Søren Brunak
Professor
Brunak Group
Blegdamsvej 3B
2200 København N
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Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study
Gudmundsdottir, V., Pedersen, H. K., Mazzoni, G., Allin, K. H., Artati, A., Beulens, J. W., Banasik, K., Brorsson, C., Cederberg, H., Chabanova, E., De Masi, F., Elders, P. J., Forgie, I., Giordano, G. N., Grallert, H., Gupta, R., Haid, M., Hansen, T., Hansen, T. H., Hattersley, A. T. & 36 others, , 2020, In: Genome Medicine. 12, 1, 17 p., 109.Research output: Contribution to journal › Journal article › Research › peer-review
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Modules, networks and systems medicine for understanding disease and aiding diagnosis
Gustafsson, M., Nestor, C. E., Zhang, H., Barabási, A., Baranzini, S., Brunak, Søren, Chung, K. F., Federoff, H. J., Gavin, A., Meehan, R. R., Picotti, P., Pujana, M. À., Rajewsky, N., Smith, K. G., Sterk, P. J., Villoslada, P. & Benson, M., Oct 2014, In: Genome Medicine. 6, 10, p. 82Research output: Contribution to journal › Journal article › Research › peer-review
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Comparison of quantitative trait loci methods: Total expression and allelic imbalance method in brain RNA-seq
Gådin, J. R., Buil, A., Colantuoni, C., Jaffe, A. E., Nielsen, J., Shin, J., Hyde, T. M., Kleinman, J. E., Plath, N., Eriksson, P., Brunak, Søren, Didriksen, M., Weinberger, D. R., Folkersen, L. & BrainSeq Consortium, B. C., 2019, In: PLoS ONE. 14, 6, 16 p., e0217765.Research output: Contribution to journal › Journal article › Research › peer-review
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The sequences of 150,119 genomes in the UK Biobank
Halldorsson, B. V., Eggertsson, H. P., Moore, K. H. S., Hauswedell, H., Eiriksson, O., Ulfarsson, M. O., Palsson, G., Hardarson, M. T., Oddsson, A., Jensson, B. O., Kristmundsdottir, S., Sigurpalsdottir, B. D., Stefansson, O. A., Beyter, D., Holley, G., Tragante, V., Gylfason, A., Olason, P. I., Zink, F., Asgeirsdottir, M. & 27 others, , 2022, In: Nature. 607Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development
Hansen, K. L., Greenway, S. C., Rosenfeld, J. A., Wakimoto, H., Gorham, J. M., Segrè, A. V., Roberts, A. E., Smoot, L. B., Pu, W. T., C Pereira, A., Mesquita, S. M., Tommerup, Niels, Brunak, Søren, Ballif, B. C., Shaffer, L. G., Donahoe, P. K., Daly, M. J., Seidman, J. G., Seidman, C. E. & Larsen, Lars Allan, 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 35, p. 14035-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes
Hansen, K. L., Hansen, N. T., Karlberg, E. O., Eklund, A. C., Roque, F. S., Donahoe, P. K., Szallasi, Z., Jensen, T. S. & Brunak, Søren, 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 52, p. 20870-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dissecting spatio-temporal protein networks driving human heart development and related disorders
Hansen, K. L., Møllgård, K., Greenway, S., Wakimoto, H., Gorham, J. M., Workman, C. T., Bendsen, E., Hansen, N. T., Rigina, O., Roque, F. S., Wiese, C., Christoffels, V. M., Roberts, A. E., Smoot, L. B., Pu, W. T., Donahoe, P. K., Tommerup, N., Brunak, S., Seidman, C. E., Seidman, J. G. & 1 others, , 2010, In: Molecular Systems Biology. 6, p. 381Research output: Contribution to journal › Journal article › Research › peer-review
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Prediction of pH-dependent aqueous solubility of druglike molecules
Hansen, N. T., Kouskoumvekaki, I., Jørgensen, Flemming Steen, Brunak, Søren & Jónsdóttir, S. O., 2012, In: Journal of Chemical Information and Modeling. 46, 6, p. 2601-2609 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors
Hansen, T. F., Banasik, K., Erikstrup, C., Pedersen, O. B., Westergaard, D., Chmura, P. J., Nielsen, K., Thørner, L., Hjalgrim, H., Paarup, H., Larsen, M. A. H., Petersen, M., Jennum, P., Andersen, S., Nyegaard, M., Jemec, G. B. E., Olesen, J., Werge, T., Johansson, P. I., Sørensen, E. & 3 others, , 9 Jun 2019, In: BMJ Open. 9, 6, p. 1-7 7 p., e028401.Research output: Contribution to journal › Journal article › Research › peer-review
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ELIXIR-EXCELERATE: establishing Europe's data infrastructure for the life science research of the future
ELIXIR-EXCELERATE Community, E. C., 2021, In: EMBO Journal. 40, 6, 9 p., e107409.Research output: Contribution to journal › Comment/debate › Research
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Linking progression patterns in ischaemic heart disease to comorbidities and genetics by integrated analysis of electronic health records and population-wide registries
Haue, Amalie Dahl, Holm, Peter Christoffer, Siggaard, T., Jørgensen, Isabella Friis, Simone, C., Eriksson, R., Orozco, A. A., Weeke, P. E., Christensen, A. H., Westergaard, David, Banasik, Karina, Køber, Lars Valeur, Ullum, H., Bundgård, Henning & Brunak, Søren, 2020, In: European Heart Journal. 41, p. 3496 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Population-wide disease trajectories in ischaemic heart disease
