Matthias Mann

Matthias Mann

Professor, head of research, Professor


  1. 2016
  2. A genome-wide resource for the analysis of protein localisation in Drosophila

    Sarov, M., Barz, C., Jambor, H., Hein, M. Y., Schmied, C., Suchold, D., Stender, B., Janosch, S., K J, V. V., Krishnan, R. T., Krishnamoorthy, A., Ferreira, I. R. S., Ejsmont, R. K., Finkl, K., Hasse, S., Kämpfer, P., Plewka, N., Vinis, E., Schloissnig, S., Knust, E. & 6 others, Hartenstein, V., Mann, Matthias, Ramaswami, M., VijayRaghavan, K., Tomancak, P. & Schnorrer, F., 20 Feb 2016, In: eLife. 5, p. e12068

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Glutathione peroxidase 3 localizes to the epithelial lining fluid and the extracellular matrix in interstitial lung disease

    Schamberger, A. C., Schiller, H. B., Fernandez, I. E., Sterclova, M., Heinzelmann, K., Hennen, E., Hatz, R., Behr, J., Vašáková, M., Mann, Matthias, Eickelberg, O. & Staab-Weijnitz, C. A., 20 Jul 2016, In: Scientific Reports. 6, p. 29952

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons

    Sivadasan, R., Hornburg, D., Drepper, C., Frank, N., Jablonka, S., Hansel, A., Lojewski, X., Sterneckert, J., Hermann, A., Shaw, P. J., Ince, P. G., Mann, Matthias, Meissner, F. & Sendtner, M., Dec 2016, In: Nature Neuroscience. 19, 12, p. 1610-1618 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

    Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., Baptista, M. A., Fiske, B. K., Fell, M. J., Morrow, J. A., Reith, A. D., Alessi, D. R. & Mann, Matthias, 29 Jan 2016, In: eLife. 5

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Homology-driven assembly of NOn-redundant protEin sequence sets (NOmESS) for mass spectrometry

    Temu, T., Mann, Matthias, Räschle, M. & Cox, J., 1 May 2016, In: Bioinformatics (Online). 32, 9, p. 1417-9 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Proteomic maps of breast cancer subtypes

    Tyanova, S., Albrechtsen, Reidar, Kronqvist, P., Cox, J., Mann, Matthias & Geiger, T., 4 Jan 2016, In: Nature Communications. 7, 11 p., 10259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. The Perseus computational platform for comprehensive analysis of (prote)omics data

    Tyanova, S., Temu, T., Sinitcyn, P., Carlson, A., Hein, M. Y., Geiger, T., Mann, Matthias & Cox, J., Sep 2016, In: Nature Methods. 13, 9, p. 731-40 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma

    Albrechtsen, Nicolai Jacob Wewer, Hornburg, D., Albrechtsen, Reidar, Svendsen, B., Toräng, S., Jepsen, Sara Lind, Kuhre, Rune Ehrenreich, Hansen, M., Janus, C., Floyd, A., Lund, Asger Bach, Vilsbøll, Tina, Knop, Filip Krag, drb459, drb459, Deacon, Carolyn F., Meissner, F., Mann, Matthias, Holst, Jens Juul & Hartmann, Bolette, May 2016, In: EBioMedicine. 7, p. 112-120 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Proteomics to study DNA-bound and chromatin-associated gene regulatory complexes

    Wierer, M. & Mann, Matthias, 1 Oct 2016, In: Human Molecular Genetics. 25, R2, p. R106-R114

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. A Proteomics Approach to the Protein Normalization Problem: Selection of Unvarying Proteins for MS-Based Proteomics and Western Blotting

    Wiśniewski, J. R. & Mann, Matthias, 1 Jul 2016, In: Journal of Proteome Research. 15, 7, p. 2321-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA

    Woerner, A. C., Frottin, F., Hornburg, D., Feng, L. R., Meissner, F., Patra, M., Tatzelt, J., Mann, Matthias, Winklhofer, K. F., Hartl, F. U. & Hipp, M. S., 8 Jan 2016, In: Science (New York, N.Y.). 351, 6269, p. 173-6 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2015
  14. Published

    Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation

    Bassani-Sternberg, M., Pletscher-Frankild, S., Jensen, Lars Juhl & Mann, Matthias, Mar 2015, In: Molecular and Cellular Proteomics. 14, 3, p. 658-73 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways and transcription factors

    Deshmukh, Atul Shahaji, Murgia, M., Nagaraja, N., Treebak, Jonas Thue, Cox, J. & Mann, Matthias, Apr 2015, In: Molecular and Cellular Proteomics. 14, 4, p. 841-853

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Secretome Analysis of Lipid-Induced Insulin Resistance in Skeletal Muscle Cells by a Combined Experimental and Bioinformatics Workflow

    Deshmukh, Atul Shahaji, Cox, J., Jensen, Lars Juhl, Meissner, F. & Mann, Matthias, 6 Nov 2015, In: Journal of Proteome Research. 14, 11, p. 4885-95 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells

    Ding, L., Paszkowski-Rogacz, M., Winzi, M., Chakraborty, D., Theis, M., Singh, S., Ciotta, G., Poser, I., Roguev, A., Chu, W. K., Choudhary, Chunaram, Mann, Matthias, Stewart, A. F., Krogan, N. & Buchholz, F., 26 Aug 2015, In: Cell Systems. 1, 2, p. 141-151 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy

    Gramlich, M., Pane, L. S., Zhou, Q., Chen, Z., Murgia, M., Schötterl, S., Goedel, A., Metzger, K., Brade, T., Parrotta, E., Schaller, M., Gerull, B., Thierfelder, L., Aartsma-Rus, A., Labeit, S., Atherton, J. J., McGaughran, J., Harvey, R. P., Sinnecker, D., Mann, M. & 3 others, Laugwitz, K., Gawaz, M. P. & Moretti, A., 9 Mar 2015, In: EMBO Molecular Medicine. 7, 5, p. 562-576 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. A double-barrel LC-MS/MS system to quantify 96 interactomes per day

    Hosp, F., Scheltema, R. A., Eberl, C., Kulak, N. A., Keilhauer, E. C., Mayr, K. & Mann, Matthias, 17 Apr 2015, In: Molecular and Cellular Proteomics. 14, 7, p. 2030-41 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Single muscle fiber proteomics reveals unexpected mitochondrial specialization

    Murgia, M., Nagaraj, N., Deshmukh, Atul Shahaji, Zeiler, M., Cancellara, P., Moretti, I., Reggiani, C., Schiaffino, S. & Mann, Matthias, 1 Mar 2015, In: E M B O Reports. 16, 3, p. 387-95 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

    Räschle, M., Smeenk, G., Hansen, R. K., Temu, T., Oka, Y., Hein, M. Y., Nagaraj, N., Long, D. T., Walter, J. C., Hofmann, K., Storchova, Z., Cox, J., Bekker-Jensen, Simon Holst, Mailand, Niels & Mann, Matthias, 2015, In: Science. 348, 6234, p. 539- 10 p., 1253671.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Mitochondrial specialization revealed by single muscle fiber proteomics: focus on the Krebs cycle

    Schiaffino, S., Reggiani, C., Kostrominova, T. Y., Mann, Matthias & Murgia, M., Dec 2015, In: Scandinavian Journal of Medicine & Science in Sports. 25, Suppl 4, p. 41-8 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  23. 2014
  24. Published

    The growing landscape of lysine acetylation links metabolism and cell signalling

    Choudhary, Chunaram, Weinert, B. T., Nishida, Y., Verdin, E. & Mann, Matthias, 23 Jul 2014, In: Nature Reviews. Molecular Cell Biology. 15, 8, p. 536-50 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF-β

    J D'Souza, R. C., Knittle, A. M., Nagaraj, N., van Dinther, M., Choudhary, Chunaram, Ten Dijke, P., Mann, Matthias & Sharma, K., Jul 2014, In: Science Signaling. 7, 335, p. rs5 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Specificity and commonality of the phosphoinositide-binding proteome analyzed by quantitative mass spectrometry

    Jungmichel, S., Sylvestersen, K. B., Choudhary, Chunaram, Nguyen, S., Mann, Matthias & Nielsen, Michael Lund, 13 Feb 2014, In: Cell Reports. 6, 3, p. 578-91 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome

