Michael Lund Nielsen
Professor
Nielsen Group
Blegdamsvej 3B
2200 København N
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Waves of sumoylation support transcription dynamics during adipocyte differentiation
Zhao, X., Hendriks, Ivo Alexander, Le Gras, S., Ye, T., Ramos-Alonso, L., Nguea P, A., Lien, G. F., Ghasemi, F., Klungland, A., Jost, B., Enserink, J. M., Nielsen, Michael Lund & Chymkowitch, P., 2022, In: Nucleic Acids Research. 50, 3, p. 1351-1369 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates
Mirsanaye, Ann Schirin, Hoffmann, Saskia, Weisser, Melanie, Mund, Andreas, Lopez Mendez, B., Typas, D., van den Boom, J., Benedict, Bente, Hendriks, Ivo Alexander, Nielsen, Michael Lund, Meyer, H., Duxin, Julien, Montoya, Guillermo & Mailand, Niels, 2024, In: Nature Communications. 15, 1, 16 p., 2459.Research output: Contribution to journal › Journal article › Research › peer-review
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Using guanidine-hydrochloride for fast and efficient protein digestion and single-step affinity-purification mass spectrometry
Poulsen, J. W., Madsen, C. T., Young, C., Poulsen, F. M. & Nielsen, Michael Lund, 2013, In: Journal of Proteome Research. 12, 2, p. 1020-30 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease
Prokhorova, E., Agnew, T., Wondisford, A. R., Tellier, M., Kaminski, N., Beijer, D., Holder, J., Groslambert, J., Suskiewicz, M. J., Zhu, K., Reber, J. M., Krassnig, S. C., Palazzo, L., Murphy, S., Nielsen, Michael Lund, Mangerich, A., Ahel, D., Baets, J., O'Sullivan, R. J. & Ahel, I., 2021, In: Molecular Cell. 81, 12, p. 2640-2655Research output: Contribution to journal › Journal article › Research › peer-review
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Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation
Mooser, C., Symeonidou, I., Leimbacher, P., Ribeiro, A., Shorrocks, A. K., Jungmichel, S., Buch-Larsen, Sara Charlotte, Knechtle, K., Jasrotia, A., Zurbriggen, D., Jeanrenaud, A., Leikauf, C., Fink, D., Nielsen, Michael Lund, Blackford, A. N. & Stucki, M., 2020, In: Nature Communications. 11, 16 p., 123.Research output: Contribution to journal › Journal article › Research › peer-review
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Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures
Cossec, J. C., Traboulsi, T., Sart, S., Loe-Mie, Y., Guthmann, M., Hendriks, Ivo Alexander, Theurillat, I., Nielsen, Michael Lund, Torres-Padilla, M. E., Baroud, C. N. & Dejean, A., 2023, In: Cell Reports. 42, 4, 27 p., 112380.Research output: Contribution to journal › Journal article › Research › peer-review
Toward error-free proteomics
Zubarev, R., Nielsen, Michael Lund, Savitski, M. & Kocher, T., 2005, In: Molecular and Cellular Proteomics. 4, 8, p. S16-S16Research output: Contribution to journal › Journal article › Research › peer-review
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Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication
Kamalyukova, I. M., Young, C., Strømme, C. B., Ménard, Patrice, Jasencakova, Zuzana, Mejlvang, J., Ask, K., Ploug, Michael, Nielsen, Michael Lund, Jensen, O. N. & Groth, Anja, 2014, In: Nature Communications. 5, p. 3394Research output: Contribution to journal › Journal article › Research › peer-review
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The ubiquitin ligase RFWD3 is required for translesion DNA synthesis
Gallina, I., Hendriks, Ivo Alexander, Hoffmann, Saskia, Larsen, N. B., Johansen, Joachim, S.Colding-Christensen, Camilla, Schubert, Lisa, Sellés Baiget, Selene, Fábián, Z., Kühbacher, U., Gao, A. O., Räschle, M., Rasmussen, Simon, Nielsen, Michael Lund, Mailand, Niels & Duxin, Julien, 2021, In: Molecular Cell. 81, 3, p. 442-458.e9 27 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The regulatory landscape of the human HPF1-and ARH3-dependent ADP-ribosylome
Hendriks, Ivo Alexander, Buch-Larsen, Sara Charlotte, Prokhorova, E., Elsborg, Jonas Damgaard, Stripp, Alexandra, Zhu, K., Ahel, D., Lukas, Claudia, Ahel, I. & Nielsen, Michael Lund, 2021, In: Nature Communications. 12, 1, 16 p., 5893.Research output: Contribution to journal › Journal article › Research › peer-review
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The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.
