Niels Mailand
Professor, head of research, Professor
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
Mailand, Niels, Bekker-Jensen, Simon Holst, Faustrup, H., Melander, F., Bartek, J., Lukas, Claudia & Lukas, Jiri, 2007, In: Cell. 131, 5, p. 887-900 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ
Mailand, Niels, 2023, In: Molecular Cell. 83, 1, p. 3-5 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.
Mailand, Niels, Podtelejnikov, A. V., Groth, Anja, Mann, M., Bartek, J. & Lukas, Jiri, 2002, In: EMBO Journal. 21, 21, p. 5911-20 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sustainability and molecular biology: An interview with Prof. Niels Mailand and Ann Schirin Mirsanaye
Mailand, Niels & Mirsanaye, Ann Schirin, 2023, In: Molecular Cell. 83, 18, p. 3222-3224 3 p.Research output: Contribution to journal › Comment/debate › Research
Rapid destruction of human Cdc25A in response to DNA damage
Mailand, Niels, Falck, J., Lukas, Claudia, Syljuåsen, R. G., Welcker, M., Bartek, J. & Lukas, Jiri, 26 May 2000, In: Science (New York, N.Y.). 288, 5470, p. 1425-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
Marteijn, J. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Lans, H., Schwertman, P., Gourdin, A. M., Dantuma, N. P., Lukas, Jiri & Vermeulen, W., 2009, In: Journal of Cell Biology. 186, 6, p. 835-47 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
Meerang, M., Ritz, D., Paliwal, S., Garajova, Z., Bosshard, M., Mailand, Niels, Janscak, P., Hübscher, U., Meyer, H. & Ramadan, K., 2011, In: Nature Cell Biology. 13, 11, p. 1376-82 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin
Melander, F., Bekker-Jensen, Simon Holst, Falck, J., Bartek, J., Mailand, Niels & Lukas, Jiri, 21 Apr 2008, In: Journal of Cell Biology. 181, 2, p. 213-26 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ubiquitylation at Stressed Replication Forks: Mechanisms and Functions
Mirsanaye, Ann Schirin, Typas, D. & Mailand, Niels, 2021, In: Trends in Cell Biology. 31, 7, p. 584-597Research output: Contribution to journal › Review › Research › peer-review
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VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates
Mirsanaye, Ann Schirin, Hoffmann, Saskia, Weisser, Melanie, Mund, Andreas, Lopez Mendez, B., Typas, D., van den Boom, J., Benedict, Bente, Hendriks, Ivo Alexander, Nielsen, Michael Lund, Meyer, H., Duxin, Julien, Montoya, Guillermo & Mailand, Niels, 2024, In: Nature Communications. 15, 1, 16 p., 2459.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases
Mosbech, A., Lukas, Claudia, Bekker-Jensen, Simon Holst & Mailand, Niels, 24 Apr 2013, In: Journal of Biological Chemistry. 288, p. 16579-16587 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks
Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, S. V., Smedegaard, S., Sedgwick, G., Lukas, Claudia, Hartmann-Petersen, Rasmus, Lukas, Jiri, Choudhary, Chunaram, Pocock, R. D. J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
Nakamura, K., Kustatscher, G., Alabert, C., Hödl, M., Forne, I., Völker-Albert, M., Satpathy, S., Beyer, T. E., Mailand, Niels, Choudhary, Chunaram, Imhof, A., Rappsilber, J. & Groth, Anja, 2021, In: Molecular Cell. 81, 3, 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway
Oka, Y., Bekker-Jensen, Simon Holst & Mailand, Niels, 9 Apr 2015, In: E M B O Journal. 34, p. 1385-1398Research output: Contribution to journal › Journal article › Research › peer-review
- Published
UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells
Oka, Y., Varmark, H., Vitting-Seerup, K., Beli, P., Waage, J. E., Hakobyan, A., Mistrik, M., Choudhary, Chunaram, Rohde, M., Bekker-Jensen, Simon Holst & Mailand, Niels, 2014, In: E M B O Reports. 15, 9, p. 956-964 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks
Poulsen, M., Lukas, C., Lukas, J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Journal of Cell Biology. 197, 2, p. 189-99 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response
Poulsen, S. L., Hansen, R. K., Wagner, S. A., van Cuijk, L., van Belle, G. J., Streicher, W., Wikström, M., Choudhary, Chunaram, Houtsmuller, A. B., Marteijn, J. A., Bekker-Jensen, Simon Holst & Mailand, Niels, 10 Jun 2013, In: Journal of Cell Biology. 201, 6, p. 797-807 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass
