Jakob Nilsson

Jakob Nilsson

Professor


  1. 2024
  2. Published

    The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions

    Garvanska, D. H., Alvarado, R. E., Mundt, F. O., Lindqvist, R., Duel, J. K., Coscia, F., Nilsson, E., Lokugamage, K., Johnson, B. A., Plante, J. A., Morris, D. R., Vu, M. N., Estes, L. K., McLeland, A. M., Walker, J., Crocquet-Valdes, P. A., Mendez, B. L., Plante, K. S., Walker, D. H., Weisser, M. B. & 4 others, Överby, A. K., Mann, Matthias, Menachery, V. D. & Nilsson, Jakob, 2024, In: EMBO Reports.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Cryo-EM structures of PP2A:B55–FAM122A and PP2A:B55–ARPP19

    Padi, S. K. R., Vos, M. R., Godek, R. J., Fuller, J. R., Kruse, Thomas, Hein, J. B., Nilsson, Jakob, Kelker, M. S., Page, R. & Peti, W., 2024, In: Nature. 625, 7993, p. 195-203 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling

    Zhang, Y., Young, R., Garvanska, Dimitriya Hristoforova, Song, C., Zhai, Y., Wang, Y., Jiang, H., Fang, J., Nilsson, Jakob, Alfieri, C. & Zhang, G., 2024, In: Communications Biology . 7, 12 p., 164.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2023
  6. Published

    Phosphatase specificity principles uncovered by MRBLE:Dephos and global substrate identification

    Hein, J. B., Nguyen, H. T., Garvanska, Dimitriya Hristoforova, Nasa, I., Kruse, Thomas, Feng, Y., Lopez Mendez, B., Davey, N., Kettenbach, A. N., Fordyce, P. M. & Nilsson, Jakob, 2023, In: Molecular Systems Biology. 19, 17 p., e11782.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The SUMO–NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure

    Hertz, Emil Peter Thrane, Alonso de Vega, Ignacio, Kruse, Thomas, Wang, Y., Hendriks, Ivo Alexander, Bizard, A. H., Eugui-Anta, A., Hay, R. T., Nielsen, Michael Lund, Nilsson, Jakob, Hickson, Ian David & Mailand, Niels, 2023, In: Nature Structural and Molecular Biology. 30, p. 1303-1313

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions

    Kliche, J., Garvanska, Dimitriya Hristoforova, Simonetti, L., Badgujar, D., Dobritzsch, D., Nilsson, Jakob, Davey, N. E. & Ivarsson, Y., 2023, In: Molecular Systems Biology. 19, 7, 21 p., e11164.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A

    Pavic, K., Gupta, N., Omella, J. D., Derua, R., Aakula, A., Huhtaniemi, R., Määttä, J. A., Höfflin, N., Okkeri, J., Wang, Z., Kauko, O., Varjus, R., Honkanen, H., Abankwa, D., Köhn, M., Hytönen, V. P., Xu, W., Nilsson, J., Page, R., Janssens, V. & 2 others, Leitner, A. & Westermarck, J., 2023, In: Nature Communications. 14, 18 p., 1143.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    SLiM-binding pockets: an attractive target for broad-spectrum antivirals

    Simonetti, L., Nilsson, Jakob, McInerney, G., Ivarsson, Y. & Davey, N. E., 2023, In: Trends in Biochemical Sciences. 48, 5, p. 420-427

    Research output: Contribution to journalReviewResearchpeer-review

  11. Published

    Spatial separation of phosphatase and kinase activity within the Bub complex is required for proper mitosis

    Wang, L., Kruse, Thomas, López-Méndez, B., Zhang, Y., Song, C., Zhu, L., Li, B., Fang, J., Lu, Z., Nilsson, Jakob & Zhang, G., 2023, In: Journal of Molecular Cell Biology. 14, 11, 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2022
  13. Published

    Chemogenetic profiling reveals PP2A-independent cytotoxicity of proposed PP2A activators iHAP1 and DT-061

    Vit, G., Duro, Joana Maria, Rajendraprasad, G., Hertz, Emil Peter Thrane, Holland, L. K. K., Weisser, Melanie, McEwan, B. C., Lopez-Mendez, B., Sotelo-Parrilla, P., Jeyaprakash, A. A., Montoya, Guillermo, Mailand, Niels, Maeda, K., Kettenbach, A., Barisic, Marin & Nilsson, Jakob, 2022, In: EMBO Journal. 41, 14, e110611.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Human SLFN5 and its Xenopus Laevis ortholog regulate entry into mitosis and oocyte meiotic resumption

    Vit, G., Hirth, A., Neugebauer, N., Kraft, B. N., Sigismondo, G., Cazzola, A., Tessmer, C., Duro, Joana Maria, Krijgsveld, J., Hofmann, I., Berger, M., Klüter, H., Niehrs, C., Nilsson, Jakob & Krämer, A., 2022, In: Cell Death Discovery. 8, 12 p., 484.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2021
  16. Published