Haue, Amalie Dahl, Jørgensen, Isabella Friis, Christensen, A. H. C., Simon, C. S., Haakonsen, M. L. H., Russo, F. R., Rodriguez, C. L. R., Orozco, A. A. O., Siggard, T. S., Banasik, Karina, Weeke, P. E. W., Westergaard, David, Moseley, P. L. M., Bundgård, Henning & Brunak, Søren, Oct 2019, In: European Heart Journal. 40, S1, p. 1214-1214 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Temporal patterns of multi-morbidity in 570157 ischemic heart disease patients: a nationwide cohort study
Haue, Amalie Dahl, Armenteros, J. J. A., Holm, Peter Christoffer, Eriksson, R., Moseley, P. L., Køber, Lars Valeur, Bundgård, Henning & Brunak, Søren, 2022, In: Cardiovascular Diabetology. 21, 13 p., 87.Research output: Contribution to journal › Journal article › Research › peer-review
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Præcisionskardiologi
Haue, Amalie Dahl, Vissing, C. R., Tfelt-Hansen, Jacob, Brunak, Søren, Bundgård, Henning & Weeke, P. E., 1 Oct 2018, In: Ugeskrift for Laeger. 180, 20A, p. 1851-54Research output: Contribution to journal › Journal article › Research › peer-review
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Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour
Hay-Schmidt, Anders, Finkielman, O. T. E., Jensen, Benjamin Anderschou Holbech, Høgsbro, C. F., Holm, J. B., Johansen, K. H., Jensen, T. K., Andrade, A. M., Swan, S. H., Bornehag, C., Brunak, Søren, Jegou, B., Kristiansen, Karsten & Kristensen, D. M., 2017, In: Reproduction. 154, 2, p. 145-152 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cholesterol not particle concentration mediates the atherogenic risk conferred by apolipoprotein B particles - A Mendelian randomization analysis
Helgadottir, A., Thorleifsson, G., Snaebjarnarson, A., Stefansdottir, L., Sveinbjornsson, G., Tragante, V., Björnsson, E., Steinthorsdottir, V., Gretarsdottir, S., Helgason, H., Saemundsdottir, J., Olafsson, I., Thune, J. J., Axelsson Raja, A., Ghouse, J., Olesen, M. S., Christensen, A., Jacobsen, R. L., Dowsett, J., Bruun, M. T. & 18 others, , 2022, In: European Journal of Preventive Cardiology. 29, 18, p. 2374–2385Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic variability in the absorption of dietary sterols affects the risk of coronary artery disease
Helgadottir, A., Thorleifsson, G., Alexandersson, K. F., Tragante, V., Thorsteinsdottir, M., Eiriksson, F. F., Gretarsdottir, S., Björnsson, E., Magnusson, O., Sveinbjornsson, G., Jonsdottir, I., Steinthorsdottir, V., Ferkingstad, E., Jensson, B. Ö., Stefansson, H., Olafsson, I., Christensen, A. H., Torp-Pedersen, C., Køber, L., Pedersen, O. B. & 23 others, , 2020, In: European Heart Journal. 41, 28, p. 2618-2628 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement
Henkel, C., Styrkársdóttir, U., Thorleifsson, G., Stefánsdóttir, L., Björnsdóttir, G., Banasik, K., Brunak, S., Erikstrup, C., Dinh, K. M., Hansen, T. F., Nielsen, K. R., Bruun, M. T., Dowsett, J., Brodersen, T., Thorgeirsson, T. E., Gromov, K., Boesen, M. P., Ullum, H., Ostrowski, S. R., Pedersen, O. B. & 3 others, , 2023, In: Annals of the Rheumatic Diseases. 82, p. 384-392Research output: Contribution to journal › Journal article › Research › peer-review
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The temporal association of hyperhidrosis and its comorbidities – a nationwide hospital-based cohort study
Henning, M. A. S., Reguant, R., Jørgensen, Isabella Friis, Andersen, Rune Kjærsgaard, Ibler, Kristina Sophie, Pedersen, Ole Birger Vesterager, Jemec, Gregor & Brunak, Søren, 2022, In: Journal of the European Academy of Dermatology and Venereology. 36, 12, p. 2504-2511Research output: Contribution to journal › Journal article › Research › peer-review
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The burden of disease of three food-associated heavy metals in clusters in the Danish population - Towards targeted public health strategies
Herrera, J. A. R., Thomsen, S. T., Jakobsen, L. S., Fagt, S., Banasik, Karina, Izarzugaza, J. M. G., Brunak, Søren & Pires, S. M., 2021, In: Food and Chemical Toxicology. 150, 112072.Research output: Contribution to journal › Journal article › Research › peer-review
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Clinical, genetic, and experimental increase in soluble urokinase plasminogen activator receptor levels promotes atherosclerosis
Hindy, G., Tyrrell, D. J., Vasbinder, A., Wei, C., Presswalla, F., Wang, H., Blakely, P. K., Ozel, A. B., Graham, S. E., Holton, G. H., Dowsett, J., Fahed, A. C., Amadi, K-M., Erne, G. K., Tekumulla, A., Ismail, A., Launius, C., Sotoodehnia, N., Pankow, J. S., Thørner, L. W. & 22 others, , 2022, In: Journal of Clinical Investigation. 132, 24, 14 p., e158788.Research output: Contribution to journal › Journal article › Research › peer-review
