Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome

Research output: Contribution to journal › Journal article › Research › peer-review

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Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome. / Fitzner, Dirk; Bader, Jakob M; Penkert, Horst; Bergner, Caroline G; Su, Minhui; Weil, Marie-Theres; Surma, Michal A; Mann, Matthias; Klose, Christian; Simons, Mikael.

In: Cell Reports, Vol. 32, 108132, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fitzner, D, Bader, JM, Penkert, H, Bergner, CG, Su, M, Weil, M-T, Surma, MA, Mann, M, Klose, C & Simons, M 2020, 'Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome', Cell Reports, vol. 32, 108132. https://doi.org/10.1016/j.celrep.2020.108132

APA

Fitzner, D., Bader, J. M., Penkert, H., Bergner, C. G., Su, M., Weil, M-T., Surma, M. A., Mann, M., Klose, C., & Simons, M. (2020). Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome. Cell Reports, 32, [108132]. https://doi.org/10.1016/j.celrep.2020.108132

Vancouver

Fitzner D, Bader JM, Penkert H, Bergner CG, Su M, Weil M-T et al. Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome. Cell Reports. 2020;32. 108132. https://doi.org/10.1016/j.celrep.2020.108132

Author

Fitzner, Dirk ; Bader, Jakob M ; Penkert, Horst ; Bergner, Caroline G ; Su, Minhui ; Weil, Marie-Theres ; Surma, Michal A ; Mann, Matthias ; Klose, Christian ; Simons, Mikael. / Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome. In: Cell Reports. 2020 ; Vol. 32.

Bibtex

@article{a00062b24cd8472abfc5dcf157da1bea,
title = "Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome",
abstract = "Gene and protein expression data provide useful resources for understanding brain function, but little is known about the lipid composition of the brain. Here, we perform quantitative shotgun lipidomics, which enables a cell-type-resolved assessment of the mouse brain lipid composition. We quantify around 700 lipid species and evaluate lipid features including fatty acyl chain length, hydroxylation, and number of acyl chain double bonds, thereby identifying cell-type- and brain-region-specific lipid profiles in adult mice, as well as in aged mice, in apolipoprotein-E-deficient mice, in a model of Alzheimer's disease, and in mice fed different diets. We also integrate lipid with protein expression profiles to predict lipid pathways enriched in specific cell types, such as fatty acid β-oxidation in astrocytes and sphingolipid metabolism in microglia. This resource complements existing brain atlases of gene and protein expression and may be useful for understanding the role of lipids in brain function.",
author = "Dirk Fitzner and Bader, {Jakob M} and Horst Penkert and Bergner, {Caroline G} and Minhui Su and Marie-Theres Weil and Surma, {Michal A} and Matthias Mann and Christian Klose and Mikael Simons",
year = "2020",
doi = "10.1016/j.celrep.2020.108132",
language = "English",
volume = "32",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",

}

RIS

TY - JOUR

T1 - Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome

AU - Fitzner, Dirk

AU - Bader, Jakob M

AU - Penkert, Horst

AU - Bergner, Caroline G

AU - Su, Minhui

AU - Weil, Marie-Theres

AU - Surma, Michal A

AU - Mann, Matthias

AU - Klose, Christian

AU - Simons, Mikael

PY - 2020

Y1 - 2020

N2 - Gene and protein expression data provide useful resources for understanding brain function, but little is known about the lipid composition of the brain. Here, we perform quantitative shotgun lipidomics, which enables a cell-type-resolved assessment of the mouse brain lipid composition. We quantify around 700 lipid species and evaluate lipid features including fatty acyl chain length, hydroxylation, and number of acyl chain double bonds, thereby identifying cell-type- and brain-region-specific lipid profiles in adult mice, as well as in aged mice, in apolipoprotein-E-deficient mice, in a model of Alzheimer's disease, and in mice fed different diets. We also integrate lipid with protein expression profiles to predict lipid pathways enriched in specific cell types, such as fatty acid β-oxidation in astrocytes and sphingolipid metabolism in microglia. This resource complements existing brain atlases of gene and protein expression and may be useful for understanding the role of lipids in brain function.

AB - Gene and protein expression data provide useful resources for understanding brain function, but little is known about the lipid composition of the brain. Here, we perform quantitative shotgun lipidomics, which enables a cell-type-resolved assessment of the mouse brain lipid composition. We quantify around 700 lipid species and evaluate lipid features including fatty acyl chain length, hydroxylation, and number of acyl chain double bonds, thereby identifying cell-type- and brain-region-specific lipid profiles in adult mice, as well as in aged mice, in apolipoprotein-E-deficient mice, in a model of Alzheimer's disease, and in mice fed different diets. We also integrate lipid with protein expression profiles to predict lipid pathways enriched in specific cell types, such as fatty acid β-oxidation in astrocytes and sphingolipid metabolism in microglia. This resource complements existing brain atlases of gene and protein expression and may be useful for understanding the role of lipids in brain function.

U2 - 10.1016/j.celrep.2020.108132

DO - 10.1016/j.celrep.2020.108132

M3 - Journal article

C2 - 32937123

VL - 32

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

M1 - 108132

ER -

ID: 248761636