What are the DNA lesions underlying formaldehyde toxicity?
Research output: Contribution to journal › Journal article › Research › peer-review
Formaldehyde is a highly reactive organic compound. Humans can be exposed to exogenous sources of formaldehyde, but formaldehyde is also produced endogenously as a byproduct of cellular metabolism. Because formaldehyde can react with DNA, it is considered a major endogenous source of DNA damage. However, the nature of the lesions underlying formaldehyde toxicity in cells remains vastly unknown. Here, we review the current knowledge of the different types of nucleic acid lesions that are induced by formaldehyde and describe the repair pathways known to counteract formaldehyde toxicity. Taking this knowledge together, we discuss and speculate on the predominant lesions generated by formaldehyde, which underly its natural toxicity.
Original language | English |
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Article number | 103667 |
Journal | DNA Repair |
Volume | 138 |
Number of pages | 14 |
ISSN | 1568-7864 |
DOIs | |
Publication status | Published - 2024 |
Bibliographical note
Publisher Copyright:
© 2024
- DNA crosslinks, DNA damage, DNA repair, DNA replication, Fanconi anemia pathway, Formaldehyde
Research areas
ID: 388582644