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Pancreatic cancer symptom trajectories from Danish registry data and free text in electronic health records
Hjaltelin, Jessica Xin, Novitski, Sif Ingibergsdóttir, Jørgensen, Isabella Friis, Siggaard, T., Vulpius, S. A., Westergaard, David, Johansen, Julia Sidenius, Chen, I. M., Jensen, Lars Juhl & Brunak, Søren, 2023, In: eLife. 12, 15 p., e84919.Research output: Contribution to journal › Journal article › Research › peer-review
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Visualising disease trajectories from population-wide data
Hjaltelin, Jessica Xin, Currant, H., Jørgensen, Isabella Friis & Brunak, Søren, 2023, In: Frontiers in Bioinformatics. 3, 5 p., 1112113.Research output: Contribution to journal › Editorial › Research › peer-review
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Identification of hyper-rewired genomic stress non-oncogene addiction genes across 15 cancer types
Hjaltelin, Jessica Xin, Izarzugaza, J. M. G., Jensen, Lars Juhl, Russo, F., Westergaard, David & Brunak, Søren, 2019, In: npj Systems Biology and Applications. 5, 10 p., 27.Research output: Contribution to journal › Journal article › Research › peer-review
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The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load
Holmkvist, J., Banasik, K., Andersen, G., Unoki, H., Jensen, T. S., Pisinger, C., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Brunak, Søren, Maeda, S., Hansen, T. & Pedersen, Oluf Borbye, 2009, In: PLoS ONE. 4, 6, p. e5872Research output: Contribution to journal › Journal article › Research › peer-review
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A large-cohort, longitudinal study determines pre-cancer disease routes across different cancer types
Hjaltelin, Jessica Xin, Helleberg, M., Jensen, A. B., Brunak, Søren & Lundgren, Jens, 2019, In: Cancer Research. 79, 4, p. 864-872Research output: Contribution to journal › Journal article › Research › peer-review
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Network biology concepts in complex disease comorbidities
Hjaltelin, Jessica Xin, Thomas, Cecilia Engel & Brunak, Søren, Oct 2016, In: Nature Reviews. Genetics. 17, p. 615–629Research output: Contribution to journal › Review › Research › peer-review
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The bio.tools registry of software tools and data resources for the life sciences
Ison, J., Ienasescu, H., Chmura, P., Rydza, E., Ménager, H., Kalaš, M., Schwämmle, V., Grüning, B., Beard, N., Lopez, R., Duvaud, S., Stockinger, H., Persson, B., Vařeková, R. S., Raček, T., Vondrášek, J., Peterson, H., Salumets, A., Jonassen, I., Hooft, R. & 16 others, , 2019, In: Genome Biology. 20, 1, 4 p., 164.Research output: Contribution to journal › Letter › Research › peer-review
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Tools and data services registry: a community effort to document bioinformatics resources
Ison, J., Rapacki, K., Ménager, H., Kalaš, M., Rydza, E., Chmura, P., Anthon, C., Beard, N., Berka, K., Bolser, D., Booth, T., Bretaudeau, A., Brezovsky, J., Casadio, R., Cesareni, G., Coppens, F., Cornell, M., Cuccuru, G., Davidsen, K., Vedova, G. D. & 49 others, , 2016, In: Nucleic Acids Research. 44, D1, p. D38-D47 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Systems genetics analysis identifies calcium-signaling defects as novel cause of congenital heart disease
Izarzugaza, J. M. G., Ellesøe, S. G., Doganli, Canan, Ehlers, Natasja Spring, Dalgaard, M. D., Audain, E., Dombrowsky, G., Banasik, Karina, Sifrim, A., Wilsdon, A., Thienpont, B., Breckpot, J., Gewillig, M., Brook, J. D., Hitz, M., Larsen, Lars Allan, Brunak, Søren & Competence Network for Congenital Heart Defects, Germany, C. N. F. C. H. D. G., 2020, In: Genome Medicine. 12, 1, 13 p., 76.Research output: Contribution to journal › Journal article › Research › peer-review
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Increase in clinically recorded type 2 diabetes after colectomy
Jensen, A. B., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye, Jess, T., Brunak, Søren & Allin, K. H., 2018, In: eLife. 7, e37420.Research output: Contribution to journal › Journal article › Research › peer-review
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Temporal disease trajectories condensed from population-wide registry data covering 6.2 million patients
Jensen, A. B., Moseley, P. L., Oprea, T. I., Ellesøe, S. G., Eriksson, R., Schmock, H., Jensen, P. B., Jensen, Lars Juhl & Brunak, Søren, 24 Jun 2014, In: Nature Communications. 5, 10 p., 4022.Research output: Contribution to journal › Journal article › Research › peer-review
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Long-term risk of cardiovascular and cerebrovascular disease after removal of the colonic microbiota by colectomy: a cohort study based on the Danish National Patient Register from 1996 to 2014
