Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle
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Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle. / Deshmukh, Atul S.
In: Hormone Molecular Biology and Clinical Investigation, Vol. 26, No. 1, 01.04.2016, p. 13-24.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle
AU - Deshmukh, Atul S
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Skeletal muscle is the largest tissues in the human body and is considered the primary target for insulin-stimulated glucose disposal. In skeletal muscle, binding of the insulin to insulin receptor (IR) initiates a signaling cascade that results in the translocation of the insulin-sensitive glucose transporter protein 4 (GLUT4) to the plasma membrane which leads to facilitated diffusion of glucose into the cell. Understanding the precise signaling events guiding insulin-stimulated glucose uptake is pivotal, because impairment in these signaling events leads to development of insulin resistance and type 2 diabetes. This review summarizes current understanding of insulin signaling pathways mediating glucose uptake in healthy and insulin-resistant skeletal muscle.
AB - Skeletal muscle is the largest tissues in the human body and is considered the primary target for insulin-stimulated glucose disposal. In skeletal muscle, binding of the insulin to insulin receptor (IR) initiates a signaling cascade that results in the translocation of the insulin-sensitive glucose transporter protein 4 (GLUT4) to the plasma membrane which leads to facilitated diffusion of glucose into the cell. Understanding the precise signaling events guiding insulin-stimulated glucose uptake is pivotal, because impairment in these signaling events leads to development of insulin resistance and type 2 diabetes. This review summarizes current understanding of insulin signaling pathways mediating glucose uptake in healthy and insulin-resistant skeletal muscle.
KW - Journal Article
U2 - 10.1515/hmbci-2015-0041
DO - 10.1515/hmbci-2015-0041
M3 - Review
C2 - 26485752
VL - 26
SP - 13
EP - 24
JO - Hormone Molecular Biology and Clinical Investigation
JF - Hormone Molecular Biology and Clinical Investigation
SN - 1868-1883
IS - 1
ER -
ID: 170597168