Søren Brunak

Søren Brunak

Professor

ORCID: 0000-0003-0316-5866

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  1. Published

    Dictionary construction and identification of possible adverse drug events in Danish clinical narrative text

    Eriksson, R., Jensen, P. B., Pletscher-Frankild, S., Jensen, Lars Juhl & Brunak, Søren, 23 May 2013, In: JAMIA - Journal of the American Medical Informatics Association. 20, 5, p. 947-953 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

    Eriksen, R., Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, L. E., Koivula, R. W., Bizzotto, R., Prehn, C., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T. J. & 18 others, Kokkola, T., Rutter, F., Teare, H., Hansen, T. H., Fernandez, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, Oluf Borbye, Ruetten, H., Forgie, I., Bell, J. D., Pearson, E. R., Franks, P. W., Adamski, J., Holmes, E. & Frost, G., Aug 2020, In: EBioMedicine. 58, p. 102932

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

    Koivula, R. W., Forgie, I. M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G. N., Hansen, T. H., Hudson, M., Koopman, A. D. M., Rutters, F., Siloaho, M., Allin, K. H., Brage, S., Brorsson, C. A., Dawed, A. Y., De Masi, F., Groves, C. J., Kokkola, T., Mahajan, A., Perry, M. H. & 31 others, Rauh, S. P., Ridderstråle, M., Teare, H. J. A., Thomas, E. L., Tura, A., drb459, drb459, White, T., Adamski, J., Bell, J. D., Beulens, J. W., Brunak, Søren, Dermitzakis, E. T., Froguel, P., Frost, G., Gupta, R., Hansen, Torben, Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T. J., Pedersen, Oluf Borbye, Schwenk, J. M., Pavo, I., Mari, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E., Franks, P. W. & IMI-DIRECT consortium, I. C., 2019, In: Diabetologia. 62, 9, p. 1601-1615

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium: Diabetologia

    Koivula, R., Heggie, A., Barnett, A., Cederberg, H., Hansen, T. H., Koopman, A., Ridderstråle, M., Rutters, F., Vestergaard, H., Gupta, R., Herrgård, S., Heymans, M., Perry, M., Rauh, S., Siloaho, M., Teare, H. A., Thorand, B., Bell, J., Brunak, S., Frost, G. & 13 others, Jablonka, B., Mari, A., McDonald, T., Dekker, J., Hansen, Torben, Hattersley, A., Laakso, M., Pedersen, Oluf Borbye, Koivisto, V., Ruetten, H., Walker, M., Pearson, E. & Franks, P., 2014, In: Diabetologia. 57, 6, p. 1-11 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models: [with Author Correction]

    Allesøe, R. L., Lundgaard, A. T., Hernández Medina, R., Aguayo-Orozco, A., Johansen, J., Nissen, J. N., Brorsson, C., Mazzoni, G., Niu, L., Biel, J. H., Brasas, V., Webel, H., Benros, M. E., Pedersen, A. G., Chmura, P. J., Jacobsen, U. P., Mari, A., Koivula, R., Mahajan, A., Vinuela, A. & 31 others, Tajes, J. F., Sharma, S., Haid, M., Hong, M., Musholt, P. B., De Masi, F., Vogt, J., Pedersen, H. K., Gudmundsdottir, V., Jones, A., Kennedy, G., Bell, J., Thomas, E. L., Frost, G., Thomsen, Henrik S., Hansen, E., Hansen, T. H., drb459, drb459, Muilwijk, M., Blom, M. T., 't Hart, L. M., Pattou, F., Raverdy, V., Brage, S., Ridderstråle, M., Pedersen, Oluf Borbye, Hansen, Torben, Banasik, Karina, Rasmussen, Simon, Brunak, Søren & IMI-DIRECT consortium, I. C., 2023, In: Nature Biotechnology. 41, 3, p. 399–408 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Discrepancies in listed adverse drug reactions in pharmaceutical product information supplied by the regulatory authorities in Denmark and the USA

    Eriksson, R., Aagaard, L., Jensen, Lars Juhl, Borisova, L., Hørlück, D., Brunak, Søren & Hansen, E. H., 2014, In: Pharmacology Research & Perspectives. 2, 3, p. 1-10 e00038.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Discrete-time survival analysis in the critically ill: a deep learning approach using heterogeneous data

    Thorsen-Meyer, H., Placido, Davide, Kaas-Hansen, Benjamin Skov, Nielsen, A. P., Lange, Theis, Nielsen, A. B., Toft, P., Schierbeck, J., Strøm, T., Chmura, Piotr Jaroslaw, Heimann, M., Belling, K., Perner, Anders & Brunak, Søren, 2022, In: npj Digital Medicine. 5, 10 p., 142.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Disease Trajectories for Hidradenitis Suppurativa in the Danish Population

    Andersen, Rune Kjærsgaard, Jørgensen, Isabella Friis, Reguant, R., Jemec, Gregor & Brunak, Søren, 2020, In: JAMA Dermatology. 156, 7, p. 780-786

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Disease trajectory browser for exploring temporal, population-wide disease progression patterns in 7.2 million Danish patients

    Siggaard, T., Reguant, R., Jørgensen, Isabella Friis, Haue, Amalie Dahl, Lademann, M., Aguayo-Orozco, A., Hjaltelin, Jessica Xin, Jensen, A. B., Banasik, Karina & Brunak, Søren, 2020, In: Nature Communications. 11, 1, 10 p., 4952.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

    Forslund, K., Hildebrand, F., Nielsen, T., Falony, G., Le Chatelier, E., Sunagawa, S., Prifti, E., Vieira-Silva, S., Gudmundsdottir, V., Pedersen, H. K., Arumugam, M., Kristiansen, K., Yvonne Voigt, A., Vestergaard, H., Hercog, R., Igor Costea, P., Roat Kultima, J., Li, J., Jørgensen, T., Levenez, F. & 9 others, Dore, J., Nielsen, H. B., Brunak, Søren, Raes, J., Hansen, Torben, Wang, J., Dusko Ehrlich, S., Bork, P. & Pedersen, Oluf Borbye, 2015, In: Nature. 528, 7581, p. 262-266 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Dissecting spatio-temporal protein networks driving human heart development and related disorders

    Hansen, K. L., Møllgård, K., Greenway, S., Wakimoto, H., Gorham, J. M., Workman, C. T., Bendsen, E., Hansen, N. T., Rigina, O., Roque, F. S., Wiese, C., Christoffels, V. M., Roberts, A. E., Smoot, L. B., Pu, W. T., Donahoe, P. K., Tommerup, N., Brunak, S., Seidman, C. E., Seidman, J. G. & 1 others, Larsen, Lars Allan, 2010, In: Molecular Systems Biology. 6, p. 381

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Dose-specific adverse drug reaction identification in electronic patient records: temporal data mining in an inpatient psychiatric population

    Eriksson, R., Werge, T., Jensen, Lars Juhl & Brunak, Søren, Apr 2014, In: Drug Safety. 37, 4, p. 237-47 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Drug dosage modifications in 24 million in-patient prescriptions covering eight years: A Danish population-wide study of polypharmacy

    Leal Rodríguez, C., Haue, Amalie Dahl, Mazzoni, G., Eriksson, R., Hernansanz Biel, J., Cantwell, Lisa, Westergaard, David, Belling, K. G. & Brunak, Søren, 2023, In: PLOS Digital Health. 2, 9, 27 p., e0000336.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Drug interactions in hospital prescriptions in Denmark: Prevalence and associations with adverse outcomes

    Rodríguez, C. L., Kaas-Hansen, Benjamin Skov, Eriksson, R., Biel, J. H., Belling, K. G., Andersen, Stig Ejdrup & Brunak, Søren, 2022, In: Pharmacoepidemiology and Drug Safety. 31, 6, p. 632-642 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Dynamic and explainable machine learning prediction of mortality in patients in the intensive care unit: a retrospective study of high-frequency data in electronic patient records

    Thorsen-Meyer, H., Nielsen, A. B., Nielsen, A. P., Kaas-Hansen, Benjamin Skov, Toft, P., Schierbeck, J., Strøm, T., Chmura, Piotr Jaroslaw, Heimann, M., Dybdahl, L., Spangsege, L., Hulsen, P., Belling, K., Brunak, Søren & Perner, Anders, 2020, In: The Lancet Digital Health. 2, 4, p. e179–91 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Dynamic complex formation during the yeast cell cycle

    de Lichtenberg, U., Jensen, L. J., Brunak, Søren & Bork, P., 2005, In: Science (New York, N.Y.). 307, 5710, p. 724-7 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    ELIXIR-EXCELERATE: establishing Europe's data infrastructure for the life science research of the future

    ELIXIR-EXCELERATE Community, E. C., 2021, In: EMBO Journal. 40, 6, 9 p., e107409.

