Guillermo Montoya
Professor, head of research, Professor
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XTACC3-XMAP215 association reveals an asymmetric interaction promoting microtubule elongation
Mortuza, G. B., Cavazza, T., Garcia-Mayoral, M. F., Hermida, D., Peset, I., Pedrero, J. G., Merino, N., Blanco, F. J., Lyngsø, J., Bruix, M., Pedersen, J. S., Vernos, I. & Montoya, Guillermo, 29 Sep 2014, In: Nature Communications. 5, p. 1-12 12 p., 5072.Research output: Contribution to journal › Journal article › Research › peer-review
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Visualizing phosphodiester-bond hydrolysis by an endonuclease
Molina, R., Stella, S., Redondo, P., Gomez, H., Marcaida, M. J., Orozco, M., Prieto, J. & Montoya, Guillermo, Jan 2015, In: Nature Structural and Molecular Biology. 22, 1, p. 65-72 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates
Mirsanaye, Ann Schirin, Hoffmann, Saskia, Weisser, Melanie, Mund, Andreas, Lopez Mendez, B., Typas, D., van den Boom, J., Benedict, Bente, Hendriks, Ivo Alexander, Nielsen, Michael Lund, Meyer, H., Duxin, Julien, Montoya, Guillermo & Mailand, Niels, 2024, In: Nature Communications. 15, 1, 16 p., 2459.Research output: Contribution to journal › Journal article › Research › peer-review
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Understanding the indirect DNA read-out specificity of I-CreI Meganuclease
Prieto, J., Redondo, P., López-Méndez, B., D'Abramo, M., Merino, N., Blanco, F. J., Duchateau, P., Montoya, Guillermo & Molina, R., 2018, In: Scientific Reports. 8, p. 1-9 10286.Research output: Contribution to journal › Journal article › Research › peer-review
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Transposons and CRISPR: Rewiring Gene Editing
Tenjo Castano, Francisco Javier, Montoya, Guillermo & Carabias del Rey, Arturo, 2023, In: Biochemistry. 62, 24, p. 3521-3532 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TnpB structure reveals minimal functional core of Cas12 nuclease family
Sasnauskas, G., Tamulaitiene, G., Druteika, G., Carabias del Rey, Arturo, Silanskas, A., Kazlauskas, D., Venclovas, Č., Montoya, Guillermo, Karvelis, T. & Siksnys, V., 2023, In: Nature. 616, 7956, p. 384-389 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The genome editing revolution: A CRISPR-Cas TALE off-target story
Stella, S. & Montoya, Guillermo, Jul 2016, In: BioEssays. 38, S1, p. S4-S13Research output: Contribution to journal › Journal article › Research › peer-review
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TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress
Hoffmann, Saskia, Smedegaard, S., Nakamura, K., Mortuza, G. B., Räschle, M., Ibañez de Opakua, A., Oka, Y., Feng, Y., Blanco, F. J., Mann, Matthias, Montoya, Guillermo, Groth, Anja, Bekker-Jensen, Simon Holst & Mailand, Niels, 4 Jan 2016, In: The Journal of Cell Biology. 212, 1, p. 63-75Research output: Contribution to journal › Journal article › Research › peer-review
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Structures of the Cmr-β Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas
Sofos, N., Feng, M., Stella, S., Pape, T., Fuglsang, Anders, Lin, Jinzhong, Huang, Q., Li, Y., She, Q. & Montoya, Guillermo, 2020, In: Molecular Cell. 79, 5, p. 741-757Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of the mini-RNA-guided endonuclease CRISPR-Cas12j3
Carabias del Rey, Arturo, Fuglsang, Anders, Temperini, Piero, Pape, T., Sofos, N., Stella, S., qrc243, qrc243 & Montoya, Guillermo, 2021, In: Nature Communications. 12, 12 p., 4476.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon
Tenjo Castano, Francisco Javier, Sofos, N., López-Méndez, B., Stutzke, L. S., Fuglsang, Anders, Stella, S. & Montoya, Guillermo, 2022, In: Nature Communications. 13, 14 p., 5792.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation
García-Alonso, S., Mesa, Pablo, Ovejero, L. D. L. P., Aizpurua, G., Lechuga, C. G., Zarzuela, E., Santiveri, C. M., Sanclemente, M., Muñoz, J., Musteanu, M., Campos-Olivas, R., Martínez-Torrecuadrada, J., Barbacid, M. & Montoya, Guillermo, 2022, In: Molecular Cell. 82, 18, p. 3438-3452.e8Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of the I-SceI nuclease complexed with its dsDNA target and three catalytic metal ions
Prieto, J., Redondo, P., Merino, N., Villate, M., Montoya, Guillermo, Blanco, F. J. & Molina, R., Jun 2016, In: Acta crystallographica. Section F, Structural biology communications. 72, Pt 6, p. 473-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage
Stella, S., Alcón, P. & Montoya, Guillermo, 22 Jun 2017, In: Nature. 546, 7659, p. 559-563 5 p.Research output: Contribution to journal › Letter › Research › peer-review
Structure of the AvrBs3-DNA complex provides new insights into the initial thymine-recognition mechanism
Stella, S., Molina, R., Yefimenko, I., Prieto, J., Silva, G., Bertonati, C., Juillerat, A., Duchateau, P. & Montoya, Guillermo, 2013, In: Acta Crystallographica Section D: Biological Crystallography. 69, 9, p. 1707-1716 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of p15PAF-PCNA complex and implications for clamp sliding during DNA replication and repair
De Biasio, A., de Opakua, A. I., Mortuza, G. B., Molina, R., Cordeiro, T. N., Castillo, F., Villate, M., Merino, N., Delgado, S., Gil-Cartón, D., Luque, I., Diercks, T., Bernadó, P., Montoya, Guillermo & Blanco, F. J., 12 Mar 2015, In: Nature Communications. 6, p. 1-12 6439.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
Molina, R., Stella, S., Feng, M., Sofos, N., Jauniskis, V., Pozdnyakova, I., López-Méndez, B., She, Q. & Montoya, Guillermo, 2019, In: Nature Communications. 10, 14 p., 4302.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and dynamics of mesophilic variants from the homing endonuclease I-DmoI
Alba, J., Marcaida, M. J., Prieto, J., Montoya, Guillermo, Molina, R. & D'Abramo, M., Dec 2017, In: Journal of Computer - Aided Molecular Design. 31, 12, p. 1063-1072 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases
Molina Monterrubio, R. A., Jensen, A. L. G., Marchena-Hurtado, J., López-Méndez, B., Stella, S. & Montoya, Guillermo, 2021, In: Nucleic Acids Research. 49, 21, p. 12577-12590 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural basis of CRISPR-Cas Type III prokaryotic defence systems
Molina, R., Sofos, N. & Montoya, Guillermo, 2020, In: Current Opinion in Structural Biology. 65, p. 119-129 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Realizing integration in structural biology: The 2022 ISBUC Annual Meeting
Kragelund, Birthe Brandt, Loland, Claus Juul, Montoya, Guillermo, Hatzakis, Nikos, Martinez, Karen Laurence, Gajhede, Michael, Christensen, Caspar Elo & Holt, Lucy, 2023, In: Structure. 31, 7, p. 747-754Research output: Contribution to journal › Journal article › Research › peer-review
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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
Lundby, Alicia, Franciosa, Giulia, Emdal, Kristina Bennet, Refsgaard, J. C., Gnosa, S. P., Bekker-Jensen, D. B., Secher, A., Maurya, S. R., Paul, I., Mendez, B. L., Kelstrup, C. D., Francavilla, C., Kveiborg, Marie, Montoya, Guillermo, Jensen, Lars Juhl & Olsen, Jesper Velgaard, 2019, In: Cell. 179, 2, p. 543-560Research output: Contribution to journal › Journal article › Research › peer-review
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Non-specific protein-DNA interactions control I-CreI target binding and cleavage
