Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
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Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins. / Erlendsson, Simon; Morado, Dustin R; Cullen, Harrison B; Feschotte, Cedric; Shepherd, Jason D; Briggs, John A G.
In: Nature Neuroscience, Vol. 23, 2020, p. 172-175.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
AU - Erlendsson, Simon
AU - Morado, Dustin R
AU - Cullen, Harrison B
AU - Feschotte, Cedric
AU - Shepherd, Jason D
AU - Briggs, John A G
PY - 2020
Y1 - 2020
N2 - Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.
AB - Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.
U2 - 10.1038/s41593-019-0569-y
DO - 10.1038/s41593-019-0569-y
M3 - Journal article
C2 - 31907439
VL - 23
SP - 172
EP - 175
JO - Nature Neuroscience
JF - Nature Neuroscience
SN - 1097-6256
ER -
ID: 233730523