Jesper Velgaard Olsen
Professor, Deputy Head of Centre, Professor
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Analytical utility of mass spectral binning in proteomic experiments by SPectral Immonium Ion Detection (SPIID)
Kelstrup, C. D., Freese, C., Heck, A. J. R., Olsen, Jesper Velgaard & Nielsen, Michael Lund, 3 Jun 2014, In: Molecular & Cellular Proteomics. 13, 8, p. 1914-1924 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Limits for resolving isobaric tandem mass tag reporter ions using phase constrained spectrum deconvolution
Kelstrup, C. D., Aizikov, K., Batth, Tanveer Singh, Kreutzman, A., Grinfeld, D., Lange, O., Mourad, D., Makarov, A. A. & Olsen, Jesper Velgaard, 2 Nov 2018, In: Journal of Proteome Research. 17, 11, p. 4008-4016 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cetuximab Resistance in Squamous Carcinomas of the Upper Aerodigestive Tract Is Driven by Receptor Tyrosine Kinase Plasticity: Potential for mAb Mixtures
Kjær, I., Lindsted, T., Fröhlich, C., Olsen, Jesper Velgaard, Horak, I. D., Kragh, M. & Pedersen, M. W., Jul 2016, In: Molecular Cancer Therapeutics. 15, 7, p. 1614-1626 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
The low molecular weight proteome of Halobacterium salinarum
Klein, C., Aivaliotis, M., Olsen, Jesper Velgaard, Falb, M., Besir, H., Scheffer, B., Bisle, B., Tebbe, A., Konstantinidis, K., Siedler, F., Pfeiffer, F., Mann, Matthias & Oesterhelt, D., 2007, In: Journal of Proteome Research. 6, 4, p. 1510-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Ubc9 sumoylation regulates SUMO target discrimination
Knipscheer, P., Flotho, A., Klug, H., Olsen, Jesper Velgaard, van Dijk, W. J., Fish, A., Johnson, E. S., Mann, M., Sixma, T. K. & Pichler, A., 2008, In: Molecular Cell. 31, 3, p. 371-82 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation
Knipscheer, P., van Dijk, W. J., Olsen, Jesper Velgaard, Mann, Matthias & Sixma, T. K., 2007, In: EMBO Journal. 26, 11, p. 2797-807 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protocol for high-throughput semi-automated label-free- or TMT-based phosphoproteome profiling
Koenig, Claire, Martinez Del Val, Ana, Naicker, P., Stoychev, S., Jordaan, J. & Olsen, Jesper Velgaard, 2023, In: STAR Protocols. 4, 3, 30 p., 102536.Research output: Contribution to journal › Journal article › Research › peer-review
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Optimal analytical strategies for sensitive and quantitative phosphoproteomics using TMT-based multiplexing
Koenig, Claire, Martinez-Val, A., Franciosa, Giulia & Olsen, Jesper Velgaard, 2022, In: Proteomics. 22, 19-20, 13 p., 2100245.Research output: Contribution to journal › Journal article › Research › peer-review
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A direct role of Mad1 in the spindle assembly checkpoint beyond Mad2 kinetochore recruitment
Kruse, Thomas, Larsen, Marie Sofie Yoo, Sedgwick, G. G., Sigurdsson, J. O., Streicher, W., Olsen, Jesper Velgaard & Nilsson, Jakob, 29 Jan 2014, In: E M B O Reports. 15, p. 282-290Research output: Contribution to journal › Journal article › Research › peer-review
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Differential ultracentrifugation enables deep plasma proteomics through enrichment of extracellular vesicles
Kverneland, Anders Handrup, Østergaard, Ole, Emdal, Kristina Bennet, Svane, Inge Marie & Olsen, Jesper Velgaard, 2023, In: Proteomics. 23, 7-8, 2200039.Research output: Contribution to journal › Journal article › Research › peer-review
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Multi-protease analysis of Pleistocene bone proteomes
