Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle

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Skeletal muscle is the largest tissues in the human body and is considered the primary target for insulin-stimulated glucose disposal. In skeletal muscle, binding of the insulin to insulin receptor (IR) initiates a signaling cascade that results in the translocation of the insulin-sensitive glucose transporter protein 4 (GLUT4) to the plasma membrane which leads to facilitated diffusion of glucose into the cell. Understanding the precise signaling events guiding insulin-stimulated glucose uptake is pivotal, because impairment in these signaling events leads to development of insulin resistance and type 2 diabetes. This review summarizes current understanding of insulin signaling pathways mediating glucose uptake in healthy and insulin-resistant skeletal muscle.

Original languageEnglish
JournalHormone Molecular Biology and Clinical Investigation
Issue number1
Pages (from-to)13-24
Number of pages12
Publication statusPublished - 1 Apr 2016

    Research areas

  • Journal Article

ID: 170597168