Proteomic approaches in circadian biology

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Proteomic approaches in circadian biology. / Robles, Maria S; Mann, Matthias.

Handbook of experimental pharmacology: Circadian Clocks. 2013. p. 389-407 (Handbook of Experimental Pharmacology).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

Harvard

Robles, MS & Mann, M 2013, Proteomic approaches in circadian biology. in Handbook of experimental pharmacology: Circadian Clocks. Handbook of Experimental Pharmacology, pp. 389-407. https://doi.org/10.1007/978-3-642-25950-0_17

APA

Robles, M. S., & Mann, M. (2013). Proteomic approaches in circadian biology. In Handbook of experimental pharmacology: Circadian Clocks (pp. 389-407). Handbook of Experimental Pharmacology https://doi.org/10.1007/978-3-642-25950-0_17

Vancouver

Robles MS, Mann M. Proteomic approaches in circadian biology. In Handbook of experimental pharmacology: Circadian Clocks. 2013. p. 389-407. (Handbook of Experimental Pharmacology). https://doi.org/10.1007/978-3-642-25950-0_17

Author

Robles, Maria S ; Mann, Matthias. / Proteomic approaches in circadian biology. Handbook of experimental pharmacology: Circadian Clocks. 2013. pp. 389-407 (Handbook of Experimental Pharmacology).

Bibtex

@inbook{9a2b9646cc53406b80b31332bd5cf803,
title = "Proteomic approaches in circadian biology",
abstract = "Circadian clocks are endogenous oscillators that drive the rhythmic expression of a broad array of genes that orchestrate metabolism and physiology. Recent evidence indicates that posttranscriptional and posttranslational mechanisms play essential roles in modulating circadian gene expression, particularly for the molecular mechanism of the clock. In contrast to genetic technologies that have long been used to study circadian biology, proteomic approaches have so far been limited and, if applied at all, have used two-dimensional gel electrophoresis (2-DE). Here, we review the proteomics approaches applied to date in the circadian field, and we also discuss the exciting potential of using cutting-edge proteomics technology in circadian biology. Large-scale, quantitative protein abundance measurements will help to understand to what extent the circadian clock drives system wide rhythms of protein abundance downstream of transcription regulation.",
keywords = "Animals, Brain, Circadian Clocks, Eye, Humans, Metabolomics, Proteomics, Suprachiasmatic Nucleus",
author = "Robles, {Maria S} and Matthias Mann",
year = "2013",
doi = "10.1007/978-3-642-25950-0_17",
language = "English",
series = "Handbook of Experimental Pharmacology",
publisher = "Springer",
pages = "389--407",
booktitle = "Handbook of experimental pharmacology",

}

RIS

TY - CHAP

T1 - Proteomic approaches in circadian biology

AU - Robles, Maria S

AU - Mann, Matthias

PY - 2013

Y1 - 2013

N2 - Circadian clocks are endogenous oscillators that drive the rhythmic expression of a broad array of genes that orchestrate metabolism and physiology. Recent evidence indicates that posttranscriptional and posttranslational mechanisms play essential roles in modulating circadian gene expression, particularly for the molecular mechanism of the clock. In contrast to genetic technologies that have long been used to study circadian biology, proteomic approaches have so far been limited and, if applied at all, have used two-dimensional gel electrophoresis (2-DE). Here, we review the proteomics approaches applied to date in the circadian field, and we also discuss the exciting potential of using cutting-edge proteomics technology in circadian biology. Large-scale, quantitative protein abundance measurements will help to understand to what extent the circadian clock drives system wide rhythms of protein abundance downstream of transcription regulation.

AB - Circadian clocks are endogenous oscillators that drive the rhythmic expression of a broad array of genes that orchestrate metabolism and physiology. Recent evidence indicates that posttranscriptional and posttranslational mechanisms play essential roles in modulating circadian gene expression, particularly for the molecular mechanism of the clock. In contrast to genetic technologies that have long been used to study circadian biology, proteomic approaches have so far been limited and, if applied at all, have used two-dimensional gel electrophoresis (2-DE). Here, we review the proteomics approaches applied to date in the circadian field, and we also discuss the exciting potential of using cutting-edge proteomics technology in circadian biology. Large-scale, quantitative protein abundance measurements will help to understand to what extent the circadian clock drives system wide rhythms of protein abundance downstream of transcription regulation.

KW - Animals

KW - Brain

KW - Circadian Clocks

KW - Eye

KW - Humans

KW - Metabolomics

KW - Proteomics

KW - Suprachiasmatic Nucleus

U2 - 10.1007/978-3-642-25950-0_17

DO - 10.1007/978-3-642-25950-0_17

M3 - Book chapter

C2 - 23604489

T3 - Handbook of Experimental Pharmacology

SP - 389

EP - 407

BT - Handbook of experimental pharmacology

ER -

ID: 88586811