Lanigan, Liam Thomas, Mackie, Meaghan, Feine, S., Hublin, J., Schmitz, R. W., Wilcke, A., Collins, Matthew James, Cappellini, Enrico, Olsen, Jesper Velgaard, Taurozzi, Alberto John & Welker, Frido, 30 Sep 2020, In: Journal of Proteomics. 228, 11 p., 103889.Research output: Contribution to journal › Journal article › Research › peer-review
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GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain
Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, , 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphorylation of the yeast γ-tubulin Tub4 regulates microtubule function
Lin, T., Gombos, L., Neuner, A., Sebastian, D., Olsen, Jesper Velgaard, Hrle, A., Benda, C. & Schiebel, E., 2011, In: P L o S One. 6, 5, p. e19700Research output: Contribution to journal › Journal article › Research › peer-review
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Quantitative proteomics of human heart samples collected In vivo reveal the remodeled protein landscape of dilated left atrium without atrial fibrillation
Linscheid, N., Poulsen, P. C., Pedersen, I. D., Gregers, E., Svendsen, Jesper Hastrup, Olesen, Morten Steen Salling, Olsen, Jesper Velgaard, Delmar, M. & Lundby, Alicia, 2020, In: Molecular and Cellular Proteomics. 19, 7, p. 1132-1144Research output: Contribution to journal › Journal article › Research › peer-review
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Quantitative proteome comparison of human hearts with those of model organisms
Linscheid, N., Santos, A., Poulsen, P. C., Mills, Robert William, Callø, Kirstine, Leurs, U., Ye, J. Z., Stolte, C., Thomsen, Morten Bækgaard, Bentzen, Bo Hjorth, Lundegaard, Pia Rengtved, Olesen, Morten Steen Salling, Jensen, Lars Juhl, Olsen, Jesper Velgaard & Lundby, Alicia, 2021, In: PLOS Biology. 19, 4, 22 p., e3001144.Research output: Contribution to journal › Journal article › Research › peer-review
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Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking
Linscheid, N., Logantha, S. J. R. J., Poulsen, C., Zhang, S., Schrölkamp, Maren, Egerod, Kristoffer Lihme, Thompson, J. J., Kitmitto, A., Galli, G., Humphries, M. J., Zhang, H., Pers, Tune H, Olsen, Jesper Velgaard, Boyett, M. & Lundby, Alicia, 2019, In: Nature Communications. 10, 19 p., 2889.Research output: Contribution to journal › Journal article › Research › peer-review
Nanoelectrospray peptide mapping revisited: Composite survey spectra allow high dynamic range protein characterization without LCMS on an orbitrap mass spectrometer
Lu, A., Waanders, L. F., Almeida, R., Li, G., Allen, M., Cox, J., Olsen, Jesper Velgaard, Bonaldi, T. & Mann, Matthias, 1 Dec 2007, In: International Journal of Mass Spectrometry. 268, 2-3, p. 158-167 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ETD-Based Proteomic Profiling Improves Arginine Methylation Identification and Reveals Novel PRMT5 Substrates
Lu, L., Ye, Z., Zhang, R., Olsen, Jesper Velgaard, Yuan, Y. & Mao, Y., 2024, In: Journal of Proteome Research. 23, 3, p. 1014-1027Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphoproteomics taken to heart
Lundby, Alicia & Olsen, Jesper Velgaard, 1 Sep 2013, In: Cell Cycle. 12, 17, p. 2707-2708 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
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Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics
Lundby, A., Rossin, E. J., Steffensen, A. B., Acha, M. R., Newton-Cheh, C., Pfeufer, A., Lynch, S. N., Olesen, S-P., Brunak, S., Ellinor, P. T., Jukema, J. W., Trompet, S., Ford, I., Macfarlane, P. W., Krijthe, B. P., Hofman, A., Uitterlinden, A. G., Stricker, B. H., Nathoe, H. M., Spiering, W. & 8 others, , 22 Jun 2014, In: Nature Methods. 11, 8, p. 868-874 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns
Lundby, Alicia, Hansen, K. L., Weinert, B. T., Breinholt Bekker-Jensen, D., Secher, A., Skovgaard, T., Kelstrup, C., Dmytriyev, A., Choudhary, Chunaram, Lundby, C. & Olsen, Jesper Velgaard, 30 Aug 2012, In: Cell Reports. 2, 2, p. 419-431 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
Lundby, Alicia, Franciosa, Giulia, Emdal, Kristina Bennet, Refsgaard, J. C., Gnosa, S. P., Bekker-Jensen, D. B., Secher, A., Maurya, S. R., Paul, I., Mendez, B. L., Kelstrup, C. D., Francavilla, C., Kveiborg, Marie, Montoya, Guillermo, Jensen, Lars Juhl & Olsen, Jesper Velgaard, 2019, In: Cell. 179, 2, p. 543-560Research output: Contribution to journal › Journal article › Research › peer-review
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Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues
Lundby, Alicia, Secher, A., Lage, K., Nordsborg, Nikolai Baastrup, Dmytriyev, A., Lundby, C. & Olsen, Jesper Velgaard, 6 Jun 2012, In: Nature Communications. 3, p. 1-10 10 p., Article 876.Research output: Contribution to journal › Journal article › Research › peer-review
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In Vivo Phosphoproteomics Analysis Reveals the Cardiac Targets of β-Adrenergic Receptor Signaling
Lundby, Alicia, Andersen, M. N., Steffensen, Annette Buur, Horn, H., Kelstrup, C. D., Francavilla, C., Jensen, Lars Juhl, Schmitt, Nicole, Thomsen, Morten Bækgaard & Olsen, Jesper Velgaard, 4 Jun 2013, In: Science Signaling. 6, 278, p. rs11 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GeLCMS for in-depth protein characterization and advanced analysis of proteomes
Lundby, Alicia & Olsen, Jesper Velgaard, 1 Jan 2011, Gel-Free Proteomics Methods and Protocols. Vol. 753. p. 143-55 13 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Separation of the gluconeogenic and mitochondrial functions of pgc-1α through s6 kinase
Lustig, Y., Ruas, J. L., Estall, J. L., Lo, J. C., Devarakonda, S., Laznik, D., Choi, J. H., Spiegelman, B. M., Ono, H. & Olsen, Jesper Velgaard, 15 Jun 2011, In: Genes & Development. 25, 12, p. 1232-1244 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Top-down protein sequencing and MS3 on a hybrid linear quadrupole ion trap-orbitrap mass spectrometer
Macek, B., Waanders, L. F., Olsen, Jesper Velgaard & Mann, Matthias, 2006, In: Molecular and Cellular Proteomics. 5, 5, p. 949-58 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis
Macek, B., Mijakovic, I., Olsen, Jesper Velgaard, Gnad, F., Kumar, C., Jensen, P. R. & Mann, Matthias, Feb 2008, In: Molecular and Cellular Proteomics. 6, 4, p. 697-707 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation
Macek, B., Gnad, F., Soufi, B., Kumar, C., Olsen, Jesper Velgaard, Mijakovic, I. & Mann, Matthias, 2007, In: Molecular and Cellular Proteomics. 7, 2, p. 299-307 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Palaeoproteomic Profiling of Conservation Layers on a 14th Century Italian Wall Painting
Mackie, Meaghan, Rüther, P. L., Samodova, D., Di Gianvincenzo, Fabiana, Granzotto, C., Lyon, D., Peggie, D. A., Howard, H., Harrison, L., Jensen, Lars Juhl, Olsen, Jesper Velgaard & Cappellini, Enrico, 2018, In: Angewandte Chemie (International ed. in English). 57, 25, p. 7369-7374 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Combining mass spectrometry and machine learning to discover bioactive peptides
Madsen, C. T., Refsgaard, J. C., Teufel, F. G., Kjærulff, S. K., Wang, Z., Meng, G., Jessen, C., Heljo, P., Jiang, Q., Zhao, X., Wu, B., Zhou, X., Tang, Y., Jeppesen, J. F., Kelstrup, C. D., Buckley, S. T., Tullin, S., Nygaard-Jensen, J., Chen, X., Zhang, F. & 4 others, , 2022, In: Nature Communications. 13, 17 p., 6235.Research output: Contribution to journal › Journal article › Research › peer-review
