Jesper Velgaard Olsen

Jesper Velgaard Olsen

Professor, Deputy Head of Centre, Professor

Member of:


    1. Published

      Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation

      Emdal, Kristina Bennet, Pedersen, A., Bekker-Jensen, D. B., Tsafou, K. P., Horn, H., Lindner, S., Schulte, J. H., Eggert, A., Jensen, Lars Juhl, Francavilla, C. & Olsen, Jesper Velgaard, 2015, In: Science Signaling. 8, 374, ra40.

      Research output: Contribution to journalJournal articleResearchpeer-review

    2. Published

      Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma

      Emdal, Kristina Bennet, Pedersen, A., Bekker-Jensen, D. B., Lundby, Alicia, Claeys, S., De Preter, K., Speleman, F., Francavilla, C. & Olsen, Jesper Velgaard, 20 Nov 2018, In: Science Signaling. 11, 557, p. 1-17 17 p., eaap9752.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance

      Emdal, Kristina Bennet, Palacio-Escat, N., Wigerup, C., Eguchi, A., Nilsson, H., Bekker-Jensen, D. B., Rönnstrand, L., Kazi, J. U., Puissant, A., Itzykson, R., Saez-Rodriguez, J., Masson, K., Blume-Jensen, P. & Olsen, Jesper Velgaard, 2022, In: Cell Reports. 40, 6, 25 p., 111177.

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      Digging deeper into ancient skeletal proteomes through consecutive digestion with multiple proteases

      Fagernäs, Zandra Selina, Troché, Gaudry Bruno, Olsen, Jesper Velgaard & Welker, Frido, 2024, In: Journal of Proteomics. 298, 10 p., 105143.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      Proteogenomic characterization of patient-derived xenografts highlights the role of REST in neuroendocrine differentiation of castration-resistant prostate cancer

      Flores-Morales, A., Bergmann, T. B., Lavallee, C., Batth, T. S., Lin, D., Lerdrup, M., Friis, S., Bartels, A., Kristensen, G., Krzyzanowska, A., Xue, H., Fazli, L., Hansen, K., Røder, M. A., Brasso, K., Moreira, J. M., Bjartell, A., Wang, Y., Olsen, J. V., Collins, C. C. & 1 others, Iglesias Gato, Diego, 2019, In: Clinical Cancer Research. 25, 2, p. 1-15

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      Control of endothelial cell tube formation by Notch ligand intracellular domain interactions with activator protein 1 (AP-1)

      Forghany, Z., Robertson, F., Lundby, Alicia, Olsen, Jesper Velgaard & Baker, D. A., 2018, In: Journal of Biological Chemistry. 293, 4, p. 1229-1242 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      Multi-omic detection of Mycobacterium leprae in archaeological human dental calculus

      Fotaki, Anna Katerina, Denham, S. D., Mackie, Meaghan, Iraeta Orbegozo, Miren, Mylopotamitaki, Dorothea, Gopalakrishnan, Shyam, Sicheritz-Pontén, Thomas, Olsen, Jesper Velgaard, Cappellini, Enrico, KU, thw266, Christophersen, A., Gilbert, M Thomas P & Vågene, Åshild Joanne, 2020, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 375, 1812, 10 p., 20190584.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      SILAC-Based Temporal Phosphoproteomics

      Francavilla, C., Hekmat, O., Blagoev, B. & Olsen, Jesper Velgaard, 2014, Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC): Methods and Protocols. Warscheid, B. (ed.). Vol. 1188. p. 125-48 24 p. (Methods in molecular biology (Clifton, N.J.)).

      Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

    9. Published

      Functional Proteomics Defines the Molecular Switch Underlying FGF Receptor Trafficking and Cellular Outputs

      Francavilla, C., Rigbolt, K. T. G., Emdal, Kristina Bennet, Carraro, G., Vernet, E., Bekker-Jensen, D. B., Streicher, W., Wikström, M., Sundström, M., Bellusci, S., Cavallaro, U., Blagoev, B. & Olsen, Jesper Velgaard, 26 Sep 2013, In: Molecular Cell. 51, 6, p. 707-22 16 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking

      Francavilla, C., Papetti, M., Rigbolt, K. T. G., Pedersen, A., Sigurdsson, J. O., Cazzamali, G., Karemore, G., Blagoev, B. & Olsen, Jesper Velgaard, Jun 2016, In: Nature Structural and Molecular Biology. 23, 6, p. 608–618 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer

      Francavilla, C., Lupia, M., Tsafou, K., Villa, A., Kowalczyk, K., Rakownikow Jersie-Christensen, R., Bertalot, G., Confalonieri, S., Brunak, Søren, Jensen, Lars Juhl, Cavallaro, U. & Olsen, Jesper Velgaard, 28 Mar 2017, In: Cell Reports. 18, 13, p. 3242-3256 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      Recent advances in kinase signaling network profiling by mass spectrometry

      Franciosa, Giulia, Locard-Paulet, Marie, Jensen, Lars Juhl & Olsen, Jesper Velgaard, 2023, In: Current Opinion in Chemical Biology. 73, 11 p., 102260.

      Research output: Contribution to journalReviewResearchpeer-review

    13. Published

      Impact of SHP2 tyrosine phosphorylation on the development of acquired resistance to allosteric SHP2 inhibitors

      Franciosa, Giulia & Olsen, Jesper Velgaard, 2023, In: OncoTarget. 14, p. 281-283 3 p.

      Research output: Contribution to journalEditorialResearchpeer-review

    14. Published

      Proteomics to study cancer immunity and improve treatment

      Franciosa, Giulia, Kverneland, Anders Handrup, Jensen, Agnete Witness Præst, dqp123, dqp123 & Olsen, Jesper Velgaard, 2023, In: Seminars in Immunopathology. 45, 11 p., 241–251.

      Research output: Contribution to journalReviewResearchpeer-review

    15. Published

      Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures

      Franciosa, Giulia, Smits, J. G. A., Minuzzo, S., Martinez Del Val, Ana, Indraccolo, S. & Olsen, Jesper Velgaard, 2021, In: Nature Communications. 12, 1, 19 p., 2507.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      Deciphering the human phosphoproteome

      Franciosa, Giulia, Martinez-Val, A. & Olsen, Jesper Velgaard, 2020, In: Nature Biotechnology. 38, p. 285-286 2 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Genomic and proteomic analyses of Prdm5 reveal interactions with insulator binding proteins in embryonic stem cells

      Galli, G. G., Carrara, M., Francavilla, C., Honnens de Lichtenberg, K., Olsen, Jesper Velgaard, Calogero, R. A. & Lund, Anders H., 16 Sep 2013, In: Molecular and Cellular Biology.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

      Gibbs-Seymour, I., Oka, Y., Rajendra, E., Weinert, B. T., Passmore, L. A., Patel, K. J., Olsen, Jesper Velgaard, Choudhary, Chunaram, Bekker-Jensen, Simon Holst & Mailand, Niels, Jan 2015, In: Molecular Cell. 57, 1, p. 150-64 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      High-accuracy identification and bioinformatic analysis of in vivo protein phosphorylation sites in yeast

      Gnad, F., de Godoy, L. M. F., Cox, J., Neuhauser, N., Ren, S., Olsen, Jesper Velgaard & Mann, Matthias, 2009, In: Proteomics. 9, 20, p. 4642-4652 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. PHOSIDA (phosphorylation site database): management, structural and evolutionary investigation, and prediction of phosphosites

      Gnad, F., Ren, S., Cox, J., Olsen, Jesper Velgaard, Macek, B., Oroshi, M. & Mann, Matthias, 2007, In: Genome Biology. 8, 11, p. R250

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway

      Gruhler, A., Olsen, Jesper Velgaard, Mohammed, S., Mortensen, P., Faergeman, N. J., Mann, Matthias & Jensen, O. N., 2005, In: Molecular and Cellular Proteomics. 4, 3, p. 310-27 17 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae

      Hernández Guzmán, Ulises, Aksnes, H., Ree, R., Krogh, Nicolai, Jakobsson, M. E., Jensen, Lars Juhl, Arnesen, T. & Olsen, Jesper Velgaard, 2023, In: Nature Communications. 14, 4517.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. E-pub ahead of print

      Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition

      Guzman, U. H., Martinez Del Val, A., Ye, Z., Damoc, E., Arrey, T. N., Pashkova, A., Renuse, S., Denisov, E., Petzoldt, J., Peterson, A. C., Harking, F., Østergaard, O., Rydbirk, R., Aznar, S., Stewart, H., Xuan, Y., Hermanson, D., Horning, S., Hock, C., Makarov, A. & 2 others, Zabrouskov, V. & Olsen, Jesper Velgaard, 2024, (E-pub ahead of print) In: Nature Biotechnology.

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      FRMD6 has tumor suppressor functions in prostate cancer

      Haldrup, J., Strand, S. H., Cieza-Borrella, C., Jakobsson, M. E., Riedel, M., Norgaard, M., Hedensted, S., Dagnaes-Hansen, F., Ulhoi, B. P., Eeles, R., Borre, M., Olsen, Jesper Velgaard, Thomsen, M., Kote-Jarai, Z. & Sorensen, K. D., 2021, In: Oncogene. 40, p. 763-776 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Published

      Dynamic lineage priming is driven via direct enhancer regulation by ERK

      Hamilton, W. B., Mosesson, Y., S. Monteiro, Rita, Emdal, Kristina Bennet, Knudsen, Teresa Emmilie Toudal, Francavilla, C., Barkai, N., Olsen, Jesper Velgaard & Brickman, Joshua Mark, 2019, In: Nature. 575, p. 355-360

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Advantages of external accumulation for electron capture dissociation in Fourier transform mass spectrometry

      Haselmann, K. F., Budnik, B. A., Olsen, Jesper Velgaard, Nielsen, Michael Lund, Reis, C. A., Clausen, H., Johnsen, A. H. & Zubarev, R. A., 2001, In: Analytical Chemistry. 73, 13, p. 2998-3005 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. Electronic excitation gives informative fragmentation of polypeptide cations and anions

      Haselmann, K. F., Budnik, B. A., Kjeldsen, F., Nielsen, Michael Lund, Olsen, Jesper Velgaard & Zubarev, R. A., 2002, In: European Journal of Mass Spectrometry. 8, 2, p. 117-121 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    28. Published

      TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells

      Hekmat, O., Munk, S., Fogh, L., Yadav, R., Francavilla, C., Horn, H., Würtz, S. Ø., Schrohl, A-S., Damsgaard, B., Romer, M. U., Belling, K., Jensen, N. F., Gromova, I., Bekker-Jensen, D. B., Moreira, J., Jensen, L. J., Gupta, R., Lademann, U. A., Brünner, N., Olsen, J. V. & 1 others, Stenvang, Jan, 5 Aug 2013, In: Journal of Proteome Research. 12, 9, p. 4136-4151 16 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    29. Published

      SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage

      Hendriks, I. A., Treffers, L. W., Verlaan-de Vries, M., Olsen, Jesper Velgaard & Vertegaal, A. C. O., 17 Mar 2015, In: Cell Reports. 10, 10, p. 1778–1791

      Research output: Contribution to journalJournal articleResearchpeer-review

    30. Published

      Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4)

      Hendriks, I. A., Schimmel, J., Eifler, K., Olsen, Jesper Velgaard & Vertegaal, A. C. O., 19 Jun 2015, In: The Journal of Biological Chemistry. 290, 25, p. 15526-37 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    31. Published

      Ancient proteins from ceramic vessels at Çatalhöyük West reveal the hidden cuisine of early farmers

      Hendy, J., Colonese, A. C., Franz, I., Fernandes, R., Fischer, R., Orton, D., Lucquin, A., Spindler, L., Anvari, J., Stroud, E., Biehl, P. F., Speller, C., Boivin, N., Mackie, Meaghan, Jersie-Christensen, R. R., Olsen, Jesper Velgaard, Collins, Matthew James, Craig, O. E. & Rosenstock, E., 1 Dec 2018, In: Nature Communications. 9, 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Published

