Jakob Nilsson
Professor
Nilsson Group
Blegdamsvej 3B
2200 København N
- Published
Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation
Zhang, G., Mendez, B. L., Sedgwick, G. G. & Nilsson, Jakob, 2016, In: Nature Communications. 7, p. 1-12 12 p., 12256.Research output: Contribution to journal › Journal article › Research › peer-review
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Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis
Sedgwick, G. G., Townsend, K., Martin, A., Shimwell, N. J., Grand, R. J. A., Stewart, G. S., Nilsson, Jakob & Turnell, A. S., 2013, In: Oncogene. 32, 39, p. 4622-4633 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells
Pedersen, R. T., Kruse, Thomas, Nilsson, Jakob, Østergaard, Vibe Hallundbæk & Lisby, Michael, 2015, In: Journal of Cell Biology. 210, 4, p. 565-582 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The internal Cdc20 binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing
Lischetti, T., Zhang, G., Sedgwick, G. G., Bolanos-Garcia, V. M. & Nilsson, Jakob, Dec 2014, In: Nature Communications. 5, p. 1-12 12 p., 5563.Research output: Contribution to journal › Journal article › Research › peer-review
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The closed form of Mad2 is bound to Mad1 and Cdc20 at unattached kinetochores
Zhang, G. & Nilsson, Jakob, 2018, In: Cell Cycle. 17, 9, p. 1087-1091Research output: Contribution to journal › Journal article › Research › peer-review
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The architecture of the BubR1 tetratricopeptide tandem repeat defines a protein motif underlying mitotic checkpoint-kinetochore communication
Bolanos-Garcia, V. M., Nilsson, Jakob & Blundell, T. L., 1 Jan 2012, In: Bioarchitecture. 2, 1, p. 23-27 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity
Wild, T., Larsen, Marie Sofie Yoo, Narita, Takeo, Schou, J., Nilsson, Jakob & Choudhary, Chunaram, 1 Mar 2016, In: Cell Reports. 14, 8, p. 1829-40 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The SUMO–NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure
Hertz, Emil Peter Thrane, Alonso de Vega, Ignacio, Kruse, Thomas, Wang, Y., Hendriks, Ivo Alexander, Bizard, A. H., Eugui-Anta, A., Hay, R. T., Nielsen, Michael Lund, Nilsson, Jakob, Hickson, Ian David & Mailand, Niels, 2023, In: Nature Structural and Molecular Biology. 30, p. 1303-1313Research output: Contribution to journal › Journal article › Research › peer-review
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The RIF1-PP1 Axis Controls Abscission Timing in Human Cells
Bhowmick, Rahul, Thakur, R. S., Venegas, A. B., Liu, Ying, Nilsson, Jakob, Barisic, Marin & Hickson, Ian David, 2019, In: Current Biology. 29, 7, p. 1232-1242.e5Research output: Contribution to journal › Journal article › Research › peer-review
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The Ndc80 internal loop is required for recruitment of the Ska complex to establish end-on microtubule attachment to kinetochores
Zhang, G., Kelstrup, C. D., Hu, X., Hansen, M. J. K., Singleton, M. R., Olsen, Jesper Velgaard & Nilsson, Jakob, 2012, In: Journal of Cell Science. p. 3243-3253 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions
Garvanska, D. H., Alvarado, R. E., Mundt, F. O., Lindqvist, R., Duel, J. K., Coscia, F., Nilsson, E., Lokugamage, K., Johnson, B. A., Plante, J. A., Morris, D. R., Vu, M. N., Estes, L. K., McLeland, A. M., Walker, J., Crocquet-Valdes, P. A., Mendez, B. L., Plante, K. S., Walker, D. H., Weisser, M. B. & 4 others, , 2024, In: EMBO Reports.Research output: Contribution to journal › Journal article › Research › peer-review
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The Ebola Virus Nucleoprotein Recruits the Host PP2A-B56 Phosphatase to Activate Transcriptional Support Activity of VP30
Kruse, Thomas, Biedenkopf, N., Hertz, Emil Peter Thrane, Dietzel, E., Stalmann, G., López-Méndez, B., Davey, N. E., Nilsson, Jakob & Becker, S., 4 Jan 2018, In: Molecular Cell. 69, 1, p. 136-145 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Drosophila Microtubule-Associated Protein Mars Stabilizes Mitotic Spindles by Crosslinking Microtubules through Its N-Terminal Region
Zhang, G., Beati, H., Nilsson, Jakob & Wodarz, A., 4 Apr 2013, In: P L o S One. 8, 4, p. e60596 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction
Nilsson, Jakob, Yekezare, M., Minshull, J. & Pines, J., 2008, In: Nature Cell Biology. 10, 12, p. 1411-20 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C
Garvanska, Dimitriya Hristoforova, Larsen, Marie Sofie Yoo & Nilsson, Jakob, 2 Sep 2016, In: Biology Open. 5, p. 1441-1448Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site
Bolanos-Garcia, V. M., Lischetti, T., Matak-Vinković, D., Cota, E., Simpson, P. J., Chirgadze, D. Y., Spring, D. R., Robinson, C. V., Nilsson, Jakob & Blundell, T. L., 9 Nov 2011, In: Structure. 19, 11, p. 1691-700 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A
Pavic, K., Gupta, N., Omella, J. D., Derua, R., Aakula, A., Huhtaniemi, R., Määttä, J. A., Höfflin, N., Okkeri, J., Wang, Z., Kauko, O., Varjus, R., Honkanen, H., Abankwa, D., Köhn, M., Hytönen, V. P., Xu, W., Nilsson, J., Page, R., Janssens, V. & 2 others, , 2023, In: Nature Communications. 14, 18 p., 1143.Research output: Contribution to journal › Journal article › Research › peer-review
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Stable MCC binding to the APC/C is required for a functional spindle assembly checkpoint
Hein, J. B. & Nilsson, Jakob, 25 Jan 2014, In: E M B O Reports. 15, p. 264-272Research output: Contribution to journal › Journal article › Research › peer-review
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Specificity determinants of phosphoprotein phosphatases controlling kinetochore functions
Garvanska, Dimitriya Hristoforova & Nilsson, Jakob, 2020, In: Essays in Biochemistry. 64, 2, p. 325-336Research output: Contribution to journal › Journal article › Research › peer-review
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Spatial separation of phosphatase and kinase activity within the Bub complex is required for proper mitosis
Wang, L., Kruse, Thomas, López-Méndez, B., Zhang, Y., Song, C., Zhu, L., Li, B., Fang, J., Lu, Z., Nilsson, Jakob & Zhang, G., 2023, In: Journal of Molecular Cell Biology. 14, 11, 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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SLiM-binding pockets: an attractive target for broad-spectrum antivirals
Simonetti, L., Nilsson, Jakob, McInerney, G., Ivarsson, Y. & Davey, N. E., 2023, In: Trends in Biochemical Sciences. 48, 5, p. 420-427Research output: Contribution to journal › Review › Research › peer-review
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SAC during early cell divisions: Sacrificing fidelity over timely division, regulated differently across organisms Chromosome alignment and segregation are left unsupervised from the onset of development until checkpoint activity is acquired, varying from species to species
Duro, Joana Maria & Nilsson, Jakob, 2021, In: BioEssays. 43, 3, 13 p., 2000174.Research output: Contribution to journal › Journal article › Research › peer-review
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Response to Raaijmakers & Medema
Zhang, G., Kruse, Thomas, Boldú, C. G., Garvanska, Dimitriya Hristoforova, Coscia, F., Mann, Matthias, Barisic, Marin & Nilsson, Jakob, 2019, In: The EMBO Journal. 38, 22, 5 p., e103547.Research output: Contribution to journal › Comment/debate › Research
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Regulation of mitotic progression by the spindle assembly checkpoint
Lischetti, T. & Nilsson, Jakob, 2015, In: Molecular & Cellular Oncology. 2, 1, e970484.Research output: Contribution to journal › Journal article › Research › peer-review
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Quantitative kinase and phosphatase profiling reveal that CDK1 phosphorylates PP2Ac to promote mitotic entry
Nasa, I., Cressey, L. E., Kruse, Thomas, Hertz, Emil Peter Thrane, Gui, J., Graves, L. M., Nilsson, Jakob & Kettenbach, A. N., 2020, In: Science Signaling. 13, 648, 15 p., eaba7823.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 8799501
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Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling
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Mechanisms of site-specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits
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120
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A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment
Research output: Contribution to journal › Journal article › Research › peer-review
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