    Research output: Contribution to journal › Comment/debate › Research

  18. Published

    Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis

    Crèvecoeur, I., Gudmundsdottir, V., Vig, S., Marques Câmara Sodré, F., D'Hertog, W., Fierro, A. C., Van Lommel, L., Gysemans, C., Marchal, K., Waelkens, E., Schuit, F., Brunak, Søren, Overbergh, L. & Mathieu, C., Mar 2017, In: Diabetologia. 60, 3, p. 475-489 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Early divergent strains of Yersinia pestis in Eurasia 5,000 years ago

    Rasmussen, S., Allentoft, M. E., Nielsen, K., Orlando, L. A. A., Sikora, M., Sjögren, K-G., Pedersen, A. G., Schubert, M., Van Dam, A., Kapel, C. M. O., Nielsen, H. B., Brunak, S., Avetisyan, P., Epimakhov, A., Khalyapin, M. V., Gnuni, A., Kriiska, A., Lasak, I., Metspalu, M., Moiseyev, V. & 11 others, Gromov, A., Pokutta, D., Saag, L., Varul, L., Yepiskoposyan, L., Sicheritz-Ponten, T., Foley, R. A., Lahr, M. M., Nielsen, R., Kristiansen, K. & Willerslev, Eske, 2015, In: Cell. 163, 3, p. 571-582 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Effects of active farnesoid X receptor on GLUTag enteroendocrine L cells

    Niss, K., Jakobsson, M. E., Westergaard, David, Belling, K. G., Olsen, Jesper Velgaard & Brunak, Søren, 2020, In: Molecular and Cellular Endocrinology. 517, 9 p., 110923.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor

    Dowsett, J., Ferkingstad, E., Rasmussen, L. J. H., Thørner, L. W., Magnússon, M. K., Sugden, K., Thorleifsson, G., Frigge, M., Burgdorf, K. S., Ostrowski, S. R., Sørensen, E., Erikstrup, C., Pedersen, O. B., Hansen, T. F., Banasik, K., Brunak, S., Tragante, V., Lund, S. H., Stefansdottir, L., Gunnarson, B. & 10 others, Poulton, R., Arseneault, L., Caspi, A., Moffitt, T. E., Gudbjartsson, D., Eugen-Olsen, J., Stefánsson, H., Stefánsson, K., Ullum, H. & DBDS Genomic Consortium, D. G. C., 2021, In: Communications Biology . 4, 1, p. 655

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Eliciting drug safety signals from patient records: a language-agnostic approach

    Kaas-Hansen, Benjamin Skov, Placido, Davide, Rodriguez, C., Thorsen-Meyer, H., Gentile, S., Nielsen, A., Brunak, Søren, Jürgens, Gesche & Andersen, S., 2022, p. S15-S16. 2 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  23. Published

    Endotrophin is associated with chronic multimorbidity and all-cause mortality in a cohort of elderly women

    Staunstrup, L. M., Bager, C. L., Frederiksen, P., Helge, Jørn Wulff, Brunak, Søren, Christiansen, C. & Karsdal, M., 2021, In: EBioMedicine. 68, 10 p., 103391.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Enterotypes of the human gut microbiome: [Plus]Corrigendum [Plus]Addendum

    Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., Batto, J-M., dos Santos, M. B. Q., Borruel, N., Casellas, F., Fernandez, L., Gautier, L., Hansen, T., Hattori, M., Hayashi, T., Kleerebezem, M., Kurokawa, K. & 31 others, Leclerc, M., Levenez, F., Manichanh, C., Nielsen, H. B., Nielsen, T., Pons, N., Poulain, J., Qin, J., Sicheritz-Ponten, T., Tims, S., Torrents, D., Ugarte, E., Zoetendal, E. G., Wang, J., Guarner, F., Pedersen, Oluf Borbye, de Vos, W. M., Brunak, Søren, Doré, J., Antolín, M., Artiguenave, F., Blottiere, H. M., Almeida, M., Brechot, C., Cara, C., Chervaux, C., Cultrone, A., Delorme, C., Denariaz, G., Kristiansen, Karsten & MetaHIT Consortium, M. C., 2011, In: Nature. 473, 7346, p. 174-180 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Erratum to: Dose-Specific Adverse Drug Reaction Identification in Electronic Patient Records: Temporal Data Mining in an Inpatient Psychiatric Population

    Eriksson, R., Werge, T., Jensen, Lars Juhl & Brunak, Søren, May 2014, In: Drug Safety. 37, 5, p. 379

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study

    DBDS Genomic Consortium, D. G. C., 2022, In: Joint Bone Spine. 89, 4, 105357.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  27. Published

    Estimating heritability and genetic correlations from large health datasets in the absence of genetic data

    Jia, G., Li, Y., Zhang, H., Chattopadhyay, I., Jensen, A. B., Blair, D. R., Davis, L., Robinson, P. N., Dahlen, T., Brunak, Søren, Benson, M., Edgren, G., Cox, N. J., Gao, X. & Rzhetsky, A., 2019, In: Nature Communications. 10, 11 p., 5508.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Estimating the effect of donor sex on red blood cell transfused patient mortality: A retrospective cohort study using a targeted learning and emulated trials-based approach

    Bruun-Rasmussen, P., Andersen, Per Kragh, Banasik, Karina, Brunak, Søren & Jo­hans­son, Pär In­ge­mar , 2022, In: EClinicalMedicine. 51, 10 p., 101628.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Evolution of cell cycle control: same molecular machines, different regulation

    de Lichtenberg, U., Jensen, T. S., Brunak, Søren, Bork, P. & Jensen, L. J., 2007, In: Cell Cycle. 6, 15, p. 1819-25 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Expression profiling of human genetic and protein interaction networks in type 1 diabetes

    Brorsson, C., Lage, K., Nielsen, J. H., Brunak, Søren & Pociot, F., 2009, In: PLoS ONE. 4, 7, p. e6250

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Extrapolation of drug induced liver injury responses from cancer cell lines using machine learning approaches

    Aguayo-Orozco, A., Brunak, Søren & Taboureau, O., 2021, In: Computational Toxicology. 17, 6 p., 100147.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Facilitating the use of large-scale biological data and tools in the era of translational bioinformatics

    Kouskoumvekaki, I., Shublaq, N. & Brunak, Søren, 1 Aug 2013, In: Briefings in Bioinformatics. 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Familial Atrial Septal Defect and Sudden Cardiac Death: Identification of a Novel NKX2-5 Mutation and a Review of the Literature

