Replicating chromatin: a tale of histones

Research output: Contribution to journalReviewResearchpeer-review

Chromatin serves structural and functional roles crucial for genome stability and correct gene expression. This organization must be reproduced on daughter strands during replication to maintain proper overlay of epigenetic fabric onto genetic sequence. Nucleosomes constitute the structural framework of chromatin and carry information to specify higher-order organization and gene expression. When replication forks traverse the chromosomes, nucleosomes are transiently disrupted, allowing the replication machinery to gain access to DNA. Histone recycling, together with new deposition, ensures reassembly on nascent DNA strands. The aim of this review is to discuss how histones - new and old - are handled at the replication fork, highlighting new mechanistic insights and revisiting old paradigms.
Original languageEnglish
JournalBiochemistry and Cell Biology
Issue number1
Pages (from-to)51-63
Number of pages12
Publication statusPublished - 2009

ID: 11085319