    A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination

    Ambjørn, Sara Marie, Duxin, Julien, Hertz, Emil Peter Thrane, Nasa, I., Duro, Joana Maria, Kruse, Thomas, Lopez-Mendez, B., Rymarczyk, B., Cressey, L. E., van Overeem Hansen, T., Kettenbach, A. N., Østergaard, Vibe Hallundbæk, Lisby, Michael & Nilsson, Jakob, 2021, In: Nature Communications. 12, 1, 11 p., 5748.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Generation and diversification of recombinant monoclonal antibodies

    DeLuca, K. F., Mick, J. E., Ide, A. H., Lima, W. C., Sherman, L., Schaller, K. L., Anderson, S. M., Zhao, N., Stasevich, T. J., Varma, D., Nilsson, Jakob & DeLuca, J. G., 2021, In: eLife. 10, 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published
  19. Published

    Coupling of Cdc20 inhibition and activation by BubR1

    Hein, J. B., Garvanska, Dimitriya Hristoforova, Nasa, I., Kettenbach, A. N. & Nilsson, Jakob, 2021, In: Journal of Cell Biology. 220, 5, e202012081.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

    Kruse, T., Benz, C., Garvanska, D. H., Lindqvist, R., Mihalic, F., Coscia, F., Inturi, R., Sayadi, A., Simonetti, L., Nilsson, E., Ali, M., Kliche, J., Moliner Morro, A., Mund, A., Andersson, E., McInerney, G., Mann, M., Jemth, P., Davey, N. E., Överby, A. K. & 2 others, Nilsson, Jakob & Ivarsson, Y., 2021, In: Nature Communications. 12, 1, 13 p., 6761.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    A highly conserved pocket on PP2A-B56 is required for hSgo1 binding and cohesion protection during mitosis

    Ueki, Y., Hadders, M. A., Weisser, Melanie, Nasa, I., Sotelo-Parrilla, P., Cressey, L. E., Gupta, T., Hertz, Emil Peter Thrane, Kruse, Thomas, Montoya, Guillermo, Jeyaprakash, A. A., Kettenbach, A., Lens, S. M. A. & Nilsson, Jakob, 2021, In: EMBO Reports. 22, 7, 13 p., e52295.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2020
  23. Published

    Specificity determinants of phosphoprotein phosphatases controlling kinetochore functions

    Garvanska, Dimitriya Hristoforova & Nilsson, Jakob, 2020, In: Essays in Biochemistry. 64, 2, p. 325-336

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Mechanisms of site-specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits

    Kruse, Thomas, Gnosa, S. P., Nasa, I., Garvanska, Dimitriya Hristoforova, Hein, J. B., Nguyen, H., Samsøe-Petersen, Jacob, Lopez-Mendez, B., Hertz, Emil Peter Thrane, Schwarz, J., Pena, H. S., Nikodemus, D., Kveiborg, Marie, Kettenbach, A. N. & Nilsson, Jakob, 2020, In: EMBO Journal. 39, 18 p., e103695.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Quantitative kinase and phosphatase profiling reveal that CDK1 phosphorylates PP2Ac to promote mitotic entry

    Nasa, I., Cressey, L. E., Kruse, Thomas, Hertz, Emil Peter Thrane, Gui, J., Graves, L. M., Nilsson, Jakob & Kettenbach, A. N., 2020, In: Science Signaling. 13, 648, 15 p., eaba7823.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Escape from the checkpoint: Nek2A binds a unique conformation of the APC/C-MCC complex

    Nilsson, Jakob, 2020, In: EMBO Reports. 21, 6, e50494.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment

    Wang, X., Garvanska, Dimitriya Hristoforova, Nasa, I., Ueki, Y., Zhang, G., Kettenbach, A. N., Peti, W., Nilsson, Jakob & Page, R., 2020, In: eLife. 9, 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2019
  29. Published

    The RIF1-PP1 Axis Controls Abscission Timing in Human Cells

    Bhowmick, Rahul, Thakur, R. S., Venegas, A. B., Liu, Ying, Nilsson, Jakob, Barisic, Marin & Hickson, Ian David, 2019, In: Current Biology. 29, 7, p. 1232-1242.e5

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Protein phosphatases in the regulation of mitosis

    Nilsson, Jakob, 2019, In: The Journal of Cell Biology. 218, 2, 15 p., 395.

    Research output: Contribution to journalReviewResearchpeer-review

  31. Published

    A Consensus Binding Motif for the PP4 Protein Phosphatase

    Ueki, Y., Kruse, Thomas, Weisser, Melanie, Sundell, G. N., Larsen, Marie Sofie Yoo, Mendez, B. L., Jenkins, N. P., Garvanska, Dimitriya Hristoforova, Cressey, L., Zhang, G., Davey, N., Montoya, Guillermo, Ivarsson, Y., Kettenbach, A. N. & Nilsson, Jakob, 2019, In: Molecular Cell. 76, 6, p. 953-964.e6

    Research output: Contribution to journalJournal articleResearchpeer-review

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