Niels Mailand

Niels Mailand

Professor, head of research, Professor

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    ORCID: 0000-0002-6623-709X

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    1. Published

      Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination

      Gao, M., Wei, W., Li, M. H., Wu, Y., Ba, Z., Jin, K., Li, M., Liao, Y., Adhikari, S., Chong, Z., Zhang, T., Guo, C., Tang, T., Zhu, B., Xu, X., Mailand, Niels, Yang, Y., Qi, Y. & Danielsen, J. M. R., May 2014, In: Cell Research. 24, 5, p. 532-41 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      SLX4: not SIMply a nuclease scaffold?

      Gibbs-Seymour, I. & Mailand, Niels, 8 Jan 2015, In: Molecular Cell. 57, 1, p. 3-5 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage

      Gibbs-Seymour, I., Markiewicz, E., Bekker-Jensen, Simon Holst, Mailand, Niels & Hutchison, C. J., Apr 2015, In: Aging Cell. 14, 2, p. 162-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

      Gibbs-Seymour, I., Oka, Y., Rajendra, E., Weinert, B. T., Passmore, L. A., Patel, K. J., Olsen, Jesper Velgaard, Choudhary, Chunaram, Bekker-Jensen, Simon Holst & Mailand, Niels, Jan 2015, In: Molecular Cell. 57, 1, p. 150-64 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy

      Grange, L. J., Reynolds, J. J., Ullah, F., Isidor, B., Shearer, R. F., Latypova, X., Baxley, R. M., Oliver, A. W., Ganesh, A., Cooke, S. L., Jhujh, S. S., McNee, G. S., Hollingworth, R., Higgs, M. R., Natsume, T., Khan, T., Martos-Moreno, G., Chupp, S., Mathew, C. G., Parry, D. & 28 others, Simpson, M. A., Nahavandi, N., Yüksel, Z., Drasdo, M., Kron, A., Vogt, P., Jonasson, A., Seth, S. A., Gonzaga-Jauregui, C., Brigatti, K. W., Stegmann, A. P. A., Kanemaki, M., Josifova, D., Uchiyama, Y., Oh, Y., Morimoto, A., Osaka, H., Ammous, Z., Argente, J., Matsumoto, N., Stumpel, C. T. R. M., Taylor, A. M. R., Jackson, A. P., Bielinsky, A. K., Mailand, Niels, Le Caignec, C., Davis, E. E. & Stewart, G. S., 2022, In: Nature Communications. 13, 22 p., 6664.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

      Gudjónsson, Thorkell, Altmeyer, M. F., Savic, V., Toledo Lazaro, L. I., Dinant, C., Grøfte, M., Bartkova, J., Poulsen, M., Oka, Y., Bekker-Jensen, Simon Holst, Mailand, Niels, Neumann, B., Heriche, J., Shearer, R., Saunders, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 17 Aug 2012, In: Cell. 150, 4, p. 697-709 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

      Gupta, R., Somyajit, K., Narita, Takeo, Maskey, E., Stanlie, A., Kremer, M., Typas, D., Lammers, M., Mailand, Niels, Nussenzweig, A., Lukas, Jiri & Choudhary, Chunaram, 2018, In: Cell. 173, 4, p. 972-988

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Multisite SUMOylation restrains DNA polymerase η interactions with DNA damage sites

      Guerillon, Claire Aline, Smedegaard, S., Hendriks, Ivo Alexander, Nielsen, Michael Lund & Mailand, Niels, 2020, In: Journal of Biological Chemistry. 295, p. 8350-8362

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen

      Gérard, A., Koundrioukoff, S., Ramillon, V., Sergère, J., Mailand, Niels, Quivy, J. & Almouzni, G., 2006, In: E M B O Reports. 7, 8, p. 817-23 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Activation of the ATR kinase by the RPA-binding protein ETAA1

      Haahr, Peter Thorlund, Hoffmann, Saskia, Tollenaere, M. A. X., Ho, T., Toledo Lazaro, L. I., Mann, Matthias, Bekker-Jensen, Simon Holst, Räschle, M. & Mailand, Niels, Nov 2016, In: Nature Cell Biology. 18, 11, p. 1196–1207

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability

      Haahr, Peter Thorlund, Borgermann, N., Guo, X., Typas, D., Achuthankutty, D., Hoffmann, Saskia, Shearer, Robert Francis, Sixma, T. K. & Mailand, Niels, 2018, In: Molecular Cell. 70, 1, p. 165-174

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      SCAI promotes DNA double-strand break repair in distinct chromosomal contexts

