Chuna Ram Choudhary
Professor, Group Leader, Professor
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HBO1 is required for the maintenance of leukaemia stem cells
MacPherson, L., Anokye, J., Yeung, M. M., Lam, E. Y. N., Chan, Y-C., Weng, C-F., Yeh, P., Knezevic, K., Butler, M. S., Hoegl, A., Chan, K-L., Burr, M. L., Gearing, L. J., Willson, T., Liu, J., Choi, J., Yang, Y., Bilardi, R. A., Falk, H., Nghi Nguyen & 28 others, , 2020, In: Nature. 577, 7789, p. 266-270Research output: Contribution to journal › Journal article › Research › peer-review
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HDAC6 modulates myofibril stiffness and diastolic function of the heart
Lin, Y., Major, J. L., Liebner, Tim, Hourani, Z., Travers, J. G., Wennersten, S. A., Haefner, K. R., Cavasin, M. A., Wilson, C. E., Jeong, M. Y., Han, Y., Gotthardt, M., Ferguson, S. K., Ambardekar, A. V., Lam, M. P., Choudhary, Chunaram, Granzier, H. L., Woulfe, K. C. & McKinsey, T. A., 2022, In: Journal of Clinical Investigation. 132, 10, 14 p., e148333.Research output: Contribution to journal › Journal article › Research › peer-review
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Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation
Khoa, L. T. P., Tsan, Y., Mao, F., Kremer, D. M., Sajjakulnukit, P., Zhang, L., Zhou, B., Tong, X., Bhanu, N. V., Choudhary, Chunaram, Garcia, B. A., Yin, L., Smith, G. D., Saunders, T. L., Bielas, S. L., Lyssiotis, C. A. & Dou, Y., 2020, In: Cell Stem Cell. 27, 3, p. 441-458.e10 29 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage
Thorslund, T., Ripplinger, A., Hoffmann, Saskia, Wild, T., Uckelmann, M., Villumsen, B., Narita, Takeo, Sixma, T. K., Choudhary, Chunaram, Bekker-Jensen, Simon Holst & Mailand, Niels, 19 Nov 2015, In: Nature. 527, 7578, p. 389-93 5 p.Research output: Contribution to journal › Letter › Research › peer-review
Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML)
Kindler, T., Breitenbuecher, F., Kasper, S., Estey, E., Giles, F., Feldman, E., Ehninger, G., Schiller, G., Klimek, V., Nimer, S. D., Gratwohl, A., Choudhary, Chunaram, Mueller-Tidow, C., Serve, H., Gschaidmeier, H., Cohen, P. S., Huber, C. & Fischer, T., 2005, In: Blood. 105, 1, p. 335-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution
Suryo Rahmanto, A., Blum, C. J., Scalera, C., Heidelberger, J. B., Mesitov, M., Horn-Ghetko, D., Gräf, J. F., Mikicic, I., Hobrecht, R., Orekhova, A., Ostermaier, M., Ebersberger, S., Möckel, M. M., Krapoth, N., Da Silva Fernandes, N., Mizi, A., Zhu, Y., Chen, J. X., Choudhary, C., Papantonis, A. & 4 others, , 2023, In: Molecular Cell. 83, 23, p. 4272-4289.e10 29 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lysine acetylation targets protein complexes and co-regulates major cellular functions
Choudhary, Chunaram, Kumar, C., Gnad, F., Nielsen, Michael Lund, Rehman, M., Walther, T. C., Olsen, Jesper Velgaard & Mann, Matthias, 2009, In: Science. 325, 5942, p. 834-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation
Weinert, B. T., Schölz, C., Wagner, S. A., Iesmantavicius, V., Su, D., Daniel, J. A. & Choudhary, Chunaram, 29 Aug 2013, In: Cell Reports. 4, 4, p. 842-51 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes
Choudhary, Chunaram, Olsen, Jesper Velgaard, Brandts, C., Cox, J., Reddy, P. N. G., Böhmer, F. D., Gerke, V., Schmidt-Arras, D., Berdel, W. E., Müller-Tidow, C., Mann, Matthias & Serve, H., 2009, In: Molecular Cell. 36, 2, p. 326-39 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance
Pinela da Silva, S. C., Altmannova, V., Luke-Glaser, S., Henriksen, P., Gallina, I., Yang, X., Choudhary, Chunaram, Luke, B., Krejci, L. & Lisby, Michael, 2016, In: Genes & Development. 30, 6, p. 700-717 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling
Fiil, Berthe Katrine, Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Komander, D. & Gyrd-Hansen, Mads, 27 Jun 2013, In: Molecular Cell. 50, 6, p. 818-30 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits
