Jesper Velgaard Olsen
Professor, Deputy Head of Centre, Professor
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Impact of SHP2 tyrosine phosphorylation on the development of acquired resistance to allosteric SHP2 inhibitors
Franciosa, Giulia & Olsen, Jesper Velgaard, 2023, In: OncoTarget. 14, p. 281-283 3 p.Research output: Contribution to journal › Editorial › Research › peer-review
Improved peptide identification in proteomics by two consecutive stages of mass spectrometric fragmentation
Olsen, Jesper Velgaard & Mann, Matthias, 2004, In: Proceedings of the National Academy of Science of the United States of America. 101, 37, p. 13417-22 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In Vivo Phosphoproteomics Analysis Reveals the Cardiac Targets of β-Adrenergic Receptor Signaling
Lundby, Alicia, Andersen, M. N., Steffensen, Annette Buur, Horn, H., Kelstrup, C. D., Francavilla, C., Jensen, Lars Juhl, Schmitt, Nicole, Thomsen, Morten Bækgaard & Olsen, Jesper Velgaard, 4 Jun 2013, In: Science Signaling. 6, 278, p. rs11 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
In-gel digestion for mass spectrometric characterization of proteins and proteomes
Shevchenko, A., Tomas, H., Havlis, J., Olsen, Jesper Velgaard & Mann, Matthias, 2006, In: Nature Protocols (Print Edition). 1, 6, p. 2856-60 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria
Mootha, V. K., Bunkenborg, J., Olsen, Jesper Velgaard, Hjerrild, M., Wisniewski, J. R., Stahl, E., Bolouri, M. S., Ray, H. N., Sihag, S., Kamal, M., Patterson, N., Lander, E. S. & Mann, Matthias, 2003, In: Cell. 115, 5, p. 629-40 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma
Emdal, Kristina Bennet, Pedersen, A., Bekker-Jensen, D. B., Lundby, Alicia, Claeys, S., De Preter, K., Speleman, F., Francavilla, C. & Olsen, Jesper Velgaard, 20 Nov 2018, In: Science Signaling. 11, 557, p. 1-17 17 p., eaap9752.Research output: Contribution to journal › Journal article › Research › peer-review
Intramolecular hydrogen atom transfer in hydrogen-deficient polypeptide radical cations
Nielsen, Michael Lund, Budnik, B. A., Haselmann, K. F., Olsen, Jesper Velgaard & Zubarev, R. A., 2000, In: Chemical Physics Letters. 330, 5-6, p. 558-562 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics
Mertins, P., Eberl, H. C., Renkawitz, J., Olsen, Jesper Velgaard, Tremblay, M. L., Mann, M., Ullrich, A. & Daub, H., 2008, In: Molecular and Cellular Proteomics. 7, 9, p. 1763-77 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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KIT(D816V) Induces SRC-Mediated Tyrosine Phosphorylation of MITF and Altered Transcription Program in Melanoma
Phung, B., Kazi, J. U., Lundby, Alicia, Bergsteinsdottir, K., Sun, J., Goding, C. R., Jönsson, G., Olsen, Jesper Velgaard, Steingrímsson, E. & Rönnstrand, L., 2017, In: Molecular cancer research : MCR. 15, 9, p. 1265-1274 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle
Daub, H., Olsen, Jesper Velgaard, Bairlein, M., Gnad, F., Oppermann, F. S., Körner, R., Greff, Z., Kéri, G., Stemmann, O. & Mann, M., 2008, In: Molecular Cell. 31, 3, p. 438-48 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling
Batth, Tanveer Singh, Papetti, M., Pfeiffer, A., Tollenaere, M. A. X., Francavilla, C. & Olsen, Jesper Velgaard, 2018, In: Cell Reports. 22, 10, p. 2784-2796 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Large-scale proteomics analysis of the human kinome
Oppermann, F. S., Gnad, F., Olsen, Jesper Velgaard, Hornberger, R., Greff, Z., Kéri, G., Mann, M. & Daub, H., 2009, In: Molecular and Cellular Proteomics. 8, 7, p. 1751-64 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Limits for resolving isobaric tandem mass tag reporter ions using phase constrained spectrum deconvolution