    Ripaud, L., Chumakova, V., Antonin, M., Hastie, A. R., Pinkert, S., Körner, R., Ruff, K. M., Pappu, R. V., Hornburg, D., Mann, Matthias, Hartl, F. U. & Hipp, M. S., 23 Dec 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 51, p. 18219-24 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2013
  29. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility

    Bassik, M. C., Kampmann, M., Lebbink, R. J., Wang, S., Hein, M. Y., Poser, I., Weibezahn, J., Horlbeck, M. A., Chen, S., Mann, Matthias, Hyman, A. A., Leproust, E. M., McManus, M. T. & Weissman, J. S., 14 Feb 2013, In: Cell. 152, 4, p. 909-22 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood Samples

    Boersema, P. J., Geiger, T., Wiśniewski, J. R. & Mann, Matthias, 1 Jan 2013, In: Molecular & Cellular Proteomics. 12, 1, p. 158-171 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. DEAD box protein DDX1 regulates cytoplasmic localization of KSRP

    Chou, C., Lin, W., Lin, C., Luber, C. A., Godbout, R., Mann, Matthias & Chen, C., 4 Sep 2013, In: P L o S One. 8, 9, e73752.

    Research output: Contribution to journalJournal articleResearch

  32. N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes

    Deeb, S. J., Cox, J., Schmidt-Supprian, M. & Mann, Matthias, 4 Nov 2013, In: Molecular & Cellular Proteomics.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Initial quantitative proteomic map of 28 mouse tissues using the SILAC mouse

    Geiger, T., Velic, A., Macek, B., Lundberg, E., Kampf, C., Nagaraj, N., Uhlen, M., Cox, J. & Mann, Matthias, Jun 2013, In: Molecular & Cellular Proteomics. 12, 6, p. 1709-22 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15

    Hirst, J., Borner, G. H. H., Edgar, J., Hein, M. Y., Mann, Matthias, Buchholz, F., Antrobus, R. & Robinson, M. S., Aug 2013, In: Molecular Biology of the Cell. 24, 16, p. 2558-69 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment

    Kappei, D., Butter, F., Benda, C., Scheibe, M., Draškovič, I., Stevense, M., Novo, C. L., Basquin, C., Araki, M., Araki, K., Krastev, D. B., Kittler, R., Jessberger, R., Londoño-Vallejo, J. A., Mann, Matthias & Buchholz, F., 12 Jun 2013, In: E M B O Journal. 32, 12, p. 1681-701 21 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Quantitative proteomic analysis reveals concurrent RNA-protein interactions and identifies new RNA-binding proteins in Saccharomyces cerevisiae

    Klass, D. M., Scheibe, M., Butter, F., Hogan, G. J., Mann, Matthias & Brown, P. O., Jun 2013, In: Genome Research. 23, 6, p. 1028-38 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Protein correlation profiles identify lipid droplet proteins with high confidence

    Krahmer, N., Hilger, M., Kory, N., Wilfling, F., Stoehr, G., Mann, Matthias, Farese, R. V. & Walther, T. C., May 2013, In: Molecular & Cellular Proteomics. 12, 5, p. 1115-26 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. The proteome of the calcified layer organic matrix of turkey (Meleagris gallopavo) eggshell

    Mann, K. & Mann, Matthias, 2013, In: Proteome Science. 11, 1, p. 40

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The Coming Age of Complete, Accurate, and Ubiquitous Proteomes

    Mann, Matthias, Kulak, N. A., Nagaraj, N. & Cox, J., 21 Feb 2013, In: Molecular Cell. 49, 4, p. 583-590 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. A large synthetic peptide and phosphopeptide reference library for mass spectrometry-based proteomics

    Marx, H., Lemeer, S., Schliep, J. E., Matheron, L., Mohammed, S., Cox, J., Mann, Matthias, Heck, A. J. R. & Kuster, B., Jun 2013, In: Nature Biotechnology. 31, 6, p. 557-64 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Direct proteomic quantification of the secretome of activated immune cells

    Meissner, F., Scheltema, R. A., Mollenkopf, H. & Mann, Matthias, 26 Apr 2013, In: Science (New York, N.Y.). 340, 6131, p. 475-8 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. High performance computational analysis of large-scale proteome data sets to assess incremental contribution to coverage of the human genome

