Matthias Mann
Professor, head of research, Professor
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Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways and transcription factors
Deshmukh, Atul Shahaji, Murgia, M., Nagaraja, N., Treebak, Jonas Thue, Cox, J. & Mann, Matthias, Apr 2015, In: Molecular and Cellular Proteomics. 14, 4, p. 841-853Research output: Contribution to journal › Journal article › Research › peer-review
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Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training
Deshmukh, Atul Shahaji, Steenberg, D. E., Hostrup, Morten, Birk, Jesper Bratz, Larsen, Jeppe Kjærgaard, Santos, A., Kjøbsted, Rasmus, Hingst, J. R., Schéele, Camilla Charlotte Nielsen, Murgia, M., Kiens, Bente, Richter, Erik A., Mann, Matthias & Wojtaszewski, Jørgen F P, 2021, In: Nature Communications. 12, 15 p., 304.Research output: Contribution to journal › Journal article › Research › peer-review
CRL2(Lrr1) promotes unloading of the vertebrate replisome from chromatin during replication termination
Dewar, J. M., Low, E., Mann, Matthias, Räschle, M. & Walter, J. C., 1 Feb 2017, In: Genes & Development. 31, 3, p. 275-290 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4
Di Stefano, B., Collombet, S., Jakobsen, J. S., Wierer, M., Sardina, J. L., Lackner, A., Stadhouders, R., Segura-Morales, C., Francesconi, M., Limone, F., Mann, Matthias, Porse, Bo Torben, Thieffry, D. & Graf, T., Apr 2016, In: Nature Cell Biology. 18, 4, p. 371-81 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
Diamanti, K., Cavalli, M., Pereira, M. J., Pan, G., Castillejo-López, C., Kumar, C., Mundt Madsen, Filip Oskar, Komorowski, J., Deshmukh, Atul Shahaji, Mann, Matthias, Korsgren, O., Eriksson, J. W. & Wadelius, C., 2022, In: Cell Reports Medicine. 3, 10, 21 p., 100763.Research output: Contribution to journal › Journal article › Research › peer-review
Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF
Dichtl, S., Sanin, D. E., Koss, C. K., Willenborg, S., Petzold, A., Tanzer, M. C., Dahl, A., Kabat, A. M., Lindenthal, L., Zeitler, L., Satzinger, S., Strasser, A., Mann, Matthias, Roers, A., Eming, S. A., El Kasmi, K. C., Pearce, E. J. & Murray, P. J., Apr 2022, In: Life Science Alliance. 5, 4Research output: Contribution to journal › Journal article › Research › peer-review
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Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells
Ding, L., Paszkowski-Rogacz, M., Winzi, M., Chakraborty, D., Theis, M., Singh, S., Ciotta, G., Poser, I., Roguev, A., Chu, W. K., Choudhary, Chunaram, Mann, Matthias, Stewart, A. F., Krogan, N. & Buchholz, F., 26 Aug 2015, In: Cell Systems. 1, 2, p. 141-151 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Case for Proteomics and Phospho-Proteomics in Personalized Cancer Medicine
Doll, S., Gnad, F. & Mann, Matthias, 2019, In: Proteomics - Clinical Applications. 13, 2, 10 p., e1800113.Research output: Contribution to journal › Review › Research › peer-review
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Region and cell-type resolved quantitative proteomic map of the human heart
Doll, S., Dreßen, M., Geyer, P. E., Itzhak, D. N., Braun, C., Doppler, S. A., Meier, F., Deutsch, M., Lahm, H., Lange, R., Krane, M. & Mann, Matthias, 13 Nov 2017, In: Nature Communications. 8, 1, 13 p., 1469.Research output: Contribution to journal › Journal article › Research › peer-review
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Rapid proteomic analysis for solid tumors reveals LSD1 as a drug target in an end-stage cancer patient