Acosta-Alvear, D., Cho, M. Y., Wild, T., Buchholz, T. J., Lerner, A. G., Simakova, O., Hahn, J., Korde, N., Landgren, O., Maric, I., Choudhary, Chunaram, Walter, P., Weissman, J. S. & Kampmann, M., 1 Sep 2015, In: eLife. 4, p. 1-19 e08153.Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth
Wild, P., Farhan, H., McEwan, D. G., Wagner, S., Rogov, V. V., Brady, N. R., Richter, B., Korac, J., Waidmann, O., Choudhary, Chunaram, Dötsch, V., Bumann, D. & Dikic, I., 8 Jul 2011, In: Science. 333, 6039, p. 228-33 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Predicting post-translational lysine acetylation using support vector machines
Gnad, F., Ren, S., Choudhary, Chunaram, Cox, J. & Mann, M., 1 Jul 2010, In: Bioinformatics. 26, 13, p. 1666-8 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
Nakamura, K., Kustatscher, G., Alabert, C., Hödl, M., Forne, I., Völker-Albert, M., Satpathy, S., Beyer, T. E., Mailand, Niels, Choudhary, Chunaram, Imhof, A., Rappsilber, J. & Groth, Anja, 2021, In: Molecular Cell. 81, 3, 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells
Bursomanno, S., Beli, P., Khan, A. M., Minocherhomji, S., Wagner, S. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Hickson, Ian David & Liu, Ying, Jan 2015, In: DNA Repair. 25, p. 84-96 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae
Henriksen, P., Wagner, S. A., Weinert, B. T., Sharma, S., Bacinskaja, G., Rehman, M., Juffer, A. H., Walther, T. C., Lisby, Michael & Choudhary, Chunaram, 2012, In: Molecular & Cellular Proteomics. 11, 11, p. 1510-1522 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation
Weinert, B. T., Wagner, S. A., Horn, H., Henriksen, P., Liu, W. R., Olsen, Jesper Velgaard, Jensen, Lars Juhl & Choudhary, Chunaram, 2011, In: Science Signaling. 4, 183, p. ra48Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic analyses reveal divergent ubiquitylation site patterns in murinetissues
Wagner, S. A., Beli, P., Weinert, B. T., Schölz, C. F., Kelstrup, C. D., Young, C., Nielsen, Michael Lund, Olsen, Jesper Velgaard, Brakebusch, Cord Herbert & Choudhary, Chunaram, 2012, In: Molecular & Cellular Proteomics.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns
Lundby, Alicia, Hansen, K. L., Weinert, B. T., Breinholt Bekker-Jensen, D., Secher, A., Skovgaard, T., Kelstrup, C., Dmytriyev, A., Choudhary, Chunaram, Lundby, C. & Olsen, Jesper Velgaard, 30 Aug 2012, In: Cell Reports. 2, 2, p. 419-431 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic exploration of lysine acetylation signaling
Choudhary, Chunaram, 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S25 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3
Sol, E. M., Wagner, S. A., Weinert, B. T., Kumar, A., Kim, H., Deng, C. & Choudhary, Chunaram, 7 Dec 2012, In: PloS one. 7, 12, p. e50545Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response
Beli, P., Lukashchuk, N., Wagner, S. A., Weinert, B. T., Olsen, Jesper Velgaard, Baskcomb, L., Mann, Matthias, Jackson, S. P. & Choudhary, Chunaram, 2012, In: Molecular Cell. 46, 2, p. 212-25 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response
Poulsen, S. L., Hansen, R. K., Wagner, S. A., van Cuijk, L., van Belle, G. J., Streicher, W., Wikström, M., Choudhary, Chunaram, Houtsmuller, A. B., Marteijn, J. A., Bekker-Jensen, Simon Holst & Mailand, Niels, 10 Jun 2013, In: Journal of Cell Biology. 201, 6, p. 797-807 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Redox-sensitive alteration of replisome architecture safeguards genome integrity
Somyajit, K., Gupta, R., Sedlackova, H., Neelsen, K. J., Ochs, Fena, Rask, M., Choudhary, Chunaram & Lukas, Jiri, 10 Nov 2017, In: Science. 358, 6364, p. 797-802 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 13781159
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Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage
Research output: Contribution to journal › Letter › Research › peer-review
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Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover
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Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance
Research output: Contribution to journal › Journal article › Research › peer-review
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