Jesper Velgaard Olsen
Professor, Deputy Head of Centre, Professor
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Recent findings and technological advances in phosphoproteomics for cells and tissues
von Stechow, L., Francavilla, C. & Olsen, Jesper Velgaard, 2015, In: Expert Review of Proteomics. 12, 5, p. 469-87 19 p.Research output: Contribution to journal › Review › Research › peer-review
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Proteomics insights into DNA damage response and translating this knowledge to clinical strategies
von Stechow, L. & Olsen, Jesper Velgaard, Feb 2017, In: Proteomics. 17, 3-4, 15 p., 1600018.Research output: Contribution to journal › Review › Research › peer-review
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52 Genetic Loci Influencing Myocardial Mass
van der Harst, P., van Setten, J., Verweij, N., Vogler, G., Franke, L., Maurano, M. T., Wang, X., Mateo Leach, I., Eijgelsheim, M., Sotoodehnia, N., Hayward, C., Sorice, R., Meirelles, O., Lyytikäinen, L-P., Polašek, O., Tanaka, T., Arking, D. E., Ulivi, S., Trompet, S., Müller-Nurasyid, M. & 140 others, , 27 Sep 2016, In: Journal of the American College of Cardiology. 68, 13, p. 1435-48 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. J. J. M., Peal, D. S., Evans, D. M., Nolte, I. M., Segrè, A. V., Holm, H., Handsaker, R. E., Westra, H-J., Johnson, T., Isaacs, A., Yang, J., Lundby, A., Zhao, J. H., Kim, Y. J., Go, M. J., Almgren, P., Bochud, M. & 31 others, , 14 Apr 2013, In: Nature Genetics. 45, 6, p. 621-631 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Status of complete proteome analysis by mass spectrometry: SILAC labeled yeast as a model system
de Godoy, L. M. F., Olsen, Jesper Velgaard, de Souza, G. A., Li, G., Mortensen, P. & Mann, Matthias, 2006, In: Genome Biology. 7, 6, p. R50Research output: Contribution to journal › Journal article › Research › peer-review
MAPU: Max-Planck Unified database of organellar, cellular, tissue and body fluid proteomes
Zhang, Y., Zhang, Y., Adachi, J., Olsen, Jesper Velgaard, Shi, R., de Souza, G., Pasini, E., Foster, L. J., Macek, B., Zougman, A., Kumar, C., Wisniewski, J. R., Jun, W. & Mann, Matthias, Jan 2007, In: Nucleic Acids Research. 35, Database issue, p. D771-9Research output: Contribution to journal › Journal article › Research › peer-review
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The Ndc80 internal loop is required for recruitment of the Ska complex to establish end-on microtubule attachment to kinetochores
Zhang, G., Kelstrup, C. D., Hu, X., Hansen, M. J. K., Singleton, M. R., Olsen, Jesper Velgaard & Nilsson, Jakob, 2012, In: Journal of Cell Science. p. 3243-3253 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth
Ye, Z., Kilic, G., Dabelsteen, Sally, Marinova, I. N., Thøfner, J. F. B., Song, Ming, Levann, Asha Maria Rudjord, Bagdonaite, Ieva , Vakhrushev, Sergey, Brakebusch, Cord Herbert, Olsen, Jesper Velgaard & Wandall, Hans H., 2022, In: Science Signaling. 15, 761, eabo2206.Research output: Contribution to journal › Journal article › Research › peer-review
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One-Tip enables comprehensive proteome coverage in minimal cells and single zygotes
Ye, Z., Sabatier, Pierre Camille, Martin Gonzalez, Javier, Eguchi, A., Lechner, Maico Yannic, Østergaard, Ole, Xie, J., Guo, Y., Schultz, L., Truffer, R., Bekker-Jensen, D. B., Bache, N. & Olsen, Jesper Velgaard, 2024, In: Nature Communications. 15, 1, 10 p., 2474.Research output: Contribution to journal › Journal article › Research › peer-review
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A deeper look at carrier proteome effects for single-cell proteomics
Ye, Z., Batth, Tanveer Singh, Rüther, P. & Olsen, Jesper Velgaard, 2022, In: Communications Biology . 5, 8 p., 150.Research output: Contribution to journal › Journal article › Research › peer-review