Doll, S., Kriegmair, M. C., Santos, A., Wierer, M., Coscia, F., Neil, H. M., Porubsky, S., Geyer, P. E., Mund, Andreas, Nuhn, P. & Mann, Matthias, 2018, In: Molecular Oncology. 12, 8, p. 1296-1307 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A spatially resolved proteomic atlas of human skin and its associated immune system
Dyring-Andersen, Beatrice, Coscia, F., Santos, A., Løvendorf, M. B., Sørensen, L. B. P., Niu, Lili, Andersen, J. L., Clark, R., Skov, L., Teunissen, M. B. & Mann, Matthias, 2019, In: Journal of Investigative Dermatology. 139, 9, suppl., p. S259 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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A spatially resolved proteomic atlas of psoriatic skin
Dyring-Andersen, Beatrice, Lovendorf, M. B., Santos, A., Coscia, F., Sørensen, L. B. P., Niu, Lili, Andersen, J. L., Teunissen, M. B., Skov, L. & Mann, Matthias, 2019, In: Journal of Investigative Dermatology. 139, 9, suppl., p. S260 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin
Dyring-Andersen, Beatrice, Løvendorf, M. B., Coscia, F., Santos, A., Møller, L. B. P., Colaço, A. R., Niu, Lili, Bzorek, M., Doll, S., Andersen, J. L., Clark, R. A., Skov, Lone, Teunissen, M. B. M. & Mann, Matthias, 2020, In: Nature Communications. 11, 1, 5587.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts
Eckert, M. A., Coscia, F., Chryplewicz, A., Chang, J. W., Hernandez, K. M., Pan, S., Tienda, S. M., Nahotko, D. A., Li, G., Blaženović, I., Lastra, R. R., Curtis, M., Yamada, S. D., Perets, R., McGregor, S. M., Andrade, J., Fiehn, O., Moellering, R. E., Mann, Matthias & Lengyel, E., 2019, In: Nature. 569, 7758, p. 723-728Research output: Contribution to journal › Letter › Research › peer-review
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Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome
Fitzner, D., Bader, J. M., Penkert, H., Bergner, C. G., Su, M., Weil, M., Surma, M. A., Mann, Matthias, Klose, C. & Simons, M., 2020, In: Cell Reports. 32, 21 p., 108132.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular response to PARP1 inhibition in ovarian cancer cells as determined by mass spectrometry based proteomics
Franz, A., Coscia, F., Shen, C., Charaoui, L., Mann, Matthias & Sander, C., 2021, In: Journal of Ovarian Research. 14, 14 p., 140.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of covalent modifications regulating immune signaling complex composition and phenotype
Frauenstein, A., Ebner, S., Hansen, F. M., Sinha, A., Phulphagar, K., Swatek, K., Hornburg, D., Mann, Matthias & Meissner, F., Jul 2021, In: Molecular Systems Biology. 17, 7, p. e10125Research output: Contribution to journal › Journal article › Research › peer-review
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Towards Precision Dermatology: Emerging Role of Proteomic Analysis of the Skin
Fredman, G., Skov, Lone, Mann, Matthias & Dyring-Andersen, Beatrice, 2022, In: Dermatology. 238, p. 185–194Research output: Contribution to journal › Review › Research › peer-review
Molecular basis of PRC1 targeting to Polycomb response elements by PhoRC
Frey, F., Sheahan, T., Finkl, K., Stoehr, G., Mann, Matthias, Benda, C. & Müller, J., 1 May 2016, In: Genes & Development. 30, 9, p. 1116-27 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanism of replication-coupled DNA-protein crosslink proteolysis by SPRTN and the proteasome
Gao, A., Larsen, N., Sparks, J., Gallina, I., Mann, Matthias, Räschle, M., Walter, J. & Duxin, Julien, 2018, bioRxiv, 54 p.Research output: Working paper › Preprint › Research
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The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions
Garvanska, D. H., Alvarado, R. E., Mundt, F. O., Lindqvist, R., Duel, J. K., Coscia, F., Nilsson, E., Lokugamage, K., Johnson, B. A., Plante, J. A., Morris, D. R., Vu, M. N., Estes, L. K., McLeland, A. M., Walker, J., Crocquet-Valdes, P. A., Mendez, B. L., Plante, K. S., Walker, D. H., Weisser, M. B. & 4 others, , 2024, In: EMBO Reports.Research output: Contribution to journal › Journal article › Research › peer-review
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
Geiger, R., Rieckmann, J. C., Wolf, T., Basso, C., Feng, Y., Fuhrer, T., Kogadeeva, M., Picotti, P., Meissner, F., Mann, Matthias, Zamboni, N., Sallusto, F. & Lanzavecchia, A., 20 Oct 2016, In: Cell. 167, 3, p. 829-842.e13Research output: Contribution to journal › Journal article › Research › peer-review
Initial quantitative proteomic map of 28 mouse tissues using the SILAC mouse
Geiger, T., Velic, A., Macek, B., Lundberg, E., Kampf, C., Nagaraj, N., Uhlen, M., Cox, J. & Mann, Matthias, Jun 2013, In: Molecular & Cellular Proteomics. 12, 6, p. 1709-22 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma Proteome Profiling to Assess Human Health and Disease
Geyer, P. E., Kulak, N. A., Pichler, G., Holdt, L. M., Teupser, D. & Mann, Matthias, 23 Mar 2016, In: Cell Systems. 2, 3, p. 185-95 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Revisiting biomarker discovery by plasma proteomics
Geyer, P. E., Holdt, L. M., Teupser, D. & Mann, Matthias, 26 Sep 2017, In: Molecular Systems Biology. 13, 9, 16 p., 942.Research output: Contribution to journal › Review › Research › peer-review
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Proteomics reveals the effects of sustained weight loss on the human plasma proteome
Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Tyanova, S., Grassl, N., Iepsen, E. P. W., Lundgren, J., Madsbad, Sten, Holst, Jens Juul, Torekov, Signe Sørensen & Mann, Matthias, 22 Dec 2016, In: Molecular Systems Biology. 12, 16 p., 901.Research output: Contribution to journal › Journal article › Research › peer-review
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High-resolution serum proteome trajectories in COVID-19 reveal patient-specific seroconversion
Geyer, P. E., Arend, F. M., Doll, S., Louiset, M., Virreira Winter, S., Müller-Reif, J. B., Torun, F. M., Weigand, M., Eichhorn, P., Bruegel, M., Strauss, M. T., Holdt, L. M., Mann, Matthias & Teupser, D., 2021, In: EMBO Molecular Medicine. 13, 8, 16 p., e14167.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma Proteome Profiling to detect and avoid sample-related biases in biomarker studies
Geyer, P. E., Voytik, E., Treit, P. V., Doll, S., Kleinhempel, A., Niu, Lili, Müller, J. B., Buchholtz, M., Bader, J. M., Teupser, D., Holdt, L. M. & Mann, Matthias, 2019, In: EMBO Molecular Medicine. 11, 11, e10427.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma proteomic data can contain personally identifiable, sensitive information and incidental findings
Geyer, P. E., Porsdam Mann, Sebastian, Treit, P. V. & Mann, Matthias, 2021, In: Molecular and Cellular Proteomics. 20, 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin
Ghanawi, H., Hennlein, L., Zare, A., Bader, J., Salehi, S., Hornburg, D., Ji, C., Sivadasan, R., Drepper, C., Meissner, F., Mann, Matthias, Jablonka, S., Briese, M. & Sendtner, M., 2021, In: Nucleic Acids Symposium Series. 49, 21, p. 12284-12305 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High-accuracy identification and bioinformatic analysis of in vivo protein phosphorylation sites in yeast
Gnad, F., de Godoy, L. M. F., Cox, J., Neuhauser, N., Ren, S., Olsen, Jesper Velgaard & Mann, Matthias, 2009, In: Proteomics. 9, 20, p. 4642-4652 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
PHOSIDA (phosphorylation site database): management, structural and evolutionary investigation, and prediction of phosphosites