Kelstrup, C. D., Aizikov, K., Batth, Tanveer Singh, Kreutzman, A., Grinfeld, D., Lange, O., Mourad, D., Makarov, A. A. & Olsen, Jesper Velgaard, 2 Nov 2018, In: Journal of Proteome Research. 17, 11, p. 4008-4016 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae
Hernández Guzmán, Ulises, Aksnes, H., Ree, R., Krogh, Nicolai, Jakobsson, M. E., Jensen, Lars Juhl, Arnesen, T. & Olsen, Jesper Velgaard, 2023, In: Nature Communications. 14, 4517.Research output: Contribution to journal › Journal article › Research › peer-review
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Lysine acetylation targets protein complexes and co-regulates major cellular functions
Choudhary, Chunaram, Kumar, C., Gnad, F., Nielsen, Michael Lund, Rehman, M., Walther, T. C., Olsen, Jesper Velgaard & Mann, Matthias, 2009, In: Science. 325, 5942, p. 834-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
MAPU: Max-Planck Unified database of organellar, cellular, tissue and body fluid proteomes
Zhang, Y., Zhang, Y., Adachi, J., Olsen, Jesper Velgaard, Shi, R., de Souza, G., Pasini, E., Foster, L. J., Macek, B., Zougman, A., Kumar, C., Wisniewski, J. R., Jun, W. & Mann, Matthias, Jan 2007, In: Nucleic Acids Research. 35, Database issue, p. D771-9Research output: Contribution to journal › Journal article › Research › peer-review
MSQuant, an Open Source Platform for Mass Spectrometry-Based Quantitative Proteomics
Mortensen, P., Gouw, J. W., Olsen, Jesper Velgaard, Ong, S., Rigbolt, K. T. G., Bunkenborg, J., Cox, J., Foster, L. J., Heck, A. J. R., Blagoev, B., Andersen, J. S. & Mann, Matthias, Jan 2010, In: Journal of Proteome Research.Research output: Contribution to journal › Journal article › Research › peer-review
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Mapping cardiac remodeling in chronic kidney disease
Kaesler, N., Cheng, M., Nagai, J., O'Sullivan, J., Peisker, F., Bindels, E. M. J., Babler, A., Moellmann, J., Droste, P., Franciosa, G., Dugourd, A., Saez-Rodriguez, J., Neuss, S., Lehrke, M., Boor, P., Goettsch, C., Olsen, J. V., Speer, T., Lu, T. S., Lim, K. & 4 others, , 2023, In: Science Advances. 9, 47, 18 p., eadj4846.Research output: Contribution to journal › Journal article › Research › peer-review
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Mass spectrometry-based proteomics of cerebrospinal fluid in pediatric central nervous system malignancies: a systematic review with meta-analysis of individual patient data
Larsen, Christian Mirian, Thastrup, M., Mathiasen, R., Schmiegelow, Kjeld, Olsen, Jesper Velgaard & Østergaard, Ole, 2024, In: Fluids and Barriers of the CNS. 21, 17 p., 14.Research output: Contribution to journal › Review › Research › peer-review
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Mass-Spectrometry Based Proteome Comparison of Extracellular Vesicle Isolation Methods: Comparison of ME-kit, Size-Exclusion Chromatography, and High-Speed Centrifugation
Askeland, A., Borup, A., Østergaard, Ole, Olsen, Jesper Velgaard, Lund, S. M., Christiansen, G., Kristensen, S. R., Heegaard, N. H. H. & Pedersen, S., 2020, In: Biomedicines. 8, 8, 15 p., 246.Research output: Contribution to journal › Journal article › Research › peer-review
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Matrix Gla Protein drives stemness and tumor initiation in ovarian cancer
Nieddu, V., Melocchi, V., Battistini, C., Franciosa, Giulia, Lupia, M., Stellato, C., Bertalot, G., Olsen, Jesper Velgaard, Colombo, N., Bianchi, F. & Cavallaro, U., 2023, In: Cell Death and Disease. 14, 3, 16 p., 220.Research output: Contribution to journal › Journal article › Research › peer-review
