Matthias Mann

Matthias Mann

Professor, head of research, Professor


  1. 2012
  2. Published

    Correction to Feasibility of Large-Scale Phosphoproteomics with Higher Energy Collisional Dissociation Fragmentation

    Nagaraj, N., D'Souza, R. C. J., Cox, J., Olsen, Jesper Velgaard & Mann, Matthias, 2012, In: Journal of Proteome Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response

    Beli, P., Lukashchuk, N., Wagner, S. A., Weinert, B. T., Olsen, Jesper Velgaard, Baskcomb, L., Mann, Matthias, Jackson, S. P. & Choudhary, Chunaram, 2012, In: Molecular Cell. 46, 2, p. 212-25 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma

    Wiśniewski, J. R., Ostasiewicz, P., Duś, K., Zielińska, D. F., Gnad, F. & Mann, Matthias, 1 Jan 2012, In: Molecular Systems Biology. 8, 611.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Proteomics for biomedicine: A half-completed journey

    Mann, Matthias, 1 Feb 2012, In: EMBO Molecular Medicine. 4, 2, p. 75-77 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Advancing cell biology through proteomics in space and time (PROSPECTS)

    Lamond, A. I., Uhlen, M., Horning, S., Makarov, A., Robinson, C. V., Serrano, L., Hartl, F. U., Baumeister, W., Werenskiold, A. K., Mann, Matthias, Andersen, J. S., Vorm, O., Linial, M. & Aebersold, R., 1 Mar 2012, In: Molecular & Cellular Proteomics. 11, 3, 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2013
  8. Proteomic approaches in circadian biology

    Robles, M. S. & Mann, Matthias, 2013, Handbook of experimental pharmacology: Circadian Clocks. p. 389-407 19 p. (Handbook of Experimental Pharmacology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  9. Published

    The SH2 domain interaction landscape

    Tinti, M., Kiemer, L., Costa, S., Miller, M. L., Sacco, F., Olsen, Jesper Velgaard, Carducci, M., Paoluzi, S., Langone, F., Workman, C., Blom, N., Machida, K., Thompson, C. M., Schutkowski, M., Brunak, Søren, Mann, Matthias, Mayer, B. J., Castagnoli, L. & Cesareni, G., 2013, In: Cell Reports. 3, 4, p. 1293-1305 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. The proteome of the calcified layer organic matrix of turkey (Meleagris gallopavo) eggshell

    Mann, K. & Mann, Matthias, 2013, In: Proteome Science. 11, 1, p. 40

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood Samples

    Boersema, P. J., Geiger, T., Wiśniewski, J. R. & Mann, Matthias, 1 Jan 2013, In: Molecular & Cellular Proteomics. 12, 1, p. 158-171 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Phosphorylation Variation during the Cell Cycle Scales with Structural Propensities of Proteins

    Tyanova, S., Frishman, D., Cox, J., Mann, Matthias & Olsen, Jesper Velgaard, 10 Jan 2013, In: P L o S Computational Biology (Online). 9, 1, p. e1002842 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Proteomic and genetic analyses demonstrate that Plasmodium berghei blood stages export a large and diverse repertoire of proteins

    Pasini, E. M., Braks, J. A., Fonager, J., Klop, O., Aime, E., Spaccapelo, R., Otto, T. D., Berriman, M., Hiss, J. A., Thomas, A. W., Mann, Matthias, Janse, C. J., Kocken, C. H. M. & Franke-Fayard, B., Feb 2013, In: Molecular & Cellular Proteomics. 12, 2, p. 426-48 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility

    Bassik, M. C., Kampmann, M., Lebbink, R. J., Wang, S., Hein, M. Y., Poser, I., Weibezahn, J., Horlbeck, M. A., Chen, S., Mann, Matthias, Hyman, A. A., Leproust, E. M., McManus, M. T. & Weissman, J. S., 14 Feb 2013, In: Cell. 152, 4, p. 909-22 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    In Vivo SILAC-Based Proteomics Reveals Phosphoproteome Changes during Mouse Skin Carcinogenesis

