Matthias Mann
Professor, head of research, Professor
- 2021
- Published
Plasma proteomic data can contain personally identifiable, sensitive information and incidental findings
Geyer, P. E., Porsdam Mann, Sebastian, Treit, P. V. & Mann, Matthias, 2021, In: Molecular and Cellular Proteomics. 20, 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein profile of fiber types in human skeletal muscle: a single-fiber proteomics study
Murgia, M., Nogara, L., Baraldo, M., Reggiani, C., Mann, Matthias & Schiaffino, S., 2021, In: Skeletal Muscle. 11, 1, 19 p., 24.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reply to "Quality control requirements for the correct annotation of lipidomics data"
Vasilopoulou, C. G., Sulek, K., Brunner, A., Meitei, N. S., Schweiger-Hufnagel, U., Meyer, S. W., Barsch, A., Mann, Matthias & Meier, F., 2021, In: Nature Communications. 12, 4 p., 4772.Research output: Contribution to journal › Journal article › Research
Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism
von Scheidt, M., Zhao, Y., de Aguiar Vallim, T. Q., Che, N., Wierer, M., Seldin, M. M., Franzén, O., Kurt, Z., Pang, S., Bongiovanni, D., Yamamoto, M., Edwards, P. A., Ruusalepp, A., Kovacic, J. C., Mann, Matthias, Björkegren, J. L. M., Lusis, A. J., Yang, X. & Schunkert, H., 2021, In: Circulation. 143, 18, p. 1809-1823Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Urinary proteome profiling for stratifying patients with familial Parkinson’s disease
Virreira Winter, S., Karayel, O., Strauss, M. T., Padmanabhan, S., Surface, M., Merchant, K., Alcalay, R. N. & Mann, Matthias, 2021, In: EMBO Molecular Medicine. 13, 3, 19 p., e13257.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
DIA-based systems biology approach unveils E3 ubiquitin ligase-dependent responses to a metabolic shift
Karayel, O., Michaelis, A. C., Mann, Matthias, Schulman, B. A. & Langlois, C. R., 22 Dec 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 51, p. 32806-32815 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Pharmacological and phosphoproteomic approaches to roles of protein kinase C in kappa opioid receptor-mediated effects in mice
Liu, J. J., Chiu, Y., Chen, C., Huang, P., Mann, Matthias & Liu-Chen, L., 15 Dec 2020, In: Neuropharmacology. 181, p. 108324Research output: Contribution to journal › Journal article › Research › peer-review
Dynamics in protein translation sustaining T cell preparedness
Wolf, T., Jin, W., Zoppi, G., Vogel, I. A., Akhmedov, M., Bleck, C. K. E., Beltraminelli, T., Rieckmann, J. C., Ramirez, N. J., Benevento, M., Notarbartolo, S., Bumann, D., Meissner, F., Grimbacher, B., Mann, Matthias, Lanzavecchia, A., Sallusto, F., Kwee, I. & Geiger, R., 6 Jul 2020, (E-pub ahead of print) In: Nature Immunology.Research output: Contribution to journal › Journal article › Research › peer-review
Atomic-resolution mapping of transcription factor-DNA interactions by femtosecond laser crosslinking and mass spectrometry
Reim, A., Ackermann, R., Font-Mateu, J., Kammel, R., Beato, M., Nolte, S., Mann, Matthias, Russmann, C. & Wierer, M., 15 Jun 2020, In: Nature Communications. 11, 1, p. 3019Research output: Contribution to journal › Journal article › Research › peer-review
Fam20C regulates protein secretion by Cab45 phosphorylation
Hecht, T. K., Blank, B., Steger, M., Lopez, V., Beck, G., Ramazanov, B., Mann, Matthias, Tagliabracci, V. & von Blume, J., 1 Jun 2020, In: The Journal of Cell Biology. 219, 6Research output: Contribution to journal › Journal article › Research › peer-review
STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer
Oberhuber, M., Pecoraro, M., Rusz, M., Oberhuber, G., Wieselberg, M., Haslinger, P., Gurnhofer, E., Schlederer, M., Limberger, T., Lagger, S., Pencik, J., Kodajova, P., Högler, S., Stockmaier, G., Grund-Gröschke, S., Aberger, F., Bolis, M., Theurillat, J-P., Wiebringhaus, R., Weiss, T. & 13 others, , Apr 2020, In: Molecular Systems Biology. 16, 4, p. e9247Research output: Contribution to journal › Journal article › Research › peer-review
Role for ribosome-associated quality control in sampling proteins for MHC class I-mediated antigen presentation
Trentini, D. B., Pecoraro, M., Tiwary, S., Cox, J., Mann, Matthias, Hipp, M. S. & Hartl, F. U., 25 Feb 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 8, p. 4099-4108 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quantitative and Dynamic Catalogs of Proteins Released during Apoptotic and Necroptotic Cell Death
