Protein interaction-based genome-wide analysis of incident coronary heart disease
Research output: Contribution to journal › Journal article › Research › peer-review
Network-based approaches may leverage genome-wide association (GWA) analysis by testing for the aggregate association across several pathway members. We aimed to examine if networks of genes that represent experimentally determined protein-protein interactions (PPIs) are enriched in genes associated with risk of coronary heart disease (CHD).
| Original language | English |
|---|---|
| Journal | Circulation: Cardiovascular Genetics |
| Volume | 4 |
| Issue number | 5 |
| Pages (from-to) | 549-56 |
| Number of pages | 8 |
| ISSN | 1942-325X |
| DOIs | |
| Publication status | Published - 2011 |
- Adult, Aged, Animals, Blood Pressure, Case-Control Studies, Coronary Disease, Female, Genetic Loci, Genome-Wide Association Study, Genotype, Humans, Incidence, Male, Mice, Mice, Knockout, Middle Aged, Polymorphism, Single Nucleotide, Protein Interaction Mapping, Receptors, Adrenergic, beta-1, Risk Factors
Research areas
ID: 40804272