      Molecular Basis of the Mechanisms Controlling MASTL

      Hermida, D., Mortuza, G. B., Pedersen, A., Pozdnyakova, I., Nguyen, T. T. T. N., Maroto, M., Williamson, M., Ebersole, T., Cazzamali, G., Rand, Kasper Dyrberg, Olsen, Jesper Velgaard, Malumbres, M. & Montoya, Guillermo, 2020, In: Molecular & Cellular Proteomics. 19, 2, p. 326-343

      Research output: Contribution to journalJournal articleResearchpeer-review

    33. Published

      A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

      Hertz, Emil Peter Thrane, Kruse, Thomas, Davey, N. E., López-Méndez, B., Sigurdsson, J. O., Montoya, Guillermo, Olsen, Jesper Velgaard & Nilsson, Jakob, 2016, In: Molecular Cell. 63, 4, p. 686-695 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    34. Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry

      Hinsby, A. M., Olsen, Jesper Velgaard, Bennett, K. L. & Mann, Matthias, 2003, In: Molecular and Cellular Proteomics. 2, 1, p. 29-36 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    35. Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4

      Hinsby, A. M., Olsen, Jesper Velgaard & Mann, Matthias, 2004, In: Journal of Biological Chemistry. 279, 45, p. 46438-47 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    36. Published

      SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability (vol 46, pg 9484, 2018)

      Hjorth-Jensen, K., Maya-Mendoza, A., Dalgaard, Nanna, Sigurosson, J. O., Bartek, J., Iglesias Gato, Diego, Olsen, Jesper Velgaard & Flores-Morales, A., 2018, In: Nucleic Acids Symposium Series. 46, 18, p. 9891-9891

      Research output: Contribution to journalJournal articleResearchpeer-review

    37. Published

      SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability

      Hjorth-Jensen, K., Maya-Mendoza, A., Dalgaard, Nanna, Sigurðsson, J. O., Bartek, J., Iglesias Gato, Diego, Olsen, Jesper Velgaard & Flores-Morales, A., 2018, In: Nucleic Acids Research. 46, 18, p. 9484-9495

      Research output: Contribution to journalJournal articleResearchpeer-review

    38. Published

      Benchmarking common quantification strategies for large-scale phosphoproteomics

      Hogrebe, A., von Stechow, L., Bekker-Jensen, D. B., Weinert, B. T., Kelstrup, C. D. & Olsen, Jesper Velgaard, 2018, In: Nature Communications. 9, 1, p. 1-13 1045.

      Research output: Contribution to journalJournal articleResearchpeer-review

    39. Phosphorylation of histone H3 Thr-45 is linked to apoptosis

      Hurd, P. J., Bannister, A. J., Halls, K., Dawson, M. A., Vermeulen, M., Olsen, Jesper Velgaard, Ismail, H., Somers, J., Mann, M., Owen-Hughes, T., Gout, I. & Kouzarides, T., 2009, In: Journal of Biological Chemistry. 284, 24, p. 16575-83 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    40. Published

      The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates

      Jakobsson, M. E., Małecki, J. M., Halabelian, L., Nilges, B. S., Pinto, R., Kudithipudi, S., Munk, S., Davydova, E., Zuhairi, F. R., Arrowsmith, C. H., Jeltsch, A., Leidel, S. A., Olsen, Jesper Velgaard & Falnes, P. Ø., 2018, In: Nature Communications. 9, 1, 3411.

      Research output: Contribution to journalJournal articleResearchpeer-review

    41. Published

      Quantitative metaproteomics of medieval dental calculus reveals individual oral health status

      Jersie-Christensen, R. R., Lanigan, Liam Thomas, Lyon, D., Mackie, Meaghan, Midjord-Belstrøm, Daniel, Kelstrup, C. D., Fotaki, Anna Katerina, Willerslev, Eske, Lynnerup, Niels, Jensen, Lars Juhl, Cappellini, Enrico & Olsen, Jesper Velgaard, 2018, In: Nature Communications. 9, p. 1-12 4744.

