A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ

Research output: Contribution to journalComment/debateResearchpeer-review

In this issue of Molecular Cell, Yaneva et al.1 demonstrate that the DNA helicase FANCJ promotes DNA replication-coupled DNA-protein crosslink (DPC) repair via an unexpected ability to unfold the protein adduct, thereby enabling its proteolysis by the DPC protease SPRTN.

Original languageEnglish
JournalMolecular Cell
Issue number1
Pages (from-to)3-5
Number of pages3
Publication statusPublished - 2023

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