Povlsen, L. K., Beli, P., Wagner, S. A., Poulsen, S. L., Sylvestersen, K. B., Poulsen, J. W., Nielsen, Michael Lund, Bekker-Jensen, Simon Holst, Mailand, Niels & Choudhary, Chunaram, Oct 2012, In: Nature Cell Biology. 14, 10, p. 1089-98 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation
Rabl, J., Bunker, R. D., Schenk, A. D., Cavadini, S., Gill, M. E., Abdulrahman, W., Andrés-Pons, A., Luijsterburg, M. S., Ibrahim, A. F. M., Branigan, E., Aguirre, J. D., Marceau, A. H., Guérillon, C., Bouwmeester, T., Hassiepen, U., Peters, A. H. F. M., Renatus, M., Gelman, L., Rubin, S. M., Mailand, N. & 3 others, , 2019, In: Molecular Cell. 75, 3, p. 483-497.e9 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links
Räschle, M., Smeenk, G., Hansen, R. K., Temu, T., Oka, Y., Hein, M. Y., Nagaraj, N., Long, D. T., Walter, J. C., Hofmann, K., Storchova, Z., Cox, J., Bekker-Jensen, Simon Holst, Mailand, Niels & Mann, Matthias, 2015, In: Science. 348, 6234, p. 539- 10 p., 1253671.Research output: Contribution to journal › Journal article › Research › peer-review
Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway
Santoni Rugiu, Eric, Falck, J., Mailand, Niels, Bartek, J. & Lukas, Jiri, May 2000, In: Molecular and Cellular Biology. 20, 10, p. 3497-509 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex
Saredi, G., Huang, H., Hammond, Colin, Alabert, C., Bekker-Jensen, Simon Holst, Forne, I., Reveron-Gomez, Nazaret, Foster, B. M., Mlejnkova, L., Bartke, T., Cejka, P., Mailand, Niels, Imhof, A., Patel, D. J. & Groth, Anja, 30 Jun 2016, In: Nature. 534, 7609, p. 714-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RADX interacts with single-stranded DNA to promote replication fork stability
Schubert, Lisa, Ho, T., Hoffmann, Saskia, Haahr, Peter Thorlund, Guérillon, C. & Mailand, Niels, Nov 2017, In: EMBO Reports. 18, 11, p. 1991-2003 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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SCAI promotes error-free repair of DNA interstrand crosslinks via the Fanconi anemia pathway
Schubert, Lisa, Hendriks, Ivo Alexander, Hertz, Emil Peter Thrane, Wu, Wei, Sellés Baiget, Selene, Hoffmann, Saskia, Bagge, Keerthana Stine Viswalingam, Gallina, I., Pentakota, S., Benedict, Bente, Johansen, Joachim, Apelt, K., Luijsterburg, M. S., Rasmussen, Simon, Lisby, Michael, Liu, Ying, Nielsen, Michael Lund, Mailand, Niels & Duxin, Julien, 2022, In: EMBO Reports. 23, 4, 20 p., e53639.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers
Schwertman, P., Bekker-Jensen, Simon Holst & Mailand, Niels, Jun 2016, In: Nature Reviews. Molecular Cell Biology. 17, 6, p. 379-94 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
Shearer, Robert Francis, Typas, D., Coscia, F., Schovsbo, Sofie Ulfbeck, Kruse, Thomas, Mund, Andreas & Mailand, Niels, 2022, In: E M B O Journal. 41, 9, 18 p., e110145.Research output: Contribution to journal › Journal article › Research › peer-review
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The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8
Singh, A. N., Oehler, J., Torrecilla, I., Kilgas, S., Li, S., Vaz, B., Guerillon, C., Fielden, J., Esperanza Hernandez-Carralero, Cabrera, E., Tullis, I. D. C., Meerang, M., Barber, P. R., Freire, R., Parsons, J., Vojnovic, B., Kiltie, A. E., Mailand, Niels & Ramadan, K., 2019, In: EMBO Journal. 38, 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling
Smeenk, G., Wiegant, W. W., Luijsterburg, M. S., Costelloe, T., Romeijn, R. J., Pastink, A., van Attikum, H., Marteijn, J. A., Vermeulen, W., Sroczynski, N. & Mailand, Niels, 15 Feb 2013, In: Journal of Cell Science. 126, 4, p. 889-903 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair
Smeenk, G. & Mailand, Niels, 28 Jun 2016, In: Frontiers in Genetics. 7, 14 p., 122.Research output: Contribution to journal › Review › Research › peer-review
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TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication
Sonneville, R., Bhowmick, Rahul, Hoffmann, Saskia, Mailand, Niels, Hickson, Ian David & Labib, K., 2019, In: eLife. 8, 19 p., e48686.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage
Thorslund, T., Ripplinger, A., Hoffmann, Saskia, Wild, T., Uckelmann, M., Villumsen, B., Narita, Takeo, Sixma, T. K., Choudhary, Chunaram, Bekker-Jensen, Simon Holst & Mailand, Niels, 19 Nov 2015, In: Nature. 527, 7578, p. 389-93 5 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA
Toledo Lazaro, L. I., Altmeyer, M., Rask, M., Lukas, Claudia, Larsen, D. H., Povlsen, L. K., Bekker-Jensen, Simon Holst, Mailand, Niels, Bartek, J. & Lukas, Jiri, 21 Nov 2013, In: Cell. 155, 5, p. 1088-1103 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling
Tollenaere, M. A. X., Tiedje, C., Rasmussen, S., Nielsen, J. C., Vind, Anna Constance, Blasius, Melanie, Batth, Tanveer Singh, Mailand, Niels, Olsen, Jesper Velgaard, Gaestel, M. & Bekker-Jensen, Simon Holst, 2019, In: Cell Reports. 26, 13, p. 3511-3521.e4 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1
Tollenaere, M. A. X., Villumsen, B. H., Blasius, M., Nielsen, J. C., Wagner, S. A., Bartek, J., Beli, P., Mailand, Niels & Bekker-Jensen, Simon Holst, 30 Nov 2015, In: Nature Communications. 6, p. 1-12 12 p., 10075.Research output: Contribution to journal › Journal article › Research › peer-review
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Centriolar satellites: key mediators of centrosome functions
Tollenaere, M. A. X., Mailand, Niels & Bekker-Jensen, Simon Holst, Jan 2015, In: Cellular and molecular life sciences : CMLS. 73, 1, p. 11-23 13 p.Research output: Contribution to journal › Review › Research › peer-review
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An unorthodox partnership in DNA repair pathway choice
Typas, D. & Mailand, Niels, 2019, In: EMBO Reports. 20, 11, e49105.Research output: Contribution to journal › Editorial › Research › peer-review
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SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair
Van Cuijk, L., Van Belle, G. J., Turkyilmaz, Y., Poulsen, S. L., Janssens, R. C., Theil, A. F., Sabatella, M., Lans, H., Mailand, Niels, Houtsmuller, A. B., Vermeulen, W. & Marteijn, J. A., 7 Jul 2015, In: Nature Communications. 6, 10 p., 7499.Research output: Contribution to journal › Journal article › Research › peer-review
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A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis
Villumsen, B. H., Danielsen, J. R., Povlsen, L., Sylvestersen, K. B., Merdes, A., Beli, P., Yang, Y., Choudhary, Chunaram, Nielsen, Michael Lund, Mailand, Niels & Bekker-Jensen, Simon Holst, 11 Oct 2013, In: E M B O Journal. 32, 23, p. 3029-3040Research output: Contribution to journal › Journal article › Research › peer-review
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Chemogenetic profiling reveals PP2A-independent cytotoxicity of proposed PP2A activators iHAP1 and DT-061
Vit, G., Duro, Joana Maria, Rajendraprasad, G., Hertz, Emil Peter Thrane, Holland, L. K. K., Weisser, Melanie, McEwan, B. C., Lopez-Mendez, B., Sotelo-Parrilla, P., Jeyaprakash, A. A., Montoya, Guillermo, Mailand, Niels, Maeda, K., Kettenbach, A., Barisic, Marin & Nilsson, Jakob, 2022, In: EMBO Journal. 41, 14, e110611.Research output: Contribution to journal › Journal article › Research › peer-review
Human Cdc14A phosphatase modulates the G2/M transition through Cdc25A and Cdc25B
Vázquez-Novelle, M. D., Mailand, Niels, Ovejero, S., Bueno, A. & Sacristán, M. P., 2010, In: Journal of Biological Chemistry. 285, 52, p. 40544-53 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ATR-Chk1-APC/C-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress
Yamada, M., Watanabe, K., Mistrik, M., Vesela, E., Protivankova, I., Mailand, Niels, Lee, M. H., Masai, H., Lukas, Jiri & Bartek, J., 15 Nov 2013, In: Genes & Development. 27, 22, p. 2459-2472 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells
Østergaard, Vibe Hallundbæk, Pentzold, C., Pedersen, R. T., Iosif, S., Alpi, A., Bekker-Jensen, Simon Holst, Mailand, Niels & Lisby, Michael, 2012, In: D N A Repair. 11, 11, p. 892–905 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 13844358
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Activation of the ATR kinase by the RPA-binding protein ETAA1
Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular basis and regulation of OTULIN-LUBAC interaction
Research output: Contribution to journal › Journal article › Research › peer-review
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Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage
Research output: Contribution to journal › Letter › Research › peer-review
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