Profiling the phospho-status of the BKCa channel alpha subunit in rat brain reveals unexpected patterns and complexity
Yan, J., Olsen, Jesper Velgaard, Park, K., Li, W., Bildl, W., Schulte, U., Aldrich, R. W., Fakler, B. & Trimmer, J. S., 2008, In: Molecular and Cellular Proteomics. 7, 11, p. 2188-98 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability
Xiao, Z., Chang, J., Hendriks, I. A., Sigurdsson, J. O., Olsen, Jesper Velgaard & Vertegaal, A. C. O., 1 May 2015, In: Molecular and Cellular Proteomics. 14, 5, p. 1419-1434Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics
Wright, S. C., Motso, A., Koutsilieri, S., Beusch, C. M., Sabatier, Pierre Camille, Berghella, A., Blondel-Tepaz, É., Mangenot, K., Pittarokoilis, I., Sismanoglou, D. C., Le Gouill, C., Olsen, Jesper Velgaard, Zubarev, R. A., Lambert, N. A., Hauser, Alexander Sebastian, Bouvier, M. & Lauschke, V. M., 2023, In: Nature Communications. 14, 1, 13 p., 6243.Research output: Contribution to journal › Journal article › Research › peer-review
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Enamel proteome shows that Gigantopithecus was an early diverging pongine
Welker, Frido, Ramos Madrigal, Jazmin, Kuhlwilm, M., Liao, W., Gutenbrunner, P., de Manuel, M., Samodova-Sommer, Diana, Mackie, Meaghan, Allentoft, Morten Erik, Bacon, A., Collins, Matthew James, Cox, J., Lalueza-Fox, C., Olsen, Jesper Velgaard, Demeter, Fabrice, Wang, W., Marques-Bonet, T. & Cappellini, Enrico, 2019, In: Nature. 576, p. 262-265Research output: Contribution to journal › Journal article › Research › peer-review
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Ancient proteins resolve the evolutionary history of Darwin's South American ungulates
Welker, F., Collins, M. J., Thomas, J. A., Wadsley, M., Brace, S., Cappellini, E., Turvey, S. T., Reguero, M., Gelfo, J. N., Kramarz, A., Burger, J., Thomas-Oates, J., Ashford, D. A., Ashton, P. D., Rowsell, K., Porter, D. M., Kessler, B., Fischer, R., Baessmann, C., Kaspar, S. & 11 others, , 4 Jun 2015, In: Nature. 522, 7554, p. 81–84 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The dental proteome of Homo antecessor: {with Author Correction]
Welker, F., Ramos-Madrigal, J., Gutenbrunner, P., Mackie, M., Tiwary, S., Rakownikow Jersie-Christensen, R., Chiva, C., Dickinson, M. R., Kuhlwilm, M., de Manuel, M., Gelabert, P., Martinón-Torres, M., Margvelashvili, A., Arsuaga, J. L., Carbonell, E., Marques-Bonet, T., Penkman, K., Sabidó, E., Cox, J., Olsen, J. V. & 6 others, , Apr 2020, In: Nature. 580, 7802, p. 235-238 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Palaeoproteomic analysis of Early Pleistocene Gigantopithecus blacki
Welker, Frido, Ramos Madrigal, Jazmin, Wang, W., Kuhlwilm, M., Montero, M. D. M., Demeter, Fabrice, Lalueza-Fox, C., Marques-Bonet, T., Olsen, Jesper Velgaard & Cappellini, Enrico, Mar 2019, In: American Journal of Physical Anthropology. 168, suppl. 68, p. 265-266Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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The phosphoproteome of toll-like receptor-activated macrophages
Weintz, G., Olsen, Jesper Velgaard, Frühauf, K., Niedzielska, M., Amit, I., Jantsch, J., Mages, J., Frech, C., Dölken, L., Mann, M. & Lang, R., 8 Jun 2010, In: Molecular Systems Biology. 6, p. 371Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation
Weinert, B. T., Wagner, S. A., Horn, H., Henriksen, P., Liu, W. R., Olsen, Jesper Velgaard, Jensen, Lars Juhl & Choudhary, Chunaram, 2011, In: Science Signaling. 4, 183, p. ra48Research output: Contribution to journal › Journal article › Research › peer-review
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Pre-Clovis mastodon hunting 13,800 years ago at the Manis site, Washington
