Niels Mailand
Professor, head of research, Professor
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A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ
Mailand, Niels, 2023, In: Molecular Cell. 83, 1, p. 3-5 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis
Villumsen, B. H., Danielsen, J. R., Povlsen, L., Sylvestersen, K. B., Merdes, A., Beli, P., Yang, Y., Choudhary, Chunaram, Nielsen, Michael Lund, Mailand, Niels & Bekker-Jensen, Simon Holst, 11 Oct 2013, In: E M B O Journal. 32, 23, p. 3029-3040Research output: Contribution to journal › Journal article › Research › peer-review
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A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure
Luijsterburg, M. S., Acs, K., Ackermann, L., Wiegant, W. W., Bekker-Jensen, Simon Holst, Larsen, D. H., Khanna, K. K., van Attikum, H., Mailand, Niels & Dantuma, N. P., 2012, In: E M B O Journal. 31, 11, p. 2511-27 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA
Toledo Lazaro, L. I., Altmeyer, M., Rask, M., Lukas, Claudia, Larsen, D. H., Povlsen, L. K., Bekker-Jensen, Simon Holst, Mailand, Niels, Bartek, J. & Lukas, Jiri, 21 Nov 2013, In: Cell. 155, 5, p. 1088-1103 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ATR-Chk1-APC/C-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress
Yamada, M., Watanabe, K., Mistrik, M., Vesela, E., Protivankova, I., Mailand, Niels, Lee, M. H., Masai, H., Lukas, Jiri & Bartek, J., 15 Nov 2013, In: Genes & Development. 27, 22, p. 2459-2472 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ATXN3 controls DNA replication and transcription by regulating chromatin structure
Hernández-Carralero, E., Cabrera, E., Rodríguez-Torres, G., Hernández-Reyes, Y., Singh, A. N., Santa-María, C., Fernández-Justel, J. M., Janssens, R. C., Marteijn, J. A., Evert, B. O., Mailand, Niels, Gómez, M., Ramadan, K., Smits, V. A. J. & Freire, R., 2023, In: Nucleic Acids Research. 51, 11, p. 5396–5413Research output: Contribution to journal › Journal article › Research › peer-review
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Activation of the ATR kinase by the RPA-binding protein ETAA1
Haahr, Peter Thorlund, Hoffmann, Saskia, Tollenaere, M. A. X., Ho, T., Toledo Lazaro, L. I., Mann, Matthias, Bekker-Jensen, Simon Holst, Räschle, M. & Mailand, Niels, Nov 2016, In: Nature Cell Biology. 18, 11, p. 1196–1207Research output: Contribution to journal › Journal article › Research › peer-review
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Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination
Gao, M., Wei, W., Li, M. H., Wu, Y., Ba, Z., Jin, K., Li, M., Liao, Y., Adhikari, S., Chong, Z., Zhang, T., Guo, C., Tang, T., Zhu, B., Xu, X., Mailand, Niels, Yang, Y., Qi, Y. & Danielsen, J. M. R., May 2014, In: Cell Research. 24, 5, p. 532-41 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An unorthodox partnership in DNA repair pathway choice
Typas, D. & Mailand, Niels, 2019, In: EMBO Reports. 20, 11, e49105.Research output: Contribution to journal › Editorial › Research › peer-review
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Assembly and function of DNA double-strand break repair foci in mammalian cells
Bekker-Jensen, Simon Holst & Mailand, Niels, 10 Dec 2010, In: D N A Repair. 9, 12, p. 1219-28 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis
Mailand, Niels & Diffley, J. F. X., 23 Sep 2005, In: Cell. 122, 6, p. 915-26 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Centriolar satellites: key mediators of centrosome functions
Tollenaere, M. A. X., Mailand, Niels & Bekker-Jensen, Simon Holst, Jan 2015, In: Cellular and molecular life sciences : CMLS. 73, 1, p. 11-23 13 p.Research output: Contribution to journal › Review › Research › peer-review
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
Krämer, A., Mailand, Niels, Lukas, Claudia, Syljuåsen, R. G., Wilkinson, C. J., Nigg, E. A., Bartek, J. & Lukas, Jiri, Sep 2004, In: Nature Cell Biology. 6, 9, p. 884-91 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemogenetic profiling reveals PP2A-independent cytotoxicity of proposed PP2A activators iHAP1 and DT-061
