Michael Lund Nielsen
Professor
Nielsen Group
Blegdamsvej 3B
2200 København N
- 2016
- Published
Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue
Martello, R., Leutert, M., Jungmichel, S., Bilan, V., Buch-Larsen, Sara Charlotte, Young, C., Hottiger, M. O. & Nielsen, Michael Lund, 1 Oct 2016, In: Nature Communications. 7, 13 p., 12917.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
Altmeyer, M., Neelsen, K. J., Teloni, F., Pozdnyakova, I., Pellegrino, S., Grøfte, M., Rask, M. D., Streicher, W., Jungmichel, S., Nielsen, Michael Lund & Lukas, Jiri, 19 Aug 2015, In: Nature Communications. 6, p. 1-12 8088.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct neuronal glucose uptake Heralds activity-dependent increases in cerebral metabolism
Lundgaard, I., Li, B., Xie, L., Kang, H., Sanggaard, S., Haswell, J. D. R., Sun, W., Goldman, S., Blekot, S., Nielsen, Michael Lund, Takano, T., Deane, R. & Nedergaard, Maiken, 2015, In: Nature Communications. 6, 12 p., 6807.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p
Madsen, C. T., Sylvestersen, K. B., Young, C., Buch-Larsen, Sara Charlotte, Poulsen, J. W., Andersen, M. A., Palmqvist, E. A., Hey-Mogensen, M., Jensen, P. B., Treebak, Jonas Thue, Lisby, Michael & Nielsen, Michael Lund, 2015, In: Nature Communications. 6, 12 p., 7726.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A two-step protein quality control pathway for a misfolded DJ-1 variant in fission yeast
Mathiassen, S. G., Larsen, I. B., Poulsen, E. G., Madsen, C. T., Papaleo, E., Lindorff-Larsen, Kresten, Kragelund, Birthe Brandt, Nielsen, Michael Lund, Kriegenburg, F. & Hartmann-Petersen, Rasmus, 2015, In: The Journal of Biological Chemistry. 290, 34, p. 21141-21153 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Large-Scale Identification of the Arginine Methylome by Mass Spectrometry
Sylvestersen, K. B. & Nielsen, Michael Lund, 2 Nov 2015, Current Protocols in Protein Science. Vol. 82. 17 p. (Current Protocols in Protein Science).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2014
- Published
Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase
Andresen, C. A., Smedegaard, S., Sylvestersen, K. B., Svensson, C., Iglesias Gato, Diego, Cazzamali, G., Nielsen, T. K., Nielsen, Michael Lund & Flores Morales, A., 24 Jan 2014, In: The Journal of Biological Chemistry. 289, 4, p. 2043-2054 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Citrullination regulates pluripotency and histone H1 binding to chromatin
Christophorou, M. A., Castelo-Branco, G., Halley-Stott, R. P., Oliveira, C. S., Loos, R., Radzisheuskaya, A., Mowen, K. A., Bertone, P., Silva, J. C. R., Zernicka-Goetz, M., Nielsen, Michael Lund, Gurdon, J. B. & Kouzarides, T., 6 Mar 2014, In: Nature. 507, p. 104-108Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Specificity and commonality of the phosphoinositide-binding proteome analyzed by quantitative mass spectrometry
Jungmichel, S., Sylvestersen, K. B., Choudhary, Chunaram, Nguyen, S., Mann, Matthias & Nielsen, Michael Lund, 13 Feb 2014, In: Cell Reports. 6, 3, p. 578-91 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication
Kamalyukova, I. M., Young, C., Strømme, C. B., Ménard, Patrice, Jasencakova, Zuzana, Mejlvang, J., Ask, K., Ploug, Michael, Nielsen, Michael Lund, Jensen, O. N. & Groth, Anja, 2014, In: Nature Communications. 5, p. 3394Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analytical utility of mass spectral binning in proteomic experiments by SPectral Immonium Ion Detection (SPIID)