Gnad, F., Ren, S., Cox, J., Olsen, Jesper Velgaard, Macek, B., Oroshi, M. & Mann, Matthias, 2007, In: Genome Biology. 8, 11, p. R250Research output: Contribution to journal › Journal article › Research › peer-review
MicroRNAs of the miR-290-295 Family Maintain Bivalency in Mouse Embryonic Stem Cells
Graham, B., Marcais, A., Dharmalingam, G., Carroll, T., Kanellopoulou, C., Graumann, J., Nesterova, T. B., Bermange, A., Brazauskas, P., Xella, B., Kriaucionis, S., Higgs, D. R., Brockdorff, N., Mann, Matthias, Fisher, A. G. & Merkenschlager, M., 10 May 2016, In: Stem Cell Reports. 6, 5, p. 635-642 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy
Gramlich, M., Pane, L. S., Zhou, Q., Chen, Z., Murgia, M., Schötterl, S., Goedel, A., Metzger, K., Brade, T., Parrotta, E., Schaller, M., Gerull, B., Thierfelder, L., Aartsma-Rus, A., Labeit, S., Atherton, J. J., McGaughran, J., Harvey, R. P., Sinnecker, D., Mann, M. & 3 others, , 9 Mar 2015, In: EMBO Molecular Medicine. 7, 5, p. 562-576 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ultra-deep and quantitative saliva proteome reveals dynamics of the oral microbiome
Grassl, N., Kulak, N. A., Pichler, G., Geyer, P. E., Jung, J., Schubert, S., Sinitcyn, P., Cox, J. & Mann, Matthias, 21 Apr 2016, In: Genome Medicine. 8, 13 p., 44.Research output: Contribution to journal › Journal article › Research › peer-review
Molecular and structural architecture of polyQ aggregates in yeast
Gruber, A., Hornburg, D., Antonin, M., Krahmer, N., Collado, J., Schaffer, M., Zubaite, G., Lüchtenborg, C., Sachsenheimer, T., Brügger, B., Mann, Matthias, Baumeister, W., Hartl, F. U., Hipp, M. S. & Fernández-Busnadiego, R., 2018, In: Proceedings of the National Academy of Sciences of the United States of America.Research output: Contribution to journal › Journal article › Research › peer-review
Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway
Gruhler, A., Olsen, Jesper Velgaard, Mohammed, S., Mortensen, P., Faergeman, N. J., Mann, Matthias & Jensen, O. N., 2005, In: Molecular and Cellular Proteomics. 4, 3, p. 310-27 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins
Guerrera, D., Shah, J., Vasileva, E., Sluysmans, S., Méan, I., Jond, L., Poser, I., Mann, Matthias, Hyman, A. A. & Citi, S., 20 May 2016, In: The Journal of Biological Chemistry. 291, 21, p. 11016-29 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mobi-DIK (Ion Mobility DIA Analysis Kit): Targeted analysis software for diaPASEF data improves proteome coverage
Ha, A., Frank, M., Meier, F., Brunner, A., Kaspar-Schoenefeld, S., Koch, S., Lubeck, M., Raether, O., Collins, B. C., Aebersold, R., Mann, Matthias & Rost, H., 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S17 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Activation of the ATR kinase by the RPA-binding protein ETAA1
Haahr, Peter Thorlund, Hoffmann, Saskia, Tollenaere, M. A. X., Ho, T., Toledo Lazaro, L. I., Mann, Matthias, Bekker-Jensen, Simon Holst, Räschle, M. & Mailand, Niels, Nov 2016, In: Nature Cell Biology. 18, 11, p. 1196–1207Research output: Contribution to journal › Journal article › Research › peer-review
Signaling defects associated with insulin resistance in nondiabetic and diabetic individuals and modification by sex
Haider, N., Lebastchi, J., Jayavelu, A. K., Batista, T. M., Pan, H., Dreyfuss, J. M., Carcamo-Orive, I., Knowles, J. W., Mann, Matthias & Kahn, C. R., 1 Nov 2021, In: The Journal of Clinical Investigation. 131, 21Research output: Contribution to journal › Journal article › Research › peer-review
Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology
Hansen, F. M., Tanzer, M. C., Brüning, F., Bludau, I., Stafford, C., Schulman, B. A., Robles, M. S., Karayel, O. & Mann, Matthias, 11 Jan 2021, In: Nature Communications. 12, 1, p. 254Research output: Contribution to journal › Journal article › Research › peer-review
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SCAI promotes DNA double-strand break repair in distinct chromosomal contexts
Hansen, R. K., Mund, A., Poulsen, S. L., Sandoval, M., Klement, K., Tsouroula, K., Tollenaere, M. A. X., Räschle, M., Soria, R., Offermanns, S., Worzfeld, T., Grosse, R., Brandt, D. T., Rozell, B., Mann, M., Cole, F., Soutoglou, E., Goodarzi, A. A., Daniel, J. A., Mailand, N. & 1 others, , 7 Nov 2016, In: Nature Cell Biology. 18, 12, p. 1357–1366Research output: Contribution to journal › Letter › Research › peer-review
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Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk
Hart, P. C., Kenny, H. A., Grassl, N., Watters, K. M., Litchfield, L. M., Coscia, F., Blaženović, I., Ploetzky, L., Fiehn, O., Mann, Matthias, Lengyel, E. & Romero, I. L., 2019, In: Cell Reports. 29, 12, p. 4086-4098.e6Research output: Contribution to journal › Journal article › Research › peer-review
Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in Arabidopsis
Hartl, M., Füßl, M., Boersema, P. J., Jost, J., Kramer, K., Bakirbas, A., Sindlinger, J., Plöchinger, M., Leister, D., Uhrig, G., Moorhead, G. B., Cox, J., Salvucci, M. E., Schwarzer, D., Mann, Matthias & Finkemeier, I., 2017, In: Molecular Systems Biology. 13, 10, 16 p., 949.Research output: Contribution to journal › Journal article › Research › peer-review
Fam20C regulates protein secretion by Cab45 phosphorylation
Hecht, T. K., Blank, B., Steger, M., Lopez, V., Beck, G., Ramazanov, B., Mann, Matthias, Tagliabracci, V. & von Blume, J., 1 Jun 2020, In: The Journal of Cell Biology. 219, 6Research output: Contribution to journal › Journal article › Research › peer-review
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Activity-based profiling of cullin–RING E3 networks by conformation-specific probes
Henneberg, L. T., Singh, J., Duda, D. M., Baek, K., Yanishevski, D., Murray, P. J., Mann, Matthias, Sidhu, S. S. & Schulman, B. A., 2023, In: Nature Chemical Biology. 19, p. 1513-1523Research output: Contribution to journal › Journal article › Research › peer-review
Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry
Hinsby, A. M., Olsen, Jesper Velgaard, Bennett, K. L. & Mann, Matthias, 2003, In: Molecular and Cellular Proteomics. 2, 1, p. 29-36 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4
Hinsby, A. M., Olsen, Jesper Velgaard & Mann, Matthias, 2004, In: Journal of Biological Chemistry. 279, 45, p. 46438-47 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15
Hirst, J., Borner, G. H. H., Edgar, J., Hein, M. Y., Mann, Matthias, Buchholz, F., Antrobus, R. & Robinson, M. S., Aug 2013, In: Molecular Biology of the Cell. 24, 16, p. 2558-69 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5650809
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2004
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Activation of the ATR kinase by the RPA-binding protein ETAA1
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
515
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Region and cell-type resolved quantitative proteomic map of the human heart
Research output: Contribution to journal › Journal article › Research › peer-review
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498
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Revisiting biomarker discovery by plasma proteomics
Research output: Contribution to journal › Review › Research › peer-review
Published