    Ellesøe, S. G., Johansen, M. M., Bjerre, J. V., Hjortdal, V. E., Brunak, Søren & Larsen, Lars Allan, 1 May 2016, In: Congenital Heart Disease. 11, 3, p. 283–290 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Familial co-occurrence of congenital heart defects follows distinct patterns

    Ellesøe, S. G., Workman, C. T., Bouvagnet, P., Loffredo, C. A., McBride, K. L., Hinton, R. B., van Engelen, K., Gertsen, E. C., Mulder, B. J. M., Postma, A. V., Anderson, R. H., Hjortdal, V. E., Brunak, Søren & Larsen, Lars Allan, Mar 2018, In: European Heart Journal. 39, 12, p. 1015–1022

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Finding Ophthalmic Risk and Evaluating the Value of Eye exams and their predictive Reliability (FOREVER)—A cohort study in a Danish high street optician setting: Design and methodology

    Freiberg, J., Rovelt, J., Gazzard, G., Cour, M. L., Kolko, M., Torp‐Pedersen, C., Benn, M., Brunak, S., Cour, M. L., Tolstrup, J., Toft‐Petersen, A. P., Burgdorf, K. S., Banasik, K., Chmura, P. J., Freiberg, J., Rovelt, J., Thornit, D. N., Foster, P., Gazzard, G., Crabb, D. P. & 4 others, Viswanathan, A., Barman, Sarah, Owen, C. G. & Rudnicka, A. R., 2024, In: Acta Ophthalmologica. 102, 1, p. 80-90 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study

    Wesolowska-Andersen, A., Brorsson, C. A., Bizzotto, R., Mari, A., Tura, A., Koivula, R., Mahajan, A., Vinuela, A., Tajes, J. F., Sharma, S., Haid, M., Prehn, C., Artati, A., Hong, M. G., Musholt, P. B., Kurbasic, A., Masi, F. D., Tsirigos, K., Pedersen, H. K., Gudmundsdottir, V. & 31 others, Thomas, Cecilia Engel, Banasik, Karina, Jennison, C., Jones, A., Kennedy, G., Bell, J., Thomas, L., Frost, G., Thomsen, H., Allin, K., Hansen, T. H., drb459, drb459, Hansen, Torben, Rutters, F., Elders, P., t'Hart, L., Bonnefond, A., Canouil, M., Brage, S., Kokkola, T., Heggie, A., McEvoy, D., Hattersley, A., McDonald, T., Teare, H., Ridderstrale, M., Walker, M., Forgie, I., Pedersen, Oluf Borbye, Brunak, Søren & IMI-DIRECT consortium, I. C., 2022, In: Cell Reports Medicine. 3, 1, 25 p., 100477.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Functionality of system components: conservation of protein function in protein feature space

    Jensen, L. J., Ussery, D. & Brunak, Søren, 2003, In: Genome Research. 13, 11, p. 2444-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Gene expression signature predicts rate of type 1 diabetes progression

    Suomi, T., Starskaia, I., Kalim, U. U., Rasool, O., Jaakkola, M. K., Grönroos, T., Välikangas, T., Brorsson, C., Mazzoni, G., Bruggraber, S., Overbergh, L., Dunger, D., Peakman, M., Chmura, P., Brunak, S., Schulte, A. M., Mathieu, C., Knip, M., Lahesmaa, R., Elo, L. L. & 4 others, Pociot, Flemming, Johannesen, Jesper, Rossing, Peter & INNODIA consortium, I. C., 2023, In: EBioMedicine. 92, 18 p., 104625.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Genetic Variants Close to TTN, NKX2-5, and MYH6 Associate With AVNRT

    Andreasen, L., Ahlberg, G., Ægisdóttir, H. M., Sveinbjörnsson, G., Lundegaard, P. R., Hartmann, J. P., Paludan-Müller, C., Hadji-Turdeghal, K., Ghouse, J., Pehrson, S., Jensen, H. K., Riahi, S., Hansen, J., Sandgaard, N., Sørensen, E., Banasik, K., Sækmose, S. G., Bruun, M. T., Hjalgrim, H., Erikstrup, C. & 18 others, Pedersen, Ole Birger Vesterager, Wittig, M., Haunsø, Stig, Ostrowski, Sisse Rye, Genomic Consortium, D., Franke, A., Brunak, Søren, Kanters, Jørgen K., Ellervik, Christina, Bundgård, Henning, Ullum, H., Gudbjartsson, D. F., Thorsteinsdottir, U., Holm, H., Arnar, D. O., Stefansson, K., Svendsen, Jesper Hastrup & Olesen, Morten Steen Salling, 2022, In: Circulation Research. 131, 10, p. 862-865

    Research output: Contribution to journal › Letter › Research › peer-review

  40. Published

    Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

    Brown, A. A., Fernandez-Tajes, J. J., Hong, M. G., Brorsson, C. A., Koivula, R. W., Davtian, D., Dupuis, T., Sartori, A., Michalettou, T. D., Forgie, I. M., Adam, J., Allin, K. H., Caiazzo, R., Cederberg, H., De Masi, F., Elders, P. J. M., Giordano, G. N., Haid, M., Hansen, T., Hansen, T. H. & 134 others, Hattersley, A. T., Heggie, A. J., Howald, C., Jones, A. G., Kokkola, T., Laakso, M., Mahajan, A., Mari, A., McDonald, T. J., McEvoy, D., Mourby, M., Musholt, P. B., Nilsson, B., Pattou, F., Penet, D., Raverdy, V., Ridderstråle, M., Romano, L., Rutters, F., Sharma, S., Teare, H., ‘t Hart, L., Tsirigos, Konstantinos, Vangipurapu, J., drb459, drb459, Brunak, Søren, Franks, P. W., Frost, G., Grallert, H., Jablonka, B., McCarthy, M. I., Pavo, I., Pedersen, Oluf Borbye, Ruetten, H., Walker, M., Adragni, K., Allesøe, R. L. L., Artati, A. A., Arumugam, Mani, Atabaki-Pasdar, N., Baltauss, T., Banasik, Karina, Barnett, A. L., Baum, P., Bell, J. D., Beulens, J. W., Bianzano, S. B., Bizzotto, R., Bonnefond, A., Cabrelli, L., Dale, M., Dawed, A. Y., de Preville, N., Dekkers, K. F., Deshmukh, H. A., Dings, C., Donnelly, L., Dutta, A., Ehrhardt, B., pjx571, pjx571, Eriksen, R., Fan, Yong, Ferrer, J., Fitipaldi, H., Forman, A., Fritsche, A., Froguel, P., Gassenhuber, J., Gough, S., Graefe-Mody, U., Grempler, R., Groeneveld, L., Groop, L., Gudmundsdóttir, V., Gupta, R., Hennige, A. M. H., Hill, A. V., Holl, R. W., Hudson, M., Jacobsen, Ulrik Plesner, Jennison, C., Johansen, Joachim, Jonsson, Anna Elisabet, Karaderi, Tugce, Kaye, J., Kennedy, G., Klintenberg, M., Kuulasmaa, T., Lehr, T., Loftus, H., Lundgaard, Agnete Troen, Mazzoni, G., McRobert, N., McVittie, I., Nice, R., Nicolay, C., Nijpels, G., Palmer, C. N., Pedersen, H. K., Perry, M. H., Pomares-Millan, H., Prehn, C. P., Ramisch, A., Rasmussen, Simon, Robertson, N., Rodriquez, M., Sackett, P., Scherer, N., Shah, N., Sihinevich, I., Slieker, R. C., Sondertoft, N. B., Steckel-Hamann, B., Thomas, M. K., Thomas, Cecilia Engel, Thomas, E. L. L., Thorand, B., Thorne, C. E., Tillner, J., Tura, A., Uhlen, M., van Leeuwen, N., van Oort, S., Verkindt, H., Vogt, J., Wad Sackett, P. W., Wesolowska-Andersen, A., Whitcher, B., White, M. W., Adamski, J., Schwenk, J. M., Pearson, E. R., Dermitzakis, E. T. & Viñuela, A., 2023, In: Nature Communications. 14, 17 p., 5062.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development

