Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins

Research output: Contribution to journalJournal articleResearchpeer-review

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Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins. / Erlendsson, Simon; Morado, Dustin R; Cullen, Harrison B; Feschotte, Cedric; Shepherd, Jason D; Briggs, John A G.

In: Nature Neuroscience, Vol. 23, 2020, p. 172-175.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Erlendsson, S, Morado, DR, Cullen, HB, Feschotte, C, Shepherd, JD & Briggs, JAG 2020, 'Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins', Nature Neuroscience, vol. 23, pp. 172-175. https://doi.org/10.1038/s41593-019-0569-y

APA

Erlendsson, S., Morado, D. R., Cullen, H. B., Feschotte, C., Shepherd, J. D., & Briggs, J. A. G. (2020). Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins. Nature Neuroscience, 23, 172-175. https://doi.org/10.1038/s41593-019-0569-y

Vancouver

Erlendsson S, Morado DR, Cullen HB, Feschotte C, Shepherd JD, Briggs JAG. Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins. Nature Neuroscience. 2020;23:172-175. https://doi.org/10.1038/s41593-019-0569-y

Author

Erlendsson, Simon ; Morado, Dustin R ; Cullen, Harrison B ; Feschotte, Cedric ; Shepherd, Jason D ; Briggs, John A G. / Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins. In: Nature Neuroscience. 2020 ; Vol. 23. pp. 172-175.

Bibtex

@article{f94dcb1b0ce84c4e891fe973452a0ac7,
title = "Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins",
abstract = "Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.",
author = "Simon Erlendsson and Morado, {Dustin R} and Cullen, {Harrison B} and Cedric Feschotte and Shepherd, {Jason D} and Briggs, {John A G}",
year = "2020",
doi = "10.1038/s41593-019-0569-y",
language = "English",
volume = "23",
pages = "172--175",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins

AU - Erlendsson, Simon

AU - Morado, Dustin R

AU - Cullen, Harrison B

AU - Feschotte, Cedric

AU - Shepherd, Jason D

AU - Briggs, John A G

PY - 2020

Y1 - 2020

N2 - Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.

AB - Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.

U2 - 10.1038/s41593-019-0569-y

DO - 10.1038/s41593-019-0569-y

M3 - Journal article

C2 - 31907439

VL - 23

SP - 172

EP - 175

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

ER -

ID: 233730523