Protein-driven inference of miRNA-disease associations
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Protein-driven inference of miRNA-disease associations. / Mørk, Søren; Pletscher-Frankild, Sune; Palleja, Albert; Gorodkin, Jan; Jensen, Lars Juhl.
In: Bioinformatics (Oxford, England), Vol. 30, No. 3, 2014, p. 392-397.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Protein-driven inference of miRNA-disease associations
AU - Mørk, Søren
AU - Pletscher-Frankild, Sune
AU - Palleja, Albert
AU - Gorodkin, Jan
AU - Jensen, Lars Juhl
PY - 2014
Y1 - 2014
N2 - MicroRNAs (miRNAs) are a highly abundant class of non-coding RNA genes involved in cellular regulation and thus also diseases. Despite miRNAs being important disease factors, miRNA-disease associations remain low in number and of variable reliability. Furthermore, existing databases and prediction methods do not explicitly facilitate forming hypotheses about the possible molecular causes of the association, thereby making the path to experimental follow-up longer.
AB - MicroRNAs (miRNAs) are a highly abundant class of non-coding RNA genes involved in cellular regulation and thus also diseases. Despite miRNAs being important disease factors, miRNA-disease associations remain low in number and of variable reliability. Furthermore, existing databases and prediction methods do not explicitly facilitate forming hypotheses about the possible molecular causes of the association, thereby making the path to experimental follow-up longer.
U2 - 10.1093/bioinformatics/btt677
DO - 10.1093/bioinformatics/btt677
M3 - Journal article
C2 - 24273243
VL - 30
SP - 392
EP - 397
JO - Computer Applications in the Biosciences
JF - Computer Applications in the Biosciences
SN - 1471-2105
IS - 3
ER -
ID: 88175763