    Hansen, K. L., Greenway, S. C., Rosenfeld, J. A., Wakimoto, H., Gorham, J. M., Segrè, A. V., Roberts, A. E., Smoot, L. B., Pu, W. T., C Pereira, A., Mesquita, S. M., Tommerup, Niels, Brunak, Søren, Ballif, B. C., Shaffer, L. G., Donahoe, P. K., Daly, M. J., Seidman, J. G., Seidman, C. E. & Larsen, Lars Allan, 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 35, p. 14035-40 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Genetic insight into sick sinus syndrome

    Thorolfsdottir, R. B., Sveinbjornsson, G., Aegisdottir, H. M., Benonisdottir, S., Stefansdottir, L., Ivarsdottir, E. V., Halldorsson, G. H., Sigurdsson, J. K., Torp-Pedersen, C., Weeke, P. E., Brunak, S., Westergaard, D., Pedersen, O. B., Sørensen, E., Nielsen, K. R., Burgdorf, K. S., Banasik, K., Brumpton, B., Zhou, W., Oddsson, A. & 25 others, Tragante, V., Hjorleifsson, K. E., Davidsson, O. B., Rajamani, S., Jonsson, S., Torfason, B., Valgardsson, A. S., Thorgeirsson, G., Frigge, M. L., Thorleifsson, G., Norddahl, G. L., Helgadottir, A., Gretarsdottir, S., Sulem, P., Jonsdottir, I., Willer, C. J., Hveem, K., Bundgård, Henning, Ullum, H., Arnar, D. O., Thorsteinsdottir, U., Gudbjartsson, D. F., Holm, H., Stefansson, K. & DBDS Genomic Consortium, D. G. C., 2021, In: European Heart Journal. 42, 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Genetic prediction of 33 blood group phenotypes using an existing genotype dataset

    Moslemi, C., Sækmose, S. G., Larsen, R., Bay, J. T., Brodersen, T., Didriksen, M., Hjalgrim, H., Banasik, K., Nielsen, K. R., Bruun, M. T., Dowsett, J., Dinh, K. M., Mikkelsen, S., Mikkelsen, C., Hansen, T. F., Ullum, H., Erikstrup, C., Brunak, S., Krogfelt, K. A., Storry, J. R. & 3 others, Ostrowski, Sisse Rye, Olsson, M. L. & Pedersen, Ole Birger Vesterager, 2023, In: Transfusion. 63, 12, p. 2297-2310 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

    Wilman, H. R., Parisinos, C. A., Atabaki-Pasdar, N., Kelly, M., Thomas, E. L., Neubauer, S., Jennison, C., Ehrhardt, B., Baum, P., Schoelsch, C., Freijer, J., Grempler, R., Graefe-Mody, U., Hennige, A., Dings, C., Lehr, T., Scherer, N., Sihinecich, I., Pattou, F., Raverdi, V. & 31 others, Caiazzo, R., Torres, F., Verkindt, H., Mari, A., Tura, A., Giorgino, T., Bizzotto, Froguel, P., Brorsson, C., Brunak, Søren, De Masi, F., Pedersen, H., Banasik, Karina, Thomas, Cecilia Engel, Lundgaard, Agnete Troen, Nielsen, A., Mazzoni, G., Karaderi, Tugce, Rasmussen, Simon, Johansen, Joachim, Allesøe, R., Arumugam, Mani, Allin, K., Hansen, Torben, Hansen, T., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Dutta, A., Vogt, J., drb459, drb459 & IMI-DIRECT consortium, I. C., 2019, In: Journal of Hepatology. 71, 3, p. 594-602 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Genetic variability in the absorption of dietary sterols affects the risk of coronary artery disease

    Helgadottir, A., Thorleifsson, G., Alexandersson, K. F., Tragante, V., Thorsteinsdottir, M., Eiriksson, F. F., Gretarsdottir, S., Björnsson, E., Magnusson, O., Sveinbjornsson, G., Jonsdottir, I., Steinthorsdottir, V., Ferkingstad, E., Jensson, B. Ö., Stefansson, H., Olafsson, I., Christensen, A. H., Torp-Pedersen, C., Køber, L., Pedersen, O. B. & 23 others, Erikstrup, C., Sørensen, E., Brunak, Søren, Banasik, Karina, Hansen, Thomas Folkmann, Nyegaard, M., Eyjolfssson, G. I., Sigurdardottir, O., Thorarinsson, B. L., Matthiasson, S. E., Steingrimsdottir, T., Bjornsson, E. S., Danielsen, R., Asselbergs, F. W., Arnar, D. O., Ullum, H., Bundgård, Henning, Sulem, P., Thorsteinsdottir, U., Thorgeirsson, G., Holm, H., Gudbjartsson, D. F. & Stefansson, K., 2020, In: European Heart Journal. 41, 28, p. 2618-2628 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Genetic variants associated with syncope implicate neural and autonomic processes

    Aegisdottir, H. M., Thorolfsdottir, R. B., Sveinbjornsson, G., Stefansson, O. A., Gunnarsson, B., Tragante, V., Thorleifsson, G., Stefansdottir, L., Thorgeirsson, T. E., Ferkingstad, E., Sulem, P., Norddahl, G., Rutsdottir, G., Banasik, K., Christensen, A. H., Mikkelsen, C., Pedersen, O. B., Brunak, S., Bruun, M. T., Erikstrup, C. & 26 others, Jacobsen, R. L., Nielsen, K. R., Sorensen, E., Frigge, M. L., Hjorleifsson, K. E., Ivarsdottir, E., Helgadottir, A., Gretarsdottir, S., Steinthorsdottir, V., Oddsson, A., Eggertsson, H. P., Halldorsson, G. H., Jones, D. A., Anderson, J. L., Knowlton, K. U., Nadauld, L. D., DBDS Genomic Consortium, D. B. D. S. G. C., Haraldsson, M., Thorgeirsson, G., Bundgård, Henning, Arnar, D. O., Thorsteinsdottir, U., Gudbjartsson, D. F., Ostrowsk, S. R., Holm, H. & Stefansson, K., 2023, In: European Heart Journal. 44, 12, p. 1070–1080 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease

    Zheng, T., Ellinghaus, D., Juzenas, S., Cossais, F., Burmeister, G., Mayr, G., Jørgensen, I. F., Teder-Laving, M., Skogholt, A. H., Chen, S., Strege, P. R., Ito, G., Banasik, K., Becker, T., Bokelmann, F., Brunak, S., Buch, S., Clausnitzer, H., Datz, C., Degenhardt, F. & 31 others, Doniec, M., Erikstrup, C., Esko, T., Forster, M., Frey, N., Fritsche, L. G., Gabrielsen, M. E., Gräßle, T., Gsur, A., Gross, J., Hampe, J., Hendricks, A., Hinz, S., Hveem, K., Jongen, J., Junker, R., Karlsen, T. H., Hemmrich-Stanisak, G., Kruis, W., Kupcinskas, J., Laubert, T., Rosenstiel, P. C., Röcken, C., Laudes, M., Leendertz, F. H., Lieb, W., Limperger, V., Pedersen, Ole Birger Vesterager, Rodriguez, C. L., Ullum, H. & DBDS Consortium, D. C., 2021, In: Gut. 70, 8, p. 1538-1549

