Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 gene encoding Miro1

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Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 gene encoding Miro1. / Chemla, Axel; Arena, Giuseppe; Onal, Gizem; Walter, Jonas; Berenguer-Escuder, Clara; Grossmann, Dajana; Grünewald, Anne; Schwamborn, Jens C.; Krüger, Rejko.

In: Stem Cell Research, Vol. 71, 103145, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Chemla, A, Arena, G, Onal, G, Walter, J, Berenguer-Escuder, C, Grossmann, D, Grünewald, A, Schwamborn, JC & Krüger, R 2023, 'Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 gene encoding Miro1', Stem Cell Research, vol. 71, 103145. https://doi.org/10.1016/j.scr.2023.103145

APA

Chemla, A., Arena, G., Onal, G., Walter, J., Berenguer-Escuder, C., Grossmann, D., Grünewald, A., Schwamborn, J. C., & Krüger, R. (2023). Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 gene encoding Miro1. Stem Cell Research, 71, [103145]. https://doi.org/10.1016/j.scr.2023.103145

Vancouver

Chemla A, Arena G, Onal G, Walter J, Berenguer-Escuder C, Grossmann D et al. Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 gene encoding Miro1. Stem Cell Research. 2023;71. 103145. https://doi.org/10.1016/j.scr.2023.103145

Author

Chemla, Axel ; Arena, Giuseppe ; Onal, Gizem ; Walter, Jonas ; Berenguer-Escuder, Clara ; Grossmann, Dajana ; Grünewald, Anne ; Schwamborn, Jens C. ; Krüger, Rejko. / Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 gene encoding Miro1. In: Stem Cell Research. 2023 ; Vol. 71.

Bibtex

@article{bbb1e8226e4f421090af53302930fb04,
title = "Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 gene encoding Miro1",
abstract = "Fibroblasts from two Parkinson's disease (PD) patients carrying either the heterozygous mutation c.815G > A (Miro1 p.R272Q) or c.1348C > T (Miro1 p.R450C) in the RHOT1 gene, were converted into induced pluripotent stem cells (iPSCs) using RNA-based and episomal reprogramming, respectively. The corresponding isogenic gene-corrected lines have been generated using CRISPR/Cas9 technology. These two isogenic pairs will be used to study Miro1-related molecular mechanisms underlying neurodegeneration in relevant iPSC-derived neuronal models (e.g., midbrain dopaminergic neurons and astrocytes).",
author = "Axel Chemla and Giuseppe Arena and Gizem Onal and Jonas Walter and Clara Berenguer-Escuder and Dajana Grossmann and Anne Gr{\"u}newald and Schwamborn, {Jens C.} and Rejko Kr{\"u}ger",
note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",
year = "2023",
doi = "10.1016/j.scr.2023.103145",
language = "English",
volume = "71",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 gene encoding Miro1

AU - Chemla, Axel

AU - Arena, Giuseppe

AU - Onal, Gizem

AU - Walter, Jonas

AU - Berenguer-Escuder, Clara

AU - Grossmann, Dajana

AU - Grünewald, Anne

AU - Schwamborn, Jens C.

AU - Krüger, Rejko

N1 - Publisher Copyright: © 2023 The Author(s)

PY - 2023

Y1 - 2023

N2 - Fibroblasts from two Parkinson's disease (PD) patients carrying either the heterozygous mutation c.815G > A (Miro1 p.R272Q) or c.1348C > T (Miro1 p.R450C) in the RHOT1 gene, were converted into induced pluripotent stem cells (iPSCs) using RNA-based and episomal reprogramming, respectively. The corresponding isogenic gene-corrected lines have been generated using CRISPR/Cas9 technology. These two isogenic pairs will be used to study Miro1-related molecular mechanisms underlying neurodegeneration in relevant iPSC-derived neuronal models (e.g., midbrain dopaminergic neurons and astrocytes).

AB - Fibroblasts from two Parkinson's disease (PD) patients carrying either the heterozygous mutation c.815G > A (Miro1 p.R272Q) or c.1348C > T (Miro1 p.R450C) in the RHOT1 gene, were converted into induced pluripotent stem cells (iPSCs) using RNA-based and episomal reprogramming, respectively. The corresponding isogenic gene-corrected lines have been generated using CRISPR/Cas9 technology. These two isogenic pairs will be used to study Miro1-related molecular mechanisms underlying neurodegeneration in relevant iPSC-derived neuronal models (e.g., midbrain dopaminergic neurons and astrocytes).

U2 - 10.1016/j.scr.2023.103145

DO - 10.1016/j.scr.2023.103145

M3 - Journal article

C2 - 37364399

AN - SCOPUS:85162887901

VL - 71

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

M1 - 103145

ER -

ID: 366993347