Niels Mailand

Niels Mailand

Professor, head of research, Professor


  1. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

    Mailand, Niels, Bekker-Jensen, Simon Holst, Faustrup, H., Melander, F., Bartek, J., Lukas, Claudia & Lukas, Jiri, 2007, In: Cell. 131, 5, p. 887-900 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ

    Mailand, Niels, 2023, In: Molecular Cell. 83, 1, p. 3-5 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  3. Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.

    Mailand, Niels, Podtelejnikov, A. V., Groth, Anja, Mann, M., Bartek, J. & Lukas, Jiri, 2002, In: EMBO Journal. 21, 21, p. 5911-20 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Sustainability and molecular biology: An interview with Prof. Niels Mailand and Ann Schirin Mirsanaye

    Mailand, Niels & Mirsanaye, Ann Schirin, 2023, In: Molecular Cell. 83, 18, p. 3222-3224 3 p.

    Research output: Contribution to journalComment/debateResearch

  5. Rapid destruction of human Cdc25A in response to DNA damage

    Mailand, Niels, Falck, J., Lukas, Claudia, Syljuåsen, R. G., Welcker, M., Bartek, J. & Lukas, Jiri, 26 May 2000, In: Science (New York, N.Y.). 288, 5470, p. 1425-9 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

    Marteijn, J. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Lans, H., Schwertman, P., Gourdin, A. M., Dantuma, N. P., Lukas, Jiri & Vermeulen, W., 2009, In: Journal of Cell Biology. 186, 6, p. 835-47 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks

    Meerang, M., Ritz, D., Paliwal, S., Garajova, Z., Bosshard, M., Mailand, Niels, Janscak, P., Hübscher, U., Meyer, H. & Ramadan, K., 2011, In: Nature Cell Biology. 13, 11, p. 1376-82 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

    Melander, F., Bekker-Jensen, Simon Holst, Falck, J., Bartek, J., Mailand, Niels & Lukas, Jiri, 21 Apr 2008, In: Journal of Cell Biology. 181, 2, p. 213-26 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Ubiquitylation at Stressed Replication Forks: Mechanisms and Functions

    Mirsanaye, Ann Schirin, Typas, D. & Mailand, Niels, 2021, In: Trends in Cell Biology. 31, 7, p. 584-597

    Research output: Contribution to journalReviewResearchpeer-review

  10. Published

    VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates

    Mirsanaye, Ann Schirin, Hoffmann, Saskia, Weisser, Melanie, Mund, Andreas, Lopez Mendez, B., Typas, D., van den Boom, J., Benedict, Bente, Hendriks, Ivo Alexander, Nielsen, Michael Lund, Meyer, H., Duxin, Julien, Montoya, Guillermo & Mailand, Niels, 2024, In: Nature Communications. 15, 1, 16 p., 2459.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases

    Mosbech, A., Lukas, Claudia, Bekker-Jensen, Simon Holst & Mailand, Niels, 24 Apr 2013, In: Journal of Biological Chemistry. 288, p. 16579-16587 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

    Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, S. V., Smedegaard, S., Sedgwick, G., Lukas, Claudia, Hartmann-Petersen, Rasmus, Lukas, Jiri, Choudhary, Chunaram, Pocock, R. D. J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination

    Nakamura, K., Kustatscher, G., Alabert, C., Hödl, M., Forne, I., Völker-Albert, M., Satpathy, S., Beyer, T. E., Mailand, Niels, Choudhary, Chunaram, Imhof, A., Rappsilber, J. & Groth, Anja, 2021, In: Molecular Cell. 81, 3, 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway

    Oka, Y., Bekker-Jensen, Simon Holst & Mailand, Niels, 9 Apr 2015, In: E M B O Journal. 34, p. 1385-1398

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells

    Oka, Y., Varmark, H., Vitting-Seerup, K., Beli, P., Waage, J. E., Hakobyan, A., Mistrik, M., Choudhary, Chunaram, Rohde, M., Bekker-Jensen, Simon Holst & Mailand, Niels, 2014, In: E M B O Reports. 15, 9, p. 956-964 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

    Poulsen, M., Lukas, C., Lukas, J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Journal of Cell Biology. 197, 2, p. 189-99 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

    Poulsen, S. L., Hansen, R. K., Wagner, S. A., van Cuijk, L., van Belle, G. J., Streicher, W., Wikström, M., Choudhary, Chunaram, Houtsmuller, A. B., Marteijn, J. A., Bekker-Jensen, Simon Holst & Mailand, Niels, 10 Jun 2013, In: Journal of Cell Biology. 201, 6, p. 797-807 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

    Povlsen, L. K., Beli, P., Wagner, S. A., Poulsen, S. L., Sylvestersen, K. B., Poulsen, J. W., Nielsen, Michael Lund, Bekker-Jensen, Simon Holst, Mailand, Niels & Choudhary, Chunaram, Oct 2012, In: Nature Cell Biology. 14, 10, p. 1089-98 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

    Rabl, J., Bunker, R. D., Schenk, A. D., Cavadini, S., Gill, M. E., Abdulrahman, W., Andrés-Pons, A., Luijsterburg, M. S., Ibrahim, A. F. M., Branigan, E., Aguirre, J. D., Marceau, A. H., Guérillon, C., Bouwmeester, T., Hassiepen, U., Peters, A. H. F. M., Renatus, M., Gelman, L., Rubin, S. M., Mailand, N. & 3 others, van Attikum, H., Hay, R. T. & Thomä, N. H., 2019, In: Molecular Cell. 75, 3, p. 483-497.e9 25 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

    Räschle, M., Smeenk, G., Hansen, R. K., Temu, T., Oka, Y., Hein, M. Y., Nagaraj, N., Long, D. T., Walter, J. C., Hofmann, K., Storchova, Z., Cox, J., Bekker-Jensen, Simon Holst, Mailand, Niels & Mann, Matthias, 2015, In: Science. 348, 6234, p. 539- 10 p., 1253671.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway

    Santoni Rugiu, Eric, Falck, J., Mailand, Niels, Bartek, J. & Lukas, Jiri, May 2000, In: Molecular and Cellular Biology. 20, 10, p. 3497-509 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

    Saredi, G., Huang, H., Hammond, Colin, Alabert, C., Bekker-Jensen, Simon Holst, Forne, I., Reveron-Gomez, Nazaret, Foster, B. M., Mlejnkova, L., Bartke, T., Cejka, P., Mailand, Niels, Imhof, A., Patel, D. J. & Groth, Anja, 30 Jun 2016, In: Nature. 534, 7609, p. 714-8 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    RADX interacts with single-stranded DNA to promote replication fork stability

    Schubert, Lisa, Ho, T., Hoffmann, Saskia, Haahr, Peter Thorlund, Guérillon, C. & Mailand, Niels, Nov 2017, In: EMBO Reports. 18, 11, p. 1991-2003 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published
  25. Published

    Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

    Schwertman, P., Bekker-Jensen, Simon Holst & Mailand, Niels, Jun 2016, In: Nature Reviews. Molecular Cell Biology. 17, 6, p. 379-94 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 13844358