What are the DNA lesions underlying formaldehyde toxicity?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

What are the DNA lesions underlying formaldehyde toxicity? / Benedict, Bente; Kristensen, Stella Munkholm; Duxin, Julien P.

In: DNA Repair, Vol. 138, 103667, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Benedict, B, Kristensen, SM & Duxin, JP 2024, 'What are the DNA lesions underlying formaldehyde toxicity?', DNA Repair, vol. 138, 103667. https://doi.org/10.1016/j.dnarep.2024.103667

APA

Benedict, B., Kristensen, S. M., & Duxin, J. P. (2024). What are the DNA lesions underlying formaldehyde toxicity? DNA Repair, 138, [103667]. https://doi.org/10.1016/j.dnarep.2024.103667

Vancouver

Benedict B, Kristensen SM, Duxin JP. What are the DNA lesions underlying formaldehyde toxicity? DNA Repair. 2024;138. 103667. https://doi.org/10.1016/j.dnarep.2024.103667

Author

Benedict, Bente ; Kristensen, Stella Munkholm ; Duxin, Julien P. / What are the DNA lesions underlying formaldehyde toxicity?. In: DNA Repair. 2024 ; Vol. 138.

Bibtex

@article{57d34acd93314d25a256f0d718126c2d,
title = "What are the DNA lesions underlying formaldehyde toxicity?",
abstract = "Formaldehyde is a highly reactive organic compound. Humans can be exposed to exogenous sources of formaldehyde, but formaldehyde is also produced endogenously as a byproduct of cellular metabolism. Because formaldehyde can react with DNA, it is considered a major endogenous source of DNA damage. However, the nature of the lesions underlying formaldehyde toxicity in cells remains vastly unknown. Here, we review the current knowledge of the different types of nucleic acid lesions that are induced by formaldehyde and describe the repair pathways known to counteract formaldehyde toxicity. Taking this knowledge together, we discuss and speculate on the predominant lesions generated by formaldehyde, which underly its natural toxicity.",
keywords = "DNA crosslinks, DNA damage, DNA repair, DNA replication, Fanconi anemia pathway, Formaldehyde",
author = "Bente Benedict and Kristensen, {Stella Munkholm} and Duxin, {Julien P.}",
note = "Publisher Copyright: {\textcopyright} 2024",
year = "2024",
doi = "10.1016/j.dnarep.2024.103667",
language = "English",
volume = "138",
journal = "DNA Repair",
issn = "1568-7864",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - What are the DNA lesions underlying formaldehyde toxicity?

AU - Benedict, Bente

AU - Kristensen, Stella Munkholm

AU - Duxin, Julien P.

N1 - Publisher Copyright: © 2024

PY - 2024

Y1 - 2024

N2 - Formaldehyde is a highly reactive organic compound. Humans can be exposed to exogenous sources of formaldehyde, but formaldehyde is also produced endogenously as a byproduct of cellular metabolism. Because formaldehyde can react with DNA, it is considered a major endogenous source of DNA damage. However, the nature of the lesions underlying formaldehyde toxicity in cells remains vastly unknown. Here, we review the current knowledge of the different types of nucleic acid lesions that are induced by formaldehyde and describe the repair pathways known to counteract formaldehyde toxicity. Taking this knowledge together, we discuss and speculate on the predominant lesions generated by formaldehyde, which underly its natural toxicity.

AB - Formaldehyde is a highly reactive organic compound. Humans can be exposed to exogenous sources of formaldehyde, but formaldehyde is also produced endogenously as a byproduct of cellular metabolism. Because formaldehyde can react with DNA, it is considered a major endogenous source of DNA damage. However, the nature of the lesions underlying formaldehyde toxicity in cells remains vastly unknown. Here, we review the current knowledge of the different types of nucleic acid lesions that are induced by formaldehyde and describe the repair pathways known to counteract formaldehyde toxicity. Taking this knowledge together, we discuss and speculate on the predominant lesions generated by formaldehyde, which underly its natural toxicity.

KW - DNA crosslinks

KW - DNA damage

KW - DNA repair

KW - DNA replication

KW - Fanconi anemia pathway

KW - Formaldehyde

U2 - 10.1016/j.dnarep.2024.103667

DO - 10.1016/j.dnarep.2024.103667

M3 - Journal article

C2 - 38554505

AN - SCOPUS:85189083850

VL - 138

JO - DNA Repair

JF - DNA Repair

SN - 1568-7864

M1 - 103667

ER -

ID: 388582644