Jensen, A. B., Ajslev, T. A., Brunak, Søren & Sørensen, Thorkild I.A., 15 Dec 2015, In: B M J Open. 5, 8 p., e008702.Research output: Contribution to journal › Journal article › Research › peer-review
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Assembly and analysis of 100 full MHC haplotypes from the Danish population
Jensen, J. M., Villesen, P., Friborg, R. M., Mailund, T., Besenbacher, S., Sørensen, L. M., Petersen, B., Sibbesen, J. A., Liu, S., Skov, L., Belling, K. G., Have, C. T., Izarzugaza, J. M. G., Grosjean, M., Bork-Jensen, J., Grove, J., Als, T. D., Huang, S., Chang, Y., Xu, R. & 39 others, , Sep 2017, In: Genome Research. 27, 9, p. 1597-1607 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of a gene panel for targeted sequencing of colorectal cancer samples
Jensen, K. H., Izarzugaza, J. M. G., Juncker, A. S., Hansen, R. B., Hansen, T. F., Timshel, P., Blondal, T., Jensen, T. S., Rygaard-Hjalsted, E., Mouritzen, P., Thorsen, M., Wernersson, R., Nielsen, H. B., Jakobsen, A., Brunak, Søren & Sørensen, F. B., 2018, In: OncoTarget. 9, 10, p. 9043-9060 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
Functionality of system components: conservation of protein function in protein feature space
Jensen, L. J., Ussery, D. & Brunak, Søren, 2003, In: Genome Research. 13, 11, p. 2444-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Circular reasoning rather than cyclic expression
Jensen, Lars Juhl, de Lichtenberg, U., Jensen, T. S., Brunak, Søren & Bork, P., 2008, In: Genome Biology. 9, 6, p. 403Research output: Contribution to journal › Journal article › Research › peer-review
Co-evolution of transcriptional and post-translational cell-cycle regulation
Jensen, L. J., Jensen, T. S., de Lichtenberg, U., Brunak, Søren & Bork, P., 2006, In: Nature Study. 443, 7111, p. 594-7 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein interaction-based genome-wide analysis of incident coronary heart disease
Jensen, Majken Karoline, Pers, Tune H, Dworzynski, P., Girman, C. J., Brunak, Søren & Rimm, E. B., 2011, In: Circulation: Cardiovascular Genetics. 4, 5, p. 549-56 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mining electronic health records: towards better research applications and clinical care
Jensen, P. B., Jensen, Lars Juhl & Brunak, Søren, 2012, In: Nature Reviews. Genetics. 13, 6, p. 395-405 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Reply to 'Mining electronic health records: An additional perspective'
Jensen, P. B., Jensen, Lars Juhl & Brunak, Søren, 1 Jan 2013, In: Nature Reviews. Genetics. 14, 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
Jia, G., Li, Y., Zhang, H., Chattopadhyay, I., Jensen, A. B., Blair, D. R., Davis, L., Robinson, P. N., Dahlen, T., Brunak, Søren, Benson, M., Edgren, G., Cox, N. J., Gao, X. & Rzhetsky, A., 2019, In: Nature Communications. 10, 11 p., 5508.Research output: Contribution to journal › Journal article › Research › peer-review
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Conflicting associations between dietary patterns and changes of anthropometric traits across subgroups of middle-aged women and men
Jiang, L., Audouze, K., Romero Herrera, J. A., Ängquist, Lars, Kjærulff, S. K., Izarzugaza, J. M. G., Tjønneland, Anne, Halkjær, J., Overvad, K., Sørensen, Thorkild I.A. & Brunak, Søren, 2020, In: Clinical Nutrition. 39, 1, p. 265-275Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma YKL-40 is associated with prognosis in patients with metastatic pancreatic cancer receiving immune checkpoint inhibitors in combination with radiotherapy
Johansen, A. Z., Novitski, Sif Ingibergsdóttir, Hjaltelin, Jessica Xin, Theile, S., Boisen, M. K., Brunak, Søren, Madsen, Daniel Hargbøl, Nielsen, Dorte Lisbet & Chen, I. M., 2023, In: Frontiers in Immunology. 14, 10 p., 1228907.Research output: Contribution to journal › Journal article › Research › peer-review
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Prediction of disease causing non-synonymous SNPs by the Artificial Neural Network Predictor NetDiseaseSNP
Johansen, M. B., Izarzugaza, J. M. G., Brunak, Søren, Petersen, T. N. & Gupta, R., Jul 2013, In: P L o S One. 8, 7, p. e68370Research output: Contribution to journal › Journal article › Research › peer-review
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Precision medicine in complex diseases - Molecular subgrouping for improved prediction and treatment stratification
Johansson, Å., Andreassen, O. A., Brunak, Søren, Franks, P. W., Hedman, H., Loos, Ruth, Meder, B., Melén, E., Wheelock, C. E. & Jacobsson, B., 2023, In: Journal of Internal Medicine. 294, 4, p. 378-396 19 p.Research output: Contribution to journal › Review › Research › peer-review
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Prediction methods and databases within chemoinformatics: emphasis on drugs and drug candidates
Jónsdóttir, S. O., Jørgensen, Flemming Steen & Brunak, Søren, 2005, In: Bioinformatics. 21, 10, p. 2145-60 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Stratification of Kidney Transplant Recipients Into Five Subgroups Based on Temporal Disease Trajectories
