Matthias Mann
Professor, head of research, Professor
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Single muscle fiber proteomics reveals unexpected mitochondrial specialization
Murgia, M., Nagaraj, N., Deshmukh, Atul Shahaji, Zeiler, M., Cancellara, P., Moretti, I., Reggiani, C., Schiaffino, S. & Mann, Matthias, 1 Mar 2015, In: E M B O Reports. 16, 3, p. 387-95 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The proteome landscape of the kingdoms of life
Müller, J. B., Geyer, P. E., Colaço, A. R., Treit, P. V., Strauss, M. T., Oroshi, M., Doll, S., Virreira Winter, S., Bader, J. M., Köhler, N., Theis, F., Santos, A. & Mann, Matthias, 2020, In: Nature. 582, p. 592-596Research output: Contribution to journal › Journal article › Research › peer-review
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A new parallel high-pressure packing system enables rapid multiplexed production of capillary columns
Müller-Reif, J. B., Hansen, F. M., Schweizer, L., Treit, P. V., Geyer, P. E. & Mann, Matthias, 2021, In: Molecular and Cellular Proteomics. 20, 10 p., 100082.Research output: Contribution to journal › Journal article › Research › peer-review
Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis
Nagao, H., Jayavelu, A. K., Cai, W., Pan, H., Dreyfuss, J. M., Batista, T. M., Brandão, B. B., Mann, Matthias & Kahn, C. R., 4 Jan 2023, In: Nature Communications. 14, 1, p. 57Research output: Contribution to journal › Journal article › Research › peer-review
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Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling
Nagao, H., Cai, W., Brandão, B. B., Albrechtsen, Nicolai Jacob Wewer, Steger, M., Gattu, A. K., Pan, H., Dreyfuss, J. M., Thomas Wunderlich, F., Mann, Matthias & Ronald Kahn, C., 2023, In: Journal of Clinical Investigation. 133, 4, 18 p., e161472.Research output: Contribution to journal › Journal article › Research › peer-review
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Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains
Nagao, H., Cai, W., Albrechtsen, Nicolai Jacob Wewer, Steger, M., Batista, T. M., Pan, H., Dreyfuss, J. M., Mann, Matthias & Kahn, C. R., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 17, e2019474118.Research output: Contribution to journal › Journal article › Research › peer-review
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Correction to Feasibility of Large-Scale Phosphoproteomics with Higher Energy Collisional Dissociation Fragmentation
Nagaraj, N., D'Souza, R. C. J., Cox, J., Olsen, Jesper Velgaard & Mann, Matthias, 2012, In: Journal of Proteome Research.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Comparative quantitative proteomic analysis of melanoma subtypes, nevus-associated melanoma, and corresponding nevi
Naimy, S., Sølberg, J. B. K., Kuczek, D. E., Løvendorf, Marianne Bengtson, Bzorek, M., Litman, Thomas, Mund, Andreas, Gjerdrum, Lise Mette Rahbek, Clark, R. A., Mann, Matthias & Dyring-Andersen, Beatrice, 5 Jan 2024, (E-pub ahead of print) In: The Journal of Investigative Dermatology.Research output: Contribution to journal › Journal article › Research › peer-review
Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins
Neufeld-Cohen, A., Robles, M. S., Aviram, R., Manella, G., Adamovich, Y., Ladeuix, B., Nir, D., Rousso-Noori, L., Kuperman, Y., Golik, M., Mann, Matthias & Asher, G., 22 Mar 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 12, p. E1673-82Research output: Contribution to journal › Journal article › Research › peer-review
High performance computational analysis of large-scale proteome data sets to assess incremental contribution to coverage of the human genome
Neuhauser, N., Nagaraj, N., McHardy, P., Zanivan, S., Scheltema, R., Cox, J. & Mann, Matthias, 7 Jun 2013, In: Journal of Proteome Research. 12, 6, p. 2858-68 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
Ngo, B., Kim, E., Osorio-Vasquez, V., Doll, S., Bustraan, S., Liang, R. J., Luengo, A., Davidson, S. M., Ali, A., Ferraro, G. B., Fischer, G. M., Eskandari, R., Kang, D. S., Ni, J., Plasger, A., Rajasekhar, V. K., Kastenhuber, E. R., Bacha, S., Sriram, R. K., Stein, B. D. & 20 others, , 2020, In: Cancer Discovery. 10, 9, p. 1352-1373Research output: Contribution to journal › Journal article › Research › peer-review
Proteomic mapping of brain plasma membrane proteins