Jungmichel, S., Clapperton, J. A., Janette, L., Hari, F. J., Spycher, C., Pavic, L., Li, J., Haire, L. F., Bonalli, M., Larsen, D. H., Lukas, C., Lukas, J., MacMillan, D., Nielsen, Michael Lund, Stucki, M. & Smerdon, S. J., 10 Jan 2012, In: Nucleic Acids Research. 40, 9, p. 4913-4928 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The SUMO–NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure
Hertz, Emil Peter Thrane, Alonso de Vega, Ignacio, Kruse, Thomas, Wang, Y., Hendriks, Ivo Alexander, Bizard, A. H., Eugui-Anta, A., Hay, R. T., Nielsen, Michael Lund, Nilsson, Jakob, Hickson, Ian David & Mailand, Niels, 2023, In: Nature Structural and Molecular Biology. 30, p. 1303-1313Research output: Contribution to journal › Journal article › Research › peer-review
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The SOCS2 Ubiquitin Ligase Complex Regulates Growth Hormone Receptor Levels
Vesterlund, M., Zadjali, F., Persson, T., Nielsen, Michael Lund, Kessler, B. M., Norstedt, G. & Flores Morales, A., 1 Jan 2011, In: P L o S One. 6, 9, p. e25358 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
The RBCC gene RFP2 (leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD
Lerner, M., Corcoran, M., Cepeda, D., Nielsen, Michael Lund, Zubarev, R., Ponten, F., Uhlen, M., Hober, S., Grander, D. & Sangfelt, O., 2007, In: Molecular Biology of the Cell. 18, 5, p. 1670-1682 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
Larsen, D. H., Hari, F., Clapperton, J. A., Gwerder, M., Gutsche, K., Altmeyer, M., Jungmichel, S., Toledo Lazaro, L. I., Fink, D., Rask, M., Grøfte, M., Lukas, Claudia, Nielsen, Michael Lund, Smerdon, S. J., Lukas, Jiri & Stucki, M., Aug 2014, In: Nature Cell Biology. 16, 8, p. 792-803 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Temporal and site-specific adp-ribosylation dynamics upon different genotoxic stresses
Buch-Larsen, Sara Charlotte, Stripp, Alexandra, Hendriks, Ivo Alexander & Nielsen, Michael Lund, 2021, In: Cells. 10, 11, 16 p., 2927.Research output: Contribution to journal › Journal article › Research › peer-review
Tandem ionization mass spectrometry of biomolecules
Zubarev, R. A., Nielsen, Michael Lund & Budnik, B. A., 2000, In: European Journal of Mass Spectrometry. 6, 3, p. 235-240 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Tandem MALDI/El ionization for tandem Fourier transform ion cyclotron resonance mass spectrometry of polypeptides
Nielsen, Michael Lund, Budnik, B. A., Haselmann, K. F. & Zubarev, R. A., 2003, In: International Journal of Mass Spectrometry. 226, 1, p. 181-187 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass
Povlsen, L. K., Beli, P., Wagner, S. A., Poulsen, S. L., Sylvestersen, K. B., Poulsen, J. W., Nielsen, Michael Lund, Bekker-Jensen, Simon Holst, Mailand, Niels & Choudhary, Chunaram, Oct 2012, In: Nature Cell Biology. 14, 10, p. 1089-98 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Systems-wide Analysis of Serine ADP-Ribosylation Reveals Widespread Occurrence and Site-Specific Overlap with Phosphorylation
Buch-Larsen, Sara Charlotte, Hendriks, Ivo Alexander, Lyon, D., Jensen, Lars Juhl & Nielsen, Michael Lund, 2018, In: Cell Reports. 24, 9, p. 2493-2505Research output: Contribution to journal › Journal article › Research › peer-review
SwedCAD, a database of annotated high-mass accuracy MS/MS spectra of tryptic peptides
Falth, M., Savitski, M. M., Nielsen, Michael Lund, Kjeldsen, F., Andren, P. E. & Zubarev, R. A., 2007, In: Journal of Proteome Research. 6, 10, p. 4063-4067 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Specifying RNA-Binding Regions in Proteins by Peptide Cross-Linking and Affinity Purification
Mullari, M., Lyon, D., Jensen, Lars Juhl & Nielsen, Michael Lund, 2017, In: Journal of Proteome Research. 16, 8, p. 2762-2772 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Specificity and commonality of the phosphoinositide-binding proteome analyzed by quantitative mass spectrometry
Jungmichel, S., Sylvestersen, K. B., Choudhary, Chunaram, Nguyen, S., Mann, Matthias & Nielsen, Michael Lund, 13 Feb 2014, In: Cell Reports. 6, 3, p. 578-91 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Site-specific phosphorylation of PSD-95 dynamically regulates the postsynaptic density as observed by phase separation
Vistrup-Parry, M., Chen, X., Johansen, T. L., Bach, S., Buch-Larsen, Sara Charlotte, Bartling, Christian Reinhard Otto, Ma, C., Clemmensen, L. S., Nielsen, Michael Lund, Zhang, M. & Strømgaard, Kristian, 2021, In: iScience. 24, 11, 103268.Research output: Contribution to journal › Journal article › Research › peer-review