Jørgensen, Isabella Friis, Muse, V. P., Aguayo-Orozco, A., Brunak, Søren & Sørensen, Søren Schwartz, 2024, In: Transplantation Direct. 10, 2, 11 p., e1576.Research output: Contribution to journal › Journal article › Research › peer-review
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Age-stratified longitudinal study of Alzheimer's and vascular dementia patients
Jørgensen, Isabella Friis, Aguayo-Orozco, A., Lademann, M. & Brunak, Søren, 2020, In: Alzheimer's & Dementia. p. 908-917Research output: Contribution to journal › Journal article › Research › peer-review
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Time-ordered comorbidity correlations identify patients at risk of mis- and overdiagnosis
Jørgensen, Isabella Friis & Brunak, Søren, 2021, In: npj Digital Medicine. 4, 10 p., 12.Research output: Contribution to journal › Journal article › Research › peer-review
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Comorbidity landscape of the Danish patient population affected by chromosome abnormalities
Jørgensen, Isabella Friis, Russo, F., Jensen, A. B., Westergaard, David, Lademann, M., Hjaltelin, Jessica Xin, Brunak, Søren & Belling, K., 2019, In: Genetics In Medicine. 21, 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo
Jørgensen, J. R., Fransson, A., Fjord-Larsen, L., Thompson, L. H., Houchins, J. P., Andrade, N., Torp, M., Kalkkinen, N., Andersson, E., Lindvall, O., Ulfendahl, M., Brunak, Søren, Johansen, T. E. & Wahlberg, L. U., 2012, In: Experimental Neurology. 233, 1, p. 172-81 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Eliciting drug safety signals from patient records: a language-agnostic approach
Kaas-Hansen, Benjamin Skov, Placido, Davide, Rodriguez, C., Thorsen-Meyer, H., Gentile, S., Nielsen, A., Brunak, Søren, Jürgens, Gesche & Andersen, S., 2022, p. S15-S16. 2 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Using Machine Learning to Identify Patients at High Risk of Inappropriate Drug Dosing in Periods with Renal Dysfunction
Kaas-Hansen, Benjamin Skov, Leal Rodríguez, C., Placido, Davide, Thorsen-Meyer, H., Nielsen, A. P., Dérian, N., Brunak, Søren & Andersen, Stig Ejdrup, 2022, In: Clinical Epidemiology. 14, p. 213-223 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Language-agnostic pharmacovigilant text mining to elicit side effects from clinical notes and hospital medication records
Kaas-Hansen, Benjamin Skov, Placido, Davide, Rodríguez, C. L., Thorsen-Meyer, H., Gentile, S., Nielsen, A. P., Brunak, Søren, Jürgens, Gesche & Andersen, Stig Ejdrup, 2022, In: Basic & clinical pharmacology & toxicology. 131, 4, p. 282-293 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identifying patients at high risk of inappropriate drug dosing in periods with renal dysfunction
Kaas-Hansen, Benjamin Skov, Rodriguez, C. L., Placido, Davide, Thorsen-Meyer, H., Nielsen, A. P., Dérian, N., Brunak, Søren & Andersen, Stig Ejdrup, 2021, medRxiv.Research output: Working paper › Preprint › Research
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Language-agnostic pharmacovigilant text mining to elicit side effects from clinical notes and hospital medication records
Kaas-Hansen, Benjamin Skov, Placido, Davide, Rodrìguez, C. L., Thorsen-Meyer, H., Gentile, S., Nielsen, A. P., Brunak, Søren, Jürgens, Gesche & Andersen, Stig Ejdrup, 2022, Authorea, (Authorea Preprints).Research output: Working paper › Preprint › Research
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Machine Learning to Identify Patients at Risk of Inappropriate Dosing for Renal Risk Medications: A Critical Comment on Kaas-Hansen et al [Response to Letter]
Kaas-Hansen, Benjamin Skov, Leal Rodríguez, C., Placido, Davide, Thorsen-Meyer, H., Nielsen, A. P., Dérian, N., Brunak, Søren & Andersen, Stig Ejdrup, 2022, In: Clinical Epidemiology. 14, p. 765-766 2 p.Research output: Contribution to journal › Comment/debate › Research
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A second update on mapping the human genetic architecture of COVID-19
Kanai, M., Andrews, S., Cordioli, M., Stevens, C., Neale, B. M., Daly, M., Ganna, A., Pathak, G. A., Ellinghaus, D., Banasik, K., Brunak, S., Pedersen, O. B., Westergaard, D., Sequeros, C. B., Nissen, J., Feldt-Rasmussen, U., Grønbæk, K., Ostrowski, S. R., Guindo-Martinez, M., Garcia, S. M. & 70 others, , 2023, In: Nature. 621, 7977, p. E7-E26 23 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Prediction of pancreatic fat and analysis of its determining factors using multi-omics datasets: an IMI DIRECTstudy
Karaderi, Tugce, Mazzoni, G., Brorsson, C., Westergaard, David, Banasik, Karina, Koivula, R., Thomas, L., Bell, J., Franks, P., Pearson, E. & Brunak, Søren, 2019, In: Diabetologia. 62, p. S166-S166Research output: Contribution to journal › Conference abstract in journal › Research
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Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review