Waters, M. R., Stafford jr., T., McDonald, H. G., Gustafson, C., Rasmussen, M., Cappellini, Enrico, Olsen, Jesper Velgaard, Szklarczyk, D. M., Jensen, Lars Juhl, Gilbert, M Thomas P & Willerslev, Eske, 2011, In: Science. 334, 6054, p. 351-353 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Atypical cofilin signaling drives dendritic cell migration through the extracellular matrix via nuclear deformation
Warner, H., Franciosa, Giulia, van der Borg, G., Coenen, B., Faas, Felix, Koenig, Claire, de Boer, R., Classens, R., Maassen, S., Baranov, M. V., Mahajan, S., Dabral, D., Bianchi, F., van Hilten, N., Risselada, H. J., Roos, W. H., Olsen, Jesper Velgaard, Cano, L. Q. & van den Bogaart, G., 2024, In: Cell Reports. 43, 3, 28 p., 113866.Research output: Contribution to journal › Journal article › Research › peer-review
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Pathogens and host immunity in the ancient human oral cavity
Warinner, C., Rodrigues, J. F. M., Vyas, R., Trachsel, C., Shved, N., Grossmann, J., Radini, A., Hancock, Y., Tito, R. Y., Fiddyment, S., Speller, C., Hendy, J., Charlton, S., Luder, H. U., Salazar-García, D. C., Eppler, E., Seiler, R., Hansen, L. H., Samaniego Castruita, J. A., Barkow-Oesterreicher, S. & 12 others, , 2014, In: Nature Genetics. 46, p. 336-344 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Direct evidence of milk consumption from ancient human dental calculus
Warinner, C., Hendy, J., Speller, C., Cappellini, E., Fischer, R., Trachsel, C., Arneborg, J., Lynnerup, N., Craig, O., Swallow, D. M., Fotakis, A. K., Christensen, R. J., Olsen, J. V., Liebert, A., Montalva, N., Fiddyment, S., Mackie, M., Canci, A., Bouwman, A., Ruhli, F. & 2 others, , 2015, In: American Journal of Physical Anthropology. 156, Suppl. 60, p. 319 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Direct evidence of milk consumption from ancient human dental calculus
Warinner, C., Hendy, J., Speller, C., Cappellini, E., Fischer, R., Trachsel, C., Arneborg, J., Lynnerup, N., Craig, O. E., Swallow, D. M., Fotakis, A. K., Jersie-Christensen, R. R., Olsen, J. V., Liebert, A., Montalva, N., Fiddyment, S., Charlton, S., Mackie, M. E., Canci, A., Bouwman, A. & 3 others, , 2014, In: Scientific Reports. 4, 6 p., 7104.Research output: Contribution to journal › Journal article › Research › peer-review
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qcML: an exchange format for quality control metrics from mass spectrometry experiments
Walzer, M., Pernas, L. E., Nasso, S., Bittremieux, W., Nahnsen, S., Kelchtermans, P., Pichler, P., van den Toorn, H. W. P., Staes, A., Vandenbussche, J., Mazanek, M., Taus, T., Scheltema, R. A., Kelstrup, C. D., Gatto, L., van Breukelen, B., Aiche, S., Valkenborg, D., Laukens, K., Lilley, K. S. & 9 others, , 23 Apr 2014, In: Molecular & Cellular Proteomics. 13, 8, p. 1905-1913 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Yeast expression proteomics by high-resolution mass spectrometry
Walther, T. C., Olsen, Jesper Velgaard & Mann, Matthias, 1 Jan 2010, In: Methods in Enzymology. 470, p. 259-80 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic analyses reveal divergent ubiquitylation site patterns in murinetissues
Wagner, S. A., Beli, P., Weinert, B. T., Schölz, C. F., Kelstrup, C. D., Young, C., Nielsen, Michael Lund, Olsen, Jesper Velgaard, Brakebusch, Cord Herbert & Choudhary, Chunaram, 2012, In: Molecular & Cellular Proteomics.Research output: Contribution to journal › Journal article › Research › peer-review
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RNF4 is required for DNA double-strand break repair in vivo
Vyas, R., Kumar, R., Clermont, F., Helfricht, A., Kalev, P., Sotiropoulou, P., Hendriks, I. A., Radaelli, E., Hochepied, T., Blanpain, C., Sablina, A., van Attikum, H., Olsen, Jesper Velgaard, Jochemsen, A. G., Vertegaal, A. C. O. & Marine, J., Mar 2013, In: Cell Death and Differentiation. 20, 3, p. 490-502 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains
Vind, Anna Constance, Snieckute, Goda, Blasius, Melanie, Tiedje, C., Krogh, Nicolai, Bekker-Jensen, D. B., Andersen, Kasper Langebjerg, Nordgaard, C., Tollenaere, M. A. X., Lund, Anders H., Olsen, Jesper Velgaard, Nielsen, Henrik & Bekker-Jensen, Simon Holst, 2020, In: Molecular Cell. 78, 4, p. 700-713.E7Research output: Contribution to journal › Journal article › Research › peer-review
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Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers
Vermeulen, M., Eberl, H. C., Matarese, F., Marks, H., Denissov, S., Butter, F., Lee, K. K., Olsen, Jesper Velgaard, Hyman, A. A., Stunnenberg, H. G. & Mann, M., 17 Sep 2010, In: Cell. 142, 6, p. 967-80 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genomic and proteomic evidence for Mycobacterium leprae in human medieval dental calculus from Trondheim, Norway
Vagene, A. J., Fotaki, Anna Katerina, Denham, S. D., Orbegozo, M., Mackie, Meaghan, Olsen, Jesper Velgaard, Cappellini, Enrico, Christophersen, A. & Gilbert, M Thomas P, 2020, In: American Journal of Physical Anthropology. 171, p. 291 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Phosphorylation Variation during the Cell Cycle Scales with Structural Propensities of Proteins
Tyanova, S., Frishman, D., Cox, J., Mann, Matthias & Olsen, Jesper Velgaard, 10 Jan 2013, In: P L o S Computational Biology (Online). 9, 1, p. e1002842 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Palaeoproteomic identification of breast milk protein residues from the archaeological skeletal remains of a neonatal dog
Tsutaya, T., Mackie, Meaghan, Koenig, C., Sato, T., Weber, A. W., Kato, H., Olsen, Jesper Velgaard & Cappellini, Enrico, 2019, In: Scientific Reports. 9, 7 p., 12841.Research output: Contribution to journal › Journal article › Research › peer-review
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Faecal proteomics as a novel method to study mammalian behaviour and physiology
Tsutaya, T., Mackie, Meaghan, Sawafuji, R., Miyabe-Nishiwaki, T., Olsen, Jesper Velgaard & Cappellini, Enrico, 2021, In: Molecular Ecology Resources. 21, 6, p. 1808-1819 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Alternative translation initiation generates a functionally distinct isoform of the stress-activated kinase MK2
Trulley, P., Snieckute, Goda, Bekker-Jensen, D. B., Menon, M. B., Freund, R., Kotlyarov, A., Olsen, Jesper Velgaard, Diaz-Muñoz, M. D., Turner, M., Bekker-Jensen, Simon Holst, Gaestel, M. & Tiedje, C., 2018, bioRxiv, 46 p. (bioRxiv).Research output: Working paper › Preprint › Research
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Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2
Trulley, P., Snieckute, Goda, Bekker-Jensen, D., Menon, M. B., Freund, R., Kotlyarov, A., Olsen, Jesper Velgaard, Diaz-Muñoz, M. D., Turner, M., Bekker-Jensen, Simon Holst, Gaestel, M. & Tiedje, C., 2019, In: Cell Reports. 27, 10, p. 2859-2870.e6 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extending the Coverage of Lys-C/Trypsin-Based Bottom-up Proteomics by Cysteine S-Aminoethylation
Tomioka, R., Tomioka, A., Ogata, K., Chan, H. J., Chen, L. Y., Hernández Guzmán, Ulises, Xuan, Y., Olsen, Jesper Velgaard, Chen, Y. J. & Ishihama, Y., 2024, In: Journal of the American Society for Mass Spectrometry. 35, 2, p. 386-396 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling
Tollenaere, M. A. X., Tiedje, C., Rasmussen, S., Nielsen, J. C., Vind, Anna Constance, Blasius, Melanie, Batth, Tanveer Singh, Mailand, Niels, Olsen, Jesper Velgaard, Gaestel, M. & Bekker-Jensen, Simon Holst, 2019, In: Cell Reports. 26, 13, p. 3511-3521.e4 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The SH2 domain interaction landscape
Tinti, M., Kiemer, L., Costa, S., Miller, M. L., Sacco, F., Olsen, Jesper Velgaard, Carducci, M., Paoluzi, S., Langone, F., Workman, C., Blom, N., Machida, K., Thompson, C. M., Schutkowski, M., Brunak, Søren, Mann, Matthias, Mayer, B. J., Castagnoli, L. & Cesareni, G., 2013, In: Cell Reports. 3, 4, p. 1293-1305 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner
Sun, J., Mohlin, S., Lundby, Alicia, Kazi, J. U., Hellman, U., Påhlman, S., Olsen, Jesper Velgaard & Rönnstrand, L., 11 Nov 2013, In: Oncogene.Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of Changes in SUMO-2/3 Modification during Breast Cancer Progression and Metastasis
Subramonian, D., Raghunayakula, S., Olsen, Jesper Velgaard, Beningo, K. A., Paschen, W. & Zhang, X., Sep 2014, In: Journal of Proteome Research. 13, 9, p. 3905–3918 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Electron capture dissociation of singly and multiply phosphorylated peptides
Stensballe, A., Jensen, O. N., Olsen, Jesper Velgaard, Haselmann, K. F. & Zubarev, R. A., 2000, In: Rapid Communications in Mass Spectrometry. 14, 19, p. 1793-800 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PKD Phosphorylation as Novel Pathway of KV11.1 Regulation
Steffensen, Annette Buur, Bomholtz, Sofia Hammami, Andersen, M. N., Olsen, Jesper Velgaard, Mutsaers, N., Lundegaard, Pia Rengtved, Lundby, Alicia & Schmitt, Nicole, 2018, In: Cellular Physiology and Biochemistry. 47, 4, p. 1742-1750 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structures of down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition
Soundararajan, M., Roos, A. K., Savitsky, P., Filippakopoulos, P., Kettenbach, A. N., Olsen, Jesper Velgaard, Gerber, S., Eswaran, J., Knapp, S. & Elkins, J. M., 4 Jun 2013, In: Structure. 21, 6, p. 986-996 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Global analysis of the yeast osmotic stress response by quantitative proteomics
Soufi, B., Kelstrup, C. D., Stoehr, G., Fröhlich, F., Walther, T. C. & Olsen, Jesper Velgaard, 2009, In: Molecular BioSystems. 5, 11, p. 1337-46 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging
Snieckute, G., Ryder, L., Vind, A. C., Wu, Z., Arendrup, F. S., Stoneley, M., Chamois, S., Martinez-Val, A., Leleu, M., Dreos, R., Russell, A., Gay, D. M., Genzor, A. V., Choi, B. S-Y., Basse, A. L., Sass, F., Dall, M., Dollet, L. C. M., Blasius, M., Willis, A. E. & 10 others, , 2023, In: Science (New York, N.Y.). 382, 6675, 14 p., eadf3208.Research output: Contribution to journal › Journal article › Research › peer-review
In-gel digestion for mass spectrometric characterization of proteins and proteomes
Shevchenko, A., Tomas, H., Havlis, J., Olsen, Jesper Velgaard & Mann, Matthias, 2006, In: Nature Protocols (Print Edition). 1, 6, p. 2856-60 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Proteomics strategy for quantitative protein interaction profiling in cell extracts
Sharma, K., Weber, C., Bairlein, M., Greff, Z., Kéri, G., Cox, J., Olsen, Jesper Velgaard & Daub, H., 2009, In: Nature Methods. 6, 10, p. 741-4 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformation-specific anti-Mad2 monoclonal antibodies for the dissection of checkpoint signaling
Sedgwick, G. G., Larsen, Marie Sofie Yoo, Lischetti, T., Streicher, W., Jersie-Christensen, R. R., Olsen, Jesper Velgaard & Nilsson, Jakob, 2016, In: mAbs. 8, 4, p. 689-697 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Analytic framework for peptidomics applied to large-scale neuropeptide identification
Secher, A., Kelstrup, C. D., Conde-Frieboes, K. W., Pyke, C., Raun, K., Wulff, B. S. & Olsen, Jesper Velgaard, 2016, In: Nature Communications. 7, 10 p., 11436.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 9925376
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Molecular basis of Tousled-Like Kinase 2 activation
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52 Genetic Loci Influencing Myocardial Mass
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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
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