Molina, R., Redondo, P., Stella, S., Marenchino, M., D'Abramo, M., Gervasio, F. L., Charles Epinat, J., Valton, J., Grizot, S., Duchateau, P., Prieto, J. & Montoya, Guillermo, 1 Aug 2012, In: Nucleic Acids Research. 40, 14, p. 6936-6945 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Molecular scissors for in situ cellular repair
Prieto, J., Molina, R. & Montoya, Guillermo, 31 Jan 2012, In: Critical Reviews in Biochemistry and Molecular Biology. 47, 3, p. 207-21 15 p.Research output: Contribution to journal › Review › Research › peer-review
Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases
Redondo, P., Prieto, J., Muñoz, I. G., Alibés, A., Stricher, F., Serrano, L., Cabaniols, J., Daboussi, F., Arnould, S., Perez, C., Duchateau, P., Pâques, F., Blanco, F. J. & Montoya, Guillermo, 6 Nov 2008, In: Nature. 456, 7218, p. 107-11 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular basis of cyclic tetra-oligoadenylate processing by small standalone CRISPR-Cas ring nucleases
Molina, R., García Martín, Ricardo, López-Méndez, B., Jensen, A. L. G., Ciges Tomas, Jose Rafael, Marchena-Hurtado, J., Stella, S. & Montoya, Guillermo, 2022, In: Nucleic Acids Research. 50, 19, p. 11199-11213 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular basis of Tousled-Like Kinase 2 activation
Mortuza, G. B., Hermida, D., Pedersen, A., Segura-Bayona, S., López-Méndez, B., Redondo, P., Rüther, P., Pozdnyakova, I., Garrote, A. M., Muñoz, I. G., Villamor-Payà, M., Jauset, C., Olsen, Jesper Velgaard, Stracker, T. H. & Montoya, Guillermo, 2018, In: Nature Communications. 9, 1, p. 2535 2535.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular architecture of the recombinant human MCM2-7 helicase in complex with nucleotides and DNA
Boskovic, J., Bragado-Nilsson, E., Saligram Prabhakar, B., Yefimenko, I., Martínez-Gago, J., Muñoz, S., Méndez, J. & Montoya, Guillermo, 16 Sep 2016, In: Cell Cycle. 15, 18, p. 2431-40 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular architecture of the Jumonji C family histone demethylase KDM5B
Dorosz, J., Kristensen, L. H., Aduri, N. G., Mirza, Osman Asghar, Lousen, R., Bucciarelli, S., Mehta, V., Sellés Baiget, Selene, Solbak, Sara Marie Øie, Bach, Anders, Mesa, Pablo, Hernandez, P. A., Montoya, Guillermo, Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Boesen, T. & Gajhede, Michael, 2019, In: Scientific Reports. 9, 13 p., 4019.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular Basis of the Mechanisms Controlling MASTL
Hermida, D., Mortuza, G. B., Pedersen, A., Pozdnyakova, I., Nguyen, T. T. T. N., Maroto, M., Williamson, M., Ebersole, T., Cazzamali, G., Rand, Kasper Dyrberg, Olsen, Jesper Velgaard, Malumbres, M. & Montoya, Guillermo, 2020, In: Molecular & Cellular Proteomics. 19, 2, p. 326-343Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanics of CRISPR-Cas12a and engineered variants on λ-DNA
Paul, B., Chaubet, L., Verver, D. E. & Montoya, Guillermo, 2022, In: Nucleic Acids Symposium Series. 50, 9, p. 5208-5225 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Key Players in I-DmoI Endonuclease Catalysis Revealed from Structure and Dynamics
Molina, R., Besker, N., Marcaida, M. J., Montoya, Guillermo, Prieto, J. & D'Abramo, M., 8 Mar 2016, In: ACS chemical biology. 11, 5, p. 1401–1407Research output: Contribution to journal › Journal article › Research › peer-review
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Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening
Lee, S., Tran, K. T., Vazquez-Uribe, R., Gotfredsen, C. H., Clausen, M. H., Mendez, B. L., Montoya, Guillermo, Bach, Anders & Sommer, M. O. A., 2022, In: Journal of Medicinal Chemistry. 65, 4, p. 3266–3305Research output: Contribution to journal › Journal article › Research › peer-review
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How do CRISPR-Cas RNA-guided endonucleases cut specific DNA regions for Genome Editing?
