Matthias Mann

Matthias Mann

Professor, head of research, Professor


  1. 2019
  2. Published

    Catching Lipid Droplet Contacts by Proteomics

    Krahmer, N. & Mann, Matthias, 2019, In: Contact. 2, p. 1-8 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  3. Published

    Myosin binding protein H-like (MYBPHL): a promising biomarker to predict atrial damage

    Lahm, H., Dressen, M., Beck, N., Doppler, S., Deutsch, M., Matsushima, S., Neb, I., Koenig, K. C., Sideris, K., Voss, S., Eschenbach, L., Puluca, N., Deisenhofer, I., Doll, S., Holdenrieder, S., Mann, Matthias, Lange, R. & Krane, M., 2019, In: Scientific Reports. 9, 8 p., 9986.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts

    Larsen, N. B., Gao, A. O., Sparks, J. L., Gallina, I., Wu, R. A., Mann, Matthias, Räschle, M., Walter, J. C. & Duxin, Julien, 2019, In: Molecular Cell. 73, 3, p. 574-588.e7 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Development, use, application of novel TIMS-Tof system

    Mann, Matthias, 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S20 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  6. Published

    The ever expanding scope of electrospray mass spectrometry-a 30 year journey

    Mann, Matthias, 2019, In: Nature Communications. 10, 3744.

    Research output: Contribution to journalComment/debateResearch

  7. Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis

    Marinkovic, M., Fuoco, C., Sacco, F., Cerquone Perpetuini, A., Giuliani, G., Micarelli, E., Pavlidou, T., Petrilli, L. L., Reggio, A., Riccio, F., Spada, F., Vumbaca, S., Zuccotti, A., Castagnoli, L., Mann, Matthias, Gargioli, C. & Cesareni, G., Jun 2019, In: Life Science Alliance. 2, 3

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Parallel accumulation - serial fragmentation combined with data-independent acquisition (diaPASEF)

    Meier, F., Brunner, A., Frank, M., Ha, A., Voytik, E., Kaspar-Schoenefeld, S., Lubeck, M., Raether, O., Aebersold, R., Collins, B. C., Roest, H. L. & Mann, Matthias, 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S17 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  9. Published

    Proteomics of Cytochrome c Oxidase-Negative versus -Positive Muscle Fiber Sections in Mitochondrial Myopathy

    Murgia, M., Tan, J., Geyer, P. E., Doll, S., Mann, Matthias & Klopstock, T., 2019, In: Cell Reports. 29, 12, p. 3825-3834 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease

    Niu, Lili, Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Treit, P. V., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Müller, T. D., Tschöp, M. H., Hofmann, S. M. & Mann, Matthias, 2019, In: Molecular Systems Biology. 15, 16 p., e8793.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Plasma proteome profiling discovers potential biomarkers of non-alcoholic fatty liver disease

    Niu, Lili, Gupta, R., Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Mueller, T. D., Tschoep, M. H., Hofmann, S. M. & Mann, Matthias, Aug 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S71 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  12. Published

    Quick and clean: Cracking sentences encoded in E. coli by LC-MS/MS, de novo sequencing, and dictionary search

    Niu, Lili & Mann, Matthias, 2019, In: EuPA Open Proteomics. 22-23, p. 30-35 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Metallopeptidase Inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer

    Nordgaard, C., Doll, S., Matos, A. L. D. S. A., Høeberg, M., Kazi, J. U., Friis, S., Stenvang, Jan, Rönnstrand, L., Mann, Matthias & Moreira, José, 2019, In: Molecular Oncology. 13, 12, p. 2646-2662

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep

    Noya, S. B., Colameo, D., Brüning, F., Spinnler, A., Mircsof, D., Opitz, L., Mann, Matthias, Tyagarajan, S. K., Robles, M. S. & Brown, S. A., 2019, In: Science. 366, 6462, eaav2642 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1

    Prestel, M., Prell-Schicker, C., Webb, T., Malik, R., Lindner, B., Ziesch, N., Rex-Haffner, M., Röh, S., Viturawong, T., Lehm, M., Mokry, M., den Ruijter, H., Haitjema, S., Asare, Y., Söllner, F., Najafabadi, M. G., Aherrahrou, R., Civelek, M., Samani, N. J., Mann, M. & 2 others, Haffner, C. & Dichgans, M., Oct 2019, In: Stroke. 50, 10, p. 2651-2660 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

    Qiao, S., Langlois, C. R., Chrustowicz, J., Sherpa, D., Karayel, O., Hansen, F. M., Beier, V., von Gronau, S., Bollschweiler, D., Schäfer, T., Alpi, A. F., Mann, Matthias, Prabu, J. R. & Schulman, B. A., 1 Nov 2019, (E-pub ahead of print) In: Molecular Cell.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease

    Ravell, J. C., Matsuda-Lennikov, M., Chauvin, S. D., Zou, J., Biancalana, M., Deeb, S. J., Price, S., Su, H. C., Notarangelo, G., Jiang, P., Morawski, A., Kanellopoulou, C., Binder, K. W., Mukherjee, R., Anibal, J. T., Sellers, B., Zheng, L., He, T., George, A. B., Pittaluga, S. & 34 others, Powers, A., Kleiner, D. E., Kapuria, D., Ghany, M., Hunsberger, S., Cohen, J. I., Uzel, G., Bergerson, J., Wolfe, L., Toro, C., Gahl, W., Folio, L. R., Matthews, H., Angelus, P., Chinn, I. K., Orange, J. S., Trujillo-Vargas, C. M., Franco, J. L., Orrego-Arango, J., Gutiérrez-Hincapié, S., Patel, N. C., Raymond, K., Patiroglu, T., Unal, E., Karakukcu, M., Day, A. G., Mehta, P., Masutani, E., De Ravin, S. S., Malech, H. L., Altan-Bonnet, G., Rao, V. K., Mann, Matthias & Lenardo, M. J., 5 Nov 2019, (E-pub ahead of print) In: The Journal of Clinical Investigation.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets

    Sacco, F., Seelig, A., Humphrey, S. J., Krahmer, N., Volta, F., Reggio, A., Marchetti, P., Gerdes, J. & Mann, Matthias, 7 Mar 2019, (E-pub ahead of print) In: Cell Metabolism.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity

    Seitz, S., Kwon, Y., Hartleben, G., Juelg, J., Sekar, R., Krahmer, N., Najafi, B., Loft, A., Gancheva, S., Stemmer, K., Feuchtinger, A., de Angelis, M. H., Mueller, T. D., Mann, M., Blueher, M., Roden, M., Diaz, M. B., Behrends, C., Gilleron, J., Herzig, S. & 1 others, Zeigerer, A., 2019, In: Nature Metabolism. 1, p. 1009-1026

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

    Sparks, J. L., Chistol, G., Gao, A. O., Räschle, M., Larsen, N. B., Mann, Matthias, Duxin, Julien & Walter, J. C., 2019, In: Cell. 176, 1-2, p. 167-181.e21

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Neurodevelopmental deficits in human isogenic fragile x syndrome neurons

    Utami, K., Skotte, N. H., Colaco, A. R. -., Yusof, N. A. B. M., Sim, B., Yeo, X. Y., Bae, H., Garcia-Miralles, M., Radulescu, C., Jung, S., Mann, Matthias & Pouladi, M., 2019, In: Journal of Neurochemistry. 150, p. 103 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  22. Published

    MaxQuant.Live enables global targeting of more than 25,000 peptides

    Wichmann, C., Meier, F., Virreira Winter, S., Brunner, A., Cox, J. & Mann, Matthias, 2019, In: Molecular and Cellular Proteomics. 18, 5, p. 982-994 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency

    Yang, P., Humphrey, S. J., Cinghu, S., Pathania, R., Oldfield, A. J., Kumar, D., Perera, D., Yang, J. Y. H., James, D. E., Mann, Matthias & Jothi, R., 22 May 2019, In: Cell Systems. 8, 5, p. 427-445.e10

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex

    Zhang, G., Kruse, Thomas, Guasch Boldú, C., Garvanska, Dimitriya Hristoforova, Coscia, F., Mann, Matthias, Barisic, Marin & Nilsson, Jakob, 2019, In: E M B O Journal. 38, 7, e100977.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Response to Raaijmakers & Medema

    Zhang, G., Kruse, Thomas, Boldú, C. G., Garvanska, Dimitriya Hristoforova, Coscia, F., Mann, Matthias, Barisic, Marin & Nilsson, Jakob, 2019, In: The EMBO Journal. 38, 22, 5 p., e103547.