    Zanivan, S., Meves, A., Behrendt, K., Schoof, E., Neilson, L. J., Cox, J., Tang, H. R., Kalna, G., van Ree, J. H., van Deursen, J. M., Trempus, C. S., Machesky, L. M., Linding, R., Wickström, S. A., Fässler, R. & Mann, Matthias, 21 Feb 2013, In: Cell Reports. 3, 2, p. 552-566 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The Coming Age of Complete, Accurate, and Ubiquitous Proteomes

    Mann, Matthias, Kulak, N. A., Nagaraj, N. & Cox, J., 21 Feb 2013, In: Molecular Cell. 49, 4, p. 583-590 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Direct proteomic quantification of the secretome of activated immune cells

    Meissner, F., Scheltema, R. A., Mollenkopf, H. & Mann, Matthias, 26 Apr 2013, In: Science (New York, N.Y.). 340, 6131, p. 475-8 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. A SILAC-based approach identifies substrates of caspase-dependent cleavage upon TRAIL-induced apoptosis

    Stoehr, G., Schaab, C., Graumann, J. & Mann, Matthias, May 2013, In: Molecular & Cellular Proteomics. 12, 5, p. 1436-50 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Protein correlation profiles identify lipid droplet proteins with high confidence

    Krahmer, N., Hilger, M., Kory, N., Wilfling, F., Stoehr, G., Mann, Matthias, Farese, R. V. & Walther, T. C., May 2013, In: Molecular & Cellular Proteomics. 12, 5, p. 1115-26 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response

    Radovanac, K., Morgner, J., Schulz, J., Blumbach, K., Patterson, C., Geiger, T., Mann, Matthias, Krieg, T., Eckes, B., Fässler, R. & Wickström, S. A., 15 May 2013, In: E M B O Journal. 32, 10, p. 1409-24 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation

    Sparmann, A., Xie, Y., Verhoeven, E., Vermeulen, M., Lancini, C., Gargiulo, G., Hulsman, D., Mann, Matthias, Knoblich, J. A. & van Lohuizen, M., 29 May 2013, In: E M B O Journal. 32, 11, p. 1598-612 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. A large synthetic peptide and phosphopeptide reference library for mass spectrometry-based proteomics

    Marx, H., Lemeer, S., Schliep, J. E., Matheron, L., Mohammed, S., Cox, J., Mann, Matthias, Heck, A. J. R. & Kuster, B., Jun 2013, In: Nature Biotechnology. 31, 6, p. 557-64 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Initial quantitative proteomic map of 28 mouse tissues using the SILAC mouse

    Geiger, T., Velic, A., Macek, B., Lundberg, E., Kampf, C., Nagaraj, N., Uhlen, M., Cox, J. & Mann, Matthias, Jun 2013, In: Molecular & Cellular Proteomics. 12, 6, p. 1709-22 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Quantitative proteomic analysis reveals concurrent RNA-protein interactions and identifies new RNA-binding proteins in Saccharomyces cerevisiae

    Klass, D. M., Scheibe, M., Butter, F., Hogan, G. J., Mann, Matthias & Brown, P. O., Jun 2013, In: Genome Research. 23, 6, p. 1028-38 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

    Schiller, H. B., Hermann, M., Polleux, J., Vignaud, T., Zanivan, S., Friedel, C. C., Sun, Z., Raducanu, A., Gottschalk, K., Théry, M., Mann, Matthias & Fässler, R., Jun 2013, In: Nature Cell Biology. 15, 6, p. 625-36 12 p.

    Research output: Contribution to journalJournal articleResearch

  26. High performance computational analysis of large-scale proteome data sets to assess incremental contribution to coverage of the human genome

    Neuhauser, N., Nagaraj, N., McHardy, P., Zanivan, S., Scheltema, R., Cox, J. & Mann, Matthias, 7 Jun 2013, In: Journal of Proteome Research. 12, 6, p. 2858-68 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment

    Kappei, D., Butter, F., Benda, C., Scheibe, M., Draškovič, I., Stevense, M., Novo, C. L., Basquin, C., Araki, M., Araki, K., Krastev, D. B., Kittler, R., Jessberger, R., Londoño-Vallejo, J. A., Mann, Matthias & Buchholz, F., 12 Jun 2013, In: E M B O Journal. 32, 12, p. 1681-701 21 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Alleles of a polymorphic ETV6 binding site in DCDC2 confer risk of reading and language impairment

