Matthias Mann

Matthias Mann

Professor, head of research, Professor


  1. Published

    In-Depth Proteomic Map of Innate Lymphoid Cells from Healthy Human Skin and Blood

    Teunissen, M. B. M., Pilgaard Møller, L. B., Løvendorf, Marianne Bengtson, Skov, Lone, Bonefeld, Charlotte Menne, Bekkenk, M. W., Clark, R. A., Mann, Matthias & Dyring-Andersen, Beatrice, 2024, In: Journal of Investigative Dermatology. 144, 2, 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Homology-driven assembly of NOn-redundant protEin sequence sets (NOmESS) for mass spectrometry

    Temu, T., Mann, Matthias, Räschle, M. & Cox, J., 1 May 2016, In: Bioinformatics (Online). 32, 9, p. 1417-9 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling

    Tanzer, M. C., Bludau, I., Stafford, C. A., Hornung, V. & Mann, Matthias, 18 Oct 2021, In: Nature Communications. 12, 1, p. 6053

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Quantitative and Dynamic Catalogs of Proteins Released during Apoptotic and Necroptotic Cell Death

    Tanzer, M. C., Frauenstein, A., Stafford, C. A., Phulphagar, K., Mann, Matthias & Meissner, F., 28 Jan 2020, In: Cell Reports. 30, 4, p. 1260-1270.e5

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway

    Takahashi, M., Lio, C. J., Campeau, A., Steger, M., Ay, F., Mann, Matthias, Gonzalez, D. J., Jain, M. & Sharma, S., Apr 2021, In: Nature Immunology. 22, 4, p. 485-496 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila

    Tain, L. S., Sehlke, R., Meilenbrock, R. L., Leech, T., Paulitz, J., Chokkalingam, M., Nagaraj, N., Grönke, S., Fröhlich, J., Atanassov, I., Mann, Matthias, Beyer, A. & Partridge, L., 21 Apr 2021, In: eLife. 10

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance

    Tain, L. S., Sehlke, R., Jain, C., Chokkalingam, M., Nagaraj, N., Essers, P., Rassner, M., Grönke, S., Froelich, J., Dieterich, C., Mann, Matthias, Alic, N., Beyer, A. & Partridge, L., 15 Sep 2017, In: Molecular Systems Biology. 13, 9, p. 939

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The Proteome of Hand Eczema Assessed by Tape Stripping

    Sølberg, J. B. K., Quaade, A. S., Drici, L., Sulek, K., Ulrich, N. H., Løvendorf, Marianne Bengtson, Thyssen, Jacob Pontoppidan, Mann, Matthias, Dyring-Andersen, Beatrice & Johansen, Jeanne Duus, 2023, In: Journal of Investigative Dermatology. 143, p. 1559-1568

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

    Stukalov, A., Girault, V., Grass, V., Karayel, O., Bergant, V., Urban, C., Haas, D. A., Huang, Y., Oubraham, L., Wang, A., Hamad, M. S., Piras, A., Hansen, F. M., Tanzer, M. C., Paron, I., Zinzula, L., Engleitner, T., Reinecke, M., Lavacca, T. M., Ehmann, R. & 10 others, Wölfel, R., Jores, J., Kuster, B., Protzer, U., Rad, R., Ziebuhr, J., Thiel, V., Scaturro, P., Mann, Matthias & Pichlmair, A., 12 Apr 2021, (E-pub ahead of print) In: Nature.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. A SILAC-based approach identifies substrates of caspase-dependent cleavage upon TRAIL-induced apoptosis

    Stoehr, G., Schaab, C., Graumann, J. & Mann, Matthias, May 2013, In: Molecular & Cellular Proteomics. 12, 5, p. 1436-50 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Full Mass Range ΦSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis

    Steigerwald, S., Sinha, A., Fort, K. L., Zeng, W., Niu, Lili, Wichmann, C., Kreutzmann, A., Mourad, D., Aizikov, K., Grinfeld, D., Makarov, A., Mann, Matthias & Meier, F., 2024, In: Molecular and Cellular Proteomics. 12 p., 100713.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

    Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., Baptista, M. A., Fiske, B. K., Fell, M. J., Morrow, J. A., Reith, A. D., Alessi, D. R. & Mann, Matthias, 29 Jan 2016, In: eLife. 5

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

    Steger, M., Diez, F., Dhekne, H. S., Lis, P., Nirujogi, R. S., Karayel, O., Tonelli, F., Martinez, T. N., Lorentzen, E., Pfeffer, S. R., Alessi, D. R. & Mann, Matthias, 10 Nov 2017, In: eLife. 6