Tanzer, M. C., Frauenstein, A., Stafford, C. A., Phulphagar, K., Mann, Matthias & Meissner, F., 28 Jan 2020, In: Cell Reports. 30, 4, p. 1260-1270.e5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
Batista, T. M., Jayavelu, A. K., Albrechtsen, Nicolai Jacob Wewer, Iovino, S., Lebastchi, J., Pan, H., Dreyfuss, J. M., Krook, A., Zierath, Juleen R, Mann, Matthias & Kahn, C. R., 2020, In: Cell Metabolism. 32, 5, p. 844-859.e5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Multi-Omics Approach to Liver Diseases: Integration of Single Nuclei Transcriptomics with Proteomics and HiCap Bulk Data in Human Liver
Cavalli, M., Diamanti, K., Pan, G., Spalinskas, R., Kumar, C., Deshmukh, Atul Shahaji, Mann, Matthias, Sahlén, P., Komorowski, J. & Wadelius, C., 2020, In: O M I C S: A Journal of Integrative Biology. 24, 4, 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A streamlined mass spectrometry-based proteomics workflow for large scale FFPE tissue analysis
Coscia, F., Doll, S., Bech, J. M., Schweizer, L., Mund, Andreas, Lengyel, E., Lindebjerg, J., Madsen, G. I., Moreira, José & Mann, Matthias, 2020, In: Journal of Pathology. 251, p. 110-112Research output: Contribution to journal › Journal article › Research › peer-review
Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson’s Disease
Karayel, O., Tonelli, F., Virreira Winter, S., Geyer, P. E., Fan, Y., Sammler, E. M., Alessi, D., Steger, M. & Mann, Matthias, 2020, In: Molecular and Cellular Proteomics. p. 1546-1560Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Atorvastatin for prevention of disease progression and hospitalisation in liver cirrhosis: protocol for a randomised, double-blind, placebo-controlled trial
Kimer, N., Grønbæk, H., Fred, Rikard Göran, Hansen, Torben, Deshmukh, Atul Shahaji, Mann, Matthias & Bendtsen, Flemming, 2020, In: BMJ Open. 10, 1, 7 p., e035284.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome
Fitzner, D., Bader, J. M., Penkert, H., Bergner, C. G., Su, M., Weil, M., Surma, M. A., Mann, Matthias, Klose, C. & Simons, M., 2020, In: Cell Reports. 32, 21 p., 108132.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease
Hoffmann, Saskia, Pentakota, S., Mund, Andreas, Haahr, Peter Thorlund, Coscia, F., Gallo, M., Mann, Matthias, Taylor, Nicholas M I & Mailand, Niels, 2020, In: EMBO Reports. 21, 10, 14 p., e50662.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrative Analysis Identifies Key Molecular Signatures Underlying Neurodevelopmental Deficits in Fragile X Syndrome
Utami, K. H., Skotte, Niels Henning, Colaço, A. R., Yusof, N. A. B. M., Sim, B., Yeo, X. Y., Bae, H., Garcia-Miralles, M., Radulescu, C. I., Chen, Q., Chaldaiopoulou, G., Liany, H., Nama, S., Peteri, U. A., Sampath, P., Castrén, M. L., Jung, S., Mann, Matthias & Pouladi, M. A., 2020, In: Biological Psychiatry. 88, 6, p. 500-511Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis
Karayel, O., Xu, P., Bludau, I., Bhoopalan, S. V., Yao, Y., Rita, F. C. A., Santos, A., Schulman, B. A., Alpi, A. F., Weiss, M. J. & Mann, Matthias, 2020, In: Molecular Systems Biology. 16, 12, 22 p., 9813.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
LifeTime and improving European healthcare through cell-based interceptive medicine
Rajewsky, N., Almouzni, G., Gorski, S. A., Aerts, S., Amit, I., Bertero, M. G., Bock, C., Bredenoord, A. L., Cavalli, G., Chiocca, S., Clevers, H., De Strooper, B., Eggert, A., Ellenberg, J., Fernández, X. M., Figlerowicz, M., Gasser, S. M., Hubner, N., Kjems, J., Knoblich, J. A. & 31 others, , 2020, In: Nature. 587, 7834, p. 377-386 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
Ngo, B., Kim, E., Osorio-Vasquez, V., Doll, S., Bustraan, S., Liang, R. J., Luengo, A., Davidson, S. M., Ali, A., Ferraro, G. B., Fischer, G. M., Eskandari, R., Kang, D. S., Ni, J., Plasger, A., Rajasekhar, V. K., Kastenhuber, E. R., Bacha, S., Sriram, R. K., Stein, B. D. & 20 others, , 2020, In: Cancer Discovery. 10, 9, p. 1352-1373Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MiT/TFEfactors controlER-phagy via transcriptional regulation ofFAM134B