Nielsen, P. A., Olsen, Jesper Velgaard, Podtelejnikov, A. V., Andersen, J. R., Mann, Matthias & Wisniewski, J. R., 2005, In: Molecular and Cellular Proteomics. 4, 4, p. 402-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Constructing a cell-type resolved human liver proteome atlas: THU-034
Niu, Lili, Geyer, P. & Mann, Matthias, 2018, In: Journal of Hepatology. 68, p. S138-S139Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Niu, Lili, Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Treit, P. V., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Müller, T. D., Tschöp, M. H., Hofmann, S. M. & Mann, Matthias, 2019, In: Molecular Systems Biology. 15, 16 p., e8793.Research output: Contribution to journal › Journal article › Research › peer-review
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Noninvasive proteomic biomarkers for alcohol-related liver disease
Niu, Lili, Thiele, M., Geyer, P. E., Rasmussen, D. N., Webel, Henry, Santos, A., Gupta, R., Meier, F., Strauss, Maximilian, Kjaergaard, M., Lindvig, K., Jacobsen, S., Rasmussen, Simon, Hansen, Torben, Krag, A. & Mann, Matthias, 2022, In: Nature Medicine. 28, 6, p. 1277-1287 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quick and clean: Cracking sentences encoded in E. coli by LC-MS/MS, de novo sequencing, and dictionary search
Niu, Lili & Mann, Matthias, 2019, In: EuPA Open Proteomics. 22-23, p. 30-35 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamic human liver proteome atlas reveals functional insights into disease pathways
Niu, Lili, Geyer, P. E., Gupta, R., Santos, A., Meier, F., Doll, S., Albrechtsen, Nicolai Jacob Wewer, Klein, S., Ortiz, C., Uschner, F. E., Schierwagen, R., Trebicka, J. & Mann, Matthias, 2022, In: Molecular Systems Biology. 18, 5, 24 p., e10947.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma proteome profiling discovers potential biomarkers of non-alcoholic fatty liver disease
Niu, Lili, Gupta, R., Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Mueller, T. D., Tschoep, M. H., Hofmann, S. M. & Mann, Matthias, Aug 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S71 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Defining NASH from a multi-omics systems biology perspective
Niu, Lili, Sulek, K., Vasilopoulou, C. G., Santos, A., Albrechtsen, Nicolai Jacob Wewer, Rasmussen, Simon, Meier, F. & Mann, Matthias, 2021, In: Journal of Clinical Medicine. 10, 20, 22 p., 4673.Research output: Contribution to journal › Review › Research › peer-review
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Proteomics in the Study of Liver Diseases
Niu, Lili, Geyer, P. E. & Mann, Matthias, 2018, The Human Gut-Liver-Axis in Health and Disease. Krag, A. & Hansen, T. (eds.). Springer, p. 165-193Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Metallopeptidase Inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer
Nordgaard, C., Doll, S., Matos, A. L. D. S. A., Høeberg, M., Kazi, J. U., Friis, S., Stenvang, Jan, Rönnstrand, L., Mann, Matthias & Moreira, José, 2019, In: Molecular Oncology. 13, 12, p. 2646-2662Research output: Contribution to journal › Journal article › Research › peer-review
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A Standardized and Reproducible Workflow for Membrane Glass Slides in Routine Histology and Spatial Proteomics
Nordmann, T. M., Schweizer, L., Metousis, A., Thielert, Marvin Christoffer, Rodriguez, E., Gjerdrum, Lise Mette Rahbek, Stadler, P., Bzorek, M., Mund, Andreas, Rosenberger, F. A. & Mann, Matthias, 2023, In: Molecular & cellular proteomics : MCP. 22, 10, 9 p., 100643.Research output: Contribution to journal › Journal article › Research › peer-review
Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification
Notenboom, V., Hibbert, R. G., van Rossum-Fikkert, S. E., Olsen, Jesper Velgaard, Mann, Matthias & Sixma, T. K., 2007, In: Nucleic Acids Research. 35, 17, p. 5819-30 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep
Noya, S. B., Colameo, D., Brüning, F., Spinnler, A., Mircsof, D., Opitz, L., Mann, Matthias, Tyagarajan, S. K., Robles, M. S. & Brown, S. A., 2019, In: Science. 366, 6462, eaav2642 .Research output: Contribution to journal › Journal article › Research › peer-review
STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer
Oberhuber, M., Pecoraro, M., Rusz, M., Oberhuber, G., Wieselberg, M., Haslinger, P., Gurnhofer, E., Schlederer, M., Limberger, T., Lagger, S., Pencik, J., Kodajova, P., Högler, S., Stockmaier, G., Grund-Gröschke, S., Aberger, F., Bolis, M., Theurillat, J-P., Wiebringhaus, R., Weiss, T. & 13 others, , Apr 2020, In: Molecular Systems Biology. 16, 4, p. e9247Research output: Contribution to journal › Journal article › Research › peer-review