Kelstrup, C. D., Freese, C., Heck, A. J. R., Olsen, Jesper Velgaard & Nielsen, Michael Lund, 3 Jun 2014, In: Molecular & Cellular Proteomics. 13, 8, p. 1914-1924 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
Larsen, D. H., Hari, F., Clapperton, J. A., Gwerder, M., Gutsche, K., Altmeyer, M., Jungmichel, S., Toledo Lazaro, L. I., Fink, D., Rask, M., Grøfte, M., Lukas, Claudia, Nielsen, Michael Lund, Smerdon, S. J., Lukas, Jiri & Stucki, M., Aug 2014, In: Nature Cell Biology. 16, 8, p. 792-803 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomic analysis of arginine methylation sites in human cells reveals dynamic regulation during transcriptional arrest
Sylvestersen, K. B., Horn, H., Jungmichel, S., Jensen, Lars Juhl & Nielsen, Michael Lund, 21 Feb 2014, In: Molecular & Cellular Proteomics. 13, p. 2072-2088 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification
Tessarz, P., Santos-Rosa, H., Robson, S. C., Sylvestersen, K. B., Nelson, C. J., Nielsen, Michael Lund & Kouzarides, T., 23 Jan 2014, In: Nature. 505, p. 564-568Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
RNA-DNA sequence differences spell genetic code ambiguities
Bentin, Thomas & Nielsen, Michael Lund, 2013, In: Artificial DNA. 2, 3, p. 69-70 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer
Cepeda, D., Ng, H-F., Sharifi, H. R., Mahmoudi, S., Cerrato, V. S., Fredlund, E., Magnusson, K., Nilsson, H., Malyukova, A., Rantala, J., Klevebring, D., Viñals, F., Bhaskaran, N., Zakaria, S. M., Rahmanto, A. S., Grotegut, S., Nielsen, M. L., Szigyarto, C. A-K., Sun, D., Lerner, M. & 10 others, , 3 Jul 2013, In: E M B O Molecular Medicine (Online). 5, 7, p. 1067-1086 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses
Jungmichel, S., Rosenthal, F., Altmeyer, M., Lukas, Jiri, Hottiger, M. O. & Nielsen, Michael Lund, 24 Oct 2013, In: Molecular Cell. 52, 2, p. 272-285 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension
Leeming, D. J., Karsdal, M. A., Byrjalsen, I., Bendtsen, Flemming, Trebicka, J., Nielsen, Michael Lund, Christiansen, C., Møller, Søren & Krag, A., 2013, In: Alimentary Pharmacology and Therapeutics. 38, 9, p. 1086-1096 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effectiveness of a coordinated and tailored return-to-work intervention for sickness absence beneficiaries with mental health problems
Martin, M., Nielsen, Michael Lund, Madsen, I., Petersen, S., Lange, Theis & Rugulies, R., 2013, In: Journal of Occupational Rehabilitation. 23, 4, p. 621-30 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Using guanidine-hydrochloride for fast and efficient protein digestion and single-step affinity-purification mass spectrometry
Poulsen, J. W., Madsen, C. T., Young, C., Poulsen, F. M. & Nielsen, Michael Lund, 2013, In: Journal of Proteome Research. 12, 2, p. 1020-30 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Advances in characterizing ubiquitylation sites by mass spectrometry
Sylvestersen, K. B., Young, C. & Nielsen, Michael Lund, 5 Jan 2013, In: Current Opinion in Chemical Biology. 17, 1, p. 49-58 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis
Villumsen, B. H., Danielsen, J. R., Povlsen, L., Sylvestersen, K. B., Merdes, A., Beli, P., Yang, Y., Choudhary, Chunaram, Nielsen, Michael Lund, Mailand, Niels & Bekker-Jensen, Simon Holst, 11 Oct 2013, In: E M B O Journal. 32, 23, p. 3029-3040Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Pdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylation
Frogne, T., Sylvestersen, K. B., Kubicek, S., Nielsen, Michael Lund & Hecksher-Sørensen, J., 2012, In: P L o S One. 7, 4, p. e35233Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.