Cinque, L., De Leonibus, C., Iavazzo, M., Krahmer, N., Intartaglia, D., Salierno, F. G., De Cegli, R., Di Malta, C., Svelto, M., Lanzara, C., Maddaluno, M., Wanderlingh, L. G., Huebner, A. K., Cesana, M., Bonn, F., Polishchuk, E., Huebner, C. A., Conte, I., Dikic, I., Mann, M. & 4 others, , 2020, In: EMBO Journal. 39, 17, 22 p., 105696.Research output: Contribution to journal › Journal article › Research › peer-review
Pervasive functional translation of noncanonical human open reading frames
Chen, J., Brunner, A., Cogan, J. Z., Nuñez, J. K., Fields, A. P., Adamson, B., Itzhak, D. N., Li, J. Y., Mann, Matthias, Leonetti, M. D. & Weissman, J. S., 2020, In: Science. 367, 6482, p. 1140-1146 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasma proteome profiles treatment efficacy of incretin dual agonism in diet-induced obese female and male mice
Sachs, S., Niu, Lili, Geyer, P., Jall, S., Kleinert, Maximilian, Feuchtinger, A., Stemmer, K., Brielmeier, M., Finan, B., DiMarchi, R. D., Tschop, M. H., Albrechtsen, Nicolai Jacob Wewer, Mann, Matthias, Mueller, T. D. & Hofmann, S. M., 2020, In: Diabetes, Obesity and Metabolism. 23, 1, p. 195-207 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease
Bader, J. M., Geyer, P. E., Müller, J. B., Strauss, M. T., Koch, M., Leypoldt, F., Koertvelyessy, P., Bittner, D., Schipke, C. G., Incesoy, E. I., Peters, O., Deigendesch, N., Simons, M., Jensen, Majken Karoline, Zetterberg, H. & Mann, Matthias, 2020, In: Molecular Systems Biology. 16, 6, 17 p., e9356.Research output: Contribution to journal › Journal article › Research › peer-review
SHP1 regulates a STAT6-ITGB3 axis in FLT3ITD-positive AML cells
Reich, D., Kresinsky, A., Müller, J. P., Bauer, R., Kallenbach, J., Schnoeder, T. M., Heidel, F. H., Fässler, R., Mann, Matthias, Böhmer, F. & Jayavelu, A. K., 2020, In: Leukemia. 34, p. 1444-1449Research output: Contribution to journal › Letter › Research › peer-review
- Published
Sequencing of the First Draft of the Human Acetylome
Choudhary, Chunaram & Mann, Matthias, 2020, In: Clinical Chemistry. 66, 6, p. 852-853 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin
Dyring-Andersen, Beatrice, Løvendorf, M. B., Coscia, F., Santos, A., Møller, L. B. P., Colaço, A. R., Niu, Lili, Bzorek, M., Doll, S., Andersen, J. L., Clark, R. A., Skov, Lone, Teunissen, M. B. M. & Mann, Matthias, 2020, In: Nature Communications. 11, 1, 5587.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Origins of Organellar Mapping by Protein Correlation Profiling
Mann, Matthias, 2020, In: Proteomics. 20, 23, 4 p., e1900330.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The proteome landscape of the kingdoms of life
Müller, J. B., Geyer, P. E., Colaço, A. R., Treit, P. V., Strauss, M. T., Oroshi, M., Doll, S., Virreira Winter, S., Bader, J. M., Köhler, N., Theis, F., Santos, A. & Mann, Matthias, 2020, In: Nature. 582, p. 592-596Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
Vasilopoulou, C. G., Sulek, K., Brunner, A., Meitei, N. S., Schweiger-Hufnagel, U., Meyer, S. W., Barsch, A., Mann, Matthias & Meier, F., 2020, In: Nature Communications. 11, 1, 11 p., 331.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
diaPASEF: parallel accumulation-serial fragmentation combined with data-independent acquisition
Meier, F., Brunner, A., Frank, M., Ha, A., Bludau, I., Voytik, E., Kaspar-Schoenefeld, S., Lubeck, M., Raether, O., Bache, N., Aebersold, R., Collins, B. C., Roest, H. L. & Mann, Matthias, 2020, In: Nature Methods. 17, 12, p. 1229-1236Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
A mass spectrometry guided approach for the identification of novel vaccine candidates in gram-negative pathogens
Hornburg, D., Kruse, T., Anderl, F., Daschkin, C., Semper, R. P., Klar, K., Guenther, A., Mejías-Luque, R., Schneiderhan-Marra, N., Mann, Matthias, Meissner, F. & Gerhard, M., 22 Nov 2019, In: Scientific Reports. 9, 1, p. 17401Research output: Contribution to journal › Journal article › Research › peer-review
Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease
Ravell, J. C., Matsuda-Lennikov, M., Chauvin, S. D., Zou, J., Biancalana, M., Deeb, S. J., Price, S., Su, H. C., Notarangelo, G., Jiang, P., Morawski, A., Kanellopoulou, C., Binder, K. W., Mukherjee, R., Anibal, J. T., Sellers, B., Zheng, L., He, T., George, A. B., Pittaluga, S. & 34 others, , 5 Nov 2019, (E-pub ahead of print) In: The Journal of Clinical Investigation.Research output: Contribution to journal › Journal article › Research › peer-review
Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly
Qiao, S., Langlois, C. R., Chrustowicz, J., Sherpa, D., Karayel, O., Hansen, F. M., Beier, V., von Gronau, S., Bollschweiler, D., Schäfer, T., Alpi, A. F., Mann, Matthias, Prabu, J. R. & Schulman, B. A., 1 Nov 2019, (E-pub ahead of print) In: Molecular Cell.Research output: Contribution to journal › Journal article › Research › peer-review
The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1
Prestel, M., Prell-Schicker, C., Webb, T., Malik, R., Lindner, B., Ziesch, N., Rex-Haffner, M., Röh, S., Viturawong, T., Lehm, M., Mokry, M., den Ruijter, H., Haitjema, S., Asare, Y., Söllner, F., Najafabadi, M. G., Aherrahrou, R., Civelek, M., Samani, N. J., Mann, M. & 2 others, , Oct 2019, In: Stroke. 50, 10, p. 2651-2660 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasma proteome profiling discovers potential biomarkers of non-alcoholic fatty liver disease
Niu, Lili, Gupta, R., Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Mueller, T. D., Tschoep, M. H., Hofmann, S. M. & Mann, Matthias, Aug 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S71 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer
Audehm, S., Glaser, M., Pecoraro, M., Bräunlein, E., Mall, S., Klar, R., Effenberger, M., Albers, J., Bianchi, H. D. O., Peper, J., Yusufi, N., Busch, D. H., Stevanović, S., Mann, Matthias, Antes, I. & Krackhardt, A. M., 28 Jun 2019, In: Frontiers in Immunology. 10, 1485.Research output: Contribution to journal › Journal article › Research › peer-review
Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis
Marinkovic, M., Fuoco, C., Sacco, F., Cerquone Perpetuini, A., Giuliani, G., Micarelli, E., Pavlidou, T., Petrilli, L. L., Reggio, A., Riccio, F., Spada, F., Vumbaca, S., Zuccotti, A., Castagnoli, L., Mann, Matthias, Gargioli, C. & Cesareni, G., Jun 2019, In: Life Science Alliance. 2, 3Research output: Contribution to journal › Journal article › Research › peer-review
Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
Yang, P., Humphrey, S. J., Cinghu, S., Pathania, R., Oldfield, A. J., Kumar, D., Perera, D., Yang, J. Y. H., James, D. E., Mann, Matthias & Jothi, R., 22 May 2019, In: Cell Systems. 8, 5, p. 427-445.e10Research output: Contribution to journal › Journal article › Research › peer-review
Cortical circuit alterations precede motor impairments in Huntington's disease mice
Burgold, J., Schulz-Trieglaff, E. K., Voelkl, K., Gutiérrez-Ángel, S., Bader, J. M., Hosp, F., Mann, Matthias, Arzberger, T., Klein, R., Liebscher, S. & Dudanova, I., 29 Apr 2019, In: Scientific Reports. 9, 1, p. 6634Research output: Contribution to journal › Journal article › Research › peer-review
Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets
Sacco, F., Seelig, A., Humphrey, S. J., Krahmer, N., Volta, F., Reggio, A., Marchetti, P., Gerdes, J. & Mann, Matthias, 7 Mar 2019, (E-pub ahead of print) In: Cell Metabolism.Research output: Contribution to journal › Journal article › Research › peer-review
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape
Hubel, P., Urban, C., Bergant, V., Schneider, W. M., Knauer, B., Stukalov, A., Scaturro, P., Mann, A., Brunotte, L., Hoffmann, H. H., Schoggins, J. W., Schwemmle, M., Mann, Matthias, Rice, C. M. & Pichlmair, A., 4 Mar 2019, (E-pub ahead of print) In: Nature Immunology.Research output: Contribution to journal › Journal article › Research › peer-review
An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
Angelidis, I., Simon, L. M., Fernandez, I. E., Strunz, M., Mayr, C. H., Greiffo, F. R., Tsitsiridis, G., Ansari, M., Graf, E., Strom, T., Nagendran, M., Desai, T., Eickelberg, O., Mann, Matthias, Theis, F. J. & Schiller, H. B., 27 Feb 2019, In: Nature Communications. 10, 1, p. 963Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A spatially resolved proteomic atlas of human skin and its associated immune system
Dyring-Andersen, Beatrice, Coscia, F., Santos, A., Løvendorf, M. B., Sørensen, L. B. P., Niu, Lili, Andersen, J. L., Clark, R., Skov, L., Teunissen, M. B. & Mann, Matthias, 2019, In: Journal of Investigative Dermatology. 139, 9, suppl., p. S259 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
A spatially resolved proteomic atlas of psoriatic skin
