Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle

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Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle. / Deshmukh, Atul S.

In: Hormone Molecular Biology and Clinical Investigation, Vol. 26, No. 1, 01.04.2016, p. 13-24.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Deshmukh, AS 2016, 'Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle', Hormone Molecular Biology and Clinical Investigation, vol. 26, no. 1, pp. 13-24. https://doi.org/10.1515/hmbci-2015-0041

APA

Deshmukh, A. S. (2016). Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle. Hormone Molecular Biology and Clinical Investigation, 26(1), 13-24. https://doi.org/10.1515/hmbci-2015-0041

Vancouver

Deshmukh AS. Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle. Hormone Molecular Biology and Clinical Investigation. 2016 Apr 1;26(1):13-24. https://doi.org/10.1515/hmbci-2015-0041

Author

Deshmukh, Atul S. / Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle. In: Hormone Molecular Biology and Clinical Investigation. 2016 ; Vol. 26, No. 1. pp. 13-24.

Bibtex

@article{2e1fe4f84c044c6daf5c87f4995675aa,
title = "Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle",
abstract = "Skeletal muscle is the largest tissues in the human body and is considered the primary target for insulin-stimulated glucose disposal. In skeletal muscle, binding of the insulin to insulin receptor (IR) initiates a signaling cascade that results in the translocation of the insulin-sensitive glucose transporter protein 4 (GLUT4) to the plasma membrane which leads to facilitated diffusion of glucose into the cell. Understanding the precise signaling events guiding insulin-stimulated glucose uptake is pivotal, because impairment in these signaling events leads to development of insulin resistance and type 2 diabetes. This review summarizes current understanding of insulin signaling pathways mediating glucose uptake in healthy and insulin-resistant skeletal muscle.",
keywords = "Journal Article",
author = "Deshmukh, {Atul S}",
year = "2016",
month = "4",
day = "1",
doi = "10.1515/hmbci-2015-0041",
language = "English",
volume = "26",
pages = "13--24",
journal = "Hormone Molecular Biology and Clinical Investigation",
issn = "1868-1883",
publisher = "Walterde Gruyter GmbH",
number = "1",

}

RIS

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T1 - Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle

AU - Deshmukh, Atul S

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Skeletal muscle is the largest tissues in the human body and is considered the primary target for insulin-stimulated glucose disposal. In skeletal muscle, binding of the insulin to insulin receptor (IR) initiates a signaling cascade that results in the translocation of the insulin-sensitive glucose transporter protein 4 (GLUT4) to the plasma membrane which leads to facilitated diffusion of glucose into the cell. Understanding the precise signaling events guiding insulin-stimulated glucose uptake is pivotal, because impairment in these signaling events leads to development of insulin resistance and type 2 diabetes. This review summarizes current understanding of insulin signaling pathways mediating glucose uptake in healthy and insulin-resistant skeletal muscle.

AB - Skeletal muscle is the largest tissues in the human body and is considered the primary target for insulin-stimulated glucose disposal. In skeletal muscle, binding of the insulin to insulin receptor (IR) initiates a signaling cascade that results in the translocation of the insulin-sensitive glucose transporter protein 4 (GLUT4) to the plasma membrane which leads to facilitated diffusion of glucose into the cell. Understanding the precise signaling events guiding insulin-stimulated glucose uptake is pivotal, because impairment in these signaling events leads to development of insulin resistance and type 2 diabetes. This review summarizes current understanding of insulin signaling pathways mediating glucose uptake in healthy and insulin-resistant skeletal muscle.

KW - Journal Article

U2 - 10.1515/hmbci-2015-0041

DO - 10.1515/hmbci-2015-0041

M3 - Review

VL - 26

SP - 13

EP - 24

JO - Hormone Molecular Biology and Clinical Investigation

JF - Hormone Molecular Biology and Clinical Investigation

SN - 1868-1883

IS - 1

ER -

ID: 170597168