Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
Research output: Contribution to journal › Journal article › Research › peer-review
Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.
Original language | English |
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Journal | Nature Neuroscience |
Volume | 23 |
Pages (from-to) | 172-175 |
ISSN | 1097-6256 |
DOIs | |
Publication status | Published - 2020 |
Externally published | Yes |
ID: 233730523