    Powers, N. R., Eicher, J. D., Butter, F., Kong, Y., Miller, L. L., Ring, S. M., Mann, Matthias & Gruen, J. R., 11 Jul 2013, In: American Journal of Human Genetics. 93, 1, p. 19-28 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15

    Hirst, J., Borner, G. H. H., Edgar, J., Hein, M. Y., Mann, Matthias, Buchholz, F., Antrobus, R. & Robinson, M. S., Aug 2013, In: Molecular Biology of the Cell. 24, 16, p. 2558-69 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

    Zanivan, S., Maione, F., Hein, M. Y., Hernández-Fernaud, J. R., Ostasiewicz, P., Giraudo, E. & Mann, Matthias, 26 Aug 2013, In: Molecular & Cellular Proteomics.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. DEAD box protein DDX1 regulates cytoplasmic localization of KSRP

    Chou, C., Lin, W., Lin, C., Luber, C. A., Godbout, R., Mann, Matthias & Chen, C., 4 Sep 2013, In: P L o S One. 8, 9, e73752.

    Research output: Contribution to journalJournal articleResearch

  32. Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators

    Scheibe, M., Arnoult, N., Kappei, D., Buchholz, F., Decottignies, A., Butter, F. & Mann, Matthias, 22 Oct 2013, In: Genome Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators

    Scheibe, M., Arnoult, N., Kappei, D., Buchholz, F., Decottignies, A., Butter, F. & Mann, Matthias, 22 Oct 2013, In: Genome Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. A DNA-Centric Protein Interaction Map of Ultraconserved Elements Reveals Contribution of Transcription Factor Binding Hubs to Conservation

    Viturawong, T., Meissner, F., Butter, F. & Mann, Matthias, 31 Oct 2013, In: Plant Cell Reports. 5, 2, p. 531-45 15 p.

    Research output: Contribution to journalJournal articleResearch

  35. Published

    Status of large-scale analysis of post-translational modifications by mass spectrometry

    Olsen, Jesper Velgaard & Mann, Matthias, 1 Nov 2013, In: Molecular & Cellular Proteomics. 12, p. 3444-52

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes

    Deeb, S. J., Cox, J., Schmidt-Supprian, M. & Mann, Matthias, 4 Nov 2013, In: Molecular & Cellular Proteomics.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 2014
  38. Published

    Specificity and commonality of the phosphoinositide-binding proteome analyzed by quantitative mass spectrometry

    Jungmichel, S., Sylvestersen, K. B., Choudhary, Chunaram, Nguyen, S., Mann, Matthias & Nielsen, Michael Lund, 13 Feb 2014, In: Cell Reports. 6, 3, p. 578-91 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF-β

    J D'Souza, R. C., Knittle, A. M., Nagaraj, N., van Dinther, M., Choudhary, Chunaram, Ten Dijke, P., Mann, Matthias & Sharma, K., Jul 2014, In: Science Signaling. 7, 335, p. rs5 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    The growing landscape of lysine acetylation links metabolism and cell signalling

    Choudhary, Chunaram, Weinert, B. T., Nishida, Y., Verdin, E. & Mann, Matthias, 23 Jul 2014, In: Nature Reviews. Molecular Cell Biology. 15, 8, p. 536-50 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  41. Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome

    Ripaud, L., Chumakova, V., Antonin, M., Hastie, A. R., Pinkert, S., Körner, R., Ruff, K. M., Pappu, R. V., Hornburg, D., Mann, Matthias, Hartl, F. U. & Hipp, M. S., 23 Dec 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 51, p. 18219-24 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. 2015
  43. Published

    Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

    Räschle, M., Smeenk, G., Hansen, R. K., Temu, T., Oka, Y., Hein, M. Y., Nagaraj, N., Long, D. T., Walter, J. C., Hofmann, K., Storchova, Z., Cox, J., Bekker-Jensen, Simon Holst, Mailand, Niels & Mann, Matthias, 2015, In: Science. 348, 6234, p. 539- 10 p., 1253671.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation

    Bassani-Sternberg, M., Pletscher-Frankild, S., Jensen, Lars Juhl & Mann, Matthias, Mar 2015, In: Molecular and Cellular Proteomics. 14, 3, p. 658-73 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Single muscle fiber proteomics reveals unexpected mitochondrial specialization

    Murgia, M., Nagaraj, N., Deshmukh, Atul Shahaji, Zeiler, M., Cancellara, P., Moretti, I., Reggiani, C., Schiaffino, S. & Mann, Matthias, 1 Mar 2015, In: E M B O Reports. 16, 3, p. 387-95 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy

    Gramlich, M., Pane, L. S., Zhou, Q., Chen, Z., Murgia, M., Schötterl, S., Goedel, A., Metzger, K., Brade, T., Parrotta, E., Schaller, M., Gerull, B., Thierfelder, L., Aartsma-Rus, A., Labeit, S., Atherton, J. J., McGaughran, J., Harvey, R. P., Sinnecker, D., Mann, M. & 3 others, Laugwitz, K., Gawaz, M. P. & Moretti, A., 9 Mar 2015, In: EMBO Molecular Medicine. 7, 5, p. 562-576 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways and transcription factors

    Deshmukh, Atul Shahaji, Murgia, M., Nagaraja, N., Treebak, Jonas Thue, Cox, J. & Mann, Matthias, Apr 2015, In: Molecular and Cellular Proteomics. 14, 4, p. 841-853

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. A double-barrel LC-MS/MS system to quantify 96 interactomes per day

    Hosp, F., Scheltema, R. A., Eberl, C., Kulak, N. A., Keilhauer, E. C., Mayr, K. & Mann, Matthias, 17 Apr 2015, In: Molecular and Cellular Proteomics. 14, 7, p. 2030-41 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells

    Ding, L., Paszkowski-Rogacz, M., Winzi, M., Chakraborty, D., Theis, M., Singh, S., Ciotta, G., Poser, I., Roguev, A., Chu, W. K., Choudhary, Chunaram, Mann, Matthias, Stewart, A. F., Krogan, N. & Buchholz, F., 26 Aug 2015, In: Cell Systems. 1, 2, p. 141-151 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Secretome Analysis of Lipid-Induced Insulin Resistance in Skeletal Muscle Cells by a Combined Experimental and Bioinformatics Workflow

    Deshmukh, Atul Shahaji, Cox, J., Jensen, Lars Juhl, Meissner, F. & Mann, Matthias, 6 Nov 2015, In: Journal of Proteome Research. 14, 11, p. 4885-95 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Mitochondrial specialization revealed by single muscle fiber proteomics: focus on the Krebs cycle

    Schiaffino, S., Reggiani, C., Kostrominova, T. Y., Mann, Matthias & Murgia, M., Dec 2015, In: Scandinavian Journal of Medicine & Science in Sports. 25, Suppl 4, p. 41-8 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  52. 2016
  53. Published

    Proteomic maps of breast cancer subtypes

    Tyanova, S., Albrechtsen, Reidar, Kronqvist, P., Cox, J., Mann, Matthias & Geiger, T., 4 Jan 2016, In: Nature Communications. 7, 11 p., 10259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress

    Hoffmann, Saskia, Smedegaard, S., Nakamura, K., Mortuza, G. B., Räschle, M., Ibañez de Opakua, A., Oka, Y., Feng, Y., Blanco, F. J., Mann, Matthias, Montoya, Guillermo, Groth, Anja, Bekker-Jensen, Simon Holst & Mailand, Niels, 4 Jan 2016, In: The Journal of Cell Biology. 212, 1, p. 63-75

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA

    Woerner, A. C., Frottin, F., Hornburg, D., Feng, L. R., Meissner, F., Patra, M., Tatzelt, J., Mann, Matthias, Winklhofer, K. F., Hartl, F. U. & Hipp, M. S., 8 Jan 2016, In: Science (New York, N.Y.). 351, 6269, p. 173-6 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 5650809