Montoya, Guillermo, 2018, In: Acta Crystallographica Section A: Foundations and Advances. 74, p. E3 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage
Slaymaker, I. M., Mesa, Pablo, Kellner, M. J., Kannan, S., Brignole, E., Koob, J., Feliciano, P. R., Stella, S., Abudayyeh, O. O., Gootenberg, J. S., Strecker, J., Montoya, Guillermo & Zhang, F., 2019, In: Cell Reports. 26, 13, p. 3741-3751.e5 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional and in silico assessment of MAX variants of unknown significance
Comino-Méndez, I., Leandro-García, L. J., Montoya, G., Inglada-Pérez, L., de Cubas, A. A., Currás-Freixes, M., Tysoe, C., Izatt, L., Letón, R., Gómez-Graña, Á., Mancikova, V., Apellániz-Ruiz, M., Mannelli, M., Schiavi, F., Favier, J., Gimenez-Roqueplo, A-P., Timmers, H. J. L. M., Roncador, G., Garcia, J. F., Rodríguez-Antona, C. & 2 others, , Nov 2015, In: Journal of Molecular Medicine. 93, 11, p. 1247-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Expression, purification, crystallization and preliminary X-ray diffraction analysis of the novel modular DNA-binding protein BurrH in its apo form and in complex with its target DNA
Stella, S., Molina, R., Bertonatti, C., Juillerrat, A. & Montoya, Guillermo, 1 Jan 2014, In: Acta Crystallographica Section F:Structural Biology Communications. 70, 1, p. 87-91 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency
Sukparangsi, W., Morganti, E., Lowndes, Molly, Mayeur, H., Weisser, Melanie, Hammachi, F., Peradziryi, H., Roske, F., Hölzenspies, J., Livigni, A., Godard, B. G., Sugahara, F., Kuratani, S., Montoya, Guillermo, Frankenberg, S. R., Mazan, S. & Brickman, Joshua Mark, 2022, In: Nature Communications. 13, 1, 21 p., 5537.Research output: Contribution to journal › Journal article › Research › peer-review
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Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold
Molina, R., Marcaida, M. J., Redondo, P., Marenchino, M., Duchateau, P., D'Abramo, M., Montoya, Guillermo & Prieto, J., 2015, In: The Journal of Biological Chemistry. 290, 30, p. 18534-18544 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Electron Microscopy Structural Insights into CPAP Oligomeric Behavior: A Plausible Assembly Process of a Supramolecular Scaffold of the Centrosome
Alvarez-Cabrera, A. L., Delgado, S., Gil-Carton, D., Mortuza, G. B., Montoya, Guillermo, Sorzano, C. O. S., Tang, T. K. & Carazo, J. M., 2017, In: Frontiers in Molecular Biosciences. 4, 14 p., 17.Research output: Contribution to journal › Journal article › Research › peer-review
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Editorial overview: Protein-nucleic acid interactions: 'Takes two to Tango'
Montoya, Guillermo & Carlomagno, T., 2020, In: Current Opinion in Structural Biology. 65, p. v-vi 2 p.Research output: Contribution to journal › Editorial › Research
Directly from the source: endogenous preparations of molecular machines
Mesa, Pablo, Deniaud, A., Montoya, Guillermo & Schaffitzel, C., Jun 2013, In: Current Opinion in Structural Biology. 23, 3, p. 319-25 7 p.Research output: Contribution to journal › Review › Research › peer-review
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Direct Observation of CRISPR-Cas12 Conformational Sampling by SM FRET and Cryo EM Reveals how Conformational Activation Promotes Catalysis and Resetting of the Endonuclease Activity