Kenner, B., Chari, S. T., Kelsen, D., Klimstra, D. S., Pandol, S. J., Rosenthal, M., Rustgi, A. K., Taylor, J. A., Yala, A., Abul-Husn, N., Andersen, D. K., Bernstein, D., Brunak, S., Canto, M. I., Eldar, Y. C., Fishman, E. K., Fleshman, J., Go, V. L. W., Holt, J. M., Field, B. & 14 others, , 2021, In: Pancreas. 50, 3, p. 251-279 29 p.Research output: Contribution to journal › Journal article › Research › peer-review
ChemProt-2.0: visual navigation in a disease chemical biology database
Kim Kjærulff, S., Wich, L., Kringelum, J., Jacobsen, U. P., Kouskoumvekaki, I., Audouze, K., Lund, O., Brunak, Søren, Oprea, T. I. & Taboureau, O., Jan 2013, In: Nucleic Acids Research. 41, Database issue, p. D464-9Research output: Contribution to journal › Journal article › Research
- Published
The impact of the protein interactome on the syntenic structure of mammalian genomes
Kirk, I. K., Weinhold, N., Brunak, Søren & Belling, K., 2017, In: PLOS ONE. 12, 9, 14 p., e0179112.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chromosome-wise Protein Interaction Patterns and Their Impact on Functional Implications of Large-Scale Genomic Aberrations
Kirk, I. K., Weinhold, N., Belling, K., Skakkebæk, Niels Erik, Jensen, T. S., Leffers, H., Juul, Anders & Brunak, Søren, 22 Mar 2017, In: Cell Systems. 4, 3, 11 p., 357-364.e3.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining
Kirk, I. K., Simon, C., Banasik, K., Holm, P. C., Haue, A. D., Jensen, P. B., Jensen, L. J., Rodriguez, C. L., Pedersen, M. K., Eriksson, R., Andersen, H. U., Almdal, T., Bork-Jensen, J., Grarup, N., Borch-Johnsen, K., Pedersen, O., Pociot, F., Hansen, T., Bergholdt, R., Rossing, P. & 1 others, , 2019, In: eLife. 8, 19 p., e44941.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors
Kjerulff, B., Dowsett, J., Jacobsen, R. L., Gladov, J., Larsen, M. H., Lundgaard, A. T., Banasik, K., Westergaard, D., Mikkelsen, S., Dinh, K. M., Hindhede, L., Kaspersen, K. A., Schwinn, M., Juul, A., Poulsen, B., Lindegaard, B., Pedersen, C. B., Sabel, C. E., Bundgaard, H., Nielsen, H. S. & 30 others, , 2024, In: Communications Medicine. 4, 15 p., 50.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disease Trajectories for Hidradenitis Suppurativa in the Danish Population
Andersen, Rune Kjærsgaard, Jørgensen, Isabella Friis, Reguant, R., Jemec, Gregor & Brunak, Søren, 2020, In: JAMA Dermatology. 156, 7, p. 780-786Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Migraine polygenic risk score associates with efficacy of migraine-specific drugs
Kogelman, L. J. A., Esserlind, A-L., Christensen, A. F., Awasthi, S., Ripke, S., Ingason, A., Davidsson, O. B., Erikstrup, C., Hjalgrim, H., Ullum, H., Olesen, J., Hansen, T. F., Gudbjartsson, D., Gastafsson, O., Stefansson, K., Stefansson, H., Porsteinsdottir, U., Andersen, S., Banasik, K., Brunak, S. & 73 others, , 2019, In: Neurology: Genetics. 5, 6, 12 p., e364.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study
Koivula, R. W., Atabaki-Pasdar, N., Giordano, G. N., White, T., Adamski, J., Bell, J. D., Beulens, J., Brage, S., Brunak, S., De Masi, F., Dermitzakis, E. T., Forgie, I. M., Frost, G., Hansen, T., Hansen, T. H., Hattersley, A., Kokkola, T., Kurbasic, A., Laakso, M., Mari, A. & 15 others, , 2020, In: Diabetologia. 63, 4, p. 744-756 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium
Koivula, R. W., Forgie, I. M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G. N., Hansen, T. H., Hudson, M., Koopman, A. D. M., Rutters, F., Siloaho, M., Allin, K. H., Brage, S., Brorsson, C. A., Dawed, A. Y., De Masi, F., Groves, C. J., Kokkola, T., Mahajan, A., Perry, M. H. & 31 others, , 2019, In: Diabetologia. 62, 9, p. 1601-1615Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium: Diabetologia
Koivula, R., Heggie, A., Barnett, A., Cederberg, H., Hansen, T. H., Koopman, A., Ridderstråle, M., Rutters, F., Vestergaard, H., Gupta, R., Herrgård, S., Heymans, M., Perry, M., Rauh, S., Siloaho, M., Teare, H. A., Thorand, B., Bell, J., Brunak, S., Frost, G. & 13 others, , 2014, In: Diabetologia. 57, 6, p. 1-11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pregnancy outcomes and lifetime fecundity - a nationwide, registry-based cohort study
Kolte, A. M., Westergaard, David, Lidegaard, Øjvind, Brunak, Søren & Nielsen, Henriette Svarre, 2020, In: Human Reproduction. 35, Suppl. 1, p. i40 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Chance of live birth: a nationwide, registry-based cohort study
Kolte, A. M., Westergaard, David, Lidegaard, Øjvind, Brunak, Søren & Nielsen, Henriette Svarre, 2021, In: Human Reproduction. 36, 4, p. 1065-1073 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The impact of early pregnancy complications on completed family size—A nationwide, registry-based cohort study with 40 years of data