Dyring-Andersen, Beatrice, Lovendorf, M. B., Santos, A., Coscia, F., Sørensen, L. B. P., Niu, Lili, Andersen, J. L., Teunissen, M. B., Skov, L. & Mann, Matthias, 2019, In: Journal of Investigative Dermatology. 139, 9, suppl., p. S260 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Catching Lipid Droplet Contacts by Proteomics
Krahmer, N. & Mann, Matthias, 2019, In: Contact. 2, p. 1-8 8 p.Research output: Contribution to journal › Review › Research › peer-review
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Development, use, application of novel TIMS-Tof system
Mann, Matthias, 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S20 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex
Zhang, G., Kruse, Thomas, Guasch Boldú, C., Garvanska, Dimitriya Hristoforova, Coscia, F., Mann, Matthias, Barisic, Marin & Nilsson, Jakob, 2019, In: E M B O Journal. 38, 7, e100977.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity
Seitz, S., Kwon, Y., Hartleben, G., Juelg, J., Sekar, R., Krahmer, N., Najafi, B., Loft, A., Gancheva, S., Stemmer, K., Feuchtinger, A., de Angelis, M. H., Mueller, T. D., Mann, M., Blueher, M., Roden, M., Diaz, M. B., Behrends, C., Gilleron, J., Herzig, S. & 1 others, , 2019, In: Nature Metabolism. 1, p. 1009-1026Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MaxQuant.Live enables global targeting of more than 25,000 peptides
Wichmann, C., Meier, F., Virreira Winter, S., Brunner, A., Cox, J. & Mann, Matthias, 2019, In: Molecular and Cellular Proteomics. 18, 5, p. 982-994 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk
Hart, P. C., Kenny, H. A., Grassl, N., Watters, K. M., Litchfield, L. M., Coscia, F., Blaženović, I., Ploetzky, L., Fiehn, O., Mann, Matthias, Lengyel, E. & Romero, I. L., 2019, In: Cell Reports. 29, 12, p. 4086-4098.e6Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metallopeptidase Inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer
Nordgaard, C., Doll, S., Matos, A. L. D. S. A., Høeberg, M., Kazi, J. U., Friis, S., Stenvang, Jan, Rönnstrand, L., Mann, Matthias & Moreira, José, 2019, In: Molecular Oncology. 13, 12, p. 2646-2662Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mobi-DIK (Ion Mobility DIA Analysis Kit): Targeted analysis software for diaPASEF data improves proteome coverage
Ha, A., Frank, M., Meier, F., Brunner, A., Kaspar-Schoenefeld, S., Koch, S., Lubeck, M., Raether, O., Collins, B. C., Aebersold, R., Mann, Matthias & Rost, H., 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S17 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Myosin binding protein H-like (MYBPHL): a promising biomarker to predict atrial damage
Lahm, H., Dressen, M., Beck, N., Doppler, S., Deutsch, M., Matsushima, S., Neb, I., Koenig, K. C., Sideris, K., Voss, S., Eschenbach, L., Puluca, N., Deisenhofer, I., Doll, S., Holdenrieder, S., Mann, Matthias, Lange, R. & Krane, M., 2019, In: Scientific Reports. 9, 8 p., 9986.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurodevelopmental deficits in human isogenic fragile x syndrome neurons
Utami, K., Skotte, N. H., Colaco, A. R. -., Yusof, N. A. B. M., Sim, B., Yeo, X. Y., Bae, H., Garcia-Miralles, M., Radulescu, C., Jung, S., Mann, Matthias & Pouladi, M., 2019, In: Journal of Neurochemistry. 150, p. 103 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Parallel accumulation - serial fragmentation combined with data-independent acquisition (diaPASEF)
Meier, F., Brunner, A., Frank, M., Ha, A., Voytik, E., Kaspar-Schoenefeld, S., Lubeck, M., Raether, O., Aebersold, R., Collins, B. C., Roest, H. L. & Mann, Matthias, 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S17 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Plasma Proteome Profiling to detect and avoid sample-related biases in biomarker studies
Geyer, P. E., Voytik, E., Treit, P. V., Doll, S., Kleinhempel, A., Niu, Lili, Müller, J. B., Buchholtz, M., Bader, J. M., Teupser, D., Holdt, L. M. & Mann, Matthias, 2019, In: EMBO Molecular Medicine. 11, 11, e10427.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Niu, Lili, Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Treit, P. V., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Müller, T. D., Tschöp, M. H., Hofmann, S. M. & Mann, Matthias, 2019, In: Molecular Systems Biology. 15, 16 p., e8793.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomics of Cytochrome c Oxidase-Negative versus -Positive Muscle Fiber Sections in Mitochondrial Myopathy