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

    Roychowdhury, T., Klarin, D., Levin, M. G., Spin, J. M., Rhee, Y. H., Deng, A., Headley, C. A., Tsao, N. L., Gellatly, C., Zuber, V., Shen, F., Hornsby, W. E., Laursen, I. H., Verma, S. S., Locke, A. E., Einarsson, G., Thorleifsson, G., Graham, S. E., Dikilitas, O., Pattee, J. W. & 74 others, Judy, R. L., Pauls-Verges, F., Nielsen, J. B., Wolford, B. N., Brumpton, B. M., Dilmé, J., Peypoch, O., Juscafresa, L. C., Edwards, T. L., Li, D., Banasik, Karina, Brunak, Søren, Jacobsen, Rikke Vita Borre, Garcia-Barrio, M. T., Zhang, J., Rasmussen, L. M., Lee, R., Handa, A., Wanhainen, A., Mani, K., Lindholt, J. S., Obel, L. M., Strauss, E., Oszkinis, G., Nelson, C. P., Saxby, K. L., van Herwaarden, J. A., van der Laan, S. W., van Setten, J., Camacho, M., Davis, F. M., Wasikowski, R., Tsoi, L. C., Gudjonsson, J. E., Eliason, J. L., Coleman, D. M., Henke, P. K., Ganesh, S. K., Chen, Y. E., Guan, W., Pankow, J. S., Pankratz, N., Pedersen, Ole Birger Vesterager, Erikstrup, C., Tang, W., Hveem, K., Gudbjartsson, D., Gretarsdottir, S., Thorsteinsdottir, U., Holm, H., Stefansson, K., Ferreira, M. A., Baras, A., Kullo, I. J., Ritchie, M. D., Christensen, Alex Hørby, Iversen, Kasper, Eldrup, Nikolaj, Sillesen, Henrik, Ostrowski, Sisse Rye, Bundgård, Henning, Ullum, H., Burgess, S., Gill, D., Gallagher, K., Sabater-Lleal, M., Dudbridge, F., Samani, N. J., Surakka, I., Jones, G. T., Bown, M. J., Tsao, P. S., Willer, C. J. & Damrauer, S. M., 2023, In: Nature Genetics. 55, p. 1831–1842 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement

    Henkel, C., Styrkársdóttir, U., Thorleifsson, G., Stefánsdóttir, L., Björnsdóttir, G., Banasik, K., Brunak, S., Erikstrup, C., Dinh, K. M., Hansen, T. F., Nielsen, K. R., Bruun, M. T., Dowsett, J., Brodersen, T., Thorgeirsson, T. E., Gromov, K., Boesen, M. P., Ullum, H., Ostrowski, S. R., Pedersen, O. B. & 3 others, Stefánsson, K., Troelsen, A. & DBDS Genomic Consortium, D. G. C., 2023, In: Annals of the Rheumatic Diseases. 82, p. 384-392

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth

    Beaumont, R. N., Flatley, C., Vaudel, M., Wu, X., Chen, J., Moen, G. H., Skotte, L., Helgeland, Ø., Solé-Navais, P., Banasik, K., Albiñana, C., Ronkainen, J., Fadista, J., Stinson, S. E., Trajanoska, K., Wang, C. A., Westergaard, D., Srinivasan, S., Sánchez-Soriano, C., Bilbao, J. R. & 68 others, Allard, C., Groleau, M., Kuulasmaa, T., Leirer, D. J., White, F., Jacques, P. É., Cheng, H., Hao, K., Andreassen, O. A., Åsvold, B. O., Atalay, M., Bhatta, L., Bouchard, L., Brumpton, B. M., Brunak, Søren, Bybjerg-Grauholm, J., Ebbing, C., Elliott, P., pjx571, pjx571, Erikstrup, C., Estarlich, M., Franks, S., Gaillard, R., Geller, F., Grove, J., Hougaard, D. M., Kajantie, E., Morgen, C. S., Nohr, E. A., Nyegaard, Mette, Palmer, C. N. A., Pedersen, Ole Birger Vesterager, Rivadeneira, F., Sebert, S., Shields, B. M., Stoltenberg, C., Surakka, I., Thørner, L. W., Ullum, H., Vaarasmaki, M., Vilhjalmsson, B. J., Willer, C. J., Lakka, T. A., Gybel-Brask, D., Bustamante, M., Hansen, Torben, Pearson, E. R., Reynolds, R. M., Ostrowski, Sisse Rye, Pennell, C. E., Jaddoe, V. W. V., Felix, J. F., Hattersley, A. T., Melbye, M., Lawlor, D. A., Hveem, K., Werge, Thomas, Nielsen, Henriette Svarre, Magnus, P., Evans, D. M., Jacobsson, B., Järvelin, M. R., Zhang, G., Hivert, M. F., Johansson, S., Freathy, R. M., Feenstra, B. & Njølstad, P. R., 2023, In: Nature Genetics. 55, 11, p. 1807-1819 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism

    Ghouse, J., Tragante, V., Ahlberg, G., Rand, S. A., Jespersen, J. B., Leinøe, E. B., Vissing, C. R., Trudsø, L., Jonsdottir, I., Banasik, K., Brunak, S., Ostrowski, S. R., Pedersen, O. B., Sørensen, E., Erikstrup, C., Bruun, M. T., Nielsen, K. R., Køber, L., Christensen, A. H., Iversen, K. & 16 others, Jones, D., Knowlton, K. U., Nadauld, L., Halldorsson, G. H., Ferkingstad, E., Olafsson, I., Gretarsdottir, S., Onundarson, P. T., Sulem, P., Thorsteinsdottir, U., Thorgeirsson, G., Gudbjartsson, D. F., Stefansson, K., Holm, H., Olesen, Morten Steen Salling & Bundgård, Henning, 2023, In: Nature Genetics. 55, p. 399-409 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Global priorities for large-scale biomarker-based prospective cohorts

    Collins, R., Balaconis, M. K., Brunak, Søren, Chen, Z., De Silva, M., Gaziano, J. M., Ginsburg, G. S., Jha, P., Kuri, P., Metspalu, A., Mulder, N. & Risch, N., 2022, In: Cell Genomics. 2, 6, 4 p., 100141.

    Research output: Contribution to journal › Comment/debate › Research

  53. Published

    Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae

    Regenberg, Birgitte, Grotkjaer, T., Winther, Ole, Fausbøll, A., Akesson, M., Bro, C., Hansen, L. K., Brunak, Søren & Nielsen, Jens Bo, 2006, In: Genome Biology (Online Edition). 7, 11, p. R107

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population

    Nissen, J., Trabjerg, B., Pedersen, M. G., Banasik, K., Pedersen, O. B., Sørensen, E., Nielsen, K. R., Erikstrup, C., Petersen, M. S., Paarup, H. M., Bruun-Rasmussen, P., Westergaard, D., Hansen, T. F., Pedersen, C. B., Werge, T., Torrey, F., Hjalgrim, H., Mortensen, P. B., Yolken, R., Brunak, S. & 2 others, Ullum, H. & Burgdorf, K. S., Oct 2019, In: Psychoneuroendocrinology. 108, p. 150-154

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    High-Throughput Sequencing-Based Investigation of Viruses in Human Cancers by Multienrichment Approach

    Mollerup, S., Asplund, M., Friis-Nielsen, J., Kjartansdóttir, K. R., Fridholm, H., Hansen, T. A., Herrera, J. A. R., Barnes, C. J., Jensen, R. H., Richter, S. R., Nielsen, I. B., Pietroni, C., Alquezar-Planas, D. E., Rey-Iglesia, A., Olsen, P. V. S., Rajpert-De Meyts, E., Groth-Pedersen, L., von Buchwald, C., Jensen, D. H., Gniadecki, R. & 20 others, Høgdall, Estrid Vilma Solyom, Langhoff, J. L., Pete, I., Vereczkey, I., Baranyai, Z., Dybkaer, K., Johnsen, H. E., Steiniche, T., Hokland, P., Rosenberg, Jacob, Baandrup, U., Sicheritz-Pontén, Thomas, Willerslev, Eske, Brunak, Søren, Lund, O., Mourier, T., Vinner, Lasse, Izarzugaza, J. M. G., Nielsen, L. P. & Hansen, Anders Johannes, 15 Oct 2019, In: The Journal of Infectious Diseases. 220, 8, p. 1312-1324