    Research output: Contribution to journalComment/debateResearch

  26. 2018
  27. UBL3 modification influences protein sorting to small extracellular vesicles

    Ageta, H., Ageta-Ishihara, N., Hitachi, K., Karayel, O., Onouchi, T., Yamaguchi, H., Kahyo, T., Hatanaka, K., Ikegami, K., Yoshioka, Y., Nakamura, K., Kosaka, N., Nakatani, M., Uezumi, A., Ide, T., Tsutsumi, Y., Sugimura, H., Kinoshita, M., Ochiya, T., Mann, M. & 2 others, Setou, M. & Tsuchida, K., 26 Sep 2018, In: Nature Communications. 9, 1, p. 3936

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    A novel LC system embeds analytes in pre-formed gradients for rapid, ultra-robust proteomics

    Bache, N., Geyer, P. E., Bekker-Jensen, D. B., Hørning, O., Falkenby, L., Treit, P. V., Doll, S., Paron, I., Müller, J. B., Meier, F., Olsen, Jesper Velgaard, Vorm, O. & Mann, Matthias, 2018, In: Molecular and Cellular Proteomics. 17, 11, p. 2284-2296 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. The hemicellulose-degrading enzyme system of the thermophilic bacterium Clostridium stercorarium: comparative characterisation and addition of new hemicellulolytic glycoside hydrolases

    Broeker, J., Mechelke, M., Baudrexl, M., Mennerich, D., Hornburg, D., Mann, Matthias, Schwarz, W. H., Liebl, W. & Zverlov, V. V., 2018, In: Biotechnology for Biofuels. 11, p. 229

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy

    Chheda, Z. S., Kohanbash, G., Okada, K., Jahan, N., Sidney, J., Pecoraro, M., Yang, X., Carrera, D. A., Downey, K. M., Shrivastav, S., Liu, S., Lin, Y., Lagisetti, C., Chuntova, P., Watchmaker, P. B., Mueller, S., Pollack, I. F., Rajalingam, R., Carcaboso, A. M., Mann, M. & 4 others, Sette, A., Garcia, K. C., Hou, Y. & Okada, H., Jan 2018, In: The Journal of Experimental Medicine. 215, 1, p. 141-157 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Proteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future

    Comes, A. L., Papiol, S., Mueller, T., Geyer, P. E., Mann, Matthias & Schulze, T. G., 1 Dec 2018, In: Translational Psychiatry. 8, p. 1-15 15 p., 160.

    Research output: Contribution to journalReviewResearchpeer-review

  32. Published

    Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer

    Coscia, F., Lengyel, E., Duraiswamy, J., Ashcroft, B., Bassani-Sternberg, M., Wierer, M., Johnson, A., Wroblewski, K., Montag, A., Yamada, S. D., López-Méndez, B., Nilsson, Jakob, Mund, Andreas, Mann, Matthias & Curtis, M., 2018, In: Cell. 175, 1, p. 159-170.e16

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Rapid proteomic analysis for solid tumors reveals LSD1 as a drug target in an end-stage cancer patient

    Doll, S., Kriegmair, M. C., Santos, A., Wierer, M., Coscia, F., Neil, H. M., Porubsky, S., Geyer, P. E., Mund, Andreas, Nuhn, P. & Mann, Matthias, 2018, In: Molecular Oncology. 12, 8, p. 1296-1307 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Mechanism of replication-coupled DNA-protein crosslink proteolysis by SPRTN and the proteasome

    Gao, A., Larsen, N., Sparks, J., Gallina, I., Mann, Matthias, Räschle, M., Walter, J. & Duxin, Julien, 2018, bioRxiv, 54 p.

    Research output: Working paperPreprintResearch

  35. Molecular and structural architecture of polyQ aggregates in yeast

    Gruber, A., Hornburg, D., Antonin, M., Krahmer, N., Collado, J., Schaffer, M., Zubaite, G., Lüchtenborg, C., Sachsenheimer, T., Brügger, B., Mann, Matthias, Baumeister, W., Hartl, F. U., Hipp, M. S. & Fernández-Busnadiego, R., 2018, In: Proceedings of the National Academy of Sciences of the United States of America.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform

    Humphrey, S. J., Karayel, O., James, D. E. & Mann, Matthias, 2018, In: Nature Protocols (Print). 13, p. 1897-1916 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The proteome of prostate cancer bone metastasis reveals heterogeneity with prognostic implications

    Iglesias Gato, Diego, Thysell, E., Tyanova, S., Crnalic, S., Santos, A., Lima, T. S., Geiger, T., Cox, J., Widmark, A., Bergh, A., Mann, Matthias, Flores-Morales, A. & Wikström, P., 1 Nov 2018, In: Clinical Cancer Research. 24, 21, p. 5433-5444 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. The non-classical nuclear import carrier Transportin 1 modulates circadian rhythms through its effect on PER1 nuclear localization

    Korge, S., Maier, B., Brüning, F., Ehrhardt, L., Korte, T., Mann, Matthias, Herrmann, A., Robles, M. S. & Kramer, A., Jan 2018, In: P L o S Genetics. 14, 1, p. e1007189