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Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation
Hendriks, Ivo Alexander, Lyon, D., Young, C., Jensen, Lars Juhl, Vertegaal, A. C. O. & Nielsen, Michael Lund, Mar 2017, In: Nature Structural and Molecular Biology. 24, 3, p. 325-336 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Site-specific characterization of endogenous SUMOylation across species and organs
Hendriks, Ivo Alexander, Lyon, D., Su, D., Skotte, Niels Henning, Daniel, J. A., Jensen, Lars Juhl & Nielsen, Michael Lund, 2018, In: Nature Communications. 9, p. 1-17 2456.Research output: Contribution to journal › Journal article › Research › peer-review
Side-chain losses in electron capture dissociation to improve peptide identification
Savitski, M. M., Nielsen, Michael Lund & Zubarev, R. A., 2007, In: Analytical Chemistry. 79, 6, p. 2296-2302 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Shifted-basis technique improves accuracy of peak position determination in Fourier transform mass spectrometry
Savitski, M. M., Ivonin, I. A., Nielsen, Michael Lund, Zubarev, R. A., Tsybin, Y. O. & Hakansson, P., 2004, In: Journal of The American Society for Mass Spectrometry. 15, 4, p. 457-461 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Serine-linked PARP1 auto-modification controls PARP inhibitor response
Prokhorova, E., Zobel, F., Smith, R., Zentout, S., Gibbs-Seymour, I., Schützenhofer, K., Peters, A., Groslambert, J., Zorzini, V., Agnew, T., Brognard, J., Nielsen, Michael Lund, Ahel, D., Huet, S., Suskiewicz, M. J. & Ahel, I., 2021, In: Nature Communications. 12, 1, 12 p., 4055.Research output: Contribution to journal › Journal article › Research › peer-review
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Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling
Fontana, P., Buch-Larsen, Sara Charlotte, Suyari, O., Smith, R., Suskiewicz, M. J., Schützenhofer, K., Ariza, A., Rack, J. G. M., Nielsen, Michael Lund & Ahel, I., 2023, In: Nature Communications. 14, 1, 3200.Research output: Contribution to journal › Journal article › Research › peer-review
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Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6
Mantri, M., Webby, C. J., Loik, N. D., Hamed, R. B., McDonough, M. A., McCullagh, J. S. O., Schofield, C. J., Wolf, A., Nielsen, Michael Lund & Böttger, A., 1 Jan 2012, In: MedChemComm. 3, 1, p. 80-85 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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SUMOylation promotes protective responses to DNA-protein crosslinks
Borgermann, N., Ackermann, Leena, Schwertman, P., Hendriks, Ivo Alexander, Thijssen, K., Liu, Julio, Lans, H., Nielsen, Michael Lund & Mailand, Niels, 2019, In: E M B O Journal. 38, 17 p., e101496.Research output: Contribution to journal › Journal article › Research › peer-review
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SCAI promotes error-free repair of DNA interstrand crosslinks via the Fanconi anemia pathway
Schubert, Lisa, Hendriks, Ivo Alexander, Hertz, Emil Peter Thrane, Wu, Wei, Sellés Baiget, Selene, Hoffmann, Saskia, Bagge, Keerthana Stine Viswalingam, Gallina, I., Pentakota, S., Benedict, Bente, Johansen, Joachim, Apelt, K., Luijsterburg, M. S., Rasmussen, Simon, Lisby, Michael, Liu, Ying, Nielsen, Michael Lund, Mailand, Niels & Duxin, Julien, 2022, In: EMBO Reports. 23, 4, 20 p., e53639.Research output: Contribution to journal › Journal article › Research › peer-review
Relative specificities of water and ammonia losses from backbone fragments in collision-activated dissociation
Savitski, M. M., Kjeldsen, F., Nielsen, Michael Lund & Zubarev, R. A., 2007, In: Journal of Proteome Research. 6, 7, p. 2669-2673 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of Rad52-dependent replication fork recovery through serine ADP-ribosylation of PolD3
Richards, F., Llorca-Cardenosa, M. J., Langton, J., Buch-Larsen, Sara Charlotte, Shamkhi, N. F., Sharma, A. B., Nielsen, Michael Lund & Lakin, N. D., 2023, In: Nature Communications. 14, 1, 14 p., 4310.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of GLI1 by cis DNA elements and epigenetic marks
Taylor, R., Long, J., Yoon, J. W., Childs, R., Sylvestersen, K. B., Nielsen, Michael Lund, Leong, K., Iannaccone, S., Walterhouse, D. O., Robbins, D. J. & Iannaccone, P., 2019, In: DNA Repair. 79, p. 10-21 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RNA-DNA sequence differences spell genetic code ambiguities
