Protein-driven inference of miRNA-disease associations

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Søren Mørk, Sune Pletscher-Frankild, Albert Palleja, Jan Gorodkin, Lars Juhl Jensen

MicroRNAs (miRNAs) are a highly abundant class of non-coding RNA genes involved in cellular regulation and thus also diseases. Despite miRNAs being important disease factors, miRNA-disease associations remain low in number and of variable reliability. Furthermore, existing databases and prediction methods do not explicitly facilitate forming hypotheses about the possible molecular causes of the association, thereby making the path to experimental follow-up longer.
Original languageEnglish
JournalBioinformatics (Oxford, England)
Volume30
Issue number3
Pages (from-to)392-397
Number of pages6
ISSN1367-4803
DOIs
Publication statusPublished - 2014

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