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    High-throughput sequencing of circulating plasma microRNAs in newly diagnosed type 1 diabetes identifies four different patient clusters

    Sebastiani, G., Grieco, G. E., Fignani, D., Chmura, Piotr Jaroslaw, Brorsson, C. A., Bruggraber, S., Pugliese, A., Evans-Molina, C., Knip, M., Peakman, M., Schulte, A. M., Brunak, Søren, Dunger, D. B., Mathieu, C. & Dotta, F., 2020, In: Diabetologia. 63, Suppl. 1, p. S160 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  57. Published

    How Suitable Are Registry Data for Recurrence Risk Calculations? Validation of Diagnoses on 1,593 Families With Congenital Heart Disease

    Ellesøe, S. G., Jensen, A. B., Ängquist, Lars, Hjortdal, V. E., Larsen, Lars Allan & Brunak, Søren, Mar 2016, In: World journal for pediatric & congenital heart surgery. 7, 2, p. 169-77 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Human gut microbes impact host serum metabolome and insulin sensitivity

    Pedersen, H. K., Gudmundsdottir, V., Nielsen, H. B., Hyotylainen, T., Nielsen, T., Jensen, B. A. H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., Le Chatelier, E., Levenez, F., Doré, J., Mattila, I., Plichta, D. R., Pöhö, P., Hellgren, L. I., Arumugam, M., Sunagawa, S., Vieira-Silva, S. & 14 others, Jørgensen, T., Holm, J. B., Trošt, K., Kristiansen, Karsten, Brix, Susanne, Raes, J., Wang, J., Hansen, Torben, Bork, P., Brunak, Søren, Oresic, M., Ehrlich, S. D., Pedersen, Oluf Borbye & MetaHIT Consortium, M. C., 2016, In: Nature. 535, 7612, p. 376-381 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis

    Berchtold, L. A., Størling, Z. M., Ortis, F., Lage, K., Bang-Berthelsen, C., Bergholdt, R., Hald, J., Brorsson, C. A., Eizirik, D. L., Pociot, Flemming, Brunak, Søren & Størling, Joachim, 2011, In: PNAS Early Edition. 108, 37, p. E681-8

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism

    Kristensen, D. M., Desdoits-Lethimonier, C., Mackey, Abigail, Dalgaard, M. D., De Masi, F., Munkbøl, C. H., Styrishave, Bjarne, Antignac, J., Le Bizec, B., Platel, C., Hay-Schmidt, Anders, Jensen, T. K., Lesné, L., Mazaud-Guittot, S., Kristiansen, Karsten, Brunak, Søren, Kjær, Michael, Juul, Anders & Jégou, B., 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. e715-e724 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Identification of Heterogenous Treatment Response Trajectories to anti-IL6 Receptor Treatment in Rheumatoid Arthritis

    Blair, J. P. M., Bager, C., Tang, M. H. E., Karsdal, M., Bay-Jensen, A. & Brunak, Søren, Oct 2019, In: Arthritis & Rheumatology. 71, S10, 3 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  62. Published

    Identification of T1D susceptibility genes within the MHC region by combining protein interaction networks and SNP genotyping data

    Brorsson, C., Hansen, N. T., Lage, K., Bergholdt, R., Brunak, Søren, Pociot, Flemming & Diabetes Genetics Consortium, D. G. C., Feb 2009, In: Diabetes, Obesity and Metabolism Online. 11, SUPPL. 1, p. 60-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer

    Börcsök, J., Sztupinszki, Z., Bekele, R., Gao, S. P., Diossy, M., Samant, A. S., Dillon, K. M., Tisza, V., Spisák, S., Rusz, O., Csabai, I., Pappot, H., Frazier, Z. J., Konieczkowski, D. J., Liu, D., Vasani, N., Rodrigues, J. A., Solit, D. B., Hoffman-Censits, J. H., Plimack, E. R. & 10 others, Rosenberg, J. E., Lazaro, J., Taplin, M., Iyer, G., Brunak, Søren, Lozsa, R., Van Allen, E. M., Szüts, D., Mouw, K. W. & Szallasi, Z., 2021, In: Clinical Cancer Research. 27, 7, p. 2011-2022 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Identification of biomarkers for glycaemic deterioration in type 2 diabetes

    Slieker, R. C., Donnelly, L. A., Akalestou, E., Lopez-Noriega, L., Melhem, R., Güneş, A., Abou Azar, F., Efanov, A., Georgiadou, E., Muniangi-Muhitu, H., Sheikh, M., Giordano, G. N., Åkerlund, M., Ahlqvist, E., Ali, A., Banasik, K., Brunak, S., Barovic, M., Bouland, G. A., Burdet, F. & 46 others, Canouil, M., Dragan, I., Elders, P. J. M., Fernandez, C., Festa, A., Fitipaldi, H., Froguel, P., Gudmundsdottir, V., Gudnason, V., Gerl, M. J., van der Heijden, A. A., Jennings, L. L., Hansen, M. K., Kim, M., Leclerc, I., Klose, C., Kuznetsov, D., Mansour Aly, D., Mehl, F., Marek, D., Melander, O., Niknejad, A., Ottosson, F., Pavo, I., Duffin, K., Syed, S. K., Shaw, J. L., Cabrera, O., Pullen, T. J., Simons, K., Solimena, M., Suvitaival, T., Wretlind, A., Rossing, Peter, Lyssenko, V., Legido Quigley, C., Groop, L., Thorens, B., Franks, P. W., Lim, G. E., Estall, J., Ibberson, M., Beulens, J. W. J., 't Hart, L. M., Pearson, E. R. & Rutter, G. A., 2023, In: Nature Communications. 14, 18 p., 2533.

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Identification of heterogenous treatment response trajectories to anti-IL6 receptor treatment in rheumatoid arthritis

    Blair, J. P. M., Bay-Jensen, A. -., Tang, M. H., Frederiksen, P., Bager, C., Karsdal, M. & Brunak, Søren, 2020, In: Scientific Reports. 10, 1, 9 p., 13975.

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Identification of hyper-rewired genomic stress non-oncogene addiction genes across 15 cancer types

    Hjaltelin, Jessica Xin, Izarzugaza, J. M. G., Jensen, Lars Juhl, Russo, F., Westergaard, David & Brunak, Søren, 2019, In: npj Systems Biology and Applications. 5, 10 p., 27.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Identification of known and novel recurrent viral sequences in data from multiple patients and multiple cancers

    Friis-Nielsen, J., Kjartansdóttir, K. R., Mollerup, S., Asplund, M., Mourier, T., Jensen, R. H., Hansen, T. A., Rey de la Iglesia, A., Richter, S. R., Nielsen, I. B., Alquezar Planas, D. E., Olsen, P. V. S., Vinner, L., Fridholm, E. M. H., Nielsen, L. P., Willerslev, E., Sicheritz-Pontén, T., Lund, O., Hansen, A. J., Izarzugaza, J. M. G. & 1 others, Brunak, Søren, 2016, In: Viruses. 8, 2, 16 p., 53.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Identification of odorant-receptor interactions by global mapping of the human odorome

    Audouze, K. M. L., Tromelin, A., Le Bon, A. M., Belloir, C., Petersen, R. K., Kristiansen, Karsten, Brunak, Søren & Taboureau, O., 2014, In: PLOS ONE. 9, 4, p. e93037 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Identifying Sepsis Phenotypes

    Moseley, P. L. & Brunak, Søren, 2019, In: J A M A: The Journal of the American Medical Association. 322, 14, p. 1416-1417 2 p.