    Neuhauser, N., Nagaraj, N., McHardy, P., Zanivan, S., Scheltema, R., Cox, J. & Mann, Matthias, 7 Jun 2013, In: Journal of Proteome Research. 12, 6, p. 2858-68 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Status of large-scale analysis of post-translational modifications by mass spectrometry

    Olsen, Jesper Velgaard & Mann, Matthias, 1 Nov 2013, In: Molecular & Cellular Proteomics. 12, p. 3444-52

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Proteomic and genetic analyses demonstrate that Plasmodium berghei blood stages export a large and diverse repertoire of proteins

    Pasini, E. M., Braks, J. A., Fonager, J., Klop, O., Aime, E., Spaccapelo, R., Otto, T. D., Berriman, M., Hiss, J. A., Thomas, A. W., Mann, Matthias, Janse, C. J., Kocken, C. H. M. & Franke-Fayard, B., Feb 2013, In: Molecular & Cellular Proteomics. 12, 2, p. 426-48 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Alleles of a polymorphic ETV6 binding site in DCDC2 confer risk of reading and language impairment

    Powers, N. R., Eicher, J. D., Butter, F., Kong, Y., Miller, L. L., Ring, S. M., Mann, Matthias & Gruen, J. R., 11 Jul 2013, In: American Journal of Human Genetics. 93, 1, p. 19-28 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response

    Radovanac, K., Morgner, J., Schulz, J., Blumbach, K., Patterson, C., Geiger, T., Mann, Matthias, Krieg, T., Eckes, B., Fässler, R. & Wickström, S. A., 15 May 2013, In: E M B O Journal. 32, 10, p. 1409-24 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Proteomic approaches in circadian biology

    Robles, M. S. & Mann, Matthias, 2013, Handbook of experimental pharmacology: Circadian Clocks. p. 389-407 19 p. (Handbook of Experimental Pharmacology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  48. Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators

    Scheibe, M., Arnoult, N., Kappei, D., Buchholz, F., Decottignies, A., Butter, F. & Mann, Matthias, 22 Oct 2013, In: Genome Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators

    Scheibe, M., Arnoult, N., Kappei, D., Buchholz, F., Decottignies, A., Butter, F. & Mann, Matthias, 22 Oct 2013, In: Genome Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

    Schiller, H. B., Hermann, M., Polleux, J., Vignaud, T., Zanivan, S., Friedel, C. C., Sun, Z., Raducanu, A., Gottschalk, K., Théry, M., Mann, Matthias & Fässler, R., Jun 2013, In: Nature Cell Biology. 15, 6, p. 625-36 12 p.

    Research output: Contribution to journalJournal articleResearch

  51. The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation

    Sparmann, A., Xie, Y., Verhoeven, E., Vermeulen, M., Lancini, C., Gargiulo, G., Hulsman, D., Mann, Matthias, Knoblich, J. A. & van Lohuizen, M., 29 May 2013, In: E M B O Journal. 32, 11, p. 1598-612 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. A SILAC-based approach identifies substrates of caspase-dependent cleavage upon TRAIL-induced apoptosis

    Stoehr, G., Schaab, C., Graumann, J. & Mann, Matthias, May 2013, In: Molecular & Cellular Proteomics. 12, 5, p. 1436-50 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    The SH2 domain interaction landscape

    Tinti, M., Kiemer, L., Costa, S., Miller, M. L., Sacco, F., Olsen, Jesper Velgaard, Carducci, M., Paoluzi, S., Langone, F., Workman, C., Blom, N., Machida, K., Thompson, C. M., Schutkowski, M., Brunak, Søren, Mann, Matthias, Mayer, B. J., Castagnoli, L. & Cesareni, G., 2013, In: Cell Reports. 3, 4, p. 1293-1305 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Phosphorylation Variation during the Cell Cycle Scales with Structural Propensities of Proteins

    Tyanova, S., Frishman, D., Cox, J., Mann, Matthias & Olsen, Jesper Velgaard, 10 Jan 2013, In: P L o S Computational Biology (Online). 9, 1, p. e1002842 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 5650809