A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ

Research output: Contribution to journalComment/debateResearchpeer-review

In this issue of Molecular Cell, Yaneva et al.1 demonstrate that the DNA helicase FANCJ promotes DNA replication-coupled DNA-protein crosslink (DPC) repair via an unexpected ability to unfold the protein adduct, thereby enabling its proteolysis by the DPC protease SPRTN.

Original languageEnglish
JournalMolecular Cell
Volume83
Issue number1
Pages (from-to)3-5
Number of pages3
ISSN1097-2765
DOIs
Publication statusPublished - 2023

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