    Research output: Contribution to journal › Comment/debate › Research

  70. Published

    Identifying patients at high risk of inappropriate drug dosing in periods with renal dysfunction

    Kaas-Hansen, Benjamin Skov, Rodriguez, C. L., Placido, Davide, Thorsen-Meyer, H., Nielsen, A. P., Dérian, N., Brunak, Søren & Andersen, Stig Ejdrup, 2021, medRxiv.

    Research output: Working paper › Preprint › Research

  71. Published

    Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers

    Tsafou, K., Katschnig, A. M., Radic-Sarikas, B., Mutz, C. N., Iljin, K., Schwentner, R., Kauer, M. O., Mühlbacher, K., Aryee, D. N. T., Westergaard, David, Haapa-Paananen, S., Fey, V., Superti-Furga, G., Toretsky, J., Brunak, Søren & Kovar, H., 2018, In: OncoTarget. 9, 57, p. 31018-31031 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Immune Profiling of Human Gut-Associated Lymphoid Tissue Identifies a Role for Isolated Lymphoid Follicles in Priming of Region-Specific Immunity

    Fenton, T. M., Jørgensen, P. B., Niss, K., Rubin, S. J. S., Mörbe, U. M., Riis, Lene Buhl, Da Silva, C., Plumb, A., Vandamme, J., Jakobsen, H. L., Brunak, Søren, Habtezion, A., Nielsen, Ole Haagen, Johansson-Lindbom, B. & Agace, W. W., 2020, In: Immunity. 52, 3, p. 557-570, e1-e6

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization

    Pappalardo, F., Halling-Brown, M. D., Rapin, N., Zhang, P., Alemani, D., Emerson, A., Paci, P., Duroux, L. P., Pennisi, M., Palladini, A., Miotto, O., Churchill, D., Rossi, E., Shepherd, A. J., Moss, D. S., Castiglione, F., Bernaschi, M., Lefranc, M-P., Brunak, S., Motta, S. & 3 others, Lollini, P., Basford, K. E. & Brusic, V., 2009, In: Briefings in Bioinformatics. 10, 3, p. 330-40 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  74. Published

    Impaired Vitamin D Signaling in T Cells From a Family With Hereditary Vitamin D Resistant Rickets

    Al-Jaberi, F. A. H., Kongsbak-Wismann, Martin, Aguayo-Orozco, A., Krogh, Nicolai, Buus, Terkild Brink, Lopez, D. V., Rode, A. K. O., Gravesen, Eva, Ølgaard, Klaus, Brunak, Søren, Woetmann, Anders , Ødum, Niels, Bonefeld, Charlotte Menne & Geisler, Carsten, 2021, In: Frontiers in Immunology. 12, 11 p., 684015.

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Published

    Implementation and comparison of two text mining methods with a standard pharmacovigilance method for signal detection of medication errors

    Eskildsen, N. K., Eriksson, R., Christensen, S. B., Aghassipour, T. S., Bygsø, M. J., Brunak, Søren & Hansen, S. L., 2020, In: BMC Medical Informatics and Decision Making. 20, 1, 11 p., 94.

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects

    Orozco, A. A., Audouze, K., Brunak, Søren & Taboureau, O., 2016, In: Current Pharmaceutical Design. 22, 46, p. 6895-6902 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    Incorporating symptom data in longitudinal disease trajectories for more detailed patient stratification

    Lademann, M., Lademann, M., Boeck Jensen, A. & Brunak, Søren, 2019, In: International Journal of Medical Informatics. 129, p. 107-113 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. Published

    Increase in clinically recorded type 2 diabetes after colectomy

    Jensen, A. B., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye, Jess, T., Brunak, Søren & Allin, K. H., 2018, In: eLife. 7, e37420.

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. Published

    Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics

    Rasmussen, Henrik Berg, Bjerre, D., Linnet, Kristian, Jürgens, G., Dalhoff, Kim, Stefansson, H., Hankemeier, T., Kaddurah-Daouk, R., Taboureau, O., Brunak, Søren, Houmann, T., Jeppesen, Pia, Pagsberg, Anne Katrine, Plessen, K., Dyrborg, J., Hansen, Peter Riis, Hansen, P. E., Hughes, T., Werge, Thomas & INDICES Consortium, I. C., Apr 2015, In: Pharmacogenomics. 16, 6, p. 649-65

    Research output: Contribution to journal › Review › Research › peer-review

  80. Infrastruktur for klinik og forskning i Nationalt Genom Center

    Ørntoft, T. F., Brunak, Søren, Jespergaard, C., Heickendorff, L., Grønkjær, K. & Løngreen, P., 1 Apr 2019, In: Ugeskrift for Laeger. 181, 7A

    Research output: Contribution to journal › Journal article › Communication

  81. Published

    Integrating Longitudinal Clinical and Baseline Multiomics Data for Predicting C-Peptide Progression in Newly Diagnosed Type 1 Diabetes: 1111-P

    Brorsson, C., Armenteros, J. J. A., Mazzoni, G., Kaur, S., Schulte, A. M., Mathieu, C. & Brunak, Søren, 2021. 1 p.

    Research output: Contribution to conference › Poster › Research

  82. Integration of clinical chemistry, expression, and metabolite data leads to better toxicological class separation

    Spicker, J., Brunak, Søren, Frederiksen, K. & Toft, H., 2008, In: Toxicological sciences : an official journal of the Society of Toxicology. 102, 2, p. 444-54 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Integration of known DNA, RNA and protein biomarkers provides prediction of anti-TNF response in rheumatoid arthritis: results from the COMBINE study

    Folkersen, L., Brynedal, B., Diaz-Gallo, L. M., Ramsköld, D., Shchetynsky, K., Westerlind, H., Sundström, Y., Schepis, D., Hensvold, A., Vivar, N., Eloranta, M., Rönnblom, L., Brunak, Søren, Malmström, V., Catrina, A. I., Mørch, U. G., Klareskog, L., Padyukov, L. & Berg, L., 2016, In: Molecular medicine (Cambridge, Mass.). 22, p. 3223328

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    Integrative analysis for finding genes and networks involved in diabetes and other complex diseases

    Bergholdt, R., Størling, Z. M., Lage, K., Karlberg, E. O., Olason, P. I., Aalund, M., Nerup, J., Brunak, Søren, Workman, C. & Pociot, Flemming, 2007, In: Genome Biology (Online Edition). 8, 11, p. R253

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. E-pub ahead of print

    Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis

    DBDS Genomic Consortium, D. G. C., 2024, (E-pub ahead of print) In: Nature Genetics. 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

    Gudmundsdottir, V., Pedersen, H. K., Allebrandt, K. V., Brorsson, C. A., van Leeuwen, N., Banasik, K., Mahajan, A., Groves, C. J., van de Bunt, M., Dawed, A. Y., Fritsche, A., Staiger, H., Simonis-Bik, A. M. C., Deelen, J., Kramer, M. H. H., Dietrich, A., Hübschle, T., Willemsen, G., Häring, H-U., de Geus, E. J. C. & 8 others, Boomsma, D. I., Eekhoff, E. M. W., Ferrer, J., McCarthy, M. I., Pearson, E. R., Gupta, R., Brunak, Søren & 't Hart, L. M., 2018, In: P L o S One. 13, 1, p. 1-19 e0189886.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    Integrative pathway enrichment analysis of multivariate omics data