Jungmichel, S., Clapperton, J. A., Janette, L., Hari, F. J., Spycher, C., Pavic, L., Li, J., Haire, L. F., Bonalli, M., Larsen, D. H., Lukas, C., Lukas, J., MacMillan, D., Nielsen, Michael Lund, Stucki, M. & Smerdon, S. J., 10 Jan 2012, In: Nucleic Acids Research. 40, 9, p. 4913-4928 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Optimized Fast and Sensitive Acquisition Methods for Shotgun Proteomics on a Quadrupole Orbitrap Mass Spectrometer
Kelstrup, C. D., Young, C., Lavallee, R., Nielsen, Michael Lund & Olsen, Jesper Velgaard, 2012, In: Journal of Proteome Research. p. 3487-3497 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6
Mantri, M., Webby, C. J., Loik, N. D., Hamed, R. B., McDonough, M. A., McCullagh, J. S. O., Schofield, C. J., Wolf, A., Nielsen, Michael Lund & Böttger, A., 1 Jan 2012, In: MedChemComm. 3, 1, p. 80-85 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comprehensive profiling of proteome changes upon sequential deletion of deubiquitylating enzymes
Poulsen, J. W., Madsen, C. T., Young, C., Kelstrup, C. D., Grell, H. C., Henriksen, P., Jensen, Lars Juhl & Nielsen, Michael Lund, 2012, In: Journal of Proteomics. 75, 13, p. 3886-97 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass
Povlsen, L. K., Beli, P., Wagner, S. A., Poulsen, S. L., Sylvestersen, K. B., Poulsen, J. W., Nielsen, Michael Lund, Bekker-Jensen, Simon Holst, Mailand, Niels & Choudhary, Chunaram, Oct 2012, In: Nature Cell Biology. 14, 10, p. 1089-98 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomic analyses reveal divergent ubiquitylation site patterns in murinetissues
Wagner, S. A., Beli, P., Weinert, B. T., Schölz, C. F., Kelstrup, C. D., Young, C., Nielsen, Michael Lund, Olsen, Jesper Velgaard, Brakebusch, Cord Herbert & Choudhary, Chunaram, 2012, In: Molecular & Cellular Proteomics.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level
Danielsen, J. M. R., Sylvestersen, K. B., Bekker-Jensen, Simon Holst, Szklarczyk, D., Poulsen, J. W., Horn, H., Jensen, Lars Juhl, Mailand, Niels & Nielsen, Michael Lund, 1 Mar 2011, In: Molecular and Cellular Proteomics. 10, 3, p. M110.003590Research output: Contribution to journal › Journal article › Research › peer-review
ATP Enhances Neuronal Differentiation of PC12 Cells by Activating PKC alpha Interactions with Cytoskeletal Proteins
Marin-Vicente, C., Guerrero-Valero, M., Nielsen, Michael Lund, Savitski, M. M., Gomez-Fernandez, J. C., Zubarev, R. A. & Corbalan-Garcia, S., 2011, In: Journal of Proteome Research. 10, 2, p. 529-540 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The SOCS2 Ubiquitin Ligase Complex Regulates Growth Hormone Receptor Levels
Vesterlund, M., Zadjali, F., Persson, T., Nielsen, Michael Lund, Kessler, B. M., Norstedt, G. & Flores Morales, A., 1 Jan 2011, In: P L o S One. 6, 9, p. e25358 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles
Wagner, S. A., Beli, P., Weinert, B. T., Nielsen, Michael Lund, Cox, J., Mann, Matthias & Choudhary, Chunaram, 1 Oct 2011, In: Molecular and Cellular Proteomics. 10, 10, p. M111.013284Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
Analysis of in vivo histone methylation kinetics by Heavy Methyl SILAC
Bonaldi, T., Vitale, E., Nielsen, Michael Lund, Cox, J. & Mann, M., 2009, In: Amino Acids. 37, p. 66 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lysine acetylation targets protein complexes and co-regulates major cellular functions
Choudhary, Chunaram, Kumar, C., Gnad, F., Nielsen, Michael Lund, Rehman, M., Walther, T. C., Olsen, Jesper Velgaard & Mann, Matthias, 2009, In: Science. 325, 5942, p. 834-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
A dual pressure linear ion trap orbitrap instrument with very high sequencing speed
Olsen, Jesper Velgaard, Schwartz, J. C., Griep-Raming, J., Nielsen, Michael Lund, Damoc, E., Denisov, E., Lange, O., Remes, P., Taylor, D., Splendore, M., Wouters, E. R., Senko, M., Makarov, A., Mann, Matthias & Horning, S., 2009, In: Molecular and Cellular Proteomics. 8, 12, p. 2759-69 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing
Webby, C. J., Wolf, A., Gromak, N., Dreger, M., Kramer, H., Kessler, B., Nielsen, Michael Lund, Schmitz, C., Butler, D. S., Yates, J. R., Delahunty, C. M., Hahn, P., Lengeling, A., Mann, M., Proudfoot, N. J., Schofield, C. J. & Boettger, A., 2009, In: Science. 325, 5936, p. 90-93 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
Analytical Utility of Small Neutral Losses from Reduced Species in Electron Capture Dissociation Studied Using SwedECD Database