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The feasibility of palaeoproteomics for studying ancient hominins from South Africa
Madupe, Palesa Petunia, Hlazo, N., Ruther, P. L., Mackie, Meaghan, Welker, Frido, Ramos Madrigal, Jazmin, Patramanis, Ioannis, Racimo, Fernando, Schroeder, L., Olsen, Jesper Velgaard, Ackermann, R. R. & Cappellini, Enrico, 2022, In: American journal of biological anthropology. 177, S73, p. 112 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Identification of new chicken egg proteins by mass spectrometry-based proteomic analysis
Mann, K., Olsen, Jesper Velgaard, MaĉEk, B., Gnad, F. & Mann, Matthias, Jun 2008, In: World's Poultry Science Journal. 64, 2, p. 209-218 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Proteomic analysis of the acid-soluble organic matrix of the chicken calcified eggshell layer
Mann, K., Macek, B. & Olsen, Jesper Velgaard, 2006, In: Proteomics. 6, 13, p. 3801-10 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Phosphoproteins of the chicken eggshell calcified layer
Mann, K., Olsen, Jesper Velgaard, Macek, B., Gnad, F. & Mann, Matthias, 2007, In: Proteomics. 7, 1, p. 106-15 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Spatial-proteomics reveal in-vivo phospho-signaling dynamics at subcellular resolution
Martinez Del Val, Ana, Bekker-Jensen, D. B., Steigerwald, S., Mehta, A., Tran, T., Sikorski, K., Torres Vega, Estefania, Kwasniewicz, E., Brynjólfsdóttir, S. H., Frankel, Lisa, Kjøbsted, Rasmus, Krogh, Nicolai, Lundby, Alicia, Bekker-Jensen, Simon Holst, Lund-Johansen, F. & Olsen, Jesper Velgaard, 2 Feb 2021, bioRxiv, p. 1-34, 34 p.Research output: Working paper › Preprint › Research
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Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution
Martinez Del Val, Ana, Bekker-Jensen, D. B., Steigerwald, S., Koenig, Claire, Østergaard, Ole, Mehta, A., Tran, T., Sikorski, K., Torres Vega, Estefania, Kwasniewicz, E., Brynjólfsdóttir, S. H., Frankel, Lisa, Kjøbsted, Rasmus, Krogh, Nicolai, Lundby, Alicia, Bekker-Jensen, Simon Holst, Lund-Johansen, F. & Olsen, Jesper Velgaard, 2021, In: Nature Communications. 12, 1, 17 p., 7113.Research output: Contribution to journal › Journal article › Research › peer-review
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Data Processing and Analysis for DIA-Based Phosphoproteomics Using Spectronaut
Martinez Del Val, Ana, Bekker-Jensen, D. B., Hogrebe, A. & Olsen, Jesper Velgaard, 2021, Proteomics Data Analysis. Cecconi, D. (ed.). Springer, p. 95-107 13 p. (Methods in Molecular Biology, Vol. 2361).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Obtaining Complete Human Proteomes
Martinez Del Val, Ana, Hernández Guzmán, Ulises & Olsen, Jesper Velgaard, 2022, In: Annual Review of Genomics and Human Genetics. 23, p. 10.1-10.23 23 p.Research output: Contribution to journal › Review › Research › peer-review
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Hybrid-DIA: intelligent data acquisition integrates targeted and discovery proteomics to analyze phospho-signaling in single spheroids
Martinez Del Val, Ana, Fort, K., Koenig, Claire, van der Hoeven, Leander Roeland, Franciosa, Giulia, Moehring, T., Ishihama, Y., Chen, Y. J., Makarov, A., Xuan, Y. & Olsen, Jesper Velgaard, 2023, In: Nature Communications. 14, 18 p., 3599.Research output: Contribution to journal › Journal article › Research › peer-review
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Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function