Murgia, M., Tan, J., Geyer, P. E., Doll, S., Mann, Matthias & Klopstock, T., 2019, In: Cell Reports. 29, 12, p. 3825-3834 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts
Eckert, M. A., Coscia, F., Chryplewicz, A., Chang, J. W., Hernandez, K. M., Pan, S., Tienda, S. M., Nahotko, D. A., Li, G., Blaženović, I., Lastra, R. R., Curtis, M., Yamada, S. D., Perets, R., McGregor, S. M., Andrade, J., Fiehn, O., Moellering, R. E., Mann, Matthias & Lengyel, E., 2019, In: Nature. 569, 7758, p. 723-728Research output: Contribution to journal › Letter › Research › peer-review
- Published
Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine
Deshmukh, A. S., Peijs, L., Beaudry, J. L., Jespersen, N. Z., Nielsen, C. H., Ma, T., Brunner, A. D., Larsen, T. J., Bayarri-Olmos, R., Prabhakar, B. S., Helgstrand, C., Severinsen, M. C. K., Holst, B., Kjaer, A., Tang-Christensen, M., Sanfridson, A., Garred, P., Privé, G. G., Pedersen, B. K., Gerhart-Hines, Z. & 4 others, , 2019, In: Cell Metabolism. 30, 5, p. 963-975.e7 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quick and clean: Cracking sentences encoded in E. coli by LC-MS/MS, de novo sequencing, and dictionary search
Niu, Lili & Mann, Matthias, 2019, In: EuPA Open Proteomics. 22-23, p. 30-35 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts
Larsen, N. B., Gao, A. O., Sparks, J. L., Gallina, I., Wu, R. A., Mann, Matthias, Räschle, M., Walter, J. C. & Duxin, Julien, 2019, In: Molecular Cell. 73, 3, p. 574-588.e7 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Response to Raaijmakers & Medema
Zhang, G., Kruse, Thomas, Boldú, C. G., Garvanska, Dimitriya Hristoforova, Coscia, F., Mann, Matthias, Barisic, Marin & Nilsson, Jakob, 2019, In: The EMBO Journal. 38, 22, 5 p., e103547.Research output: Contribution to journal › Comment/debate › Research
- Published
SILAC-based quantitative mass spectrometry-based proteomics quantifies endoplasmic reticulum stress in whole HeLa cells
Itzhak, D. N., Sacco, F., Nagaraj, N., Tyanova, S., Mann, Matthias & Murgia, M., 2019, In: Disease Models & Mechanisms. 12, 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sleep-wake cycles drive daily dynamics of synaptic phosphorylation
Brüning, F., Noya, S. B., Bange, T., Koutsouli, S., Rudolph, J. D., Tyagarajan, S. K., Cox, J., Mann, Matthias, Brown, S. A. & Robles, M. S., 2019, In: Science (New York, N.Y.). 366, 6462, eaav3617 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair
Sparks, J. L., Chistol, G., Gao, A. O., Räschle, M., Larsen, N. B., Mann, Matthias, Duxin, Julien & Walter, J. C., 2019, In: Cell. 176, 1-2, p. 167-181.e21Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Case for Proteomics and Phospho-Proteomics in Personalized Cancer Medicine
Doll, S., Gnad, F. & Mann, Matthias, 2019, In: Proteomics - Clinical Applications. 13, 2, 10 p., e1800113.Research output: Contribution to journal › Review › Research › peer-review
- Published
The ever expanding scope of electrospray mass spectrometry-a 30 year journey
Mann, Matthias, 2019, In: Nature Communications. 10, 3744.Research output: Contribution to journal › Comment/debate › Research
- Published
The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep
Noya, S. B., Colameo, D., Brüning, F., Spinnler, A., Mircsof, D., Opitz, L., Mann, Matthias, Tyagarajan, S. K., Robles, M. S. & Brown, S. A., 2019, In: Science. 366, 6462, eaav2642 .Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Proteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future
Comes, A. L., Papiol, S., Mueller, T., Geyer, P. E., Mann, Matthias & Schulze, T. G., 1 Dec 2018, In: Translational Psychiatry. 8, p. 1-15 15 p., 160.Research output: Contribution to journal › Review › Research › peer-review
- Published
The proteome of prostate cancer bone metastasis reveals heterogeneity with prognostic implications
Iglesias Gato, Diego, Thysell, E., Tyanova, S., Crnalic, S., Santos, A., Lima, T. S., Geiger, T., Cox, J., Widmark, A., Bergh, A., Mann, Matthias, Flores-Morales, A. & Wikström, P., 1 Nov 2018, In: Clinical Cancer Research. 24, 21, p. 5433-5444 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex
Link, S., Spitzer, R. M. M., Sana, M., Torrado, M., Völker-Albert, M. C., Keilhauer, E. C., Burgold, T., Pünzeler, S., Low, J. K. K., Lindström, I., Nist, A., Regnard, C., Stiewe, T., Hendrich, B., Imhof, A., Mann, Matthias, Mackay, J. P., Bartkuhn, M. & Hake, S. B., 16 Oct 2018, In: Nature Communications. 9, 1, p. 4300Research output: Contribution to journal › Journal article › Research › peer-review
UBL3 modification influences protein sorting to small extracellular vesicles
Ageta, H., Ageta-Ishihara, N., Hitachi, K., Karayel, O., Onouchi, T., Yamaguchi, H., Kahyo, T., Hatanaka, K., Ikegami, K., Yoshioka, Y., Nakamura, K., Kosaka, N., Nakatani, M., Uezumi, A., Ide, T., Tsutsumi, Y., Sugimura, H., Kinoshita, M., Ochiya, T., Mann, M. & 2 others, , 26 Sep 2018, In: Nature Communications. 9, 1, p. 3936Research output: Contribution to journal › Journal article › Research › peer-review
Phosphoproteomic approach for agonist-specific signaling in mouse brains: mTOR pathway is involved in κ opioid aversion
Liu, J. J., Chiu, Y., DiMattio, K. M., Chen, C., Huang, P., Gentile, T. A., Muschamp, J. W., Cowan, A., Mann, Matthias & Liu-Chen, L., 20 Jul 2018, (E-pub ahead of print) In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.Research output: Contribution to journal › Journal article › Research › peer-review
Compartment-resolved Proteomic Analysis of Mouse Aorta during Atherosclerotic Plaque Formation Reveals Osteoclast-specific Protein Expression
Wierer, M., Prestel, M., Schiller, H., Yan, G., Schaab, C., Azghandi, S., Werner, J., Kessler, T., Malik, R., Murgia, M., Aherrahrou, Z., Schunkert, H., Dichgans, M. & Mann, Matthias, Feb 2018, In: Molecular and Cellular Proteomics.Research output: Contribution to journal › Journal article › Research › peer-review
Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase
Lis, P., Burel, S., Steger, M., Mann, Matthias, Brown, F., Diez, F., Tonelli, F., Holton, J. L., Ho, P. W., Ho, S., Chou, M., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R., Jan 2018, In: Biochemical Journal. 475, 1, 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy
Chheda, Z. S., Kohanbash, G., Okada, K., Jahan, N., Sidney, J., Pecoraro, M., Yang, X., Carrera, D. A., Downey, K. M., Shrivastav, S., Liu, S., Lin, Y., Lagisetti, C., Chuntova, P., Watchmaker, P. B., Mueller, S., Pollack, I. F., Rajalingam, R., Carcaboso, A. M., Mann, M. & 4 others, , Jan 2018, In: The Journal of Experimental Medicine. 215, 1, p. 141-157 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
The non-classical nuclear import carrier Transportin 1 modulates circadian rhythms through its effect on PER1 nuclear localization
Korge, S., Maier, B., Brüning, F., Ehrhardt, L., Korte, T., Mann, Matthias, Herrmann, A., Robles, M. S. & Kramer, A., Jan 2018, In: P L o S Genetics. 14, 1, p. e1007189Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel LC system embeds analytes in pre-formed gradients for rapid, ultra-robust proteomics
Bache, N., Geyer, P. E., Bekker-Jensen, D. B., Hørning, O., Falkenby, L., Treit, P. V., Doll, S., Paron, I., Müller, J. B., Meier, F., Olsen, Jesper Velgaard, Vorm, O. & Mann, Matthias, 2018, In: Molecular and Cellular Proteomics. 17, 11, p. 2284-2296 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
BoxCar acquisition method enables single-shot proteomics at a depth of 10,000 proteins in 100 minutes
Meier, F., Geyer, P. E., Virreira Winter, S., Cox, J. & Mann, Matthias, 2018, In: Nature Methods. 15, 6, p. 440-448 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Constructing a cell-type resolved human liver proteome atlas: THU-034
Niu, Lili, Geyer, P. & Mann, Matthias, 2018, In: Journal of Hepatology. 68, p. S138-S139Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
EASI-tag enables accurate multiplexed and interference-free MS2-based proteome quantification
Virreira Winter, S., Meier, F., Wichmann, C., Cox, J., Mann, Matthias & Meissner, F., 2018, In: Nature Methods. 15, 7, p. 527-530 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform
Humphrey, S. J., Karayel, O., James, D. E. & Mann, Matthias, 2018, In: Nature Protocols (Print). 13, p. 1897-1916 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo brain GPCR signaling elucidated by phosphoproteomics