A dual pressure linear ion trap orbitrap instrument with very high sequencing speed
Olsen, Jesper Velgaard, Schwartz, J. C., Griep-Raming, J., Nielsen, Michael Lund, Damoc, E., Denisov, E., Lange, O., Remes, P., Taylor, D., Splendore, M., Wouters, E. R., Senko, M., Makarov, A., Mann, Matthias & Horning, S., 2009, In: Molecular and Cellular Proteomics. 8, 12, p. 2759-69 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Status of large-scale analysis of post-translational modifications by mass spectrometry
Olsen, Jesper Velgaard & Mann, Matthias, 1 Nov 2013, In: Molecular & Cellular Proteomics. 12, p. 3444-52Research output: Contribution to journal › Journal article › Research › peer-review
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Effective representation and storage of mass spectrometry-based proteomic data sets for the scientific community
Olsen, Jesper Velgaard & Mann, Matthias, 1 Jan 2011, In: Science Signaling. 4, 160, p. pe7Research output: Contribution to journal › Journal article › Research › peer-review
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Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis
Olsen, Jesper Velgaard, Vermeulen, M., Santamaria, A., Kumar, C., Miller, M. L., Jensen, Lars Juhl, Gnad, F., Cox, J., Jensen, T. S., Nigg, E. A., Brunak, Søren & Mann, Matthias, 2010, In: Science Signaling. 3, 104, p. ra3 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Improved peptide identification in proteomics by two consecutive stages of mass spectrometric fragmentation
Olsen, Jesper Velgaard & Mann, Matthias, 2004, In: Proceedings of the National Academy of Science of the United States of America. 101, 37, p. 13417-22 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Higher-energy C-trap dissociation for peptide modification analysis
Olsen, Jesper Velgaard, Macek, B., Lange, O., Makarov, A., Horning, S. & Mann, Matthias, 2007, In: Nature Methods. 4, 9, p. 709-12 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
HysTag--a novel proteomic quantification tool applied to differential display analysis of membrane proteins from distinct areas of mouse brain
Olsen, Jesper Velgaard, Andersen, J. R., Nielsen, P. A., Nielsen, Michael Lund, Figeys, D., Mann, Matthias & Wisniewski, J. R., Jan 2004, In: Molecular and Cellular Proteomics. 3, 1, p. 82-92 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quantitative proteomic profiling of membrane proteins from the mouse brain cortex, hippocampus, and cerebellum using the HysTag reagent: mapping of neurotransmitter receptors and ion channels
Olsen, Jesper Velgaard, Nielsen, P. A., Andersen, J. R., Mann, Matthias & Wisniewski, J. R., 2007, In: Brain Research. 1134, 1, p. 95-106 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Trypsin cleaves exclusively C-terminal to arginine and lysine residues
Olsen, Jesper Velgaard, Ong, S. & Mann, Matthias, 2004, In: Molecular and Cellular Proteomics. 3, 6, p. 608-14 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap
Olsen, Jesper Velgaard, de Godoy, L. M. F., Li, G., Macek, B., Mortensen, P., Pesch, R., Makarov, A., Lange, O., Horning, S. & Mann, Matthias, 2005, In: Molecular and Cellular Proteomics. 4, 12, p. 2010-21 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
Olsen, Jesper Velgaard, Blagoev, B., Gnad, F., Macek, B., Kumar, C., Mortensen, P. & Mann, Matthias, 2006, In: Cell. 127, 3, p. 635-48 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics
Pan, C., Olsen, Jesper Velgaard, Daub, H. & Mann, Matthias, 2009, In: Molecular and Cellular Proteomics. 8, 12, p. 2796-808 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors
Pan, C., Gnad, F., Olsen, Jesper Velgaard & Mann, Matthias, 2008, In: Proteomics. 8, 21, p. 4534-46 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cohort profile: the MUNICH Preterm and Term Clinical study (MUNICH-PreTCl), a neonatal birth cohort with focus on prenatal and postnatal determinants of infant and childhood morbidity
Pangratz-Fuehrer, S., Genzel-Boroviczény, O., Bodensohn, W. E., Eisenburger, R., Scharpenack, J., Geyer, P. E., Müller-Reif, J. B., van Hagen, N., Müller, A. M., Jensen, Majken Karoline, Klein, C., Mann, Matthias & Nussbaum, C., 2021, In: BMJ Open. 11, 6, 13 p., e050652.Research output: Contribution to journal › Journal article › Research › peer-review
