Proteomic approaches in circadian biology
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
Circadian clocks are endogenous oscillators that drive the rhythmic expression of a broad array of genes that orchestrate metabolism and physiology. Recent evidence indicates that posttranscriptional and posttranslational mechanisms play essential roles in modulating circadian gene expression, particularly for the molecular mechanism of the clock. In contrast to genetic technologies that have long been used to study circadian biology, proteomic approaches have so far been limited and, if applied at all, have used two-dimensional gel electrophoresis (2-DE). Here, we review the proteomics approaches applied to date in the circadian field, and we also discuss the exciting potential of using cutting-edge proteomics technology in circadian biology. Large-scale, quantitative protein abundance measurements will help to understand to what extent the circadian clock drives system wide rhythms of protein abundance downstream of transcription regulation.
Original language | English |
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Title of host publication | Handbook of experimental pharmacology : Circadian Clocks |
Number of pages | 19 |
Publication date | 2013 |
Pages | 389-407 |
DOIs | |
Publication status | Published - 2013 |
Externally published | Yes |
Series | Handbook of Experimental Pharmacology |
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ISSN | 0171-2004 |
- Animals, Brain, Circadian Clocks, Eye, Humans, Metabolomics, Proteomics, Suprachiasmatic Nucleus
Research areas
ID: 88586811