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. Published

      Simple and Reproducible Sample Preparation for Single-Shot Phosphoproteomics with High Sensitivity

      Jersie-Christensen, R. R., Sultan, A. & Olsen, Jesper Velgaard, 2016, Phospho-Proteomics: Methods and Protocols. Stechow, L. V. (ed.). p. 251-60 10 p. (Methods in molecular biology (Clifton, N.J.), Vol. 1355).

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    43. Published

      In vivo quantitative phosphoproteomic profiling identifies novel regulators of castration-resistant prostate cancer growth

      Jiang, N., Hjorth-Jensen, K., Hekmat, O., Iglesias Gato, Diego, Kruse, Thomas, Wang, C., Wei, W., Ke, B., Yan, B., Niu, Y., Olsen, Jesper Velgaard & Flores Morales, A., 2015, In: Oncogene. 34, p. 2764–2776 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    44. Published

      Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

      Jones, M. J. K., Gelot, C., Munk, S., Koren, A., Kawasoe, Y., George, K. A., Santos, R. E., Olsen, Jesper Velgaard, McCarroll, S. A., Frattini, M. G., Takahashi, T. S. & Jallepalli, P. V., 2021, In: Molecular Cell. 81, 3, p. 426-441.e8 24 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    45. Published

      Mapping cardiac remodeling in chronic kidney disease

      Kaesler, N., Cheng, M., Nagai, J., O'Sullivan, J., Peisker, F., Bindels, E. M. J., Babler, A., Moellmann, J., Droste, P., Franciosa, G., Dugourd, A., Saez-Rodriguez, J., Neuss, S., Lehrke, M., Boor, P., Goettsch, C., Olsen, J. V., Speer, T., Lu, T. S., Lim, K. & 4 others, Floege, J., Denby, L., Costa, I. & Kramann, R., 2023, In: Science Advances. 9, 47, 18 p., eadj4846.

      Research output: Contribution to journalJournal articleResearchpeer-review

    46. Published

      THO complex deficiency impairs DNA double-strand break repair via the RNA surveillance kinase SMG-1

      Kamp, J. A., Lemmens, B. B. L. G., Romeijn, R. J., González-Prieto, R., Olsen, Jesper Velgaard, Vertegaal, A. C. O., van Schendel, R. & Tijsterman, M., 2022, In: Nucleic Acids Research. 50, 11, p. 6235-6250 16 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      Rapid and Deep Proteomes by Faster Sequencing on a Benchtop Quadrupole Ultra-High-Field Orbitrap Mass Spectrometer

      Kelstrup, C. D., Jersie-Christensen, R. R., Batth, Tanveer Singh, Arrey, T. N., Kuehn, A., Kellmann, M. & Olsen, Jesper Velgaard, 28 Oct 2014, In: Journal of Proteome Research. 13, 12, p. 6187-95 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. Published

      Performance evaluation of the Q Exactive HF-X for shotgun proteomics

      Kelstrup, C. D., Bekker-Jensen, D. B., Arrey, T. N., Hogrebe, A., Harder, A. & Olsen, Jesper Velgaard, Jan 2018, In: Journal of Proteome Research. 17, 1, p. 727-738 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    49. Published

      Analytical utility of mass spectral binning in proteomic experiments by SPectral Immonium Ion Detection (SPIID)

      Kelstrup, C. D., Freese, C., Heck, A. J. R., Olsen, Jesper Velgaard & Nielsen, Michael Lund, 3 Jun 2014, In: Molecular & Cellular Proteomics. 13, 8, p. 1914-1924 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. Published

      Limits for resolving isobaric tandem mass tag reporter ions using phase constrained spectrum deconvolution

      Kelstrup, C. D., Aizikov, K., Batth, Tanveer Singh, Kreutzman, A., Grinfeld, D., Lange, O., Mourad, D., Makarov, A. A. & Olsen, Jesper Velgaard, 2 Nov 2018, In: Journal of Proteome Research. 17, 11, p. 4008-4016 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    ID: 9925376