Proteomic and genetic analyses demonstrate that Plasmodium berghei blood stages export a large and diverse repertoire of proteins
Pasini, E. M., Braks, J. A., Fonager, J., Klop, O., Aime, E., Spaccapelo, R., Otto, T. D., Berriman, M., Hiss, J. A., Thomas, A. W., Mann, Matthias, Janse, C. J., Kocken, C. H. M. & Franke-Fayard, B., Feb 2013, In: Molecular & Cellular Proteomics. 12, 2, p. 426-48 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
YBX1 mediates translation of oncogenic transcripts to control cell competition in AML
Perner, F., Schnoeder, T. M., Xiong, Y., Jayavelu, A. K., Mashamba, N., Santamaria, N. T., Huber, N., Todorova, K., Hatton, C., Perner, B., Eifert, T., Murphy, C., Hartmann, M., Hoell, J. I., Schröder, N., Brandt, S., Hochhaus, A., Mertens, P. R., Mann, M., Armstrong, S. A. & 2 others, , Feb 2022, In: Leukemia. 36, 2, p. 426-437 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Alleles of a polymorphic ETV6 binding site in DCDC2 confer risk of reading and language impairment
Powers, N. R., Eicher, J. D., Butter, F., Kong, Y., Miller, L. L., Ring, S. M., Mann, Matthias & Gruen, J. R., 11 Jul 2013, In: American Journal of Human Genetics. 93, 1, p. 19-28 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1
Prestel, M., Prell-Schicker, C., Webb, T., Malik, R., Lindner, B., Ziesch, N., Rex-Haffner, M., Röh, S., Viturawong, T., Lehm, M., Mokry, M., den Ruijter, H., Haitjema, S., Asare, Y., Söllner, F., Najafabadi, M. G., Aherrahrou, R., Civelek, M., Samani, N. J., Mann, M. & 2 others, , Oct 2019, In: Stroke. 50, 10, p. 2651-2660 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
JAZF1, A Novel p400/TIP60/NuA4 Complex Member, Regulates H2A.Z Acetylation at Regulatory Regions
Procida, T., Friedrich, T., Jack, A. P. M., Peritore, M., Bönisch, C., Eberl, H. C., Daus, N., Kletenkov, K., Nist, A., Stiewe, T., Borggrefe, T., Mann, Matthias, Bartkuhn, M. & Hake, S. B., 12 Jan 2021, In: International Journal of Molecular Sciences. 22, 2Research output: Contribution to journal › Journal article › Research › peer-review
Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation
Pünzeler, S., Link, S., Wagner, G., Keilhauer, E. C., Kronbeck, N., Spitzer, R. M., Leidescher, S., Markaki, Y., Mentele, E., Regnard, C., Schneider, K., Takahashi, D., Kusakabe, M., Vardabasso, C., Zink, L. M., Straub, T., Bernstein, E., Harata, M., Leonhardt, H., Mann, M. & 2 others, , 1 Aug 2017, In: E M B O Journal. 36, 15, p. 2263-2279 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation
Qiao, S., Lee, C., Sherpa, D., Chrustowicz, J., Cheng, J., Duennebacke, M., Steigenberger, B., Karayel, O., Vu, D. T., von Gronau, S., Mann, Matthias, Wilfling, F. & Schulman, B. A., 2022, In: Nature Communications. 13, 3041.Research output: Contribution to journal › Journal article › Research › peer-review
Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly
Qiao, S., Langlois, C. R., Chrustowicz, J., Sherpa, D., Karayel, O., Hansen, F. M., Beier, V., von Gronau, S., Bollschweiler, D., Schäfer, T., Alpi, A. F., Mann, Matthias, Prabu, J. R. & Schulman, B. A., 1 Nov 2019, (E-pub ahead of print) In: Molecular Cell.Research output: Contribution to journal › Journal article › Research › peer-review
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D13 Saliva biomarker discovery in Huntington’s disease
Qvist, Filippa Liliendahl, Hellem, M. N., Nielsen, Jørgen Erik, Mann, Matthias & Skotte, Niels Henning, 2022, In: Journal of Neurology, Neurosurgery and Psychiatry. 93, Suppl. 1, p. A24-A25Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response
Radovanac, K., Morgner, J., Schulz, J., Blumbach, K., Patterson, C., Geiger, T., Mann, Matthias, Krieg, T., Eckes, B., Fässler, R. & Wickström, S. A., 15 May 2013, In: E M B O Journal. 32, 10, p. 1409-24 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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LifeTime and improving European healthcare through cell-based interceptive medicine
Rajewsky, N., Almouzni, G., Gorski, S. A., Aerts, S., Amit, I., Bertero, M. G., Bock, C., Bredenoord, A. L., Cavalli, G., Chiocca, S., Clevers, H., De Strooper, B., Eggert, A., Ellenberg, J., Fernández, X. M., Figlerowicz, M., Gasser, S. M., Hubner, N., Kjems, J., Knoblich, J. A. & 31 others, , 2020, In: Nature. 587, 7834, p. 377-386 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease
Ravell, J. C., Matsuda-Lennikov, M., Chauvin, S. D., Zou, J., Biancalana, M., Deeb, S. J., Price, S., Su, H. C., Notarangelo, G., Jiang, P., Morawski, A., Kanellopoulou, C., Binder, K. W., Mukherjee, R., Anibal, J. T., Sellers, B., Zheng, L., He, T., George, A. B., Pittaluga, S. & 34 others, , 5 Nov 2019, (E-pub ahead of print) In: The Journal of Clinical Investigation.Research output: Contribution to journal › Journal article › Research › peer-review
SHP1 regulates a STAT6-ITGB3 axis in FLT3ITD-positive AML cells
Reich, D., Kresinsky, A., Müller, J. P., Bauer, R., Kallenbach, J., Schnoeder, T. M., Heidel, F. H., Fässler, R., Mann, Matthias, Böhmer, F. & Jayavelu, A. K., 2020, In: Leukemia. 34, p. 1444-1449Research output: Contribution to journal › Letter › Research › peer-review
Atomic-resolution mapping of transcription factor-DNA interactions by femtosecond laser crosslinking and mass spectrometry
Reim, A., Ackermann, R., Font-Mateu, J., Kammel, R., Beato, M., Nolte, S., Mann, Matthias, Russmann, C. & Wierer, M., 15 Jun 2020, In: Nature Communications. 11, 1, p. 3019Research output: Contribution to journal › Journal article › Research › peer-review
Social network architecture of human immune cells unveiled by quantitative proteomics
Rieckmann, J. C., Geiger, R., Hornburg, D., Wolf, T., Kveler, K., Jarrossay, D., Sallusto, F., Shen-Orr, S. S., Lanzavecchia, A., Mann, Matthias & Meissner, F., May 2017, In: Nature Immunology. 18, 5, p. 583-593 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons
Riemenschneider, H., Guo, Q., Bader, J., Frottin, F., Farny, D., Kleinberger, G., Haass, C., Mann, Matthias, Hartl, F. U., Baumeister, W., Hipp, M. S., Meissner, F., Fernández-Busnadiego, R. & Edbauer, D., 2022, In: EMBO Reports. 23, 6, e53890.Research output: Contribution to journal › Journal article › Research › peer-review
Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity
Riera-Tur, I., Schäfer, T., Hornburg, D., Mishra, A., da Silva Padilha, M., Fernández-Mosquera, L., Feigenbutz, D., Auer, P., Mann, Matthias, Baumeister, W., Klein, R., Meissner, F., Raimundo, N., Fernández-Busnadiego, R. & Dudanova, I., Mar 2022, In: Life Science Alliance. 5, 3Research output: Contribution to journal › Journal article › Research › peer-review
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System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation
Rigbolt, K. T. G., Prokhorova, T., Akimov, V., Løkkegaard, Jeanette, Johansen, P. T., Kratchmarova, I., Kassem, M. S. E., Mann, Matthias, Olsen, Jesper Velgaard & Blagoev, B., 2011, In: Science Signaling. 4, 164, p. rs3Research output: Contribution to journal › Journal article › Research › peer-review
Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome
Ripaud, L., Chumakova, V., Antonin, M., Hastie, A. R., Pinkert, S., Körner, R., Ruff, K. M., Pappu, R. V., Hornburg, D., Mann, Matthias, Hartl, F. U. & Hipp, M. S., 23 Dec 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 51, p. 18219-24 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology
Robles, M. S., Humphrey, S. J. & Mann, Matthias, 10 Jan 2017, In: Cell Metabolism. 25, 1, p. 118-127 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia
Rommel, C., Rösner, S., Lother, A., Barg, M., Schwaderer, M., Gilsbach, R., Bömicke, T., Schnick, T., Mayer, S., Doll, S., Hesse, M., Kretz, O., Stiller, B., Neumann, F., Mann, Matthias, Krane, M., Fleischmann, B. K., Ravens, U. & Hein, L., 2018, In: Circulation Research. 123, 5, p. 550-563 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Making single-cell proteomics biologically relevant
Rosenberger, F. A., Thielert, Marvin Christoffer & Mann, Matthias, 2023, In: Nature Methods. 20, p. 320-323 4 p.Research output: Contribution to journal › Comment/debate › Research
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Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome
Rosenberger, F. A., Thielert, Marvin Christoffer, Strauss, Maximilian, Schweizer, L., Ammar, C., Mädler, S. C., Metousis, A., Skowronek, P., Wahle, M., Madden, K., Gote-Schniering, J., Semenova, A., Schiller, H. B., Rodriguez, E., Nordmann, T. M., Mund, Andreas & Mann, Matthias, 2023, In: Nature Methods. 20, 10, p. 1530-1536 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links
Räschle, M., Smeenk, G., Hansen, R. K., Temu, T., Oka, Y., Hein, M. Y., Nagaraj, N., Long, D. T., Walter, J. C., Hofmann, K., Storchova, Z., Cox, J., Bekker-Jensen, Simon Holst, Mailand, Niels & Mann, Matthias, 2015, In: Science. 348, 6234, p. 539- 10 p., 1253671.Research output: Contribution to journal › Journal article › Research › peer-review
Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion
Sacco, F., Humphrey, S. J., Cox, J., Mischnik, M., Schulte, A., Klabunde, T., Schäfer, M. & Mann, Matthias, 14 Nov 2016, In: Nature Communications. 7, p. 13250Research output: Contribution to journal › Journal article › Research › peer-review
Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets
Sacco, F., Seelig, A., Humphrey, S. J., Krahmer, N., Volta, F., Reggio, A., Marchetti, P., Gerdes, J. & Mann, Matthias, 7 Mar 2019, (E-pub ahead of print) In: Cell Metabolism.Research output: Contribution to journal › Journal article › Research › peer-review
Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State
Sacco, F., Silvestri, A., Posca, D., Pirrò, S., Gherardini, P. F., Castagnoli, L., Mann, Matthias & Cesareni, G., 23 Mar 2016, In: Cell Systems. 2, 3, p. 159-71 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasma proteome profiles treatment efficacy of incretin dual agonism in diet-induced obese female and male mice
Sachs, S., Niu, Lili, Geyer, P., Jall, S., Kleinert, Maximilian, Feuchtinger, A., Stemmer, K., Brielmeier, M., Finan, B., DiMarchi, R. D., Tschop, M. H., Albrechtsen, Nicolai Jacob Wewer, Mann, Matthias, Mueller, T. D. & Hofmann, S. M., 2020, In: Diabetes, Obesity and Metabolism. 23, 1, p. 195-207 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr
Salehi, S., Zare, A., Prezza, G., Bader, J., Schneider, C., Fischer, U., Meissner, F., Mann, Matthias, Briese, M. & Sendtner, M., 2023, In: Nature Communications. 14, 19 p., 4158.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A knowledge graph to interpret clinical proteomics data
Santos, A., Colaço, A. R., Nielsen, A. B., Niu, Lili, Strauss, Maximilian, Geyer, P. E., Coscia, F., Albrechtsen, Nicolai Jacob Wewer, Mundt, F., Jensen, Lars Juhl & Mann, Matthias, 2022, In: Nature Biotechnology. 40, p. 692–702Research output: Contribution to journal › Journal article › Research › peer-review
A genome-wide resource for the analysis of protein localisation in Drosophila
Sarov, M., Barz, C., Jambor, H., Hein, M. Y., Schmied, C., Suchold, D., Stender, B., Janosch, S., K J, V. V., Krishnan, R. T., Krishnamoorthy, A., Ferreira, I. R. S., Ejsmont, R. K., Finkl, K., Hasse, S., Kämpfer, P., Plewka, N., Vinis, E., Schloissnig, S., Knust, E. & 6 others, , 20 Feb 2016, In: eLife. 5, p. e12068Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mast cells in lung damage of COVID-19 autopsies: A descriptive study
Schaller, T., Märkl, B., Claus, R., Sholl, L., Hornick, J. L., Giannetti, M. P., Schweizer, L., Mann, Matthias & Castells, M., 2022, In: Allergy. 77, 7, p. 2237-2239 3 p.Research output: Contribution to journal › Comment/debate › Research
Glutathione peroxidase 3 localizes to the epithelial lining fluid and the extracellular matrix in interstitial lung disease
Schamberger, A. C., Schiller, H. B., Fernandez, I. E., Sterclova, M., Heinzelmann, K., Hennen, E., Hatz, R., Behr, J., Vašáková, M., Mann, Matthias, Eickelberg, O. & Staab-Weijnitz, C. A., 20 Jul 2016, In: Scientific Reports. 6, p. 29952Research output: Contribution to journal › Journal article › Research › peer-review
A mass spectrometry-friendly database for cSNP identification
Schandorff, S., Olsen, Jesper Velgaard, Bunkenborg, J., Blagoev, B., Zhang, Y., Andersen, J. S. & Mann, Matthias, 2007, In: Nature Methods. 4, 6, p. 465-6 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators
Scheibe, M., Arnoult, N., Kappei, D., Buchholz, F., Decottignies, A., Butter, F. & Mann, Matthias, 22 Oct 2013, In: Genome Research.Research output: Contribution to journal › Journal article › Research › peer-review
Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators
Scheibe, M., Arnoult, N., Kappei, D., Buchholz, F., Decottignies, A., Butter, F. & Mann, Matthias, 22 Oct 2013, In: Genome Research.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mitochondrial specialization revealed by single muscle fiber proteomics: focus on the Krebs cycle
Schiaffino, S., Reggiani, C., Kostrominova, T. Y., Mann, Matthias & Murgia, M., Dec 2015, In: Scandinavian Journal of Medicine & Science in Sports. 25, Suppl 4, p. 41-8 8 p.Research output: Contribution to journal › Review › Research › peer-review
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments
Schiller, H. B., Hermann, M., Polleux, J., Vignaud, T., Zanivan, S., Friedel, C. C., Sun, Z., Raducanu, A., Gottschalk, K., Théry, M., Mann, Matthias & Fässler, R., Jun 2013, In: Nature Cell Biology. 15, 6, p. 625-36 12 p.Research output: Contribution to journal › Journal article › Research