Kolte, A. M., Westergaard, David, Lidegaard, Øjvind, Brunak, Søren & Nielsen, Henriette Svarre, 2021, In: Acta Obstetricia et Gynecologica Scandinavica. 100, 12, p. 2226-2233Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Facilitating the use of large-scale biological data and tools in the era of translational bioinformatics
Kouskoumvekaki, I., Shublaq, N. & Brunak, Søren, 1 Aug 2013, In: Briefings in Bioinformatics. 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ChemProt-3.0: a global chemical biology diseases mapping
Kringelum, J. V., Kjærulff, S. K., Brunak, Søren, Lund, O., Oprea, T. I. & Taboureau, O. T., 2016, In: Database: The Journal of Biological Databases and Curation. 2016, 7 p., bav123.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Many putative endocrine disruptors inhibit prostaglandin synthesis
Kristensen, D. M., Skalkam, M. L., Audouze, K. M. L., Lesné, L., Desdoits-Lethimonier, C., Frederiksen, H., Brunak, Søren, Skakkebæk, Niels Erik, Jégou, B., Hansen, Jacob B., Junker, S. & Leffers, H., 1 Apr 2011, In: Environmental Health Perspectives. 119, 4, p. 534-41 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
OCT4 and downstream factors are expressed in human somatic urogenital epithelia and in culture of epididymal spheres
Kristensen, D. M., Nielsen, J. E., Kalisz, M., Dalgaard, M. D., Audouze, K., Larsen, M. E., Jacobsen, G. K., Horn, T., Brunak, S., Skakkebaek, N. E., Leffers, H., Kristensen, D. M., Nielsen, J. E., Kalisz, M., Dalgaard, M. D., Audouze, K. M. L., Larsen, M. E., Jacobsen, G. K., Horn, T., Brunak, S. & 2 others, , 1 Nov 2010, In: Molecular Human Reproduction. 16, 11, p. 835-45 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism
Kristensen, D. M., Desdoits-Lethimonier, C., Mackey, Abigail, Dalgaard, M. D., De Masi, F., Munkbøl, C. H., Styrishave, Bjarne, Antignac, J., Le Bizec, B., Platel, C., Hay-Schmidt, Anders, Jensen, T. K., Lesné, L., Mazaud-Guittot, S., Kristiansen, Karsten, Brunak, Søren, Kjær, Michael, Juul, Anders & Jégou, B., 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. e715-e724 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat
Kristensen, D. M., Hass, U., Lesné, L., Lottrup, G., Jacobsen, P. R., Desdoits-Lethimonier, C., Boberg, J., Petersen, Jørgen Holm, Toppari, J., Jensen, T. K., Brunak, Søren, Skakkebæk, Niels Erik, Nellemann, C., Main, Katharina Maria, Jégou, B. & Leffers, H., 2011, In: Human Reproduction. 26, 1, p. 235-44 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Country-specific chemical signatures of persistent environmental compounds in breast milk
Krysiak-Baltyn, K., Toppari, J., Skakkebaek, N. E., Jensen, T. S., Virtanen, H. E., Schramm, K-W., Shen, H., Vartiainen, T., Kiviranta, H., Taboureau, O., Brunak, S., Main, K. M., Krysiak-Baltyn, K., Toppari, J., Skakkebaek, N. E., Jensen, T. S., Virtanen, H. E., Schramm, K-W., Shen, H., Vartiainen, T. & 4 others, , 1 Apr 2010, In: International Journal of Andrology. 33, 2, p. 270-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Compass: A hybrid method for clinical and biobank data mining
Krysiak-Baltyn, K., Nordahl Petersen, T., Audouze, K. M. L., Jørgensen, N., Ängquist, Lars & Brunak, Søren, Feb 2014, In: Journal of Biomedical Informatics. 47, p. 160-170Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures
Krysiak-Baltyn, K., Toppari, J., Skakkebæk, Niels Erik, Jensen, T. S., Virtanen, H. E., Schramm, K., Shen, H., Vartiainen, T., Kiviranta, H., Taboureau, O., Audouze, K. M. L., Brunak, Søren & Main, Katharina Maria, 2012, In: International Journal of Andrology. 35, 3, p. 294-302 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Incorporating symptom data in longitudinal disease trajectories for more detailed patient stratification
Lademann, M., Lademann, M., Boeck Jensen, A. & Brunak, Søren, 2019, In: International Journal of Medical Informatics. 129, p. 107-113 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cohort profile: Copenhagen Hospital Biobank - Cardiovascular Disease Cohort (CHB-CVDC): Construction of a large-scale genetic cohort to facilitate a better understanding of heart diseases
Laursen, I. H., Banasik, K., Haue, A. D., Petersen, O., Holm, P. C., Westergaard, D., Bundgaard, H., Brunak, S., Frikke-Schmidt, R., Holm, H., Sørensen, E., Thorner, L. W., Larsen, M. A. H., Schwinn, M., Køber, L., Torp-Pedersen, C., Ostrowski, S. R., Erikstrup, C., Nyegaard, M., Stefansson, H. & 11 others, , 2021, In: BMJ Open. 11, 12, 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drug dosage modifications in 24 million in-patient prescriptions covering eight years: A Danish population-wide study of polypharmacy
Leal Rodríguez, C., Haue, Amalie Dahl, Mazzoni, G., Eriksson, R., Hernansanz Biel, J., Cantwell, Lisa, Westergaard, David, Belling, K. G. & Brunak, Søren, 2023, In: PLOS Digital Health. 2, 9, 27 p., e0000336.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study
DBDS Genomic Consortium, D. G. C., 2022, In: Joint Bone Spine. 89, 4, 105357.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Sex differences in oncogenic mutational processes