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation

    Stafford, C. A., Gassauer, A. M., de Oliveira Mann, C. C., Tanzer, M. C., Fessler, E., Wefers, B., Nagl, D., Kuut, G., Sulek, K., Vasilopoulou, C., Schwojer, S. J., Wiest, A., Pfautsch, M. K., Wurst, W., Yabal, M., Fröhlich, T., Mann, Matthias, Gisch, N., Jae, L. T. & Hornung, V., 2022, In: Nature. 609, p. 590-596 28 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation

    Sparmann, A., Xie, Y., Verhoeven, E., Vermeulen, M., Lancini, C., Gargiulo, G., Hulsman, D., Mann, Matthias, Knoblich, J. A. & van Lohuizen, M., 29 May 2013, In: E M B O Journal. 32, 11, p. 1598-612 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

    Sparks, J. L., Chistol, G., Gao, A. O., Räschle, M., Larsen, N. B., Mann, Matthias, Duxin, Julien & Walter, J. C., 2019, In: Cell. 176, 1-2, p. 167-181.e21

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Homology-directed repair protects the replicating genome from metabolic assaults

    Somyajit, K., Spies, J., Coscia, F., Kirik, U., Rask, M., Lee, J., Neelsen, K. J., Mund, Andreas, Jensen, Lars Juhl, Paull, T. T., Mann, Matthias & Lukas, Jiri, 2021, In: Developmental Cell. 56, 4, p. 461-477.e7

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Synchro-PASEF allows precursor-specific fragment ion extraction and interference removal in data-independent acquisition

    Skowronek, P., Krohs, F., Lubeck, M., Wallmann, G., Itang, E. C. M., Koval, P., Wahle, M., Thielert, Marvin Christoffer, Meier, F., Willems, S., Raether, O. & Mann, Matthias, 2023, In: Molecular and Cellular Proteomics. 22, 2, 14 p., 100489.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Rapid and In-Depth Coverage of the (Phospho-)Proteome With Deep Libraries and Optimal Window Design for dia-PASEF

    Skowronek, P., Thielert, Marvin Christoffer, Voytik, E., Tanzer, M. C., Hansen, F. M., Willems, S., Karayel, O., Brunner, A., Meier, F. & Mann, Matthias, 2022, In: Molecular and Cellular Proteomics. 21, 9, 15 p., 100279.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Quality control for plasma and cerebrospinal fluid samples using mass spectrometry

    Skotte, N. H., Geyer, P. E., Steger, M., Treit, P. V., Voytik, E., Hellem, M. N., Nielsen, Jørgen Erik & Mann, Matthias, 2018, In: Journal of Neurology, Neurosurgery and Psychiatry. 89, p. A31-A32

    Research output: Contribution to journalConference abstract in journalResearch

  21. C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons

    Sivadasan, R., Hornburg, D., Drepper, C., Frank, N., Jablonka, S., Hansel, A., Lojewski, X., Sterneckert, J., Hermann, A., Shaw, P. J., Ince, P. G., Mann, Matthias, Meissner, F. & Sendtner, M., Dec 2016, In: Nature Neuroscience. 19, 12, p. 1610-1618 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness

    Sirinian, C., Papanastasiou, A. D., Karayel, O., Degn, S. E., Peroukidis, S., Chaniotis, D., Nonni, A., Repanti, M., Kriegsmann, M., Makatsoris, T., Koutras, A., Mann, Matthias & Kalofonos, H. P., Nov 2022, In: Neoplasia (New York, N.Y.). 33, p. 100836

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. In-gel digestion for mass spectrometric characterization of proteins and proteomes

    Shevchenko, A., Tomas, H., Havlis, J., Olsen, Jesper Velgaard & Mann, Matthias, 2006, In: Nature Protocols (Print Edition). 1, 6, p. 2856-60 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

    Sherpa, D., Chrustowicz, J., Qiao, S., Langlois, C. R., Hehl, L. A., Gottemukkala, K. V., Hansen, F. M., Karayel, O., von Gronau, S., Prabu, J. R., Mann, Matthias, Alpi, A. F. & Schulman, B. A., 22 Apr 2021, (E-pub ahead of print) In: Molecular Cell.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity

    Seitz, S., Kwon, Y., Hartleben, G., Juelg, J., Sekar, R., Krahmer, N., Najafi, B., Loft, A., Gancheva, S., Stemmer, K., Feuchtinger, A., de Angelis, M. H., Mueller, T. D., Mann, M., Blueher, M., Roden, M., Diaz, M. B., Behrends, C., Gilleron, J., Herzig, S. & 1 others, Zeigerer, A., 2019, In: Nature Metabolism. 1, p. 1009-1026