Bentin, Thomas & Nielsen, Michael Lund, 2013, In: Artificial DNA. 2, 3, p. 69-70 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
Proteomics-grade de novo sequencing approach
Savitski, M. M., Nielsen, Michael Lund, Kjeldsen, F. & Zubarev, R. A., 2005, In: Journal of Proteome Research. 4, 6, p. 2348-2354 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic analysis of arginine methylation sites in human cells reveals dynamic regulation during transcriptional arrest
Sylvestersen, K. B., Horn, H., Jungmichel, S., Jensen, Lars Juhl & Nielsen, Michael Lund, 21 Feb 2014, In: Molecular & Cellular Proteomics. 13, p. 2072-2088 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic analyses reveal divergent ubiquitylation site patterns in murinetissues
Wagner, S. A., Beli, P., Weinert, B. T., Schölz, C. F., Kelstrup, C. D., Young, C., Nielsen, Michael Lund, Olsen, Jesper Velgaard, Brakebusch, Cord Herbert & Choudhary, Chunaram, 2012, In: Molecular & Cellular Proteomics.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue
Martello, R., Leutert, M., Jungmichel, S., Bilan, V., Buch-Larsen, Sara Charlotte, Young, C., Hottiger, M. O. & Nielsen, Michael Lund, 1 Oct 2016, In: Nature Communications. 7, 13 p., 12917.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells
Buch-Larsen, Sara Charlotte, Sylvestersen, K. B., Mund, Andreas, Lyon, D., Mullari, M., Madsen, M. V., Daniel, J. A., Jensen, Lars Juhl & Nielsen, Michael Lund, 30 Aug 2016, In: Science Signaling. 9, 443, 14 p., rs9.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses
Jungmichel, S., Rosenthal, F., Altmeyer, M., Lukas, Jiri, Hottiger, M. O. & Nielsen, Michael Lund, 24 Oct 2013, In: Molecular Cell. 52, 2, p. 272-285 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-Wide Identification of In Vivo ADP-Ribose Acceptor Sites by Liquid Chromatography-Tandem Mass Spectrometry
Buch-Larsen, Sara Charlotte, Leutert, M., Bilan, V., Martello, R., Jungmichel, S., Young, C., Hottiger, M. O. & Nielsen, Michael Lund, 2017, Poly(ADP-Ribose) Polymerase. Tulin, A. V. (ed.). Humana Press, Vol. 1608. p. 149-162 14 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase
Andresen, C. A., Smedegaard, S., Sylvestersen, K. B., Svensson, C., Iglesias Gato, Diego, Cazzamali, G., Nielsen, T. K., Nielsen, Michael Lund & Flores Morales, A., 24 Jan 2014, In: The Journal of Biological Chemistry. 289, 4, p. 2043-2054 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Profiling ubiquitin signalling with UBIMAX reveals DNA damage- and SCFβ-Trcp1-dependent ubiquitylation of the actin-organizing protein Dbn1
S.Colding-Christensen, Camilla, Kakulidis, Ellen Sofia, Arroyo Gomez, Javier, Hendriks, Ivo Alexander, Arkinson, C., Fábián, Z., Gambus, A., Mailand, Niels, Duxin, Julien & Nielsen, Michael Lund, 2023, In: Nature Communications. 14, 19 p., 8293.Research output: Contribution to journal › Journal article › Research › peer-review
Physicochemical properties determining the detection probability of tryptic peptides in Fourier transform mass spectrometry. A correlation study
Nielsen, Michael Lund, Savitski, M. M., Kjeldsen, F. & Zubarev, R. A., 2004, In: Analytical Chemistry. 76, 19, p. 5872-5877 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
PhosTShunter: A fast and reliable tool to detect phosphorylated peptides in liquid chromatography Fourier transform tandem mass spectrometry data sets
Kocher, T., Savitski, M. M., Nielsen, Michael Lund & Zubarev, R. A., 2006, In: Journal of Proteome Research. 5, 3, p. 659-668 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Peptide end sequencing by orthogonal MALDI tandem mass spectrometry
Nielsen, Michael Lund, Bennett, K. L., Larsen, B., Moniatte, M. & Mann, M., 2002, In: Journal of Proteome Research. 1, 1, p. 63-71 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylation
Frogne, T., Sylvestersen, K. B., Kubicek, S., Nielsen, Michael Lund & Hecksher-Sørensen, J., 2012, In: P L o S One. 7, 4, p. e35233Research output: Contribution to journal › Journal article › Research › peer-review
ID: 13143239
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Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p
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An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes
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Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism
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