Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues
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Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues. / Emdal, Kristina B.; Lundby, Alicia.
In: Molecular & Cellular Oncology, Vol. 7, No. 1, e1692643, 2020.Research output: Contribution to journal › Comment/debate › Research › peer-review
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TY - JOUR
T1 - Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues
AU - Emdal, Kristina B.
AU - Lundby, Alicia
PY - 2020
Y1 - 2020
N2 - We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation.
AB - We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation.
KW - Proteomics
KW - tyrosine kinase signaling
KW - interaction proteomics
KW - oncogenic signaling rewiring
U2 - 10.1080/23723556.2019.1692643
DO - 10.1080/23723556.2019.1692643
M3 - Comment/debate
C2 - 31993501
VL - 7
JO - Molecular & Cellular Oncology
JF - Molecular & Cellular Oncology
SN - 2372-3556
IS - 1
M1 - e1692643
ER -
ID: 232009636