In: Nature Structural and Molecular Biology. 22, 8, p. 618-626 9 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

7. Published

   Two distinct modes for propagation of histone PTMs across the cell cycle

   Alabert, C., Barth, T. K., Reveron-Gomez, Nazaret, Sidoli, S., Kelager, Andreas, Jensen, O. N., Imhof, A. & Groth, Anja, 15 Mar 2015, In: Genes & Development. 29, 6, p. 585-90 6 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

8. Published

   Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components

   Alabert, C., Bukowski-Wills, J., Lee, S., Kustatscher, G., Nakamura, K., de Lima Alves, F., Ménard, Patrice, Mejlvang, J., Rappsilber, J. & Groth, Anja, 23 Feb 2014, In: Nature Cell Biology.

   Research output: Contribution to journal › Journal article › Research › peer-review

9. Published

   Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication

   Kamalyukova, I. M., Young, C., Strømme, C. B., Ménard, Patrice, Jasencakova, Zuzana, Mejlvang, J., Ask, K., Ploug, Michael, Nielsen, Michael Lund, Jensen, O. N. & Groth, Anja, 2014, In: Nature Communications. 5, p. 3394

   Research output: Contribution to journal › Journal article › Research › peer-review