C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies

Research output: Contribution to journal › Comment/debate › Research › peer-review

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C3G self-regulatory mechanism revealed : implications for hematopoietic malignancies. / Carabias, Arturo; Guerrero, Carmen; de Pereda, José M.

In: Molecular and Cellular Oncology, Vol. 8, No. 1, 1837581, 2021.

Research output: Contribution to journal › Comment/debate › Research › peer-review

Harvard

Carabias, A, Guerrero, C & de Pereda, JM 2021, 'C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies', Molecular and Cellular Oncology, vol. 8, no. 1, 1837581. https://doi.org/10.1080/23723556.2020.1837581

APA

Carabias, A., Guerrero, C., & de Pereda, J. M. (2021). C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies. Molecular and Cellular Oncology, 8(1), [1837581]. https://doi.org/10.1080/23723556.2020.1837581

Vancouver

Carabias A, Guerrero C, de Pereda JM. C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies. Molecular and Cellular Oncology. 2021;8(1). 1837581. https://doi.org/10.1080/23723556.2020.1837581

Author

Carabias, Arturo ; Guerrero, Carmen ; de Pereda, José M. / C3G self-regulatory mechanism revealed : implications for hematopoietic malignancies. In: Molecular and Cellular Oncology. 2021 ; Vol. 8, No. 1.

Bibtex

@article{c1c683032aea4633bfa2b81273f056cf,
title = "C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies",
abstract = "Abnormally increased signaling by the GTPase RAP1 favors progression of diverse tumors. We have characterized the auto-regulation and activation of C3G (RAPGEF1), an activator of RAP1. This led us to discover mutations in non-Hodgkin{\textquoteright}s lymphomas that activate C3G-RAP1 constitutively, suggesting that deregulation of C3G may favor the dissemination of tumor cells.",
keywords = "guanine nucleotide exchange factor, non-Hodgkin{\textquoteright}s lymphoma, RAP1, RAPGEF1, signaling",
author = "Arturo Carabias and Carmen Guerrero and {de Pereda}, {Jos{\'e} M.}",
year = "2021",
doi = "10.1080/23723556.2020.1837581",
language = "English",
volume = "8",
journal = "Molecular & Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - C3G self-regulatory mechanism revealed

T2 - implications for hematopoietic malignancies

AU - Carabias, Arturo

AU - Guerrero, Carmen

AU - de Pereda, José M.

PY - 2021

Y1 - 2021

N2 - Abnormally increased signaling by the GTPase RAP1 favors progression of diverse tumors. We have characterized the auto-regulation and activation of C3G (RAPGEF1), an activator of RAP1. This led us to discover mutations in non-Hodgkin’s lymphomas that activate C3G-RAP1 constitutively, suggesting that deregulation of C3G may favor the dissemination of tumor cells.

AB - Abnormally increased signaling by the GTPase RAP1 favors progression of diverse tumors. We have characterized the auto-regulation and activation of C3G (RAPGEF1), an activator of RAP1. This led us to discover mutations in non-Hodgkin’s lymphomas that activate C3G-RAP1 constitutively, suggesting that deregulation of C3G may favor the dissemination of tumor cells.

KW - guanine nucleotide exchange factor

KW - non-Hodgkin’s lymphoma

KW - RAP1

KW - RAPGEF1

KW - signaling

U2 - 10.1080/23723556.2020.1837581

DO - 10.1080/23723556.2020.1837581

M3 - Comment/debate

C2 - 33553598

AN - SCOPUS:85097016445

VL - 8

JO - Molecular & Cellular Oncology

JF - Molecular & Cellular Oncology

SN - 2372-3556

IS - 1

M1 - 1837581

ER -

ID: 254668212