      Hansen, R. K., Mund, A., Poulsen, S. L., Sandoval, M., Klement, K., Tsouroula, K., Tollenaere, M. A. X., Räschle, M., Soria, R., Offermanns, S., Worzfeld, T., Grosse, R., Brandt, D. T., Rozell, B., Mann, M., Cole, F., Soutoglou, E., Goodarzi, A. A., Daniel, J. A., Mailand, N. & 1 others, Bekker-Jensen, Simon Holst, 7 Nov 2016, In: Nature Cell Biology. 18, 12, p. 1357–1366

      Research output: Contribution to journal › Letter › Research › peer-review

    13. Published

      ATXN3 controls DNA replication and transcription by regulating chromatin structure

      Hernández-Carralero, E., Cabrera, E., Rodríguez-Torres, G., Hernández-Reyes, Y., Singh, A. N., Santa-María, C., Fernández-Justel, J. M., Janssens, R. C., Marteijn, J. A., Evert, B. O., Mailand, Niels, Gómez, M., Ramadan, K., Smits, V. A. J. & Freire, R., 2023, In: Nucleic Acids Research. 51, 11, p. 5396–5413

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      The SUMO–NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure

      Hertz, Emil Peter Thrane, Alonso de Vega, Ignacio, Kruse, Thomas, Wang, Y., Hendriks, Ivo Alexander, Bizard, A. H., Eugui-Anta, A., Hay, R. T., Nielsen, Michael Lund, Nilsson, Jakob, Hickson, Ian David & Mailand, Niels, 2023, In: Nature Structural and Molecular Biology. 30, p. 1303-1313

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease

      Hoffmann, Saskia, Pentakota, S., Mund, Andreas, Haahr, Peter Thorlund, Coscia, F., Gallo, M., Mann, Matthias, Taylor, Nicholas M I & Mailand, Niels, 2020, In: EMBO Reports. 21, 10, 14 p., e50662.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress

      Hoffmann, Saskia, Smedegaard, S., Nakamura, K., Mortuza, G. B., Räschle, M., Ibañez de Opakua, A., Oka, Y., Feng, Y., Blanco, F. J., Mann, Matthias, Montoya, Guillermo, Groth, Anja, Bekker-Jensen, Simon Holst & Mailand, Niels, 4 Jan 2016, In: The Journal of Cell Biology. 212, 1, p. 63-75

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

      Krämer, A., Mailand, Niels, Lukas, Claudia, Syljuåsen, R. G., Wilkinson, C. J., Nigg, E. A., Bartek, J. & Lukas, Jiri, Sep 2004, In: Nature Cell Biology. 6, 9, p. 884-91 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway

      Liu, Julio, Kühbacher, U., Larsen, N. B., Borgermann, N., Garvanska, Dimitriya Hristoforova, Hendriks, Ivo Alexander, Ackermann, Leena, Haahr, Peter Thorlund, Gallina, I., Guérillon, C., Branigan, E., Hay, R. T., Azuma, Y., Nielsen, Michael Lund, Duxin, Julien & Mailand, Niels, 2021, In: E M B O Journal. 40, 21 p., e107413.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

      Liu, S., Bekker-Jensen, Simon Holst, Mailand, Niels, Lukas, Claudia, Bartek, J. & Lukas, Jiri, 2006, In: Molecular and Cellular Biology. 26, 16, p. 6056-64 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

      Luijsterburg, M. S., Acs, K., Ackermann, L., Wiegant, W. W., Bekker-Jensen, Simon Holst, Larsen, D. H., Khanna, K. K., van Attikum, H., Mailand, Niels & Dantuma, N. P., 2012, In: E M B O Journal. 31, 11, p. 2511-27 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology

      Lukas, Claudia, Bartkova, J., Latella, L., Falck, J., Mailand, Niels, Schroeder, T., Sehested, M., Lukas, Jiri & Bartek, J., 1 Jul 2001, In: Cancer Research. 61, 13, p. 4990-3 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

      Mailand, Niels, Bekker-Jensen, Simon Holst, Bartek, J. & Lukas, Jiri, 2006, In: Molecular Cell. 23, 3, p. 307-18 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.

      Mailand, Niels, Podtelejnikov, A. V., Groth, Anja, Mann, M., Bartek, J. & Lukas, Jiri, 2002, In: EMBO Journal. 21, 21, p. 5911-20 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Sustainability and molecular biology: An interview with Prof. Niels Mailand and Ann Schirin Mirsanaye

      Mailand, Niels & Mirsanaye, Ann Schirin, 2023, In: Molecular Cell. 83, 18, p. 3222-3224 3 p.

      Research output: Contribution to journal › Comment/debate › Research

    25. Rapid destruction of human Cdc25A in response to DNA damage

      Mailand, Niels, Falck, J., Lukas, Claudia, Syljuåsen, R. G., Welcker, M., Bartek, J. & Lukas, Jiri, 26 May 2000, In: Science (New York, N.Y.). 288, 5470, p. 1425-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 13844358