Chromatin replication and histone dynamics

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Inheritance of the DNA sequence and its proper organization into chromatin is fundamental for genome stability and function. Therefore, how specific chromatin structures are restored on newly synthesized DNA and transmitted through cell division remains a central question to understand cell fate choices and self-renewal. Propagation of genetic information and chromatin-based information in cycling cells entails genome-wide disruption and restoration of chromatin, coupled with faithful replication of DNA. In this chapter, we describe how cells duplicate the genome while maintaining its proper organization into chromatin. We reveal how specialized replication-coupled mechanisms rapidly assemble newly synthesized DNA into nucleosomes, while the complete restoration of chromatin organization including histone marks is a continuous process taking place throughout the cell cycle. Because failure to reassemble nucleosomes at replication forks blocks DNA replication progression in higher eukaryotes and leads to genomic instability, we further underline the importance of the mechanistic link between DNA replication and chromatin duplication.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
EditorsH. Masai, M. Foiani
Number of pages23
PublisherSpringer New York LLC
Publication date2017
ISBN (Print)978-981-10-6954-3
ISBN (Electronic)978-981-10-6955-0
Publication statusPublished - 2017
SeriesAdvances in Experimental Medicine and Biology

    Research areas

  • Chromatin, DNA replication, Epigenetics, Histone chaperone, Histone recycling, Nucleosome assembly

ID: 189254113