Falth, M., Savitski, M. M., Nielsen, Michael Lund, Kjeldsen, F., Andren, P. E. & Zubarev, R. A., 2008, In: Analytical Chemistry. 80, 21, p. 8089-8094 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Immunoaffinity enrichments followed by mass spectrometric detection for studying global protein tyrosine phosphorylation
Lind, S. B., Molin, M., Savitski, M. M., Emilsson, L., Astrom, J., Hedberg, L., Adams, C., Nielsen, Michael Lund, Engstrom, A., Elfineh, L., Andersson, E., Zubarev, R. A. & Pettersson, U., 2008, In: Journal of Proteome Research. 7, 7, p. 2897-2910 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Iodoacetamide-induced artifact mimics ubiquitination in mass spectrometry
Nielsen, Michael Lund, Vermeulen, M., Bonaldi, T., Cox, J., Moroder, L. & Mann, M., 2008, In: Nature Methods. 5, 6, p. 459-460 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of dominant signaling pathways from proteomics expression data
Zubarev, R. A., Nielsen, Michael Lund, Fung, E. M., Savitski, M. M., Kel-Margoulis, O., Wingender, E. & Kel, A., 2008, In: Journal of Proteomics. 71, 1, p. 89-96 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast
de Godoy, L. M. F., Olsen, J. V., Cox, J., Nielsen, Michael Lund, Hubner, N. C., Fröhlich, F., Walther, T. C. & Mann, M., 2008, In: Nature. 455, 7217, p. 1251-4 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
SwedCAD, a database of annotated high-mass accuracy MS/MS spectra of tryptic peptides
Falth, M., Savitski, M. M., Nielsen, Michael Lund, Kjeldsen, F., Andren, P. E. & Zubarev, R. A., 2007, In: Journal of Proteome Research. 6, 10, p. 4063-4067 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
De novo peptide sequencing and identification with precision mass spectrometry
Frank, A. M., Savitski, M. M., Nielsen, Michael Lund, Zubarev, R. A. & Pevzner, P. A., 2007, In: Journal of Proteome Research. 6, 1, p. 114-123 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
On studying protein phosphorylation patterns using bottom-up LC-MS/MS: the case of human alpha-casein
Kjeldsen, F., Savitski, M. M., Nielsen, Michael Lund, Shi, L. & Zubarev, R. A., 2007, In: Analyst. 132, 8, p. 768-776 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
The RBCC gene RFP2 (leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD
Lerner, M., Corcoran, M., Cepeda, D., Nielsen, Michael Lund, Zubarev, R., Ponten, F., Uhlen, M., Hober, S., Grander, D. & Sangfelt, O., 2007, In: Molecular Biology of the Cell. 18, 5, p. 1670-1682 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Electrospray ionization tandem mass spectrometry sequencing of novel skin peptides from Ranid frogs containing disulfide bridges
Samgina, T., Arternenko, K., Gorshkov, V., Lebedev, A., Nielsen, Michael Lund, Savitski, M. & Zubarev, R., 2007, In: European Journal of Mass Spectrometry. 13, 2, p. 155-163 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Backbone carbonyl group basicities are related to gas-phase fragmentation of peptides and protein folding
Savitski, M. M., Kjeldsen, F., Nielsen, Michael Lund, Garbuzynskiy, S. O., Galzitskaya, O. V., Surin, A. K. & Zubarev, R. A., 2007, In: Angewandte Chemie International Edition. 46, 9, p. 1481-1484 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Hydrogen rearrangement to and from radical z fragments in electron capture dissociation of peptides
Savitski, M. M., Kjeldsen, F., Nielsen, Michael Lund & Zubarev, R. A., 2007, In: Journal of The American Society for Mass Spectrometry. 18, 1, p. 113-120 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Relative specificities of water and ammonia losses from backbone fragments in collision-activated dissociation
Savitski, M. M., Kjeldsen, F., Nielsen, Michael Lund & Zubarev, R. A., 2007, In: Journal of Proteome Research. 6, 7, p. 2669-2673 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 13143239
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Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p
Research output: Contribution to journal › Journal article › Research › peer-review
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An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes
Research output: Contribution to journal › Journal article › Research › peer-review
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Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism
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Published