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis

    Krahmer, N., Najafi, B., Schueder, F., Quagliarini, F., Steger, M., Seitz, S., Kasper, R., Salinas, F., Cox, J., Uhlenhaut, N. H., Walther, T. C., Jungmann, R., Zeigerer, A., Borner, G. H. H. & Mann, Matthias, 2018, In: Developmental Cell. 47, 2, p. 205-221.E7

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex

    Link, S., Spitzer, R. M. M., Sana, M., Torrado, M., Völker-Albert, M. C., Keilhauer, E. C., Burgold, T., Pünzeler, S., Low, J. K. K., Lindström, I., Nist, A., Regnard, C., Stiewe, T., Hendrich, B., Imhof, A., Mann, Matthias, Mackay, J. P., Bartkuhn, M. & Hake, S. B., 16 Oct 2018, In: Nature Communications. 9, 1, p. 4300

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase

    Lis, P., Burel, S., Steger, M., Mann, Matthias, Brown, F., Diez, F., Tonelli, F., Holton, J. L., Ho, P. W., Ho, S., Chou, M., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R., Jan 2018, In: Biochemical Journal. 475, 1, 22 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    In vivo brain GPCR signaling elucidated by phosphoproteomics

    Liu, J. J., Sharma, K., Zangrandi, L., Chen, C., Humphrey, S. J., Chiu, Y., Spetea, M., Liu-Chen, L., Schwarzer, C. & Mann, Matthias, 2018, In: Science (New York, N.Y.). 360, 6395, p. 1-11

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Phosphoproteomic approach for agonist-specific signaling in mouse brains: mTOR pathway is involved in κ opioid aversion

    Liu, J. J., Chiu, Y., DiMattio, K. M., Chen, C., Huang, P., Gentile, T. A., Muschamp, J. W., Cowan, A., Mann, Matthias & Liu-Chen, L., 20 Jul 2018, (E-pub ahead of print) In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. In-depth proteomic analyses of (greenlip abalone) nacre and prismatic organic shell matrix

    Mann, K., Cerveau, N., Gummich, M., Fritz, M., Mann, Matthias & Jackson, D. J., 2018, In: Proteome Science. 16, p. 11

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    BoxCar acquisition method enables single-shot proteomics at a depth of 10,000 proteins in 100 minutes

    Meier, F., Geyer, P. E., Virreira Winter, S., Cox, J. & Mann, Matthias, 2018, In: Nature Methods. 15, 6, p. 440-448 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Online parallel accumulation - serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer

    Meier, F., Brunner, A., Koch, S., Koch, H., Lubeck, M., Krause, M., Goedecke, N., Decker, J., Kosinski, T., Park, M. A., Bache, N., Hoerning, O., Cox, J., Räther, O. & Mann, Matthias, 2018, In: Molecular and Cellular Proteomics. 17, 12, p. 2534-2545

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Constructing a cell-type resolved human liver proteome atlas: THU-034

    Niu, Lili, Geyer, P. & Mann, Matthias, 2018, In: Journal of Hepatology. 68, p. S138-S139

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  48. Published

    Proteomics in the Study of Liver Diseases

    Niu, Lili, Geyer, P. E. & Mann, Matthias, 2018, The Human Gut-Liver-Axis in Health and Disease. Krag, A. & Hansen, T. (eds.). Springer, p. 165-193

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  49. Published

    Opinion: Advocating for science progress as a human right

    Porsdam Mann, Sebastian, Donders, Y., Mitchell, C., Bradley, V. J., Chou, M. F., Mann, Matthias, Church, G. & Porsdam, Helle, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 43, p. 10820-10823 4 p.

    Research output: Contribution to journalComment/debateCommunication

  50. The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia

    Rommel, C., Rösner, S., Lother, A., Barg, M., Schwaderer, M., Gilsbach, R., Bömicke, T., Schnick, T., Mayer, S., Doll, S., Hesse, M., Kretz, O., Stiller, B., Neumann, F., Mann, Matthias, Krane, M., Fleischmann, B. K., Ravens, U. & Hein, L., 2018, In: Circulation Research. 123, 5, p. 550-563 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Quality control for plasma and cerebrospinal fluid samples using mass spectrometry

    Skotte, N. H., Geyer, P. E., Steger, M., Treit, P. V., Voytik, E., Hellem, M. N., Nielsen, Jørgen Erik & Mann, Matthias, 2018, In: Journal of Neurology, Neurosurgery and Psychiatry. 89, p. A31-A32

    Research output: Contribution to journalConference abstract in journalResearch

  52. Published

    EASI-tag enables accurate multiplexed and interference-free MS2-based proteome quantification

    Virreira Winter, S., Meier, F., Wichmann, C., Cox, J., Mann, Matthias & Meissner, F., 2018, In: Nature Methods. 15, 7, p. 527-530 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 5650809