Li, C. H., Prokopec, S. D., Sun, R. X., Yousif, F., Schmitz, N., Boutros, P. C., PCAWG Tumour Subtypes and Clinical Translation, P. T. S. A. C. T. & Brunak, Søren, 2020, In: Nature Communications. 11, 1, 24 p., 4330.Research output: Contribution to journal › Journal article › Research › peer-review
Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response
Li, Q., Eklund, A. C., Birkbak, N. J., Desmedt, C., Haibe-Kains, B., Sotiriou, C., Symmans, W. F., Pusztai, L., Brunak, Søren, Richardson, A. L. & Szallasi, Z. I., 2011, In: B M C Bioinformatics. 12, p. 310Research output: Contribution to journal › Journal article › Research › peer-review
- Published
hERG classification model based on a combination of support vector machine method and GRIND descriptors
Li, Q., Jørgensen, Flemming Steen, Oprea, T., Brunak, Søren & Taboureau, O., 2012, In: Molecular Pharmaceutics. 5, 1, p. 117-127 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A scored human protein-protein interaction network to catalyze genomic interpretation
Li, T., Wernersson, R., Hansen, R. B., Horn, H., Mercer, J., Slodkowicz, G., Workman, C. T., Rigina, O., Rapacki, K., Stærfeldt, H. H., Brunak, Søren, Jensen, T. S. & Hansen, K. L., Jan 2017, In: Nature Methods. 14, 1, p. 61–64Research output: Contribution to journal › Letter › Research › peer-review
- Published
Comparison of global gene expression profiles of microdissected human foetal Leydig cells with their normal and hyperplastic adult equivalents
Lottrup, G., Belling, K., Leffers, H., Nielsen, J. E., Dalgaard, M. D., Juul, Anders, Skakkebæk, Niels Erik, Brunak, Søren & Meyts, E. R., 1 May 2017, In: Molecular Human Reproduction. 23, 5, p. 339-354 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics
Lundby, A., Rossin, E. J., Steffensen, A. B., Acha, M. R., Newton-Cheh, C., Pfeufer, A., Lynch, S. N., Olesen, S-P., Brunak, S., Ellinor, P. T., Jukema, J. W., Trompet, S., Ford, I., Macfarlane, P. W., Krijthe, B. P., Hofman, A., Uitterlinden, A. G., Stricker, B. H., Nathoe, H. M., Spiering, W. & 8 others, , 22 Jun 2014, In: Nature Methods. 11, 8, p. 868-874 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Modeling the adaptive immune system: predictions and simulations
Lundegaard, C., Lund, O., Kesmir, C., Brunak, Søren & Nielsen, M., 2007, In: Bioinformatics (Online). 23, 24, p. 3265-75 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
BALDR: A Web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus
Lundgaard, Agnete Troen, Burdet, F., Siggaard, T., Westergaard, David, Vagiaki, D., Cantwell, Lisa, Röder, T., Vistisen, D., Sparsø, T., Giordano, G. N., Ibberson, M., Banasik, Karina & Brunak, Søren, 2023, In: PLOS Computational Biology. 19, 8, 13 p., e1011403.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Question Answering for Health Professionals and Laypersons
Maegaard, Bente, Hahn, U., Brunak, Søren, Schulz, S., Andersen, U. & Welter, S., 2013, MEDINFO 2013. Lehmann et al., C. U. (ed.). København: IMIA and IOS PressResearch output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
- Published
A genomic history of aboriginal Australia
Malaspinas, A. S., Westaway, M. C., Muller, C. E., Sousa, V. C., Lao, O., Alves, I., Bergström, A., Athanasiadis, G., Cheng, J. Y., Crawford, J. E., Heupink, T. H., Macholdt, E., Peischl, S., Rasmussen, S., Schiffels, S., Subramanian, S., Wright, J. L., Albrechtsen, A., Barbieri, C., Dupanloup, I. & 55 others, , 2016, In: Nature. 538, 7624, p. 207-214 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Benchmarking the HLA typing performance of Polysolver and Optitype in 50 Danish parental trios
Matey-Hernandez, M. L., Danish Pan Genome Consortium, D. P. G. C., Brunak, Søren, Izarzugaza, J. M. G., Sørensen, L. M., Petersen, Bent, Sibbesen, Jonas Andreas, Liu, S., Belling, K. G., Have, C. T., Bork-Jensen, J., Sun, J., Hansen, Torben, Krogh, Anders, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye, Wang, J., Eiberg, Hans Rudolf Lytchoff & Kristiansen, Karsten, 2018, In: BMC Bioinformatics. 19, p. 1-12 239.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Linear motif atlas for phosphorylation-dependent signaling
Miller, M. L., Jensen, L. J., Diella, F., Jørgensen, C., Tinti, M., Li, L., Hsiung, M., Parker, S. A., Bordeaux, J., Sicheritz-Ponten, T., Olhovsky, M., Pasculescu, A., Alexander, J., Knapp, S., Blom, N., Bork, P., Li, S., Cesareni, G., Pawson, T., Turk, B. E. & 3 others, , 2008, In: Science Signaling. 1, 35, p. ra2Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ARDD 2020: from aging mechanisms to interventions
Mkrtchyan, G. V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., Cabo, R. D., Campisi, J., Cuervo, A. M., Demaria, M., Ewald, C. Y., Fang, E. F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C. G., Georgievskaya, A., Gladyshev, V. N., Glass, D. J. & 46 others, , 2020, In: Aging. 12, 24, p. 24486-24503 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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