SLiM-binding pockets: an attractive target for broad-spectrum antivirals

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  • Leandro Simonetti
  • Nilsson, Jakob
  • Gerald McInerney
  • Ylva Ivarsson
  • Norman E. Davey

Short linear motif (SLiM)-mediated interactions offer a unique strategy for viral intervention due to their compact interfaces, ease of convergent evolution, and key functional roles. Consequently, many viruses extensively mimic host SLiMs to hijack or deregulate cellular pathways and the same motif-binding pocket is often targeted by numerous unrelated viruses. A toolkit of therapeutics targeting commonly mimicked SLiMs could provide prophylactic and therapeutic broad-spectrum antivirals and vastly improve our ability to treat ongoing and future viral outbreaks. In this opinion article, we discuss the therapeutic relevance of SLiMs, advocating their suitability as targets for broad-spectrum antiviral inhibitors.

Original languageEnglish
JournalTrends in Biochemical Sciences
Issue number5
Pages (from-to)420-427
Publication statusPublished - 2023

Bibliographical note

Publisher Copyright:
© 2022 The Authors

    Research areas

  • inhibitors, protein–protein interactions, short linear motifs, viral outbreak preparedness, viruses

ID: 335963235