Deep Proteome Profiling Reveals Common Prevalence of MZB1-positive Plasma B Cells in Human Lung and Skin Fibrosis
Schiller, H. B., Mayr, C. H., Leuschner, G., Strunz, M., Staab-Weijnitz, C., Preisendörfer, S., Eckes, B., Moinzadeh, P., Krieg, T., Schwartz, D. A., Hatz, R. A., Behr, J., Mann, Matthias & Eickelberg, O., 2017, In: American Journal of Respiratory and Critical Care Medicine. 196, 10, p. 1298–1310Research output: Contribution to journal › Journal article › Research › peer-review
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network
Schmacke, N. A., O'Duill, F., Gaidt, M. M., Szymanska, I., Kamper, J. M., Schmid-Burgk, J. L., Mädler, S. C., Mackens-Kiani, T., Kozaki, T., Chauhan, D., Nagl, D., Stafford, C. A., Harz, H., Fröhlich, A. L., Pinci, F., Ginhoux, F., Beckmann, R., Mann, Matthias, Leonhardt, H. & Hornung, V., 2022, In: Immunity. 55, 12, p. 2271-2284.e7Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A reversible state of hypometabolism in a human cellular model of sporadic Parkinson’s disease
Schmidt, S., Stautner, C., Vu, D. T., Heinz, A., Regensburger, M., Karayel, O., Trümbach, D., Artati, A., Kaltenhäuser, S., Nassef, M. Z., Hembach, S., Steinert, L., Winner, B., Jürgen, W., Jastroch, M., Luecken, M. D., Theis, F. J., Westmeyer, G. G., Adamski, J., Mann, M. & 4 others, , 2023, In: Nature Communications. 14, 1, 24 p., 7674.Research output: Contribution to journal › Journal article › Research › peer-review
PLCG1 is required for AML1-ETO leukemia stem cell self-renewal
Schnoeder, T. M., Schwarzer, A., Jayavelu, A. K., Hsu, C-J., Kirkpatrick, J., Döhner, K., Perner, F., Eifert, T., Huber, N., Arreba-Tutusaus, P., Dolnik, A., Assi, S. A., Nafria, M., Jiang, L., Dai, Y-T., Chen, Z., Chen, S-J., Kellaway, S. G., Ptasinska, A., Ng, E. S. & 17 others, , 2022, In: Blood. 139, 7, p. 1080-1097 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity
Seitz, S., Kwon, Y., Hartleben, G., Juelg, J., Sekar, R., Krahmer, N., Najafi, B., Loft, A., Gancheva, S., Stemmer, K., Feuchtinger, A., de Angelis, M. H., Mueller, T. D., Mann, M., Blueher, M., Roden, M., Diaz, M. B., Behrends, C., Gilleron, J., Herzig, S. & 1 others, , 2019, In: Nature Metabolism. 1, p. 1009-1026Research output: Contribution to journal › Journal article › Research › peer-review
GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme
Sherpa, D., Chrustowicz, J., Qiao, S., Langlois, C. R., Hehl, L. A., Gottemukkala, K. V., Hansen, F. M., Karayel, O., von Gronau, S., Prabu, J. R., Mann, Matthias, Alpi, A. F. & Schulman, B. A., 22 Apr 2021, (E-pub ahead of print) In: Molecular Cell.Research output: Contribution to journal › Journal article › Research › peer-review
In-gel digestion for mass spectrometric characterization of proteins and proteomes
Shevchenko, A., Tomas, H., Havlis, J., Olsen, Jesper Velgaard & Mann, Matthias, 2006, In: Nature Protocols (Print Edition). 1, 6, p. 2856-60 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness
Sirinian, C., Papanastasiou, A. D., Karayel, O., Degn, S. E., Peroukidis, S., Chaniotis, D., Nonni, A., Repanti, M., Kriegsmann, M., Makatsoris, T., Koutras, A., Mann, Matthias & Kalofonos, H. P., Nov 2022, In: Neoplasia (New York, N.Y.). 33, p. 100836Research output: Contribution to journal › Journal article › Research › peer-review
C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons
Sivadasan, R., Hornburg, D., Drepper, C., Frank, N., Jablonka, S., Hansel, A., Lojewski, X., Sterneckert, J., Hermann, A., Shaw, P. J., Ince, P. G., Mann, Matthias, Meissner, F. & Sendtner, M., Dec 2016, In: Nature Neuroscience. 19, 12, p. 1610-1618 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quality control for plasma and cerebrospinal fluid samples using mass spectrometry
Skotte, N. H., Geyer, P. E., Steger, M., Treit, P. V., Voytik, E., Hellem, M. N., Nielsen, Jørgen Erik & Mann, Matthias, 2018, In: Journal of Neurology, Neurosurgery and Psychiatry. 89, p. A31-A32Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Rapid and In-Depth Coverage of the (Phospho-)Proteome With Deep Libraries and Optimal Window Design for dia-PASEF
Skowronek, P., Thielert, Marvin Christoffer, Voytik, E., Tanzer, M. C., Hansen, F. M., Willems, S., Karayel, O., Brunner, A., Meier, F. & Mann, Matthias, 2022, In: Molecular and Cellular Proteomics. 21, 9, 15 p., 100279.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synchro-PASEF allows precursor-specific fragment ion extraction and interference removal in data-independent acquisition