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

    Schnoeder, T. M., Schwarzer, A., Jayavelu, A. K., Hsu, C-J., Kirkpatrick, J., Döhner, K., Perner, F., Eifert, T., Huber, N., Arreba-Tutusaus, P., Dolnik, A., Assi, S. A., Nafria, M., Jiang, L., Dai, Y-T., Chen, Z., Chen, S-J., Kellaway, S. G., Ptasinska, A., Ng, E. S. & 17 others, Stanley, E. G., Elefanty, A. G., Buschbeck, M., Bierhoff, H., Brodt, S., Matziolis, G., Fischer, K., Hochhaus, A., Chen, C., Heidenreich, O., Mann, Matthias, Lane, S. W., Bullinger, L., Ori, A., von Eyss, B., Bonifer, C. & Heidel, F. H., 2022, In: Blood. 139, 7, p. 1080-1097 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    A reversible state of hypometabolism in a human cellular model of sporadic Parkinson’s disease

    Schmidt, S., Stautner, C., Vu, D. T., Heinz, A., Regensburger, M., Karayel, O., Trümbach, D., Artati, A., Kaltenhäuser, S., Nassef, M. Z., Hembach, S., Steinert, L., Winner, B., Jürgen, W., Jastroch, M., Luecken, M. D., Theis, F. J., Westmeyer, G. G., Adamski, J., Mann, M. & 4 others, Hiller, K., Giesert, F., Vogt Weisenhorn, D. M. & Wurst, W., 2023, In: Nature Communications. 14, 1, 24 p., 7674.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network

    Schmacke, N. A., O'Duill, F., Gaidt, M. M., Szymanska, I., Kamper, J. M., Schmid-Burgk, J. L., Mädler, S. C., Mackens-Kiani, T., Kozaki, T., Chauhan, D., Nagl, D., Stafford, C. A., Harz, H., Fröhlich, A. L., Pinci, F., Ginhoux, F., Beckmann, R., Mann, Matthias, Leonhardt, H. & Hornung, V., 2022, In: Immunity. 55, 12, p. 2271-2284.e7

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

    Schiller, H. B., Hermann, M., Polleux, J., Vignaud, T., Zanivan, S., Friedel, C. C., Sun, Z., Raducanu, A., Gottschalk, K., Théry, M., Mann, Matthias & Fässler, R., Jun 2013, In: Nature Cell Biology. 15, 6, p. 625-36 12 p.

    Research output: Contribution to journalJournal articleResearch

  30. Deep Proteome Profiling Reveals Common Prevalence of MZB1-positive Plasma B Cells in Human Lung and Skin Fibrosis

    Schiller, H. B., Mayr, C. H., Leuschner, G., Strunz, M., Staab-Weijnitz, C., Preisendörfer, S., Eckes, B., Moinzadeh, P., Krieg, T., Schwartz, D. A., Hatz, R. A., Behr, J., Mann, Matthias & Eickelberg, O., 2017, In: American Journal of Respiratory and Critical Care Medicine. 196, 10, p. 1298–1310

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Mitochondrial specialization revealed by single muscle fiber proteomics: focus on the Krebs cycle

    Schiaffino, S., Reggiani, C., Kostrominova, T. Y., Mann, Matthias & Murgia, M., Dec 2015, In: Scandinavian Journal of Medicine & Science in Sports. 25, Suppl 4, p. 41-8 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  32. Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators

    Scheibe, M., Arnoult, N., Kappei, D., Buchholz, F., Decottignies, A., Butter, F. & Mann, Matthias, 22 Oct 2013, In: Genome Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators

    Scheibe, M., Arnoult, N., Kappei, D., Buchholz, F., Decottignies, A., Butter, F. & Mann, Matthias, 22 Oct 2013, In: Genome Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. A mass spectrometry-friendly database for cSNP identification

    Schandorff, S., Olsen, Jesper Velgaard, Bunkenborg, J., Blagoev, B., Zhang, Y., Andersen, J. S. & Mann, Matthias, 2007, In: Nature Methods. 4, 6, p. 465-6 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Glutathione peroxidase 3 localizes to the epithelial lining fluid and the extracellular matrix in interstitial lung disease

    Schamberger, A. C., Schiller, H. B., Fernandez, I. E., Sterclova, M., Heinzelmann, K., Hennen, E., Hatz, R., Behr, J., Vašáková, M., Mann, Matthias, Eickelberg, O. & Staab-Weijnitz, C. A., 20 Jul 2016, In: Scientific Reports. 6, p. 29952

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Mast cells in lung damage of COVID-19 autopsies: A descriptive study

    Schaller, T., Märkl, B., Claus, R., Sholl, L., Hornick, J. L., Giannetti, M. P., Schweizer, L., Mann, Matthias & Castells, M., 2022, In: Allergy. 77, 7, p. 2237-2239 3 p.