    Paczkowska, M., Barenboim, J., Sintupisut, N., Fox, N. S., Zhu, H., Abd-Rabbo, D., Mee, M. W., Boutros, P. C., Abascal, F., Amin, S. B., Bader, G. D., Beroukhim, R., Bertl, J., Boroevich, K. A., Brunak, S., Campbell, P. J., Carlevaro-Fita, J., Chakravarty, D., Chan, C. W. Y., Chen, K. & 30 others, Choi, J. K., Deu-Pons, J., Dhingra, P., Diamanti, K., Feuerbach, L., Fink, J. L., Fonseca, N. A., Frigola, J., Gambacorti-Passerini, C., Garsed, D. W., Gerstein, M., Getz, G., Gonzalez-Perez, A., Guo, Q., Gut, I. G., Haan, D., Hamilton, M. P., Haradhvala, N. J., Harmanci, A. O., Helmy, M., Herrmann, C., Hess, J. M., Hobolth, A., Hodzic, E., Hong, C., Hornshøj, H., Nielsen, M. M., Pedersen, J. S., Sidiropoulos, N. & Weischenfeldt, Joachim Lütken, 5 Feb 2020, In: Nature Communications. 11, 1, 735.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    Intervening on the Storage Time of RBC Units and its Effects on Adverse Recipient Outcomes using Real-World Data

    Bruun-Rasmussen, P., Andersen, Per Kragh, Banasik, Karina, Brunak, Søren & Jo­hans­son, Pär In­ge­mar , 2022, In: Blood. 139, 25, p. 3647–3654

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

    Kristensen, D. M., Hass, U., Lesné, L., Lottrup, G., Jacobsen, P. R., Desdoits-Lethimonier, C., Boberg, J., Petersen, Jørgen Holm, Toppari, J., Jensen, T. K., Brunak, Søren, Skakkebæk, Niels Erik, Nellemann, C., Main, Katharina Maria, Jégou, B. & Leffers, H., 2011, In: Human Reproduction. 26, 1, p. 235-44 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Investigating the impact of missense mutations in hCES1 by in silico structure-based approaches

    Nzabonimpa, G. S., Rasmussen, Henrik Berg, Brunak, Søren, Taboureau, O. & INDICES Consortium, I. C., Jun 2016, In: Drug Metabolism and Personalized Therapy. 31, 2, p. 97-106 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    Investigation of human cancers for retrovirus by low-stringency target enrichment and high-throughput sequencing

    Vinner, Lasse, Mourier, T., Friis-Nielsen, J., Gniadecki, R., Dybkaer, K., Rosenberg, J., Langhoff, J. L., Flores Santa Cruz, D., Fonager, J., Izarzugaza, J. M. G., Gupta, R., Sicheritz-Ponten, T., Brunak, Søren, Willerslev, Eske, Nielsen, L. P. & Hansen, Anders Johannes, 2015, In: Scientific Reports. 5, 13 p., 13201.

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    KinMutRF: a random forest classifier of sequence variants in the human protein kinase superfamily

    Pons, T., Vazquez, M., Matey-Hernandez, M. L., Brunak, Søren, Valencia, A. & Izarzugaza, J. M., 23 Jun 2016, In: BMC Genomics. 17, Suppl 2, 11 p., 396.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    Klinefelter syndrome comorbidities linked to increased X chromosome gene dosage and altered protein interactome activity

    Belling, K., Russo, F., Jensen, A. B., Dalgaard, M. D., Westergaard, David, Rajpert-De Meyts, E., Skakkebæk, Niels Erik, Juul, Anders & Brunak, Søren, 1 Apr 2017, In: Human Molecular Genetics. 26, 7, p. 1219-1229 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. Published

    Knowledge engineering for health: a new discipline required to bridge the "ICT gap" between research and healthcare

    Beck, T., Gollapudi, S., Brunak, Søren, Graf, N., Lemke, H. U., Dash, D., Buchan, I., Díaz, C., Sanz, F. & Brookes, A. J., May 2012, In: Human Mutation. 33, 5, p. 797-802 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    Language-agnostic pharmacovigilant text mining to elicit side effects from clinical notes and hospital medication records

    Kaas-Hansen, Benjamin Skov, Placido, Davide, Rodríguez, C. L., Thorsen-Meyer, H., Gentile, S., Nielsen, A. P., Brunak, Søren, Jürgens, Gesche & Andersen, Stig Ejdrup, 2022, In: Basic & clinical pharmacology & toxicology. 131, 4, p. 282-293 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Published

    Language-agnostic pharmacovigilant text mining to elicit side effects from clinical notes and hospital medication records

    Kaas-Hansen, Benjamin Skov, Placido, Davide, Rodrìguez, C. L., Thorsen-Meyer, H., Gentile, S., Nielsen, A. P., Brunak, Søren, Jürgens, Gesche & Andersen, Stig Ejdrup, 2022, Authorea, (Authorea Preprints).

    Research output: Working paper › Preprint › Research

  97. Lapatinib potentiates cytotoxicity of  YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter

    Radic-Sarikas, B., Halasz, M., Huber, K. V. M., Winter, G. E., Tsafou, K. P., Papamarkou, T., Brunak, Søren, Kolch, W. & Superti-Furga, G., 8 Jun 2017, In: Scientific Reports. 7, 1, p. 3091

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders

    Burgdorf, K. S., Trabjerg, B., Giørtz Pedersen, M., Nissen, J., Banasik, K., Birger Pedersen, O., Sørensen, E., René Nielsen, K., Hørup Larsen, M., Erikstrup, C., Bruun-Rasmussen, P., Westergaard, D., Wegner Thørner, L., Hjalgrim, H., Martina Paarup, H., Brunak, S., Pedersen, C. B., Fuller Torrey, E., Werge, T., Bo Mortensen, P. & 2 others, Yolken, R. & Ullum, H., 2019, In: Brain, Behavior, and Immunity. 79, p. 152-158

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Legacy data sharing to improve drug safety assessment: the eTOX project

    Sanz, F., Pognan, F., Steger-Hartmann, T., Díaz, C., Cases, M., Pastor, M., Marc, P., Wichard, J., Briggs, K., Watson, D. K., Kleinöder, T., Yang, C., Amberg, A., Beaumont, M., Brookes, A. J., Brunak, S., Cronin, M. T. D., Ecker, G. F., Escher, S., Greene, N. & 17 others, Guzmán, A., Hersey, A., Jacques, P., Lammens, L., Mestres, J., Muster, W., Northeved, H., Pinches, M., Saiz, J., Sajot, N., Valencia, A., van der Lei, J., Vermeulen, N. P. E., Vock, E., Wolber, G., Zamora, I. & eTOX, E., Dec 2017, In: Nature Reviews. Drug Discovery. 16, 12, p. 811-812 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. Published

    Leveraging European infrastructures to access 1 million human genomes by 2022

    Saunders, G., Baudis, M., Becker, R., Beltran, S., Béroud, C., Birney, E., Brooksbank, C., Brunak, S., Van den Bulcke, M., Drysdale, R., Capella-Gutierrez, S., Flicek, P., Florindi, F., Goodhand, P., Gut, I., Heringa, J., Holub, P., Hooyberghs, J., Juty, N., Keane, T. M. & 21 others, Korbel, J. O., Lappalainen, I., Leskosek, B., Matthijs, G., Mayrhofer, M. T., Metspalu, A., Navarro, A., Newhouse, S., Nyrönen, T., Page, A., Persson, B., Palotie, A., Parkinson, H., Rambla, J., Salgado, D., Steinfelder, E., Swertz, M. A., Valencia, A., Varma, S., Blomberg, N. & Scollen, S., 2019, In: Nature Reviews. Genetics. 20, p. 693-701 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

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