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Metaproteomics of saliva identifies human protein markers specific for individuals with periodontitis and dental caries compared to orally healthy controls
Midjord-Belstrøm, Daniel, Jersie-Christensen, R. R., Lyon, D., Damgaard, Christian, Jensen, Lars Juhl, Holmstrup, Palle & Olsen, Jesper Velgaard, 2016, In: PeerJ. 4, 17 p., e2433.Research output: Contribution to journal › Journal article › Research › peer-review
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Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes
Choudhary, Chunaram, Olsen, Jesper Velgaard, Brandts, C., Cox, J., Reddy, P. N. G., Böhmer, F. D., Gerke, V., Schmidt-Arras, D., Berdel, W. E., Müller-Tidow, C., Mann, Matthias & Serve, H., 2009, In: Molecular Cell. 36, 2, p. 326-39 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular Basis of the Mechanisms Controlling MASTL
Hermida, D., Mortuza, G. B., Pedersen, A., Pozdnyakova, I., Nguyen, T. T. T. N., Maroto, M., Williamson, M., Ebersole, T., Cazzamali, G., Rand, Kasper Dyrberg, Olsen, Jesper Velgaard, Malumbres, M. & Montoya, Guillermo, 2020, In: Molecular & Cellular Proteomics. 19, 2, p. 326-343Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular basis of Tousled-Like Kinase 2 activation
Mortuza, G. B., Hermida, D., Pedersen, A., Segura-Bayona, S., López-Méndez, B., Redondo, P., Rüther, P., Pozdnyakova, I., Garrote, A. M., Muñoz, I. G., Villamor-Payà, M., Jauset, C., Olsen, Jesper Velgaard, Stracker, T. H. & Montoya, Guillermo, 2018, In: Nature Communications. 9, 1, p. 2535 2535.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular evidence of use of hide glue in 4th millennium BC Europe
Bleicher, N., Kelstrup, C., Olsen, Jesper Velgaard & Cappellini, Enrico, 2015, In: Journal of Archaeological Science. 63, p. 65-71 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Multi-omic detection of Mycobacterium leprae in archaeological human dental calculus
Fotaki, Anna Katerina, Denham, S. D., Mackie, Meaghan, Iraeta Orbegozo, Miren, Mylopotamitaki, Dorothea, Gopalakrishnan, Shyam, Sicheritz-Pontén, Thomas, Olsen, Jesper Velgaard, Cappellini, Enrico, KU, thw266, Christophersen, A., Gilbert, M Thomas P & Vågene, Åshild Joanne, 2020, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 375, 1812, 10 p., 20190584.Research output: Contribution to journal › Journal article › Research › peer-review
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Multi-protease analysis of Pleistocene bone proteomes
Lanigan, Liam Thomas, Mackie, Meaghan, Feine, S., Hublin, J., Schmitz, R. W., Wilcke, A., Collins, Matthew James, Cappellini, Enrico, Olsen, Jesper Velgaard, Taurozzi, Alberto John & Welker, Frido, 30 Sep 2020, In: Journal of Proteomics. 228, 11 p., 103889.Research output: Contribution to journal › Journal article › Research › peer-review
Multi-spectra peptide sequencing and its applications to multistage mass spectrometry
Bandeira, N., Olsen, Jesper Velgaard, Mann, M. & Pevzner, P. A., 2008, In: Bioinformatics. 24, 13, p. i416-23Research output: Contribution to journal › Journal article › Research › peer-review
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Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking
Francavilla, C., Papetti, M., Rigbolt, K. T. G., Pedersen, A., Sigurdsson, J. O., Cazzamali, G., Karemore, G., Blagoev, B. & Olsen, Jesper Velgaard, Jun 2016, In: Nature Structural and Molecular Biology. 23, 6, p. 608–618 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Nanoelectrospray peptide mapping revisited: Composite survey spectra allow high dynamic range protein characterization without LCMS on an orbitrap mass spectrometer