Skowronek, P., Krohs, F., Lubeck, M., Wallmann, G., Itang, E. C. M., Koval, P., Wahle, M., Thielert, Marvin Christoffer, Meier, F., Willems, S., Raether, O. & Mann, Matthias, 2023, In: Molecular and Cellular Proteomics. 22, 2, 14 p., 100489.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Homology-directed repair protects the replicating genome from metabolic assaults
Somyajit, K., Spies, J., Coscia, F., Kirik, U., Rask, M., Lee, J., Neelsen, K. J., Mund, Andreas, Jensen, Lars Juhl, Paull, T. T., Mann, Matthias & Lukas, Jiri, 2021, In: Developmental Cell. 56, 4, p. 461-477.e7Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair
Sparks, J. L., Chistol, G., Gao, A. O., Räschle, M., Larsen, N. B., Mann, Matthias, Duxin, Julien & Walter, J. C., 2019, In: Cell. 176, 1-2, p. 167-181.e21Research output: Contribution to journal › Journal article › Research › peer-review
The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation
Sparmann, A., Xie, Y., Verhoeven, E., Vermeulen, M., Lancini, C., Gargiulo, G., Hulsman, D., Mann, Matthias, Knoblich, J. A. & van Lohuizen, M., 29 May 2013, In: E M B O Journal. 32, 11, p. 1598-612 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation
Stafford, C. A., Gassauer, A. M., de Oliveira Mann, C. C., Tanzer, M. C., Fessler, E., Wefers, B., Nagl, D., Kuut, G., Sulek, K., Vasilopoulou, C., Schwojer, S. J., Wiest, A., Pfautsch, M. K., Wurst, W., Yabal, M., Fröhlich, T., Mann, Matthias, Gisch, N., Jae, L. T. & Hornung, V., 2022, In: Nature. 609, p. 590-596 28 p.Research output: Contribution to journal › Journal article › Research › peer-review
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., Baptista, M. A., Fiske, B. K., Fell, M. J., Morrow, J. A., Reith, A. D., Alessi, D. R. & Mann, Matthias, 29 Jan 2016, In: eLife. 5Research output: Contribution to journal › Journal article › Research › peer-review
Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
Steger, M., Diez, F., Dhekne, H. S., Lis, P., Nirujogi, R. S., Karayel, O., Tonelli, F., Martinez, T. N., Lorentzen, E., Pfeffer, S. R., Alessi, D. R. & Mann, Matthias, 10 Nov 2017, In: eLife. 6Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Full Mass Range ΦSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis
Steigerwald, S., Sinha, A., Fort, K. L., Zeng, W., Niu, Lili, Wichmann, C., Kreutzmann, A., Mourad, D., Aizikov, K., Grinfeld, D., Makarov, A., Mann, Matthias & Meier, F., 2024, In: Molecular and Cellular Proteomics. 12 p., 100713.Research output: Contribution to journal › Journal article › Research › peer-review
A SILAC-based approach identifies substrates of caspase-dependent cleavage upon TRAIL-induced apoptosis
Stoehr, G., Schaab, C., Graumann, J. & Mann, Matthias, May 2013, In: Molecular & Cellular Proteomics. 12, 5, p. 1436-50 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
Stukalov, A., Girault, V., Grass, V., Karayel, O., Bergant, V., Urban, C., Haas, D. A., Huang, Y., Oubraham, L., Wang, A., Hamad, M. S., Piras, A., Hansen, F. M., Tanzer, M. C., Paron, I., Zinzula, L., Engleitner, T., Reinecke, M., Lavacca, T. M., Ehmann, R. & 10 others, , 12 Apr 2021, (E-pub ahead of print) In: Nature.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Proteome of Hand Eczema Assessed by Tape Stripping
Sølberg, J. B. K., Quaade, A. S., Drici, L., Sulek, K., Ulrich, N. H., Løvendorf, Marianne Bengtson, Thyssen, Jacob Pontoppidan, Mann, Matthias, Dyring-Andersen, Beatrice & Johansen, Jeanne Duus, 2023, In: Journal of Investigative Dermatology. 143, p. 1559-1568Research output: Contribution to journal › Journal article › Research › peer-review
A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance
Tain, L. S., Sehlke, R., Jain, C., Chokkalingam, M., Nagaraj, N., Essers, P., Rassner, M., Grönke, S., Froelich, J., Dieterich, C., Mann, Matthias, Alic, N., Beyer, A. & Partridge, L., 15 Sep 2017, In: Molecular Systems Biology. 13, 9, p. 939Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5650809
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Activation of the ATR kinase by the RPA-binding protein ETAA1
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Region and cell-type resolved quantitative proteomic map of the human heart
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Revisiting biomarker discovery by plasma proteomics
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