Stella, S., Mesa, Pablo, Thomsen, J., Paul, B., Alcon, P., Jensen, S. B., Moses, M. E., Montoya, Guillermo & Hatzakis, Nikos, 7 Feb 2020, In: Biophysical Journal. 118, 3, p. 223A-224A 2 p.Research output: Contribution to journal › Conference abstract in journal › Research
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DeepFRET, a software for rapid and automated single-molecule FRET data classification using deep learning
Thomsen, J., Sletfjerding, M. B., Jensen, S. B., Stella, S., Paul, B., Malle, M. G., Montoya, Guillermo, Petersen, Troels Christian & Hatzakis, Nikos, Nov 2020, In: eLife. 9, 21 p., e60404.Research output: Contribution to journal › Journal article › Research › peer-review
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DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network
Carraro, Massimo, Hendriks, Ivo Alexander, Hammond, Colin, Solis-Mezarino, V., Völker-Albert, M., Elsborg, Jonas Damgaard, Weisser, Melanie, Spanos, C., Montoya, Guillermo, Rappsilber, J., Imhof, A., Nielsen, Michael Lund & Groth, Anja, 2023, In: Molecular Cell. 83, 7, p. 1075-1092.e9 28 p.Research output: Contribution to journal › Journal article › Research › peer-review
Crystallization and preliminary X-ray diffraction analysis of the homing endonuclease I-CvuI from Chlorella vulgaris in complex with its target DNA
Redondo, P., Merino, N., Villate, M., Blanco, F. J., Montoya, Guillermo & Molina, R., Feb 2014, In: Acta crystallographica. Section F, Structural biology communications. 70, Pt 2, p. 256-9 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin
Muñoz, I. G., Yébenes, H., Zhou, M., Mesa, Pablo, Serna, M., Park, A. Y., Bragado-Nilsson, E., Beloso, A., de Cárcer, G., Malumbres, M., Robinson, C. V., Valpuesta, J. M. & Montoya, Guillermo, Jan 2011, In: Nature Structural & Molecular Biology. 18, 1, p. 14-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal Structure of the Homing Endonuclease I-CvuI Provides a New Template for Genome Modification
Molina, R., Redondo, P., López-Méndez, B., Villate, M., Merino, N., Blanco, F. J., Valton, J., Grizot, S., Duchateau, P., Prieto, J. & Montoya, Guillermo, 27 Nov 2015, In: The Journal of Biological Chemistry. 290, 48, p. 28727-36 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity
Stella, S., Mesa, Pablo, Thomsen, J., Paul, B., Alcón, P., Jensen, S. B., Saligram, B., Moses, M. E., Hatzakis, Nikos & Montoya, Guillermo, 13 Dec 2018, In: Cell. 175, 7, p. 1856-1871.e21 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comprehensive analysis of the specificity of transcription activator-like effector nucleases
Juillerat, A., Dubois, G., Valton, J., Thomas, S., Stella, S., Maréchal, A., Langevin, S., Benomari, N., Bertonati, C., Silva, G. H., Daboussi, F., Epinat, J., Montoya, Guillermo, Duclert, A. & Duchateau, P., Apr 2014, In: Nucleic Acids Research. 42, 8, p. 5390-402 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 93716435
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Molecular basis of Tousled-Like Kinase 2 activation
Research output: Contribution to journal › Journal article › Research › peer-review
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TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress
Research output: Contribution to journal › Journal article › Research › peer-review
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423
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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
Research output: Contribution to journal › Journal article › Research › peer-review
Published