Liu, J. J., Sharma, K., Zangrandi, L., Chen, C., Humphrey, S. J., Chiu, Y., Spetea, M., Liu-Chen, L., Schwarzer, C. & Mann, Matthias, 2018, In: Science (New York, N.Y.). 360, 6395, p. 1-11Research output: Contribution to journal › Journal article › Research › peer-review
In-depth proteomic analyses of (greenlip abalone) nacre and prismatic organic shell matrix
Mann, K., Cerveau, N., Gummich, M., Fritz, M., Mann, Matthias & Jackson, D. J., 2018, In: Proteome Science. 16, p. 11Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanism of replication-coupled DNA-protein crosslink proteolysis by SPRTN and the proteasome
Gao, A., Larsen, N., Sparks, J., Gallina, I., Mann, Matthias, Räschle, M., Walter, J. & Duxin, Julien, 2018, bioRxiv, 54 p.Research output: Working paper › Preprint › Research
Molecular and structural architecture of polyQ aggregates in yeast
Gruber, A., Hornburg, D., Antonin, M., Krahmer, N., Collado, J., Schaffer, M., Zubaite, G., Lüchtenborg, C., Sachsenheimer, T., Brügger, B., Mann, Matthias, Baumeister, W., Hartl, F. U., Hipp, M. S. & Fernández-Busnadiego, R., 2018, In: Proceedings of the National Academy of Sciences of the United States of America.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer
Coscia, F., Lengyel, E., Duraiswamy, J., Ashcroft, B., Bassani-Sternberg, M., Wierer, M., Johnson, A., Wroblewski, K., Montag, A., Yamada, S. D., López-Méndez, B., Nilsson, Jakob, Mund, Andreas, Mann, Matthias & Curtis, M., 2018, In: Cell. 175, 1, p. 159-170.e16Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Online parallel accumulation - serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer
Meier, F., Brunner, A., Koch, S., Koch, H., Lubeck, M., Krause, M., Goedecke, N., Decker, J., Kosinski, T., Park, M. A., Bache, N., Hoerning, O., Cox, J., Räther, O. & Mann, Matthias, 2018, In: Molecular and Cellular Proteomics. 17, 12, p. 2534-2545Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Opinion: Advocating for science progress as a human right
Porsdam Mann, Sebastian, Donders, Y., Mitchell, C., Bradley, V. J., Chou, M. F., Mann, Matthias, Church, G. & Porsdam, Helle, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 43, p. 10820-10823 4 p.Research output: Contribution to journal › Comment/debate › Communication
- Published
Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis
Krahmer, N., Najafi, B., Schueder, F., Quagliarini, F., Steger, M., Seitz, S., Kasper, R., Salinas, F., Cox, J., Uhlenhaut, N. H., Walther, T. C., Jungmann, R., Zeigerer, A., Borner, G. H. H. & Mann, Matthias, 2018, In: Developmental Cell. 47, 2, p. 205-221.E7Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery
Albrechtsen, Nicolai Jacob Wewer, Geyer, P. E., Doll, S., Treit, P. V., Bojsen-Møller, K. N., Martinussen, C., Jørgensen, N. B., Torekov, Signe Sørensen, Meier, F., Niu, Lili, Santos, A., Keilhauer, E. C., Holst, Jens Juul, Madsbad, Sten & Mann, Matthias, 2018, In: Cell Systems. 7, 6, p. 601-612Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomics in the Study of Liver Diseases
Niu, Lili, Geyer, P. E. & Mann, Matthias, 2018, The Human Gut-Liver-Axis in Health and Disease. Krag, A. & Hansen, T. (eds.). Springer, p. 165-193Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Quality control for plasma and cerebrospinal fluid samples using mass spectrometry
Skotte, N. H., Geyer, P. E., Steger, M., Treit, P. V., Voytik, E., Hellem, M. N., Nielsen, Jørgen Erik & Mann, Matthias, 2018, In: Journal of Neurology, Neurosurgery and Psychiatry. 89, p. A31-A32Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Rapid proteomic analysis for solid tumors reveals LSD1 as a drug target in an end-stage cancer patient
Doll, S., Kriegmair, M. C., Santos, A., Wierer, M., Coscia, F., Neil, H. M., Porubsky, S., Geyer, P. E., Mund, Andreas, Nuhn, P. & Mann, Matthias, 2018, In: Molecular Oncology. 12, 8, p. 1296-1307 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5650809
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2003
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Activation of the ATR kinase by the RPA-binding protein ETAA1
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Region and cell-type resolved quantitative proteomic map of the human heart
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Revisiting biomarker discovery by plasma proteomics
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