Lu, A., Waanders, L. F., Almeida, R., Li, G., Allen, M., Cox, J., Olsen, Jesper Velgaard, Bonaldi, T. & Mann, Matthias, 1 Dec 2007, In: International Journal of Mass Spectrometry. 268, 2-3, p. 158-167 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation
Knipscheer, P., van Dijk, W. J., Olsen, Jesper Velgaard, Mann, Matthias & Sixma, T. K., 2007, In: EMBO Journal. 26, 11, p. 2797-807 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Obtaining Complete Human Proteomes
Martinez Del Val, Ana, Hernández Guzmán, Ulises & Olsen, Jesper Velgaard, 2022, In: Annual Review of Genomics and Human Genetics. 23, p. 10.1-10.23 23 p.Research output: Contribution to journal › Review › Research › peer-review
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Off-Line High-pH Reversed-Phase Fractionation for In-Depth Phosphoproteomics
Batth, Tanveer Singh, Francavilla, C. & Olsen, Jesper Velgaard, 4 Nov 2014, In: Journal of Proteome Research. 13, 12, p. 6176-86 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Offline High pH Reversed-Phase Peptide Fractionation for Deep Phosphoproteome Coverage
Batth, Tanveer Singh & Olsen, Jesper Velgaard, 2016, Phospho-Proteomics: Methods and Protocols. Stechow, L. V. (ed.). Springer, Vol. 1355. p. 179-92 14 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
Lundby, Alicia, Franciosa, Giulia, Emdal, Kristina Bennet, Refsgaard, J. C., Gnosa, S. P., Bekker-Jensen, D. B., Secher, A., Maurya, S. R., Paul, I., Mendez, B. L., Kelstrup, C. D., Francavilla, C., Kveiborg, Marie, Montoya, Guillermo, Jensen, Lars Juhl & Olsen, Jesper Velgaard, 2019, In: Cell. 179, 2, p. 543-560Research output: Contribution to journal › Journal article › Research › peer-review
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One-Tip enables comprehensive proteome coverage in minimal cells and single zygotes: [Inkl. Correction]
Ye, Z., Sabatier, Pierre Camille, Martin Gonzalez, Javier, Eguchi, A., Lechner, Maico Yannic, Østergaard, Ole, Xie, J., Guo, Y., Schultz, L., Truffer, R., Bekker-Jensen, D. B., Bache, N. & Olsen, Jesper Velgaard, 2024, In: Nature Communications. 15, 1, 10 p., 2474.Research output: Contribution to journal › Journal article › Research › peer-review
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Optimal analytical strategies for sensitive and quantitative phosphoproteomics using TMT-based multiplexing
Koenig, Claire, Martinez-Val, A., Franciosa, Giulia & Olsen, Jesper Velgaard, 2022, In: Proteomics. 22, 19-20, 13 p., 2100245.Research output: Contribution to journal › Journal article › Research › peer-review
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Optimized Fast and Sensitive Acquisition Methods for Shotgun Proteomics on a Quadrupole Orbitrap Mass Spectrometer
Kelstrup, C. D., Young, C., Lavallee, R., Nielsen, Michael Lund & Olsen, Jesper Velgaard, 2012, In: Journal of Proteome Research. p. 3487-3497 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Optimizing Linear Ion-Trap Data-Independent Acquisition toward Single-Cell Proteomics
Phlairaharn, T., Ye, Z., Krismer, Elena, Pedersen, A. K., Pietzner, M., Olsen, Jesper Velgaard, Schoof, E. M. & Searle, B. C., 2023, In: Analytical Chemistry. 95, 26, p. 9881-9891 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
PHOSIDA (phosphorylation site database): management, structural and evolutionary investigation, and prediction of phosphosites
Gnad, F., Ren, S., Cox, J., Olsen, Jesper Velgaard, Macek, B., Oroshi, M. & Mann, Matthias, 2007, In: Genome Biology. 8, 11, p. R250Research output: Contribution to journal › Journal article › Research › peer-review
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PKD Phosphorylation as Novel Pathway of KV11.1 Regulation