    Research output: Contribution to journalComment/debateResearch

  37. A genome-wide resource for the analysis of protein localisation in Drosophila

    Sarov, M., Barz, C., Jambor, H., Hein, M. Y., Schmied, C., Suchold, D., Stender, B., Janosch, S., K J, V. V., Krishnan, R. T., Krishnamoorthy, A., Ferreira, I. R. S., Ejsmont, R. K., Finkl, K., Hasse, S., Kämpfer, P., Plewka, N., Vinis, E., Schloissnig, S., Knust, E. & 6 others, Hartenstein, V., Mann, Matthias, Ramaswami, M., VijayRaghavan, K., Tomancak, P. & Schnorrer, F., 20 Feb 2016, In: eLife. 5, p. e12068

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    A knowledge graph to interpret clinical proteomics data

    Santos, A., Colaço, A. R., Nielsen, A. B., Niu, Lili, Strauss, Maximilian, Geyer, P. E., Coscia, F., Albrechtsen, Nicolai Jacob Wewer, Mundt, F., Jensen, Lars Juhl & Mann, Matthias, 2022, In: Nature Biotechnology. 40, p. 692–702

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr

    Salehi, S., Zare, A., Prezza, G., Bader, J., Schneider, C., Fischer, U., Meissner, F., Mann, Matthias, Briese, M. & Sendtner, M., 2023, In: Nature Communications. 14, 19 p., 4158.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Plasma proteome profiles treatment efficacy of incretin dual agonism in diet-induced obese female and male mice

    Sachs, S., Niu, Lili, Geyer, P., Jall, S., Kleinert, Maximilian, Feuchtinger, A., Stemmer, K., Brielmeier, M., Finan, B., DiMarchi, R. D., Tschop, M. H., Albrechtsen, Nicolai Jacob Wewer, Mann, Matthias, Mueller, T. D. & Hofmann, S. M., 2020, In: Diabetes, Obesity and Metabolism. 23, 1, p. 195-207 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion

    Sacco, F., Humphrey, S. J., Cox, J., Mischnik, M., Schulte, A., Klabunde, T., Schäfer, M. & Mann, Matthias, 14 Nov 2016, In: Nature Communications. 7, p. 13250

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets

    Sacco, F., Seelig, A., Humphrey, S. J., Krahmer, N., Volta, F., Reggio, A., Marchetti, P., Gerdes, J. & Mann, Matthias, 7 Mar 2019, (E-pub ahead of print) In: Cell Metabolism.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State

    Sacco, F., Silvestri, A., Posca, D., Pirrò, S., Gherardini, P. F., Castagnoli, L., Mann, Matthias & Cesareni, G., 23 Mar 2016, In: Cell Systems. 2, 3, p. 159-71 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

    Räschle, M., Smeenk, G., Hansen, R. K., Temu, T., Oka, Y., Hein, M. Y., Nagaraj, N., Long, D. T., Walter, J. C., Hofmann, K., Storchova, Z., Cox, J., Bekker-Jensen, Simon Holst, Mailand, Niels & Mann, Matthias, 2015, In: Science. 348, 6234, p. 539- 10 p., 1253671.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Making single-cell proteomics biologically relevant

    Rosenberger, F. A., Thielert, Marvin Christoffer & Mann, Matthias, 2023, In: Nature Methods. 20, p. 320-323 4 p.

    Research output: Contribution to journalComment/debateResearch

  46. Published

    Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome

    Rosenberger, F. A., Thielert, Marvin Christoffer, Strauss, Maximilian, Schweizer, L., Ammar, C., Mädler, S. C., Metousis, A., Skowronek, P., Wahle, M., Madden, K., Gote-Schniering, J., Semenova, A., Schiller, H. B., Rodriguez, E., Nordmann, T. M., Mund, Andreas & Mann, Matthias, 2023, In: Nature Methods. 20, 10, p. 1530-1536 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia

    Rommel, C., Rösner, S., Lother, A., Barg, M., Schwaderer, M., Gilsbach, R., Bömicke, T., Schnick, T., Mayer, S., Doll, S., Hesse, M., Kretz, O., Stiller, B., Neumann, F., Mann, Matthias, Krane, M., Fleischmann, B. K., Ravens, U. & Hein, L., 2018, In: Circulation Research. 123, 5, p. 550-563 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Proteomic approaches in circadian biology

    Robles, M. S. & Mann, Matthias, 2013, Handbook of experimental pharmacology: Circadian Clocks. p. 389-407 19 p. (Handbook of Experimental Pharmacology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  49. Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology

    Robles, M. S., Humphrey, S. J. & Mann, Matthias, 10 Jan 2017, In: Cell Metabolism. 25, 1, p. 118-127 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome

    Ripaud, L., Chumakova, V., Antonin, M., Hastie, A. R., Pinkert, S., Körner, R., Ruff, K. M., Pappu, R. V., Hornburg, D., Mann, Matthias, Hartl, F. U. & Hipp, M. S., 23 Dec 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 51, p. 18219-24 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 5650809