SLiM-binding pockets: an attractive target for broad-spectrum antivirals

Research output: Contribution to journal › Review › Research › peer-review

Standard

SLiM-binding pockets : an attractive target for broad-spectrum antivirals. / Simonetti, Leandro; Nilsson, Jakob; McInerney, Gerald; Ivarsson, Ylva; Davey, Norman E.

In: Trends in Biochemical Sciences, Vol. 48, No. 5, 2023, p. 420-427.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Simonetti, L, Nilsson, J, McInerney, G, Ivarsson, Y & Davey, NE 2023, 'SLiM-binding pockets: an attractive target for broad-spectrum antivirals', Trends in Biochemical Sciences, vol. 48, no. 5, pp. 420-427. https://doi.org/10.1016/j.tibs.2022.12.004

APA

Simonetti, L., Nilsson, J., McInerney, G., Ivarsson, Y., & Davey, N. E. (2023). SLiM-binding pockets: an attractive target for broad-spectrum antivirals. Trends in Biochemical Sciences, 48(5), 420-427. https://doi.org/10.1016/j.tibs.2022.12.004

Vancouver

Simonetti L, Nilsson J, McInerney G, Ivarsson Y, Davey NE. SLiM-binding pockets: an attractive target for broad-spectrum antivirals. Trends in Biochemical Sciences. 2023;48(5):420-427. https://doi.org/10.1016/j.tibs.2022.12.004

Author

Simonetti, Leandro ; Nilsson, Jakob ; McInerney, Gerald ; Ivarsson, Ylva ; Davey, Norman E. / SLiM-binding pockets : an attractive target for broad-spectrum antivirals. In: Trends in Biochemical Sciences. 2023 ; Vol. 48, No. 5. pp. 420-427.

Bibtex

@article{8b1cbe173b684124a4311b6ff947a59c,
title = "SLiM-binding pockets: an attractive target for broad-spectrum antivirals",
abstract = "Short linear motif (SLiM)-mediated interactions offer a unique strategy for viral intervention due to their compact interfaces, ease of convergent evolution, and key functional roles. Consequently, many viruses extensively mimic host SLiMs to hijack or deregulate cellular pathways and the same motif-binding pocket is often targeted by numerous unrelated viruses. A toolkit of therapeutics targeting commonly mimicked SLiMs could provide prophylactic and therapeutic broad-spectrum antivirals and vastly improve our ability to treat ongoing and future viral outbreaks. In this opinion article, we discuss the therapeutic relevance of SLiMs, advocating their suitability as targets for broad-spectrum antiviral inhibitors.",
keywords = "inhibitors, protein–protein interactions, short linear motifs, viral outbreak preparedness, viruses",
author = "Leandro Simonetti and Jakob Nilsson and Gerald McInerney and Ylva Ivarsson and Davey, {Norman E.}",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2023",
doi = "10.1016/j.tibs.2022.12.004",
language = "English",
volume = "48",
pages = "420--427",
journal = "Trends in Biochemical Sciences",
issn = "0968-0004",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - SLiM-binding pockets

T2 - an attractive target for broad-spectrum antivirals

AU - Simonetti, Leandro

AU - Nilsson, Jakob

AU - McInerney, Gerald

AU - Ivarsson, Ylva

AU - Davey, Norman E.

N1 - Publisher Copyright: © 2022 The Authors

PY - 2023

Y1 - 2023

N2 - Short linear motif (SLiM)-mediated interactions offer a unique strategy for viral intervention due to their compact interfaces, ease of convergent evolution, and key functional roles. Consequently, many viruses extensively mimic host SLiMs to hijack or deregulate cellular pathways and the same motif-binding pocket is often targeted by numerous unrelated viruses. A toolkit of therapeutics targeting commonly mimicked SLiMs could provide prophylactic and therapeutic broad-spectrum antivirals and vastly improve our ability to treat ongoing and future viral outbreaks. In this opinion article, we discuss the therapeutic relevance of SLiMs, advocating their suitability as targets for broad-spectrum antiviral inhibitors.

AB - Short linear motif (SLiM)-mediated interactions offer a unique strategy for viral intervention due to their compact interfaces, ease of convergent evolution, and key functional roles. Consequently, many viruses extensively mimic host SLiMs to hijack or deregulate cellular pathways and the same motif-binding pocket is often targeted by numerous unrelated viruses. A toolkit of therapeutics targeting commonly mimicked SLiMs could provide prophylactic and therapeutic broad-spectrum antivirals and vastly improve our ability to treat ongoing and future viral outbreaks. In this opinion article, we discuss the therapeutic relevance of SLiMs, advocating their suitability as targets for broad-spectrum antiviral inhibitors.

KW - inhibitors

KW - protein–protein interactions

KW - short linear motifs

KW - viral outbreak preparedness

KW - viruses

U2 - 10.1016/j.tibs.2022.12.004

DO - 10.1016/j.tibs.2022.12.004

M3 - Review

C2 - 36623987

AN - SCOPUS:85146064804

VL - 48

SP - 420

EP - 427

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0968-0004

IS - 5

ER -

ID: 335963235