Vit, G., Duro, Joana Maria, Rajendraprasad, G., Hertz, Emil Peter Thrane, Holland, L. K. K., Weisser, Melanie, McEwan, B. C., Lopez-Mendez, B., Sotelo-Parrilla, P., Jeyaprakash, A. A., Montoya, Guillermo, Mailand, Niels, Maeda, K., Kettenbach, A., Barisic, Marin & Nilsson, Jakob, 2022, In: EMBO Journal. 41, 14, e110611.Research output: Contribution to journal › Journal article › Research › peer-review
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
Liu, S., Bekker-Jensen, Simon Holst, Mailand, Niels, Lukas, Claudia, Bartek, J. & Lukas, Jiri, 2006, In: Molecular and Cellular Biology. 26, 16, p. 6056-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
Gupta, R., Somyajit, K., Narita, Takeo, Maskey, E., Stanlie, A., Kremer, M., Typas, D., Lammers, M., Mailand, Niels, Nussenzweig, A., Lukas, Jiri & Choudhary, Chunaram, 2018, In: Cell. 173, 4, p. 972-988Research output: Contribution to journal › Journal article › Research › peer-review
DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology
Lukas, Claudia, Bartkova, J., Latella, L., Falck, J., Mailand, Niels, Schroeder, T., Sehested, M., Lukas, Jiri & Bartek, J., 1 Jul 2001, In: Cancer Research. 61, 13, p. 4990-3 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger
Danielsen, J. M. R., Povlsen, L. K., Villumsen, B. H., Streicher, W., Nilsson, Jakob, Wikström, M., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Journal of Cell Biology. 197, 2, p. 179-87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks
Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, S. V., Smedegaard, S., Sedgwick, G., Lukas, Claudia, Hartmann-Petersen, Rasmus, Lukas, Jiri, Choudhary, Chunaram, Pocock, R. D. J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation
Mailand, Niels, Lukas, Claudia, Kaiser, B. K., Jackson, P. K., Bartek, J. & Lukas, Jiri, Apr 2002, In: Nature Cell Biology. 4, 4, p. 317-22 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
Mailand, Niels, Bekker-Jensen, Simon Holst, Bartek, J. & Lukas, Jiri, 2006, In: Molecular Cell. 23, 3, p. 307-18 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling
Damgaard, R. B., Fiil, Berthe Katrine, Speckmann, C., Yabal, M., Stadt, U. Z., Bekker-Jensen, Simon Holst, Jost, P. J., Ehl, S., Mailand, Niels & Gyrd-Hansen, Mads, 1 Jul 2013, In: E M B O Journal. 5, p. 1278-1295 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease
Hoffmann, Saskia, Pentakota, S., Mund, Andreas, Haahr, Peter Thorlund, Coscia, F., Gallo, M., Mann, Matthias, Taylor, Nicholas M I & Mailand, Niels, 2020, In: EMBO Reports. 21, 10, 14 p., e50662.Research output: Contribution to journal › Journal article › Research › peer-review
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GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling
Tollenaere, M. A. X., Tiedje, C., Rasmussen, S., Nielsen, J. C., Vind, Anna Constance, Blasius, Melanie, Batth, Tanveer Singh, Mailand, Niels, Olsen, Jesper Velgaard, Gaestel, M. & Bekker-Jensen, Simon Holst, 2019, In: Cell Reports. 26, 13, p. 3511-3521.e4 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex
Saredi, G., Huang, H., Hammond, Colin, Alabert, C., Bekker-Jensen, Simon Holst, Forne, I., Reveron-Gomez, Nazaret, Foster, B. M., Mlejnkova, L., Bartke, T., Cejka, P., Mailand, Niels, Imhof, A., Patel, D. J. & Groth, Anja, 30 Jun 2016, In: Nature. 534, 7609, p. 714-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 13844358
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2009
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Activation of the ATR kinase by the RPA-binding protein ETAA1
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
1721
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Molecular basis and regulation of OTULIN-LUBAC interaction
Research output: Contribution to journal › Journal article › Research › peer-review
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901
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Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage
Research output: Contribution to journal › Letter › Research › peer-review
Published