Małecki, J. M., Odonohue, M., Kim, Y., Jakobsson, M. E., Gessa, L., Pinto, R., Wu, J., Davydova, E., Moen, A., Olsen, Jesper Velgaard, Thiede, B., Gleizes, P., Leidel, S. A. & Falnes, P. Ø., 2021, In: Nucleic Acids Research. 49, 6, p. 3185-3203 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics
Mertins, P., Eberl, H. C., Renkawitz, J., Olsen, Jesper Velgaard, Tremblay, M. L., Mann, M., Ullrich, A. & Daub, H., 2008, In: Molecular and Cellular Proteomics. 7, 9, p. 1763-77 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mass spectrometry-based proteomics of cerebrospinal fluid in pediatric central nervous system malignancies: a systematic review with meta-analysis of individual patient data
Larsen, Christian Mirian, Thastrup, M., Mathiasen, R., Schmiegelow, Kjeld, Olsen, Jesper Velgaard & Østergaard, Ole, 2024, In: Fluids and Barriers of the CNS. 21, 17 p., 14.Research output: Contribution to journal › Review › Research › peer-review
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria
Mootha, V. K., Bunkenborg, J., Olsen, Jesper Velgaard, Hjerrild, M., Wisniewski, J. R., Stahl, E., Bolouri, M. S., Ray, H. N., Sihag, S., Kamal, M., Patterson, N., Lander, E. S. & Mann, Matthias, 2003, In: Cell. 115, 5, p. 629-40 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
MSQuant, an Open Source Platform for Mass Spectrometry-Based Quantitative Proteomics
Mortensen, P., Gouw, J. W., Olsen, Jesper Velgaard, Ong, S., Rigbolt, K. T. G., Bunkenborg, J., Cox, J., Foster, L. J., Heck, A. J. R., Blagoev, B., Andersen, J. S. & Mann, Matthias, Jan 2010, In: Journal of Proteome Research.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular basis of Tousled-Like Kinase 2 activation
Mortuza, G. B., Hermida, D., Pedersen, A., Segura-Bayona, S., López-Méndez, B., Redondo, P., Rüther, P., Pozdnyakova, I., Garrote, A. M., Muñoz, I. G., Villamor-Payà, M., Jauset, C., Olsen, Jesper Velgaard, Stracker, T. H. & Montoya, Guillermo, 2018, In: Nature Communications. 9, 1, p. 2535 2535.Research output: Contribution to journal › Journal article › Research › peer-review
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From Phosphosites to Kinases
Munk, S., Refsgaard, J. C., Olsen, Jesper Velgaard & Jensen, Lars Juhl, 2016, Phospho-Proteomics: Methods and Protocols. Stechow, L. V. (ed.). Springer, Vol. 1355. p. 307-21 15 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress
Munk, S., Sigurðsson, J. O., Xiao, Z., Batth, Tanveer Singh, Franciosa, Giulia, von Stechow, L., Lopez-Contreras, Andres, Vertegaal, A. C. O. & Olsen, Jesper Velgaard, 2017, In: Cell Reports. 21, 2, p. 546-558 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Systems Analysis for Interpretation of Phosphoproteomics Data
Munk, S., Refsgaard, J. C. & Olsen, Jesper Velgaard, 2016, Phospho-Proteomics: Methods and Protocols. Stechow, L. V. (ed.). Springer, Vol. 1355. p. 341-60 20 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Comparing extraction method efficiency for high-throughput palaeoproteomic bone species identification
Mylopotamitaki, Dorothea, Harking, F. S., Taurozzi, Alberto John, Fagernäs, Zandra Selina, Godinho, R. M., Smith, G. M., Weiss, M., Schüler, T., McPherron, S. P., Meller, H., Cascalheira, J., Bicho, N., Olsen, Jesper Velgaard, Hublin, J. & Welker, Frido, 2023, In: Scientific Reports. 13, 14 p., 18345.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 9925376
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Molecular basis of Tousled-Like Kinase 2 activation
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52 Genetic Loci Influencing Myocardial Mass
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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
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