Steffensen, Annette Buur, Bomholtz, Sofia Hammami, Andersen, M. N., Olsen, Jesper Velgaard, Mutsaers, N., Lundegaard, Pia Rengtved, Lundby, Alicia & Schmitt, Nicole, 2018, In: Cellular Physiology and Biochemistry. 47, 4, p. 1742-1750 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PRIME-XS, a European infrastructure for proteomics
Raijmakers, R., Olsen, Jesper Velgaard, Aebersold, R. & Heck, A. J. R., 23 Jun 2014, In: Molecular & Cellular Proteomics. 13, 8, p. 1901-1904 4 p.Research output: Contribution to journal › Editorial › Research › peer-review
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PRMT5-mediated regulatory arginine methylation of RIPK3
Chauhan, C., Martinez Del Val, Ana, Niedenthal, R., Olsen, Jesper Velgaard, Kotlyarov, A., Bekker-Jensen, Simon Holst, Gaestel, M. & Menon, M. B., 2023, In: Cell Death Discovery. 9, 9 p., 14.Research output: Contribution to journal › Journal article › Research › peer-review
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Palaeoproteomic Profiling of Conservation Layers on a 14th Century Italian Wall Painting
Mackie, Meaghan, Rüther, P. L., Samodova, D., Di Gianvincenzo, Fabiana, Granzotto, C., Lyon, D., Peggie, D. A., Howard, H., Harrison, L., Jensen, Lars Juhl, Olsen, Jesper Velgaard & Cappellini, Enrico, 2018, In: Angewandte Chemie (International ed. in English). 57, 25, p. 7369-7374 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Palaeoproteomic analysis of Early Pleistocene Gigantopithecus blacki
Welker, Frido, Ramos Madrigal, Jazmin, Wang, W., Kuhlwilm, M., Montero, M. D. M., Demeter, Fabrice, Lalueza-Fox, C., Marques-Bonet, T., Olsen, Jesper Velgaard & Cappellini, Enrico, Mar 2019, In: American Journal of Physical Anthropology. 168, suppl. 68, p. 265-266Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Palaeoproteomic identification of breast milk protein residues from the archaeological skeletal remains of a neonatal dog
Tsutaya, T., Mackie, Meaghan, Koenig, C., Sato, T., Weber, A. W., Kato, H., Olsen, Jesper Velgaard & Cappellini, Enrico, 2019, In: Scientific Reports. 9, 7 p., 12841.Research output: Contribution to journal › Journal article › Research › peer-review
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Palaeoproteomics resolves sloth relationships
Presslee, S., Slater, G. J., Pujos, F., Forasiepi, A. M., Fischer, R., Molloy, K., Mackie, M., Olsen, J. V., Kramarz, A., Taglioretti, M., Scaglia, F., Lezcano, M., Lanata, J. L., Southon, J., Feranec, R., Bloch, J., Hajduk, A., Martin, F. M., Salas Gismondi, R., Reguero, M. & 6 others, , 2019, In: Nature Ecology & Evolution. 3, p. 1121-1130Research output: Contribution to journal › Journal article › Research › peer-review
Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap
Olsen, Jesper Velgaard, de Godoy, L. M. F., Li, G., Macek, B., Mortensen, P., Pesch, R., Makarov, A., Lange, O., Horning, S. & Mann, Matthias, 2005, In: Molecular and Cellular Proteomics. 4, 12, p. 2010-21 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pathogens and host immunity in the ancient human oral cavity
Warinner, C., Rodrigues, J. F. M., Vyas, R., Trachsel, C., Shved, N., Grossmann, J., Radini, A., Hancock, Y., Tito, R. Y., Fiddyment, S., Speller, C., Hendy, J., Charlton, S., Luder, H. U., Salazar-García, D. C., Eppler, E., Seiler, R., Hansen, L. H., Samaniego Castruita, J. A., Barkow-Oesterreicher, S. & 12 others, , 2014, In: Nature Genetics. 46, p. 336-344 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 9925376
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Molecular basis of Tousled-Like Kinase 2 activation
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52 Genetic Loci Influencing Myocardial Mass
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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
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