Anja Groth

Anja Groth

Research director, professor

  • Groth Group

    Blegdamsvej 3B, 2200 København N.

    Phone: +45 35 32 55 38Mobile: +45 30 50 73 07

Prof. Anja Groth leads a research group at the Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen. Anja Groth received her PhD in Molecular Biology from the University of Copenhagen in 2004 for her research in the laboratory of Drs. Lukas and Bartek. She did her postdoctoral training from 2005 to 2007 with Dr. Almouzni at Institut Curie, Paris, focusing on histone dynamics during DNA replication. In 2008 Dr. Groth started as a junior group leader at BRIC, supported by a Junior Group Leader Fellowship from the Lundbeck Foundation. She was tenured in 2013 and promoted to professor in 2016. Prof. Anja Groth has received several prestigious awards, including the Danish Research Council Young Elite Researcher Prize (2009), the Danish Cancer Society Junior Research Prize (2011), the Heirloom Award for Women Scientist Leaders (2014) and the Elite Research Prize by the Danish Ministry of Higher Education and Science (2018). She was elected as a member of the Royal Danish Academy of Sciences and Letters in 2016 and EMBO in 2017. The scientific focus of Anja Groth is epigenetic cell memory, chromatin replication and the interplay between genome and epigenome stability. Her research group has contributed with seminal discoveries on histone chaperone function, chromatin replication mechanisms, inheritance of histone post-translational modifications and functions of new/old histones in DNA repair. The Groth group has a strong record track in collaborative interdisciplinary research and developing new tailored technologies to address epigenetic cell memory (Nascent Chromatin Capture, ChOR-seq and SCAR-seq). In 2018, Dr. Groth founded Ankrin Therapeutics, a drug discovery company with the aim to develop new targeted cancer therapy based on her discovery of a new chromatin-linked DNA repair mechanism.

Fields of interest

  • Epigenetics
  • Genome maintenance
  • Cancer biology

Primary fields of research

  • Histone metabolism
  • Chromatin replication
  • Epigenetic cell memory
  • Genome stability and cancer

Selected publications

  1. Published

    Chromatin replication and epigenetic cell memory

    Stewart-Morgan, Kathleen, Petryk, N. & Groth, Anja, 2020, In : Nature Cell Biology. 22, p. 361-371

    Research output: Contribution to journalReviewResearchpeer-review

  2. Published

    Transcription Restart Establishes Chromatin Accessibility after DNA Replication

    Stewart-Morgan, Kathleen, Reveron-Gomez, Nazaret & Groth, Anja, 2019, In : Molecular Cell. 75, 2, p. 284-297 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    MCM2 promotes symmetric inheritance of modified histones during DNA replication

    Petryk, N., Dalby, M., Wenger, Alice, Stromme, C. B., Strandsby, A., Andersson, Robin & Groth, Anja, 2018, In : Science. 361, 6409, p. 1389-1392 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication

    Reveron-Gomez, Nazaret, González-Aguilera, C., Stewart-Morgan, Kathleen, Petryk, N., Flury, V., Graziano, Simona, Johansen, Jens Vilstrup, Jakobsen, J. S., Alabert, C. & Groth, Anja, 2018, In : Molecular Cell. 72, 2, p. 239-249 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

    Saredi, G., Huang, H., Hammond, Colin, Alabert, C., Bekker-Jensen, Simon Holst, Forne, I., Reveron-Gomez, Nazaret, Foster, B. M., Mlejnkova, L., Bartke, T., Cejka, P., Mailand, Niels, Imhof, A., Patel, D. J. & Groth, Anja, 30 Jun 2016, In : Nature. 534, 7609, p. 714-8 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks

    Huang, H., Strømme, C. B., Saredi, G., Hödl, M., Strandsby, A., González-Aguilera, C., Chen, S., Groth, Anja & Patel, D. J., 2015, In : Nature Structural and Molecular Biology. 22, 8, p. 618-626 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Two distinct modes for propagation of histone PTMs across the cell cycle

    Alabert, C., Barth, T. K., Reveron-Gomez, Nazaret, Sidoli, S., Schmidt, A., Jensen, O. N., Imhof, A. & Groth, Anja, 15 Mar 2015, In : Genes & Development. 29, 6, p. 585-90 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components

    Alabert, C., Bukowski-Wills, J., Lee, S., Kustatscher, G., Nakamura, Kyosuke, de Lima Alves, F., Ménard, Patrice, Mejlvang, J., Rappsilber, J. & Groth, Anja, 23 Feb 2014, In : Nature Cell Biology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication

    Kamalyukova, I. M., Young, C., Strømme, C. B., Ménard, Patrice, Jasencakova, Zuzana, Mejlvang, J., Ask, K., Ploug, Michael, Nielsen, Michael Lund, Jensen, O. N. & Groth, Anja, 2014, In : Nature Communications. 5, p. 3394

    Research output: Contribution to journalJournal articleResearchpeer-review

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