Chromatin replication and epigenome maintenance
The Protein Memory Program investigates how proteins control cellular identity via epigenetic mechanisms that govern the expression of the genetic information encoded in DNA.
We have 10 quadrillion cell divisions across a human lifetime. Understanding how memory about cell identity is copied to new cells is essential for healthy life and understanding diseases like cancer.
In a cross-disciplinary approach the program combines functional genomics with proteomics, structural biology, and big data analysis to reveal protein function in genome regulation. They aim to fully dissect the epigenetic copying process and understand how cell identity and fate is maintained during cell division to prevent functional decline and disease.
Professor Anja Groth is Research Director of the Protein Memory Program. The program has two research groups.